CA2777055C - Methods for treating, diagnosing, and monitoring lupus - Google Patents

Methods for treating, diagnosing, and monitoring lupus Download PDF

Info

Publication number: CA2777055C
Authority: CA; Canada
Prior art keywords: variation; allele; snp; locus; sle
Prior art date: 2009-10-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

CA2777055A

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English (en)

French (fr)

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CA2777055A1 (en

Inventor

Timothy W. Behrens

Robert R. Graham

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Genentech Inc

Original Assignee

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-10-07

Filing date

2010-10-06

Publication date

2021-04-06

2010-10-06 Application filed by Genentech Inc filed Critical Genentech Inc

2011-04-14 Publication of CA2777055A1 publication Critical patent/CA2777055A1/en

2021-04-06 Application granted granted Critical

2021-04-06 Publication of CA2777055C publication Critical patent/CA2777055C/en

Status Active legal-status Critical Current

2030-10-06 Anticipated expiration legal-status Critical

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Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR101824744B1 (ko) *	2009-10-07	2018-03-15	제넨테크, 인크.	루푸스의 치료, 진단 및 모니터링 방법
WO2012031122A2 (en) *	2010-09-03	2012-03-08	Immport Therapeutics, Inc.	Methods and compositions for the diagnosis and treatment of cancer and autoimmune disorders
KR20140034529A (ko)	2012-09-12	2014-03-20	삼성전기주식회사	전기 동도금 장치
KR101491214B1 (ko) *	2012-10-10	2015-02-06	가톨릭대학교 산학협력단	１ｑ２５．１(RABGAP1L) 위치, 6p21.32 (C4) 위치 및 １０ｑ２１．３위치의 ＤＮＡ 복제 수 변이 검출용 프라이머를 포함하는 전신성 홍반성 루푸스 발병 위험도 예측용 조성물
WO2014058254A1 (ko) *	2012-10-10	2014-04-17	가톨릭대학교 산학협력단	１ｑ２５．１(RABGAP1L) 위치, 6P21.32 (C4) 위치 및 １０ｑ２１．３위치의 ＤＮＡ 복제 수 변이 검출용 프라이머를 포함하는 전신성 홍반성 루푸스 발병 위험도 예측용 조성물
US20170081723A1 (en) *	2014-03-21	2017-03-23	Agency For Science, Technology And Research	Fusion Genes in Cancer
KR20190034511A (ko)	2019-03-22	2019-04-02	아주대학교산학협력단	Aimp1을 포함하는 전신 홍반성 루프스 진단용 바이오마커 조성물 및 이를 이용한 전신 홍반성 루프스 진단 방법
WO2021127589A1 (en) *	2019-12-18	2021-06-24	The Children's Hospital Of Philadelphia	Novel druggable targets for the treatment of inflammatory diseases such as systemic lupus erythematosus (sle) and methods for diagnosis and treatment using the same

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4657760A (en)	1979-03-20	1987-04-14	Ortho Pharmaceutical Corporation	Methods and compositions using monoclonal antibody to human T cells
US4816567A (en)	1983-04-08	1989-03-28	Genentech, Inc.	Recombinant immunoglobin preparations
US4683203A (en)	1984-04-14	1987-07-28	Redco N.V.	Immobilized enzymes, processes for preparing same, and use thereof
US4683195A (en)	1986-01-30	1987-07-28	Cetus Corporation	Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5206344A (en)	1985-06-26	1993-04-27	Cetus Oncology Corporation	Interleukin-2 muteins and polymer conjugation thereof
IE61148B1 (en)	1988-03-10	1994-10-05	Ici Plc	Method of detecting nucleotide sequences
GB8823869D0 (en)	1988-10-12	1988-11-16	Medical Res Council	Production of antibodies
DE3920358A1 (de)	1989-06-22	1991-01-17	Behringwerke Ag	Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5225212A (en)	1989-10-20	1993-07-06	Liposome Technology, Inc.	Microreservoir liposome composition and method
SG48759A1 (en)	1990-01-12	2002-07-23	Abgenix Inc	Generation of xenogenic antibodies
US5545806A (en)	1990-08-29	1996-08-13	Genpharm International, Inc.	Ransgenic non-human animals for producing heterologous antibodies
US5625126A (en)	1990-08-29	1997-04-29	Genpharm International, Inc.	Transgenic non-human animals for producing heterologous antibodies
EP0814159B1 (de)	1990-08-29	2005-07-27	GenPharm International, Inc.	Transgene Mäuse fähig zur Produktion heterologer Antikörper
US5661016A (en)	1990-08-29	1997-08-26	Genpharm International Inc.	Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5633425A (en)	1990-08-29	1997-05-27	Genpharm International, Inc.	Transgenic non-human animals capable of producing heterologous antibodies
GB9114948D0 (en)	1991-07-11	1991-08-28	Pfizer Ltd	Process for preparing sertraline intermediates
CA2219361C (en)	1995-04-27	2012-02-28	Abgenix, Inc.	Human antibodies derived from immunized xenomice
AU2466895A (en)	1995-04-28	1996-11-18	Abgenix, Inc.	Human antibodies derived from immunized xenomice
AU730633B2 (en)	1996-05-29	2001-03-08	Phillip Belgrader	Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
KR100942002B1 (ko)	1996-12-03	2010-02-12	암젠 프레몬트 인코포레이티드	복수의 ｖｈ 및 ｖｋ 부위를 함유하는 사람 면역글로불린 유전자좌를 갖는 형질전환된 포유류 및 이로부터 생성된 항체
AU6534600A (en) *	1999-08-09	2001-03-05	Uab Research Foundation	Genetic polymorphism in the il-10 promoter
JP2004507226A (ja)	2000-05-30	2004-03-11	ピーイー　コーポレイション　（エヌワイ）	ライゲーションおよび増幅の組み合わせを用いて標的核酸を検出するための方法
WO2002018414A2 (en) *	2000-08-29	2002-03-07	Genaissance Pharmaceuticals, Inc.	Haplotypes of the bf gene
US6900016B1 (en)	2000-09-08	2005-05-31	Applera Corporation	Polymorphisms in known genes associated with inflammatory autoimmune disease, methods of detection and uses thereof
WO2002057414A2 (en)	2000-10-20	2002-07-25	Expression Diagnostics, Inc.	Leukocyte expression profiling
US7205106B1 (en)	2001-07-20	2007-04-17	Roche Molecular Systems, Inc.	Association of polymorphisms in IL4-related genes with autoimmune disease
JP2003061677A (ja)	2001-08-28	2003-03-04	Olympus Optical Co Ltd	全身性エリテマトーデスの感受性遺伝子およびその使用
US20030119004A1 (en)	2001-12-05	2003-06-26	Wenz H. Michael	Methods for quantitating nucleic acids using coupled ligation and amplification
US7022476B2 (en)	2002-02-26	2006-04-04	New York Society For Ruptured And Crippled Maintaining The Hospital For Special Surgery	Human FcγRIIB gene polymorphisms for assessing development of systemic lupus erythematosus and compositions for use thereof
US7584058B2 (en) *	2003-02-27	2009-09-01	Methexis Genomics N.V.	Genetic diagnosis using multiple sequence variant analysis
US7811794B2 (en)	2003-03-18	2010-10-12	Celera Corporation	Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof
WO2005086872A2 (en)	2004-03-10	2005-09-22	Celera, An Applera Corporation Business	Ptpn22 polymorphisms in diagnosis and therapy
DE102005003686A1 (de)	2005-01-26	2006-08-03	Rohde & Schwarz Gmbh & Co. Kg	Anordnung zum Glätten des einem Verbraucher zugeführten Verbraucherstromes
AU2006272597A1 (en) *	2005-07-25	2007-02-01	Emergent Product Development Seattle Llc	Single dose use of CD20-specific binding molecules
ATE549416T1 (de)	2005-08-05	2012-03-15	Genentech Inc	Verfahren und zusammensetzungen zum nachweis von autoimmunkrankheiten
US20070238094A1 (en) *	2005-12-09	2007-10-11	Baylor Research Institute	Diagnosis, prognosis and monitoring of disease progression of systemic lupus erythematosus through blood leukocyte microarray analysis
US20070231816A1 (en) *	2005-12-09	2007-10-04	Baylor Research Institute	Module-Level Analysis of Peripheral Blood Leukocyte Transcriptional Profiles
CN101443040A (zh) *	2006-03-16	2009-05-27	基因技术股份有限公司	用cd4抗体治疗狼疮的方法
MX2008011785A (es)	2006-03-16	2008-09-25	Genentech Inc	Metodos de tratamiento de lupus utilizando anticuerpos cd4.
US20070269827A1 (en)	2006-05-18	2007-11-22	Oklahoma Medical Research Foundation	Predicting and Diagnosing Patients With Autoimmune Disease
EP2639318B1 (de) *	2006-09-11	2015-04-08	Celera Corporation	Psoriaseassoziierte genetische Polymorphismen, Nachweisverfahren dafür und ihre Verwendung
WO2008087647A2 (en) *	2007-01-19	2008-07-24	Yeda Research And Development Co. Ltd.	Methods of diagnosing, monitoring treatment and treating systemic lupus erythematosus (sle)
US7695916B2 (en) *	2007-03-22	2010-04-13	Celera Corporation	Genetic polymorphisms associated with coronary events and drug response, methods of detection and uses thereof
CN104593488B (zh) *	2007-05-21	2018-06-12	健泰科生物技术公司	用于鉴定和治疗狼疮的方法和组合物
US20110092446A1 (en) *	2007-07-20	2011-04-21	Cedric Francois	Compositions and methods for treatment of trauma
WO2009065132A1 (en) *	2007-11-16	2009-05-22	Oklahoma Medical Research Foundation	Predicting and diagnosing patients with autoimmune disease
EP2227780A4 (de) *	2008-03-19	2011-08-03	Existence Genetics Llc	Genetische analyse
DE102008031958A1 (de)	2008-07-07	2010-01-14	Klebchemie M.G. Becker Gmbh & Co. Kg	Verfahren zum Laminieren von Hochglanzoberflächen
MX2011003273A (es) *	2008-09-26	2011-04-28	Genentech Inc	Metodo para tratar, diagnosticar y supervisar lupus.
KR101824744B1 (ko)	2009-10-07	2018-03-15	제넨테크, 인크.	루푸스의 치료, 진단 및 모니터링 방법

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Publication number	Publication date
EP2486152B1 (de)	2017-12-06
CN102803509A (zh)	2012-11-28
RU2016131167A (ru)	2018-12-07
BR112012007778A2 (pt)	2020-08-11
EP3219813A2 (de)	2017-09-20
KR101953075B1 (ko)	2019-02-27
EP3219813B1 (de)	2020-11-18
US10053734B2 (en)	2018-08-21
JP5937008B2 (ja)	2016-06-22
EP3219813A3 (de)	2018-01-10
WO2011044205A1 (en)	2011-04-14
EP2486152A1 (de)	2012-08-15
RU2012118596A (ru)	2013-11-20
US20190211398A1 (en)	2019-07-11
HK1176384A1 (zh)	2013-07-26
US20160273044A1 (en)	2016-09-22
CN106929568A (zh)	2017-07-07
EP2486152A4 (de)	2013-05-22
KR101824744B1 (ko)	2018-03-15
KR20120100969A (ko)	2012-09-12
EP3839068A2 (de)	2021-06-23
JP6321717B2 (ja)	2018-05-09
KR20180012344A (ko)	2018-02-05
EP3839068A3 (de)	2021-10-20
CA2777055A1 (en)	2011-04-14
US20130034544A1 (en)	2013-02-07
CN113025703A (zh)	2021-06-25
JP2013507127A (ja)	2013-03-04
RU2596391C2 (ru)	2016-09-10
JP2017012158A (ja)	2017-01-19

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Publication	Publication Date	Title
US10053734B2 (en)	2018-08-21	Methods for treating, diagnosing, and monitoring lupus
EP2612924B1 (de)	2017-12-20	Verfahren und zusammensetzungen zum identifizieren und behandeln von lupus
US20100099101A1 (en)	2010-04-22	Methods for treating, diagnosing, and monitoring lupus
BEHRENS et al.	0	Sommaire du brevet 2690608
BEHRENS et al.	0	Patent 2690608 Summary