CL2008002169A1 - Metodo para preparar un compuesto derivado de tetrahidro-2h-piran-3,4,5-triol-2,6-disustituido, inhibidor del contransportador de sodio y glucosa 2; compuestos intermediarios; y metodo de preparacion de los compuestos intermediarios. - Google Patents

Metodo para preparar un compuesto derivado de tetrahidro-2h-piran-3,4,5-triol-2,6-disustituido, inhibidor del contransportador de sodio y glucosa 2; compuestos intermediarios; y metodo de preparacion de los compuestos intermediarios.

Info

Publication number
CL2008002169A1
CL2008002169A1 CL2008002169A CL2008002169A CL2008002169A1 CL 2008002169 A1 CL2008002169 A1 CL 2008002169A1 CL 2008002169 A CL2008002169 A CL 2008002169A CL 2008002169 A CL2008002169 A CL 2008002169A CL 2008002169 A1 CL2008002169 A1 CL 2008002169A1
Authority
CL
Chile
Prior art keywords
intermediate compounds
preparing
preparation
triol
pyran
Prior art date
Application number
CL2008002169A
Other languages
English (en)
Inventor
Zhang
Nicole Cathleen Goodwin
Bryce Alden Harrison
Shinya Iimura
Ross Mabon
Qiuling Song
Wenxue Wu
Jie Yan
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of CL2008002169A1 publication Critical patent/CL2008002169A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02Acyclic radicals, not substituted by cyclic structures
    • C07H15/04Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04Carbocyclic radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04Cyclic acetals
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Cocristal que comprende un compuesto derivado de tetrahidropirano y un aminoácido aceptable farmacéuticamente; procedimiento de preparación; compuestos intermediarios; procedimiento de preparación, útil para preparar inhibidores del cotransportador de sodio y glucosa 2.
CL2008002169A 2007-07-26 2008-07-24 Metodo para preparar un compuesto derivado de tetrahidro-2h-piran-3,4,5-triol-2,6-disustituido, inhibidor del contransportador de sodio y glucosa 2; compuestos intermediarios; y metodo de preparacion de los compuestos intermediarios. CL2008002169A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95212207P 2007-07-26 2007-07-26

Publications (1)

Publication Number Publication Date
CL2008002169A1 true CL2008002169A1 (es) 2009-03-20

Family

ID=39877996

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008002169A CL2008002169A1 (es) 2007-07-26 2008-07-24 Metodo para preparar un compuesto derivado de tetrahidro-2h-piran-3,4,5-triol-2,6-disustituido, inhibidor del contransportador de sodio y glucosa 2; compuestos intermediarios; y metodo de preparacion de los compuestos intermediarios.

Country Status (25)

Country Link
US (2) US8026347B2 (es)
EP (1) EP2183263B1 (es)
JP (2) JP5653213B2 (es)
KR (1) KR101663324B1 (es)
CN (1) CN101801989B (es)
AR (2) AR067701A1 (es)
AT (1) ATE530558T1 (es)
AU (1) AU2008279424B2 (es)
BR (1) BRPI0813840A2 (es)
CA (1) CA2694029C (es)
CL (1) CL2008002169A1 (es)
CO (1) CO6260141A2 (es)
DK (1) DK2183263T3 (es)
EA (1) EA017411B1 (es)
EC (1) ECSP109987A (es)
ES (1) ES2375800T3 (es)
HK (1) HK1143982A1 (es)
IL (1) IL203209A (es)
NZ (1) NZ582536A (es)
PL (1) PL2183263T3 (es)
PT (1) PT2183263E (es)
TW (2) TWI506024B (es)
UA (1) UA107175C2 (es)
WO (1) WO2009014970A1 (es)
ZA (1) ZA201000219B (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI499414B (zh) 2006-09-29 2015-09-11 Lexicon Pharmaceuticals Inc 鈉與葡萄糖第2型共同運輸體(co-transporter 2)的抑制物與其應用方法
TWI523652B (zh) 2008-07-15 2016-03-01 泰瑞克公司 氘化苄基苯衍生物及使用方法
TWI472521B (zh) * 2008-07-17 2015-02-11 Lexicon Pharmaceuticals Inc (2s,3r,4r,5s,6r)-2-(4-氯-3-(4-乙氧苄基)苯基)-6-(甲硫)四氫-2h-哌喃-3,4,5-三醇的固體形態與其使用方法
BRPI0918841B8 (pt) 2008-08-28 2021-05-25 Pfizer derivados de dioxa-biciclo[3.2.1]octano-2,3,4-triol, seus cristais, composições farmacêuticas e usos
SI2496583T1 (sl) 2009-11-02 2015-02-27 Pfizer Inc. Derivati dioksa-biciklo(3.2.1)oktan-2,3,4-triola
PL2498758T3 (pl) 2009-11-13 2019-02-28 Astrazeneca Ab Formulacje tabletek dwuwarstwowych
MX2012005365A (es) 2009-11-13 2012-05-29 Bristol Myers Squibb Co Formulaciones de tableta de liberacion inmediata.
CA2780938A1 (en) 2009-11-13 2011-05-19 Bristol-Myers Squibb Company Reduced mass metformin formulations
TWI562775B (en) * 2010-03-02 2016-12-21 Lexicon Pharmaceuticals Inc Methods of using inhibitors of sodium-glucose cotransporters 1 and 2
WO2011153712A1 (en) * 2010-06-12 2011-12-15 Theracos, Inc. Crystalline form of benzylbenzene sglt2 inhibitor
EP2611442B1 (en) 2010-09-03 2018-07-04 Bristol-Myers Squibb Company Drug formulations using water soluble antioxidants
WO2012106303A1 (en) 2011-02-01 2012-08-09 Bristol-Myers Squibb Company Pharmaceutical formulations including an amine compound
CN103596564B (zh) 2011-06-01 2016-05-04 株式会社绿十字 作为sglt2抑制剂的二苯基甲烷衍生物
WO2012163990A1 (en) 2011-06-03 2012-12-06 Boehringer Ingelheim International Gmbh Sglt-2 inhibitors for treating metabolic disorders in patients treated with neuroleptic agents
US9193751B2 (en) 2012-04-10 2015-11-24 Theracos, Inc. Process for the preparation of benzylbenzene SGLT2 inhibitors
DK2925735T3 (da) * 2012-11-20 2019-06-17 Lexicon Pharmaceuticals Inc Inhibitorer for natriumglucose-cotransporter 1
PT2981269T (pt) 2013-04-04 2023-10-10 Boehringer Ingelheim Vetmedica Gmbh Tratamento de distúrbios metabólicos em animais equinos
ES2605886T3 (es) 2013-09-27 2017-03-16 Sunshine Lake Pharma Co., Ltd. Derivados de glucopiranosilo y sus usos en medicina
CN105611920B (zh) 2013-10-12 2021-07-16 泰拉科斯萨普有限责任公司 羟基-二苯甲烷衍生物的制备
CN111494357A (zh) 2013-12-17 2020-08-07 勃林格殷格翰动物保健有限公司 猫科动物中代谢紊乱的治疗
MX2016009421A (es) 2014-01-23 2016-09-16 Boehringer Ingelheim Vetmedica Gmbh Tratamiento de trastornos metabolicos en animales caninos.
HUE050095T2 (hu) 2014-04-01 2020-11-30 Boehringer Ingelheim Vetmedica Gmbh Anyagcsere-rendellenességek kezelése lófélékben
JP6727419B2 (ja) * 2016-05-25 2020-07-22 クリスタル ファーマシューティカル(スーチョウ)カンパニー,リミテッド ナトリウム−グルコース共輸送体阻害薬の新規な結晶形及びその製造方法並びに用途
JP6785523B2 (ja) * 2016-05-28 2020-11-18 ジ・リン・フイ・シェン・バイオ−ファーマシューティカル・カンパニー・リミテッドJi Lin Hui Sheng Bio−Pharmaceutical Co., Ltd. ナトリウム−グルコース共輸送体2阻害剤の結晶形
HRP20211670T8 (hr) 2016-06-17 2022-03-18 Daewoong Pharmaceutical Co., Ltd. Derivat difenilmetana u kristalnom obliku
WO2018073154A1 (en) 2016-10-19 2018-04-26 Boehringer Ingelheim International Gmbh Combinations comprising an ssao/vap-1 inhibitor and a sglt2 inhibitor, uses thereof
CN107540685B (zh) * 2017-09-04 2020-05-05 杭州科巢生物科技有限公司 一种Sotagliflozin的制备方法及其中间体
EP3781166A1 (en) 2018-04-17 2021-02-24 Boehringer Ingelheim International GmbH Pharmaceutical composition, methods for treating and uses thereof
CN108675976B (zh) * 2018-05-14 2020-07-14 浙江宏元药业股份有限公司 一种6-卤代葡萄糖碳苷及其制备方法和应用
BR112021002523A2 (pt) 2018-08-13 2021-05-04 Daewoong Pharmaceutical Co., Ltd. método para preparar um composto
CN110818722B (zh) * 2018-08-14 2022-12-02 苏州鹏旭医药科技有限公司 三种化合物及其制备方法和在合成索格列净中的用途
JP7441946B2 (ja) 2019-11-28 2024-03-01 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー 非ヒト動物の乾乳におけるsglt-2阻害剤の使用
CA3167531A1 (en) 2020-02-17 2021-08-26 Boehringer Ingelheim Vetmedica Gmbh Use of sglt-2 inhibitors for the prevention and/or treatment of cardiac diseases in felines
WO2023006745A1 (en) 2021-07-28 2023-02-02 Boehringer Ingelheim Vetmedica Gmbh Use of sglt-2 inhibitors for the prevention and/or treatment of hypertension in non-human mammals
WO2023006747A1 (en) 2021-07-28 2023-02-02 Boehringer Ingelheim Vetmedica Gmbh Use of sglt-2 inhibitors for the prevention and/or treatment of renal diseases in non-human mammals
KR20240041966A (ko) 2021-07-28 2024-04-01 베링거잉겔하임베트메디카게엠베하 고양이를 제외한 비인간 포유류, 특히 개에서 심장 질환의 예방 및/또는 치료를 위한 sglt-2 억제제의 용도
CN113880701A (zh) * 2021-10-10 2022-01-04 浙江司太立制药股份有限公司 一种抗糖尿病药物中间体及其制备方法
US20230381101A1 (en) 2022-05-25 2023-11-30 Boehringer Ingelheim Vetmedica Gmbh Aqueous pharmaceutical compositions comprising sglt-2 inhibitors

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
US6515117B2 (en) * 1999-10-12 2003-02-04 Bristol-Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
PH12000002657B1 (en) * 1999-10-12 2006-02-21 Bristol Myers Squibb Co C-aryl glucoside SGLT2 inhibitors
BR0109323A (pt) * 2000-03-17 2002-12-24 Kissei Pharmaceutical Derivados de gluco piranosiloxi benzil benzeno, composições medicinais contendo os mesmos e intermediários para a preparação dos derivados
US6555519B2 (en) * 2000-03-30 2003-04-29 Bristol-Myers Squibb Company O-glucosylated benzamide SGLT2 inhibitors and method
US6683056B2 (en) * 2000-03-30 2004-01-27 Bristol-Myers Squibb Company O-aryl glucoside SGLT2 inhibitors and method
AU2002223127A1 (en) * 2000-11-30 2002-06-11 Kissei Pharmaceutical Co., Ltd. Intellectual Property Glucopyranosyloxybenzyl benzene derivatives, medicinal compositions containing the same and intermediates in the production thereof
US6936590B2 (en) * 2001-03-13 2005-08-30 Bristol Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
CA2444481A1 (en) * 2001-04-11 2002-10-24 Bristol-Myers Squibb Company Amino acid complexes of c-aryl glucosides for treatment of diabetes and method
US6562791B1 (en) * 2002-03-29 2003-05-13 Council Of Scientific And Industrial Research Glucopyranoside, process for isolation thereof, pharmaceutical composition containing same and use thereof
CN1329407C (zh) * 2002-04-12 2007-08-01 阿奇林医药品公司 合成β-L-5-氟-2′,3′-双脱氧-2′,3′-双脱氢胞嘧啶核苷的方法
BR0310006A (pt) * 2002-08-09 2005-02-15 Taisho Pharmaceutical Co Ltd Derivados de 5-tio-beta-d-glicopiranosìdeo de arila e agentes terapêuticos para diabetes contendo os mesmos
BR0317929A (pt) 2003-01-03 2006-04-11 Bristol Myers Squibb Co métodos de produzir inibidores de sglt2 de glicosìdeo de c-arila
US7368475B2 (en) * 2003-03-12 2008-05-06 Kemin Pharma Bvba Furanose-type bicyclic carbohydrates with biological activity
US7202350B2 (en) * 2003-03-14 2007-04-10 Astellas Pharma Inc. C-glycoside derivatives and salts thereof
WO2006018150A1 (de) * 2004-08-11 2006-02-23 Boehringer Ingelheim International Gmbh D-xylopyranosyl-phenyl-substituierte cyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
ATE445608T1 (de) * 2005-02-23 2009-10-15 Boehringer Ingelheim Int Glucopyranosylsubstituierte ((hetero)arylethynyl- benzyl)-benzenderivative und deren verwendung als inhibitoren des natriumabhängigen glucose- cotransporters typ 2 (sglt2)
TWI499414B (zh) * 2006-09-29 2015-09-11 Lexicon Pharmaceuticals Inc 鈉與葡萄糖第2型共同運輸體(co-transporter 2)的抑制物與其應用方法
WO2008044268A1 (fr) * 2006-10-05 2008-04-17 Panasonic Corporation Appareil et procédé de transmission
US7846945B2 (en) * 2007-03-08 2010-12-07 Lexicon Pharmaceuticals, Inc. Piperdine-based inhibitors of sodium glucose co-transporter 2 and methods of their use
TWI472521B (zh) * 2008-07-17 2015-02-11 Lexicon Pharmaceuticals Inc (2s,3r,4r,5s,6r)-2-(4-氯-3-(4-乙氧苄基)苯基)-6-(甲硫)四氫-2h-哌喃-3,4,5-三醇的固體形態與其使用方法

Also Published As

Publication number Publication date
AR112669A2 (es) 2019-11-27
AU2008279424B2 (en) 2013-06-13
AR067701A1 (es) 2009-10-21
PT2183263E (pt) 2012-01-11
CN101801989A (zh) 2010-08-11
CA2694029C (en) 2016-10-04
US20120095197A1 (en) 2012-04-19
ES2375800T3 (es) 2012-03-06
TWI419886B (zh) 2013-12-21
ECSP109987A (es) 2010-03-31
IL203209A (en) 2014-02-27
UA107175C2 (uk) 2014-12-10
AU2008279424A1 (en) 2009-01-29
JP2014001230A (ja) 2014-01-09
TW201350473A (zh) 2013-12-16
KR20100040869A (ko) 2010-04-21
US8026347B2 (en) 2011-09-27
EP2183263A1 (en) 2010-05-12
PL2183263T3 (pl) 2012-03-30
TW200914434A (en) 2009-04-01
ZA201000219B (en) 2011-03-30
DK2183263T3 (da) 2012-01-30
EA201070186A1 (ru) 2010-08-30
JP5764174B2 (ja) 2015-08-12
ATE530558T1 (de) 2011-11-15
JP5653213B2 (ja) 2015-01-14
CN101801989B (zh) 2015-11-25
CA2694029A1 (en) 2009-01-29
TWI506024B (zh) 2015-11-01
KR101663324B1 (ko) 2016-10-06
US20090030198A1 (en) 2009-01-29
JP2010534661A (ja) 2010-11-11
HK1143982A1 (zh) 2011-01-21
EA017411B1 (ru) 2012-12-28
BRPI0813840A2 (pt) 2017-06-06
WO2009014970A1 (en) 2009-01-29
NZ582536A (en) 2012-01-12
CO6260141A2 (es) 2011-03-22
US8293878B2 (en) 2012-10-23
EP2183263B1 (en) 2011-10-26

Similar Documents

Publication Publication Date Title
CL2008002169A1 (es) Metodo para preparar un compuesto derivado de tetrahidro-2h-piran-3,4,5-triol-2,6-disustituido, inhibidor del contransportador de sodio y glucosa 2; compuestos intermediarios; y metodo de preparacion de los compuestos intermediarios.
NO20080865L (no) Spirokromanonderivater som acetyl-koenzym-A-karboksylase(ACC)inhibitorer
RS53292B (en) CRYSTAL FORMS 2-THIAZOLYL-4-HINOLINYL-OXY DERIVATIVES, POWERFUL HCV INHIBITOR
UY32490A (es) Inhibidores de beta-secretasa
EA200970585A1 (ru) Бензамидные производные как агонисты ер-рецепторов
CL2012000024A1 (es) Composicion farmaceutica que comprende 100 a 2000 mg de metformina y 10 a 300 mg de un compuesto inhibidor de sglt-2 derivado de glucopiranosil fenil sustituidos, celulosa microcristalina, un aglutinante y croscaramelosa.
AR049681A1 (es) Macrolidos preparados a partir de actinomicetos. composiciones farmaceuticas
UY30444A1 (es) Derivados de pirimidina, procesos para su preparacinn, composiciones farmaccuticos y usos de los mismos.
UY32062A (es) Inhibidores de beta-secretasa
CL2012001722A1 (es) Compuestos derivados de 3-hidroxi-5-arilisotiazol, agonistas del receptor 40 acoplado a la proteina g (gpr40); composición farmacéutica que los comprende; y método para el tratamiento o la prevención de la diabetes.
UY32174A (es) Nuevos heterociclos sustituidos, composiciones farmaceuticas conteniendolos, procedimientos de preparacion y aplicaciones
UY32156A (es) Derivados sustituidos de la n2 - [1-(5 - fluoropirimidin -2-il) etil] - n4 - (1-metil - 1h-imidazol - 4 - il)) - pirimidina - 2,4 - diaminas y sus sales farmacéuticamente aceptables, proceso de preparación, composiciones conteniéndolos y aplicaciones.
NO20065719L (no) I det vesentlige rene 2-{[2-(2-metylamino-pyrimidin-4-yl)-1H-indol-5-karbonyl]-amlno}-3-(fenylpyridin-2-yl-amino)-propionsyre som en IkB kinaseinhibitor.
BR112013028877A2 (pt) derivados de piperidina e composições para a inibição de nicotinamida fosforibosiltransferase (nampt)
ECSP088700A (es) Acidos 4-fenil-tiazol-5-carboxilicos y amidas de acidos 4-fenil-tiazol-5-carboxilicos como inhibidores de la plk1
AR062211A1 (es) Derivados de 6-carboxi-normorfinano. composiciones farmaceuticas
MX2009003739A (es) Derivados de hidrobenzamida como inhibidores de hsp90.
EA201100994A1 (ru) Способ получения производных бисфуранового спирта, соединения, соль, фармацевтическая композиция на ее основе, способ лечения или профилактики ретровирусных инфекций с ее помощью
MX2009010302A (es) Derivados de indol que tienen actividad inhibidora de cpla2 y aplicaciones y metodos de produccion.
BR112019004449A2 (pt) heparina biossintética
EA200801893A1 (ru) Производные тетрагидронафталина, способ их получения и их применение в качестве ингибиторов воспаления
CR9391A (es) Derivados de indanil-piperazinas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
WO2008001391A3 (en) Site-specific inhibitors of histone methyltransferase [hmtase] and process of preparation thereof
AU2010321366A8 (en) Compound, certain novel forms thereof, pharmaceutical compositions thereof and methods for preparation and use
DK1931636T3 (da) Isoquinoliner som IGF-1R-inhibitorer