BR112019004449A2 - heparina biossintética - Google Patents

heparina biossintética

Info

Publication number
BR112019004449A2
BR112019004449A2 BR112019004449A BR112019004449A BR112019004449A2 BR 112019004449 A2 BR112019004449 A2 BR 112019004449A2 BR 112019004449 A BR112019004449 A BR 112019004449A BR 112019004449 A BR112019004449 A BR 112019004449A BR 112019004449 A2 BR112019004449 A2 BR 112019004449A2
Authority
BR
Brazil
Prior art keywords
heparin
biosynthetic heparin
synthesis
biosynthetic
heparosan
Prior art date
Application number
BR112019004449A
Other languages
English (en)
Other versions
BR112019004449B1 (pt
Inventor
Onishi Akihiro
Mori Daisuke
Paskaleva Elena
Dordick Jonathan
Li Kevin
Lin Lei
Fu Li
Hirakane Makoto
Douaisi Marc
Grover Navdeep
Brodfuehrer Paul
Datta Payel
J Linhardt Robert
J Simmons Trevor
Original Assignee
Rensselaer Polytech Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=61561551&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112019004449(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rensselaer Polytech Inst filed Critical Rensselaer Polytech Inst
Publication of BR112019004449A2 publication Critical patent/BR112019004449A2/pt
Publication of BR112019004449B1 publication Critical patent/BR112019004449B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/10—Heparin; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y208/00—Transferases transferring sulfur-containing groups (2.8)
    • C12Y208/02—Sulfotransferases (2.8.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y208/00—Transferases transferring sulfur-containing groups (2.8)
    • C12Y208/02—Sulfotransferases (2.8.2)
    • C12Y208/02001—Aryl sulfotransferase (2.8.2.1)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)

Abstract

a presente revelação refere-se a síntese de heparina, que pode ser bioequivalente a heparina sódica usp porcina. a síntese pode envolver três intermediários a partir do heparosano.
BR112019004449-3A 2016-09-07 2017-09-07 Glicosaminoglicano, método para a produção de uma heparina biossintética e métodos de produção de um segundo e terceiro intermediários compreendendo glicosaminoglicano BR112019004449B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662384341P 2016-09-07 2016-09-07
US62/384,341 2016-09-07
PCT/US2017/050385 WO2018048973A1 (en) 2016-09-07 2017-09-07 Biosynthetic heparin

Publications (2)

Publication Number Publication Date
BR112019004449A2 true BR112019004449A2 (pt) 2019-05-28
BR112019004449B1 BR112019004449B1 (pt) 2023-04-04

Family

ID=61561551

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019004449-3A BR112019004449B1 (pt) 2016-09-07 2017-09-07 Glicosaminoglicano, método para a produção de uma heparina biossintética e métodos de produção de um segundo e terceiro intermediários compreendendo glicosaminoglicano

Country Status (16)

Country Link
US (2) US11591628B2 (pt)
EP (1) EP3510147B1 (pt)
JP (1) JP7033330B2 (pt)
KR (1) KR102560632B1 (pt)
CN (1) CN109923208B (pt)
AU (1) AU2017324960B2 (pt)
BR (1) BR112019004449B1 (pt)
CA (1) CA3035912A1 (pt)
ES (1) ES2952428T3 (pt)
HU (1) HUE062448T2 (pt)
MY (1) MY193343A (pt)
PH (1) PH12019500459A1 (pt)
PL (1) PL3510147T3 (pt)
SG (2) SG10202101954TA (pt)
TW (1) TWI769176B (pt)
WO (1) WO2018048973A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020209822A1 (en) 2019-01-15 2021-09-09 Optimvia, Llc Engineered aryl sulfate-dependent enzymes
EP3997238A1 (en) 2019-07-09 2022-05-18 Optimvia, LLC Methods for synthesizing anticoagulant polysaccharides
CN110982864A (zh) * 2019-12-30 2020-04-10 孙军亭 一种3’,5’-二磷酸腺苷(pap)的酶合成方法及其应用
CN111154819B (zh) * 2020-01-15 2022-08-30 山东大学 一种非动物源低分子量肝素及其制备方法与应用
WO2021199444A1 (en) 2020-04-03 2021-10-07 Rensselaer Polytechnic Institute Method for producing heparosan and bacterium of genus escherichia having heparosan-producing ability
WO2021199445A1 (en) 2020-04-03 2021-10-07 Rensselaer Polytechnic Institute Method for producing sulfated polysaccharide and method for producing paps
CN114763570B (zh) * 2021-09-10 2024-02-27 江南大学 制备不同分子量肝素的磺酸化修饰体系构建及其应用
TW202338098A (zh) * 2021-11-05 2023-10-01 美商瑞瑟勒綜合技術協會 自低分子量肝素前體化學酶合成低分子量肝素之方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5153324B2 (ja) * 2005-03-14 2013-02-27 生化学工業株式会社 硬組織形成促進剤
WO2006124801A2 (en) * 2005-05-12 2006-11-23 The University Of North Carolina At Chapel Hill Enzymatic synthesis of sulfated polysaccharides
CN101724086B (zh) 2009-11-25 2012-09-26 深圳海王药业有限公司 低聚凤梨参糖胺聚糖及其制备方法
WO2012116048A1 (en) * 2011-02-22 2012-08-30 Rensselaer Polytechnic Institute Single step heparosan n-deacetylation and depolymerization for making bioengineered heparin
US20140349962A1 (en) 2013-05-24 2014-11-27 Massachusetts Institute Of Technology Rapid two-step synthesis of anti-coagulants
WO2014204929A2 (en) 2013-06-17 2014-12-24 The University Of North Carolina At Chapel Hill Reversible heparin molecules and methods of making and using the same

Also Published As

Publication number Publication date
JP7033330B2 (ja) 2022-03-10
AU2017324960A1 (en) 2019-03-21
SG11201901795QA (en) 2019-03-28
CA3035912A1 (en) 2018-03-15
PH12019500459A1 (en) 2019-12-16
WO2018048973A1 (en) 2018-03-15
CN109923208B (zh) 2023-06-23
AU2017324960B2 (en) 2022-11-10
HUE062448T2 (hu) 2023-11-28
US20230151400A1 (en) 2023-05-18
KR20190052025A (ko) 2019-05-15
US11591628B2 (en) 2023-02-28
SG10202101954TA (en) 2021-04-29
RU2019105262A (ru) 2020-10-08
US20190225998A1 (en) 2019-07-25
KR102560632B1 (ko) 2023-07-27
TW201812012A (zh) 2018-04-01
PL3510147T3 (pl) 2023-11-27
JP2019531067A (ja) 2019-10-31
CN109923208A (zh) 2019-06-21
MY193343A (en) 2022-10-06
EP3510147A4 (en) 2020-05-27
EP3510147A1 (en) 2019-07-17
RU2019105262A3 (pt) 2021-04-29
EP3510147B1 (en) 2023-05-17
TWI769176B (zh) 2022-07-01
RU2760706C2 (ru) 2021-11-29
BR112019004449B1 (pt) 2023-04-04
ES2952428T3 (es) 2023-10-31

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Legal Events

Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 07/09/2017, OBSERVADAS AS CONDICOES LEGAIS