CA2230896A1 - Carboxylates de pyrimidine, composes connexes et methodes de traitement des etats inflammatoires - Google Patents

Carboxylates de pyrimidine, composes connexes et methodes de traitement des etats inflammatoires Download PDF

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Publication number
CA2230896A1
CA2230896A1 CA002230896A CA2230896A CA2230896A1 CA 2230896 A1 CA2230896 A1 CA 2230896A1 CA 002230896 A CA002230896 A CA 002230896A CA 2230896 A CA2230896 A CA 2230896A CA 2230896 A1 CA2230896 A1 CA 2230896A1
Authority
CA
Canada
Prior art keywords
ethyl
carboxylate
mmol
aminocitraconamido
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002230896A
Other languages
English (en)
Inventor
Mark J. Suto
Leah M. Gayo
Moorthy S. S. Palanki
Lynn J. Ransone-Fong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Signal Pharmaceuticals LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/574,406 external-priority patent/US5852028A/en
Application filed by Individual filed Critical Individual
Publication of CA2230896A1 publication Critical patent/CA2230896A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Composés s'avérant utiles comme agents anti-inflammatoires d'une manière générale et, plus spécifiquement, pour la prévention et/ou le traitement des maladies immuno-inflammatoires et auto-immunes. Ces composés sont des composés contenant de la pyrimidine et, dans un mode de réalisation, sont des esters de celle-ci. L'invention porte également sur des méthodes de prévention et/ou de traitement des états inflammatoires par administration à un animal en ayant besoin d'une dose efficace d'un composé de cette invention, de préférence sous forme d'une composition pharmaceutique.
CA002230896A 1995-09-01 1996-08-30 Carboxylates de pyrimidine, composes connexes et methodes de traitement des etats inflammatoires Abandoned CA2230896A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US310995P 1995-09-01 1995-09-01
US08/574,406 1995-12-18
US60/003,109 1995-12-18
US08/574,406 US5852028A (en) 1995-12-18 1995-12-18 Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions

Publications (1)

Publication Number Publication Date
CA2230896A1 true CA2230896A1 (fr) 1997-03-13

Family

ID=26671335

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002230896A Abandoned CA2230896A1 (fr) 1995-09-01 1996-08-30 Carboxylates de pyrimidine, composes connexes et methodes de traitement des etats inflammatoires

Country Status (4)

Country Link
JP (1) JPH11512390A (fr)
AU (1) AU726058B2 (fr)
CA (1) CA2230896A1 (fr)
WO (1) WO1997009325A1 (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6245774B1 (en) 1994-06-21 2001-06-12 Celltech Therapeutics Limited Tri-substituted phenyl or pyridine derivatives
US5935966A (en) * 1995-09-01 1999-08-10 Signal Pharmaceuticals, Inc. Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions
US5939421A (en) * 1997-07-01 1999-08-17 Signal Pharmaceuticals, Inc. Quinazoline analogs and related compounds and methods for treating inflammatory conditions
US6200977B1 (en) * 1998-02-17 2001-03-13 Tularik Inc. Pyrimidine derivatives
ES2219033T3 (es) * 1998-07-22 2004-11-16 Daiichi Suntory Pharma Co., Ltd. Inhibidores de nf-kappa b que contienen derivados de indano como ingrediente activo.
WO2000012487A1 (fr) 1998-08-27 2000-03-09 Sumitomo Pharmaceuticals Co., Ltd. Derives de pyrimidine
GB9914258D0 (en) * 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
CA2350992C (fr) 1999-09-17 2009-06-23 Suntory Limited Moyens de prevention ou therapeutique contre la myocardite, la cardiomyopathie dilatee et l'insuffisance cardiaque contenant des inhibiteurs nf-kb en tant qu'ingredient actif
US6660731B2 (en) 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
ATE294797T1 (de) 2000-09-15 2005-05-15 Vertex Pharma Pyrazolverbindungen als protein-kinasehemmer
PL210066B1 (pl) 2000-12-21 2011-11-30 Vertex Pharma Związek pirazolowy, kompozycja zawierająca ten związek i jego zastosowania
DE60214701T2 (de) 2001-04-13 2007-09-13 Vertex Pharmaceuticals Inc., Cambridge Inhibitoren von c-jun-n-terminalen-kinasen (jnk) und anderen proteinkinasen
EP1392300A1 (fr) * 2001-05-11 2004-03-03 Vertex Pharmaceuticals Incorporated Derives de pyridine, pyrimidine, pyridazine 2,5-disubstitues et de 1, 2, 4-triazine utilises comme inhibiteurs de p38
AU2002312933B2 (en) 2001-05-29 2007-12-06 Schering Ag CDK inhibiting pyrimidines, production thereof and their use as medicaments
SE0104140D0 (sv) 2001-12-07 2001-12-07 Astrazeneca Ab Novel Compounds
MY141867A (en) 2002-06-20 2010-07-16 Vertex Pharma Substituted pyrimidines useful as protein kinase inhibitors
MXPA05001367A (es) 2002-08-02 2005-04-28 Vertex Pharma Composiciones de pirazol utiles como inhibidores de gsk-3.
CA2571710A1 (fr) 2004-06-24 2006-11-02 Nicholas Valiante Immuno-potentialisateurs a petites molecules et analyses visant a detecter leur presence
AU2006215386B2 (en) 2005-02-16 2009-06-11 Astrazeneca Ab Chemical compounds
JP2008540622A (ja) 2005-05-16 2008-11-20 アストラゼネカ アクチボラグ 化合物
DK1945631T3 (da) 2005-10-28 2012-10-22 Astrazeneca Ab 4- (3-aminopyrazole) pyrimidinderivater til anvendelse som tyrosinkinaseinhibitorer til behandling af cancer
KR20080066069A (ko) 2005-11-03 2008-07-15 버텍스 파마슈티칼스 인코포레이티드 키나제 억제제로서 유용한 아미노피리미딘
GB0524427D0 (en) * 2005-11-30 2006-01-11 7Tm Pharma As Use of receptor ligands in threapy
EP2474546A1 (fr) 2006-01-23 2012-07-11 Vertex Pharmaceuticals Inc. Tiophène-carboxamides utiles en tant qu'inhibiteurs de kinases de protéine
WO2007120760A2 (fr) 2006-04-13 2007-10-25 Vertex Pharmaceuticals Incorporated Thiophène-carboxamides servant d'inhibiteurs de protéines kinases
CN101495474A (zh) 2006-05-23 2009-07-29 沃泰克斯药物股份有限公司 可用作蛋白激酶抑制剂的噻吩-甲酰胺类
EP2027116A2 (fr) 2006-05-23 2009-02-25 Vertex Pharmaceuticals Incorporated Thiophène-carboxamides pouvant être employés en tant qu'inhibiteurs de protéine kinase
US8258129B2 (en) * 2006-07-06 2012-09-04 Boehringer Ingelheim International Gmbh 4-heterocycloalkylpyri(mi)dines, process for the preparation thereof and their use as medicaments
IL309201A (en) * 2007-04-11 2024-02-01 Canbas Co Ltd Compounds with anticancer activity
MX2009011810A (es) 2007-05-02 2010-01-14 Vertex Pharma Tiazoles y pirazoles utiles como inhibidores de cinasa.
UA99459C2 (en) 2007-05-04 2012-08-27 Астразенека Аб 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer
WO2009018415A1 (fr) 2007-07-31 2009-02-05 Vertex Pharmaceuticals Incorporated Procédé de préparation de la 5-fluoro-1h-pyrazolo[3,4-b]pyridin-3-amine et des dérivés de celle-ci
JP2012501971A (ja) 2008-09-03 2012-01-26 バーテックス ファーマシューティカルズ インコーポレイテッド 共結晶および共結晶を含む薬学的処方物
RU2011143740A (ru) * 2009-03-30 2013-05-10 Астеллас Фарма Инк. Соединение пиримидина
CN108148003B (zh) * 2018-01-16 2021-03-26 棓诺(苏州)新材料有限公司 Oled材料中间体苯甲酰嘧啶类化合物的合成方法
CN117180122B (zh) * 2023-11-02 2024-04-09 杭州湃肽生化科技有限公司 一种舒敏修复组合物及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4983608A (en) * 1989-09-05 1991-01-08 Hoechst-Roussell Pharmaceuticals, Inc. N-substituted-4-pyrimidinamines and pyrimidinediamines

Also Published As

Publication number Publication date
AU7013096A (en) 1997-03-27
WO1997009325A1 (fr) 1997-03-13
JPH11512390A (ja) 1999-10-26
AU726058B2 (en) 2000-10-26

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