CH626883A5 - - Google Patents

Download PDF

Info

Publication number: CH626883A5
Authority: CH; Switzerland
Prior art keywords: group; general formula; methyl; compounds; radical
Prior art date: 1975-05-21

Application number

CH620376A

Other languages

German (de)

English (en)

Inventor

Graham John Durant

Charon Robin Ganellin

Geoffrey Robert Owen

Rodney Christopher Young

Original Assignee

Smith Kline French Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-05-21

Filing date

1976-05-18

Publication date

1981-12-15

1975-05-21 Priority claimed from GB21817/75A external-priority patent/GB1553070A/en

1976-05-18 Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab

1981-12-15 Publication of CH626883A5 publication Critical patent/CH626883A5/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/26—Radicals substituted by sulfur atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CH620376A 1975-05-21 1976-05-18 CH626883A5 (sv)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB21817/75A GB1553070A (en)	1975-05-21	1975-05-21	Thiourea guanidine and 1-nitro-2,2-diaminoethylene derivatives
GB4778275		1975-11-20

Publications (1)

Publication Number	Publication Date
CH626883A5 true CH626883A5 (sv)	1981-12-15

Family

ID=26255540

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
CH620376A CH626883A5 (sv)	1975-05-21	1976-05-18
CH388580A CH624941A5 (sv)	1975-05-21	1980-05-19

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
CH388580A CH624941A5 (sv)	1975-05-21	1980-05-19

Country Status (13)

Country	Link
US (6)	US4098898A (sv)
JP (1)	JPS51141865A (sv)
AT (1)	AT356131B (sv)
AU (1)	AU503525B2 (sv)
CA (1)	CA1076581A (sv)
CH (2)	CH626883A5 (sv)
DE (1)	DE2621834A1 (sv)
DK (1)	DK145541C (sv)
FR (1)	FR2311536A1 (sv)
IE (1)	IE44062B1 (sv)
IL (1)	IL49528A (sv)
NL (1)	NL7605405A (sv)
SE (1)	SE419544B (sv)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4170652A (en) *	1974-03-12	1979-10-09	Smith Kline & French Laboratories Limited	Heterocyclic-methylthioalkyl-guanidines
IL49528A (en) *	1975-05-21	1980-11-30	Smith Kline French Lab	Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them
DE2905134A1 (de) *	1978-02-17	1979-08-23	Degussa	Neue acylierte aminoalkyl-cyanoguanidine mit einem heterocyclischen rest
IL57415A (en) *	1978-05-30	1984-08-31	Smith Kline French Lab	Nitropyrrole compounds,process for preparing them and pharmaceutical compositions containing them
US4200760A (en) *	1978-09-26	1980-04-29	Bristol-Myers Company	Imidazolylalkylthioalkylamino-ethylene derivatives
CA1140925A (en) *	1978-10-16	1983-02-08	Derrick F. Jones	Antisecretory branched chain heterocyclic derivatives, processes for their manufacture and pharmaceutical compositions containing them
US4282363A (en) *	1978-11-24	1981-08-04	Bristol-Myers Company	1-Nitro-2-(2-alkynylamino)-2-[(2-pyridylmethylthio)-ethylamino]ethylene derivatives
JPS568357A (en) *	1979-02-16	1981-01-28	Eisai Co Ltd	Cyanoguanidine derivative and its production
US4220654A (en) *	1979-06-04	1980-09-02	Merck & Co., Inc.	Cyclic imidazole cyanoguanidines
US4394508A (en) *	1980-06-07	1983-07-19	Bristol-Myers Company	Chemical compounds
US4315024A (en) *	1980-08-08	1982-02-09	Cooper Laboratories, Inc.	Compositions and method for treating red eye
US4382090A (en) *	1980-10-02	1983-05-03	Eli Lilly And Company	N-Thiazolylmethylthioalkyl-N'alkylamidines and related compounds
US4443456A (en) *	1981-05-12	1984-04-17	William H. Rorer, Inc.	Pyridyl alkylene amidinoureas
US4810717A (en) *	1981-11-12	1989-03-07	E. I. Du Pont De Nemours And Company	2-hydroxypropylamine aryl ester derivatives
DE3232462A1 (de) *	1982-09-01	1984-03-01	Bayer Ag, 5090 Leverkusen	2-nitro-1,1-ethendiamine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
AU2222083A (en) *	1982-12-14	1984-06-21	Smith Kline & French Laboratories Limited	Pyridine derivatives
US4560690A (en) *	1984-04-30	1985-12-24	Pfizer Inc.	2-(N-substituted guanidino)-4-hetero-arylthiazole antiulcer agents
US4795719A (en) *	1984-05-15	1989-01-03	Waferscale Integration, Inc.	Self-aligned split gate eprom process
EP0199845B1 (de) *	1985-04-02	1990-08-01	HEUMANN PHARMA GMBH & CO	Imidazolylalkylguanidinderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US4617311A (en) *	1985-05-17	1986-10-14	Eli Lilly And Company	Antiasthmatic method
NL8601585A (nl) *	1986-06-19	1988-01-18	Vereniging Voor Christelijk Wetenschappelijk Onderwijs	N-(2-gesubstitueerde alkyl)-n-imidazol-4-yl alkyl guanidine.
DE3631334A1 (de) *	1986-09-15	1988-03-17	Heumann Pharma Gmbh & Co	Neue imidazolylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4996221A (en) *	1987-01-13	1991-02-26	The Board Of Trustees Of The Leland Stanford Junior University	Histamine derivatives as immune modulators
US5229386A (en) *	1989-01-05	1993-07-20	Fujisawa Pharmaceutical Co., Ltd.	Thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same
US5145860A (en) *	1989-01-05	1992-09-08	Fujisawa Pharmaceutical Co., Ltd.	Thiazole compounds and pharmaceutical composition comprising the same
NL9100365A (nl) *	1991-02-27	1992-09-16	Seed Capital Investments	Imidazoolderivaten met agonistische of antagonistische activiteit op de histamine h3-receptor.
DK0573542T3 (da) *	1991-02-27	1998-05-18	Seed Capital Investments	Imidazolderivater med antagonistisk aktivitet over for histamin-H3-receptoren
WO1993014753A1 (en) *	1992-01-27	1993-08-05	The Board Of Trustees Of The Leland Stanford Junior University	Histamine derivatives and methods for their use
US5808090A (en) *	1996-02-22	1998-09-15	Endo Pharmaceuticals Inc.	Process for preventing precipitation in cimetidine injection solutions
CN1319007A (zh) *	1998-09-22	2001-10-24	石原产业株式会社	含有硝基乙烯胺衍生物或其盐作为有效成分的医药组合物
GB0404434D0 (en)	2004-02-27	2004-03-31	Novartis Ag	Organic compounds
US20230349922A1 (en)	2020-08-11	2023-11-02	Université De Strasbourg	H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3868457A (en) *	1969-10-29	1975-02-25	Smith Kline French Lab	Method of inhibiting histamine activity with guanidine compounds
US3968216A (en) *	1969-10-29	1976-07-06	Smith Kline & French Laboratories Limited	Method of inhibiting histamine activity with guanidine compounds
GB1305549A (sv) *	1969-10-29	1973-02-07
US3808336A (en) *	1970-06-25	1974-04-30	Smithkline Corp	Pharmaceutical compositions and methods of inhibiting histamine activity with thiourea derivatives
US3950353A (en) *	1971-03-09	1976-04-13	Smith Kline & French Laboratories Limited	Pharmacologically active thiourea and urea compounds
GB1338169A (en) *	1971-03-09	1973-11-21	Smith Kline French Lab	Ureas thioureas and guanidines
US3905984A (en) *	1971-03-09	1975-09-16	Smith Kline French Lab	Pyridyl substituted thioalkyl-and oxyalkyl-thioureas and ureas
US4000302A (en) *	1972-04-20	1976-12-28	Smith Kline & French Laboratories Limited	Pharmaceutical compositions and methods of inhibiting H-1 and H-2 histamine receptors
US4000296A (en) *	1972-09-05	1976-12-28	Smith Kline & French Laboratories Limited	Imidazole alkylguanidine compounds
US3979398A (en) *	1973-02-08	1976-09-07	Smith Kline & French Laboratories Limited	Sulphoxides
US4124717A (en) *	1973-05-17	1978-11-07	Smith Kline & French Laboratories Limited	Thiazolyl alkylaminoethylene compounds
US4046907A (en) *	1973-05-17	1977-09-06	Smith Kline & French Laboratories Limited	Imidazole alkylaminoethylene compounds
GB1421792A (en) *	1973-05-17	1976-01-21	Smith Kline French Lab	Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
GB1431589A (en) *	1973-07-13	1976-04-07	Smith Kline French Lab	Ureas, thioureas and guanidines n,n-disubstituted by heterocyclo- alkylene and/or heterocycloalkylenethioalkylene groups
US4152443A (en) *	1973-07-13	1979-05-01	Smith Kline & French Laboratories Limited	Imidazolyl thioureas, ureas and guanidines
GB1493931A (en) *	1974-02-07	1977-11-30	Smith Kline French Lab	Guanidines isothioureas and thioureas
US4107319A (en) *	1974-03-12	1978-08-15	Smith Kline & French Laboratories Limited	Pharmacologically active compounds
US4013769A (en) *	1974-05-09	1977-03-22	Smith Kline & French Laboratories Limited	Pyridyl-alkylaminoethylene compounds
GB1497260A (en) *	1974-06-28	1978-01-05	Smith Kline French Lab	Guanidine derivatives
US4093621A (en) *	1974-09-02	1978-06-06	Smith Kline & French Laboratories Limited	Process for preparing heterocyclicalkylthioalkyl-N-cyanoguanidines and thioureas
IL49528A (en) *	1975-05-21	1980-11-30	Smith Kline French Lab	Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them
US4156727A (en) *	1975-07-31	1979-05-29	Smith Kline & French Laboratories Limited	Alkoxy pyridine compounds
ZA782129B (en) *	1977-04-20	1979-03-28	Ici Ltd	Hertocyclic derivatives
US4165378A (en) *	1977-04-20	1979-08-21	Ici Americas Inc.	Guanidine derivatives of imidazoles and thiazoles

1976
- 1976-05-06 IL IL49528A patent/IL49528A/xx unknown
- 1976-05-10 DK DK206576A patent/DK145541C/da not_active IP Right Cessation
- 1976-05-11 CA CA252,248A patent/CA1076581A/en not_active Expired
- 1976-05-13 US US05/686,185 patent/US4098898A/en not_active Expired - Lifetime
- 1976-05-14 JP JP51056418A patent/JPS51141865A/ja active Pending
- 1976-05-17 DE DE19762621834 patent/DE2621834A1/de not_active Ceased
- 1976-05-18 CH CH620376A patent/CH626883A5/de not_active IP Right Cessation
- 1976-05-18 AT AT361576A patent/AT356131B/de not_active IP Right Cessation
- 1976-05-18 SE SE7605620A patent/SE419544B/sv unknown
- 1976-05-20 IE IE1068/76A patent/IE44062B1/en unknown
- 1976-05-20 FR FR7615253A patent/FR2311536A1/fr active Granted
- 1976-05-20 NL NL7605405A patent/NL7605405A/xx not_active Application Discontinuation
- 1976-05-21 AU AU14195/76A patent/AU503525B2/en not_active Expired
1979
- 1979-05-02 US US06/035,152 patent/US4247558A/en not_active Expired - Lifetime
- 1979-08-27 US US06/070,184 patent/US4276301A/en not_active Expired - Lifetime
1980
- 1980-05-19 CH CH388580A patent/CH624941A5/de not_active IP Right Cessation
- 1980-09-02 US US06/183,555 patent/US4347250A/en not_active Expired - Lifetime
1981
- 1981-01-29 US US06/229,435 patent/US4333946A/en not_active Expired - Lifetime
1982
- 1982-06-18 US US06/389,837 patent/US4440775A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US4098898A (en)	1978-07-04
JPS51141865A (en)	1976-12-07
SE7605620L (sv)	1976-11-22
DK206576A (da)	1976-11-22
NL7605405A (nl)	1976-11-23
IL49528A0 (en)	1976-07-30
DK145541B (da)	1982-12-06
DE2621834A1 (de)	1976-12-02
US4347250A (en)	1982-08-31
AU1419576A (en)	1977-11-24
US4333946A (en)	1982-06-08
CH624941A5 (sv)	1981-08-31
AT356131B (de)	1980-04-10
US4276301A (en)	1981-06-30
FR2311536B1 (sv)	1979-03-23
IE44062B1 (en)	1981-08-12
SE419544B (sv)	1981-08-10
DK145541C (da)	1983-05-16
IE44062L (en)	1976-11-21
FR2311536A1 (fr)	1976-12-17
CA1076581A (en)	1980-04-29
US4440775A (en)	1984-04-03
US4247558A (en)	1981-01-27
IL49528A (en)	1980-11-30
AU503525B2 (en)	1979-09-06
ATA361576A (de)	1979-09-15

Legal Events

Date	Code	Title	Description
1985-01-31	PL	Patent ceased

Publication	Publication Date	Title
CH626883A5 (sv)	1981-12-15
DE2265369C3 (de)	1988-03-24	Heterocyclische Aminoäther und -thioäther und ihre Salze mit Säuren
US3881015A (en)	1975-04-29	Pharmaceutical compositions and methods of inhibiting histamine activity with isothiourea compounds
DE2951675C2 (de)	1982-07-01	Guanidinothiazolverbindungen, Verfahren zu deren Herstellung und Arzneimittelzubereitungen
DE2344779A1 (de)	1974-03-14	Cyanguanidine, ihre salze, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
SU1400508A3 (ru)	1988-05-30	Способ получени производных арилтиазолов
DE2643670C2 (de)	1982-07-01	5-Benzyl-4-pyrimidon-Derivate, ihre Salze mit Säuren, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2421548A1 (de)	1974-11-21	Amine und ihre salze, verfahren zu ihrer herstellung und arzneimittel
DD202426A5 (de)	1983-09-14	Verfahren zur herstellung von 1,2-diaminocyclobuten-3,4-dionen
DE2433625A1 (de)	1975-01-30	Harnstoff-derivate, verfahren zu ihrer herstellung und arzneimittel
CH615669A5 (sv)	1980-02-15
DE2634429A1 (de)	1977-02-10	Cyclobutendion- und -dithionderivate, ihre salze mit saeuren, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
CH624938A5 (sv)	1981-08-31
DE2504794A1 (de)	1975-08-14	Alpha, omega-diamino- oder -dithioalkylenverbindungen
DE2344833A1 (de)	1974-03-14	Guanidine, ihre salze, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4013659A (en)	1977-03-22	Certain n,n'-disubstituted guanidine compounds and their use
DE2950838A1 (de)	1980-07-03	Neue thiazolylmethylthioderivate, verfahren zu deren herstellung und arzneimittel
CH645354A5 (de)	1984-09-28	Chinolyl-guanidine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mischungen.
DE2630060C2 (de)	1984-04-19	2-(2-Brom-6-fluor-phenylimino)-imidazolidin, dessen Säureadditionssalze, diese enthaltende Arzneimittel und Verfahren zu deren Herstellung
DE2604056A1 (de)	1976-08-05	Thiocarbaminsaeure-derivate
DE2819874A1 (de)	1978-11-09	Bisamidine, verfahren zu ihrer herstellung und ihre verwendung als histamin- h tief 2 - receptor-antagonisten
CS196352B2 (en)	1980-03-31	Process for preparing derivatives of amidinformic acid
DE69813539T2 (de)	2003-12-18	Neue amid-derivate und medizinische zusammensetzungen die diese enthalten
EP0160173B1 (de)	1989-06-14	Benzothiazolderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltendes Arzneimittel
DE2634432A1 (de)	1977-02-10	Sulfoxide, ihre salze mit saeuren, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel