CO2017000011A2 - Derivados de quinolizinona como inhibidores de pi3k - Google Patents
Derivados de quinolizinona como inhibidores de pi3kInfo
- Publication number
- CO2017000011A2 CO2017000011A2 CONC2017/0000011A CO2017000011A CO2017000011A2 CO 2017000011 A2 CO2017000011 A2 CO 2017000011A2 CO 2017000011 A CO2017000011 A CO 2017000011A CO 2017000011 A2 CO2017000011 A2 CO 2017000011A2
- Authority
- CO
- Colombia
- Prior art keywords
- pi3k inhibitors
- prevention
- treatment
- quinolizinone derivatives
- quinolizinone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
Se divulgan compuestos de la fórmula I, sus formas tautoméricas, estereoisómeros y sales farmacéuticamente aceptables de los mismos, en donde R1-R4 y n son como se define en la descripción, las composiciones farmacéuticas incluyen un compuesto, tautómero, estereoisómero o sal del mismo, y métodos para el tratamiento o prevención de enfermedades o trastornos, por ejemplo, cáncer, que son susceptibles de tratamiento o prevención inhibiendo la enzima PI3K de un sujeto.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2182MU2014 | 2014-07-04 | ||
PCT/IB2015/054958 WO2016001855A1 (en) | 2014-07-04 | 2015-07-01 | Quinolizinone derivatives as pi3k inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2017000011A2 true CO2017000011A2 (es) | 2017-04-10 |
Family
ID=53716533
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2017/0000011A CO2017000011A2 (es) | 2014-07-04 | 2017-01-03 | Derivados de quinolizinona como inhibidores de pi3k |
Country Status (25)
Country | Link |
---|---|
US (1) | US9944639B2 (es) |
EP (1) | EP3164400A1 (es) |
JP (1) | JP6291601B2 (es) |
KR (1) | KR20170082490A (es) |
CN (1) | CN106470996B (es) |
AP (1) | AP2016009661A0 (es) |
AU (1) | AU2015283671B2 (es) |
BR (1) | BR112017000132A2 (es) |
CA (1) | CA2954231A1 (es) |
CL (1) | CL2017000006A1 (es) |
CO (1) | CO2017000011A2 (es) |
CR (1) | CR20160600A (es) |
CU (1) | CU24428B1 (es) |
EA (1) | EA201692557A1 (es) |
GE (1) | GEP20186934B (es) |
HK (1) | HK1232227A1 (es) |
IL (1) | IL249674B (es) |
MA (1) | MA40250A (es) |
MX (1) | MX2017000208A (es) |
PE (1) | PE20170640A1 (es) |
PH (1) | PH12017500007A1 (es) |
SG (1) | SG11201610770PA (es) |
SV (1) | SV2017005354A (es) |
UA (1) | UA115296C2 (es) |
WO (1) | WO2016001855A1 (es) |
Families Citing this family (7)
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EP3224248B1 (en) * | 2014-11-01 | 2021-05-05 | Shanghai Fochon Pharmaceutical Co. Ltd | Certain protein kinase inhibitors |
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KR20200112900A (ko) | 2018-01-20 | 2020-10-05 | 선샤인 레이크 파르마 컴퍼니 리미티드 | 치환된 아미노피리미딘 화합물 및 이의 사용 방법 |
WO2020038394A1 (zh) * | 2018-08-21 | 2020-02-27 | 南京明德新药研发有限公司 | 吡唑并嘧啶衍生物及其作为pi3k抑制剂的应用 |
SG11202111119PA (en) * | 2019-04-23 | 2021-11-29 | Evotec Int Gmbh | Modulators of the integrated stress response pathway |
WO2021164789A1 (zh) * | 2020-02-21 | 2021-08-26 | 南京明德新药研发有限公司 | 一种吡唑并嘧啶类化合物的晶型及其应用 |
IL310588A (en) * | 2021-08-09 | 2024-04-01 | Scorpion Therapeutics Inc | Compounds that inhibit PI3K isoform alpha and methods for treating cancer |
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WO2015168079A1 (en) | 2014-04-29 | 2015-11-05 | Infinity Pharmaceuticals, Inc. | Pyrimidine or pyridine derivatives useful as pi3k inhibitors |
CN105130966B (zh) | 2014-05-07 | 2019-05-24 | 广东东阳光药业有限公司 | 炔基化合物及其使用方法和用途 |
WO2015175579A1 (en) | 2014-05-15 | 2015-11-19 | Calitor Sciences, Llc | Alkynyl compounds and methods of use |
CN106459005A (zh) | 2014-06-13 | 2017-02-22 | 吉利德科学公司 | 磷脂酰肌醇3‑激酶抑制剂 |
MX2016016528A (es) | 2014-06-13 | 2017-03-27 | Gilead Sciences Inc | Inhibidores de fosfatidilinositol 3-quinasa. |
CA2952037A1 (en) | 2014-06-13 | 2015-12-17 | Gilead Sciences, Inc. | Phosphatidylinositol 3-kinase inhibitors |
MX2016017110A (es) | 2014-06-24 | 2017-05-01 | Gilead Sciences Inc | Inhibidores de fosfatidilinositol 3-cinasa. |
EP3224248B1 (en) | 2014-11-01 | 2021-05-05 | Shanghai Fochon Pharmaceutical Co. Ltd | Certain protein kinase inhibitors |
CN105130984B (zh) | 2015-09-23 | 2017-03-29 | 前湾医药科技(深圳)有限公司 | 一种咪唑并吡啶类化合物与在制备pi3k抑制剂中的应用 |
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2015
- 2015-07-01 WO PCT/IB2015/054958 patent/WO2016001855A1/en active Application Filing
- 2015-07-01 MA MA040250A patent/MA40250A/fr unknown
- 2015-07-01 US US15/323,565 patent/US9944639B2/en not_active Expired - Fee Related
- 2015-07-01 CN CN201580036482.9A patent/CN106470996B/zh not_active Expired - Fee Related
- 2015-07-01 CA CA2954231A patent/CA2954231A1/en not_active Abandoned
- 2015-07-01 KR KR1020177003196A patent/KR20170082490A/ko unknown
- 2015-07-01 CU CU2016000195A patent/CU24428B1/es unknown
- 2015-07-01 MX MX2017000208A patent/MX2017000208A/es unknown
- 2015-07-01 SG SG11201610770PA patent/SG11201610770PA/en unknown
- 2015-07-01 JP JP2016575554A patent/JP6291601B2/ja not_active Expired - Fee Related
- 2015-07-01 AU AU2015283671A patent/AU2015283671B2/en not_active Ceased
- 2015-07-01 CR CR20160600A patent/CR20160600A/es unknown
- 2015-07-01 EP EP15739683.9A patent/EP3164400A1/en not_active Withdrawn
- 2015-07-01 GE GEAP201514408A patent/GEP20186934B/en unknown
- 2015-07-01 UA UAA201701013A patent/UA115296C2/uk unknown
- 2015-07-01 BR BR112017000132A patent/BR112017000132A2/pt not_active Application Discontinuation
- 2015-07-01 AP AP2016009661A patent/AP2016009661A0/en unknown
- 2015-07-01 EA EA201692557A patent/EA201692557A1/ru unknown
- 2015-07-01 PE PE2016002810A patent/PE20170640A1/es unknown
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2016
- 2016-12-20 IL IL249674A patent/IL249674B/en not_active IP Right Cessation
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2017
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- 2017-01-03 SV SV2017005354A patent/SV2017005354A/es unknown
- 2017-01-03 PH PH12017500007A patent/PH12017500007A1/en unknown
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- 2017-06-16 HK HK17106009.7A patent/HK1232227A1/zh unknown
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US20170137421A1 (en) | 2017-05-18 |
CL2017000006A1 (es) | 2017-06-02 |
JP2017519786A (ja) | 2017-07-20 |
MA40250A (fr) | 2017-05-10 |
IL249674B (en) | 2019-06-30 |
IL249674A0 (en) | 2017-02-28 |
HK1232227A1 (zh) | 2018-01-05 |
WO2016001855A1 (en) | 2016-01-07 |
MX2017000208A (es) | 2017-05-01 |
JP6291601B2 (ja) | 2018-03-14 |
US9944639B2 (en) | 2018-04-17 |
CU20160195A7 (es) | 2017-05-10 |
EA201692557A1 (ru) | 2017-05-31 |
CN106470996A (zh) | 2017-03-01 |
GEP20186934B (en) | 2018-12-10 |
SV2017005354A (es) | 2018-10-05 |
CA2954231A1 (en) | 2016-01-07 |
CU24428B1 (es) | 2019-06-04 |
SG11201610770PA (en) | 2017-01-27 |
PH12017500007A1 (en) | 2017-05-15 |
EP3164400A1 (en) | 2017-05-10 |
UA115296C2 (uk) | 2017-10-10 |
AU2015283671B2 (en) | 2018-07-05 |
CR20160600A (es) | 2017-03-07 |
AP2016009661A0 (en) | 2016-12-31 |
CN106470996B (zh) | 2019-02-22 |
PE20170640A1 (es) | 2017-05-26 |
AU2015283671A1 (en) | 2017-02-02 |
KR20170082490A (ko) | 2017-07-14 |
BR112017000132A2 (pt) | 2018-01-09 |
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