JPS568357A - Cyanoguanidine derivative and its production - Google Patents

Cyanoguanidine derivative and its production

Info

Publication number
JPS568357A
JPS568357A JP1598979A JP1598979A JPS568357A JP S568357 A JPS568357 A JP S568357A JP 1598979 A JP1598979 A JP 1598979A JP 1598979 A JP1598979 A JP 1598979A JP S568357 A JPS568357 A JP S568357A
Authority
JP
Japan
Prior art keywords
formula
compound
lower alkyl
pyridyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1598979A
Other languages
Japanese (ja)
Inventor
Satoru Tanaka
Katsutoshi Shimada
Kazunori Hashimoto
Kiichi Ema
Koichiro Ueda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Priority to JP1598979A priority Critical patent/JPS568357A/en
Priority to US06/120,876 priority patent/US4287346A/en
Priority to NL8000869A priority patent/NL8000869A/en
Priority to CH123280A priority patent/CH641772A5/en
Priority to SE8001216A priority patent/SE8001216L/en
Priority to CA000345777A priority patent/CA1145751A/en
Priority to DE19803005786 priority patent/DE3005786A1/en
Priority to IT19938/80A priority patent/IT1141214B/en
Priority to GB8005465A priority patent/GB2046736B/en
Priority to GB08211155A priority patent/GB2107306B/en
Priority to FR8003470A priority patent/FR2453155A1/en
Priority to US06/178,017 priority patent/US4327217A/en
Publication of JPS568357A publication Critical patent/JPS568357A/en
Priority to US06/253,276 priority patent/US4363921A/en
Priority to US06/302,360 priority patent/US4396764A/en
Priority to US06/344,079 priority patent/US4426521A/en
Priority to CA000410453A priority patent/CA1158648A/en
Priority to SE8403871A priority patent/SE8403871D0/en
Pending legal-status Critical Current

Links

Landscapes

  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

NEW MATERIAL:Compound of formula I [A is phenyl, furyl, thienyl; B is pyridyl, phenyl; R is lower alkyl, lower alkenyl, group of formula IV (R1 and R2 are lower alkyl; n is 1W3) or formula V (R3 is lower alkyl; n is 4, 5) or their acid adducts.
EXAMPLE: N-Cyano-N'-[α-(2-pyridyl)-o-methylbenzyl]guanidine.
USE: Antitumorigenic, antidepressant, local anesthetic, anti-inflammatory or diuretic.
PREPARATION: A compound of formula II and an isothiourea or isourea of formula III (Y is lower alkoxy, lower alkylthio) are subjected to reaction by standing them together at room temperature or with heating in the presence or absence of a solvent such as methanol to give a compound of formula I in one step.
COPYRIGHT: (C)1981,JPO&Japio
JP1598979A 1979-02-16 1979-02-16 Cyanoguanidine derivative and its production Pending JPS568357A (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
JP1598979A JPS568357A (en) 1979-02-16 1979-02-16 Cyanoguanidine derivative and its production
US06/120,876 US4287346A (en) 1979-02-16 1980-02-12 Cyanoguanidine derivatives
NL8000869A NL8000869A (en) 1979-02-16 1980-02-12 CYANOGUANIDINE DERIVATIVES AND METHOD FOR THE PREPARATION THEREOF.
CH123280A CH641772A5 (en) 1979-02-16 1980-02-14 Cyanoguanidine DERIVATIVES AND PROCESS FOR PRODUCING.
SE8001216A SE8001216L (en) 1979-02-16 1980-02-15 GUANIDINE DERIVATIVES AND SET TO MAKE THEM
CA000345777A CA1145751A (en) 1979-02-16 1980-02-15 Cyanoguanidine derivatives and process for the preparation thereof
DE19803005786 DE3005786A1 (en) 1979-02-16 1980-02-15 CYANOGUANID DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
IT19938/80A IT1141214B (en) 1979-02-16 1980-02-15 CYANOGUANIDINE DERIVATIVES AND PROCEDURE FOR THE PREPARATION OF THEMSELVES
GB08211155A GB2107306B (en) 1979-02-16 1980-02-18 Isothiourea and isourea derivatives and process for the preparation thereof
GB8005465A GB2046736B (en) 1979-02-16 1980-02-18 Cyanoguanidine isothiourea and isourea derivatives
FR8003470A FR2453155A1 (en) 1979-02-16 1980-02-18 CYANOGUANIDINE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATIONS
US06/178,017 US4327217A (en) 1979-02-16 1980-08-13 Cyanoguanidine derivatives
US06/253,276 US4363921A (en) 1979-02-16 1981-04-13 Cyanoguanidine derivatives
US06/302,360 US4396764A (en) 1979-02-16 1981-09-15 Cyanoguanidine derivatives
US06/344,079 US4426521A (en) 1979-02-16 1982-01-28 Cyanoguanidine derivatives
CA000410453A CA1158648A (en) 1979-02-16 1982-08-30 Cyanoguanidine derivatives and process for the preparation thereof
SE8403871A SE8403871D0 (en) 1979-02-16 1984-07-26 CHEMICAL COMPOUND, USED AS INTERMEDIATE IN THE PREPARATION OF CERTAIN CYANOGUANIDE INGREDIENTS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1598979A JPS568357A (en) 1979-02-16 1979-02-16 Cyanoguanidine derivative and its production

Publications (1)

Publication Number Publication Date
JPS568357A true JPS568357A (en) 1981-01-28

Family

ID=11904062

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1598979A Pending JPS568357A (en) 1979-02-16 1979-02-16 Cyanoguanidine derivative and its production

Country Status (1)

Country Link
JP (1) JPS568357A (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51141865A (en) * 1975-05-21 1976-12-07 Smith Kline French Lab Heterocyclic compound
JPS5283573A (en) * 1976-01-01 1977-07-12 Leo Pharm Prod As Guanidine derivatives and hypotensive agents containing same
JPS53108970A (en) * 1977-03-07 1978-09-22 Yamanouchi Pharmaceut Co Ltd Novel guanidine derivative and its preparation
JPS57191334A (en) * 1981-05-14 1982-11-25 Mitsubishi Rayon Co Production of special crimp yarn

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51141865A (en) * 1975-05-21 1976-12-07 Smith Kline French Lab Heterocyclic compound
JPS5283573A (en) * 1976-01-01 1977-07-12 Leo Pharm Prod As Guanidine derivatives and hypotensive agents containing same
JPS53108970A (en) * 1977-03-07 1978-09-22 Yamanouchi Pharmaceut Co Ltd Novel guanidine derivative and its preparation
JPS57191334A (en) * 1981-05-14 1982-11-25 Mitsubishi Rayon Co Production of special crimp yarn

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