CA1068698A - Process for preparing substituted aminoquinazoline derivatives and intermediates therefor - Google Patents

Process for preparing substituted aminoquinazoline derivatives and intermediates therefor

Info

Publication number
CA1068698A
CA1068698A CA278,728A CA278728A CA1068698A CA 1068698 A CA1068698 A CA 1068698A CA 278728 A CA278728 A CA 278728A CA 1068698 A CA1068698 A CA 1068698A
Authority
CA
Canada
Prior art keywords
formula
process according
reaction
carbon atoms
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA278,728A
Other languages
English (en)
French (fr)
Inventor
Philip D. Hammen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc.
Philip D. Hammen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc., Philip D. Hammen filed Critical Pfizer Inc.
Application granted granted Critical
Publication of CA1068698A publication Critical patent/CA1068698A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
CA278,728A 1976-06-15 1977-05-18 Process for preparing substituted aminoquinazoline derivatives and intermediates therefor Expired CA1068698A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69620176A 1976-06-15 1976-06-15

Publications (1)

Publication Number Publication Date
CA1068698A true CA1068698A (en) 1979-12-25

Family

ID=24796111

Family Applications (1)

Application Number Title Priority Date Filing Date
CA278,728A Expired CA1068698A (en) 1976-06-15 1977-05-18 Process for preparing substituted aminoquinazoline derivatives and intermediates therefor

Country Status (34)

Country Link
JP (1) JPS52153985A (sv)
AR (1) AR218251A1 (sv)
AT (1) AT356115B (sv)
BE (1) BE855656A (sv)
BG (3) BG35594A3 (sv)
CA (1) CA1068698A (sv)
CH (3) CH638203A5 (sv)
CS (1) CS202069B2 (sv)
DD (1) DD131021A5 (sv)
DE (1) DE2725019A1 (sv)
DK (1) DK146625C (sv)
EG (1) EG12922A (sv)
ES (1) ES459364A1 (sv)
FI (1) FI66853C (sv)
FR (1) FR2355015A1 (sv)
GB (1) GB1548856A (sv)
GR (1) GR72288B (sv)
HK (1) HK31481A (sv)
HU (1) HU177883B (sv)
IE (1) IE45423B1 (sv)
IL (1) IL52167A (sv)
LU (1) LU77530A1 (sv)
MY (1) MY8100270A (sv)
NL (1) NL172543C (sv)
NO (1) NO147838C (sv)
NZ (1) NZ184168A (sv)
PH (1) PH22196A (sv)
PL (3) PL113012B1 (sv)
PT (1) PT66617B (sv)
RO (3) RO77308A (sv)
SE (2) SE435380B (sv)
SU (2) SU1033002A3 (sv)
YU (1) YU40164B (sv)
ZA (1) ZA773014B (sv)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3346675A1 (de) * 1983-12-23 1985-07-04 Beiersdorf Ag, 2000 Hamburg Substituierte 1-(4-amino-6,7-dialkoxy-chinazolinyl)-4- cyclohexenyl-derivate des piperazins und homopiperazins, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen und zwischenprodukte
AT384218B (de) * 1985-12-04 1987-10-12 Gerot Pharmazeutika Verfahren zur herstellung von neuen chinazolin-derivaten
CA2077252C (en) * 1992-08-31 2001-04-10 Khashayar Karimian Methods of making ureas and guanidines, and intermediates therefor
IL112248A0 (en) 1994-01-25 1995-03-30 Warner Lambert Co Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
IL112249A (en) * 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
US5679683A (en) * 1994-01-25 1997-10-21 Warner-Lambert Company Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
US5932538A (en) * 1996-02-02 1999-08-03 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3511836A (en) 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines
US3669968A (en) 1970-05-21 1972-06-13 Pfizer Trialkoxy quinazolines
JPS536156B2 (sv) * 1972-10-30 1978-03-04
US3935213A (en) 1973-12-05 1976-01-27 Pfizer Inc. Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives
JPS50126682A (sv) * 1974-03-25 1975-10-04

Also Published As

Publication number Publication date
SU946402A3 (ru) 1982-07-23
DK240877A (da) 1977-12-16
ZA773014B (en) 1978-04-26
EG12922A (en) 1980-03-31
BG35594A3 (en) 1984-05-15
NO771919L (no) 1977-12-16
SE435380B (sv) 1984-09-24
DK146625B (da) 1983-11-21
FI66853B (fi) 1984-08-31
NL172543B (nl) 1983-04-18
RO77308A (ro) 1981-08-17
FI66853C (fi) 1984-12-10
NL172543C (nl) 1983-09-16
AU2558377A (en) 1978-09-07
HU177883B (en) 1982-01-28
DE2725019A1 (de) 1977-12-22
PT66617B (en) 1978-10-27
SU1033002A3 (ru) 1983-07-30
FI771741A (sv) 1977-12-16
PT66617A (en) 1977-06-01
PH22196A (en) 1988-06-28
SE7705745L (sv) 1977-12-16
YU132677A (en) 1982-08-31
FR2355015A1 (fr) 1978-01-13
BE855656A (fr) 1977-12-14
PL105558B1 (pl) 1979-10-31
GR72288B (sv) 1983-10-17
FR2355015B1 (sv) 1981-07-24
PL111221B1 (en) 1980-08-30
CS202069B2 (en) 1980-12-31
DK146625C (da) 1984-06-04
IL52167A (en) 1981-01-30
NO147838B (no) 1983-03-14
NO147838C (no) 1983-06-22
DD131021A5 (de) 1978-05-24
CH638203A5 (en) 1983-09-15
ATA386977A (de) 1979-09-15
JPS5543465B2 (sv) 1980-11-06
SE8107554L (sv) 1981-12-16
LU77530A1 (fr) 1979-03-26
PL113012B1 (en) 1980-11-29
PL198874A1 (pl) 1978-04-10
BG35747A3 (en) 1984-06-15
AR218251A1 (es) 1980-05-30
ES459364A1 (es) 1978-03-16
CH638516A5 (en) 1983-09-30
NZ184168A (en) 1979-08-31
BG35748A3 (en) 1984-06-15
JPS52153985A (en) 1977-12-21
SE450120B (sv) 1987-06-09
GB1548856A (en) 1979-07-18
IE45423L (en) 1977-12-15
AT356115B (de) 1980-04-10
RO73050A (ro) 1981-08-30
IL52167A0 (en) 1977-07-31
RO77330A (ro) 1981-06-22
IE45423B1 (en) 1982-08-25
CH638517A5 (en) 1983-09-30
HK31481A (en) 1981-07-10
MY8100270A (en) 1981-12-31
NL7705939A (nl) 1977-12-19
YU40164B (en) 1985-08-31

Similar Documents

Publication Publication Date Title
CA1175432A (en) N-oxacyclyl-alkylpiperidine derivatives, process for their preparation, pharmaceutical products containing them, and their use
EP0237781A2 (en) Phenyl and heterocyclic tetrahydropyridyl and piperazinyl alkoxy-benzheterocyclic compounds as antipsychotic agents
CA1068698A (en) Process for preparing substituted aminoquinazoline derivatives and intermediates therefor
US4314943A (en) Heterocyclic substituted aryloxy 3-indolyl-tertiary butylaminopropanols
US4377576A (en) 5-(Heterocyclic amino-propionyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-ones
CA1211445A (en) Isoquinoline derivatives, a process for their preparation, pharmaceutical formulations based on these compounds and the use thereof
US4507478A (en) 2-Mercaptopyrimidohexahydroquinolines and related compounds
EP0117345B1 (en) Aminopyrimidinones as histamine h2-antagonists
US4705787A (en) Quinazolinone derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same
US4575553A (en) Antitumor m-AMSA analog
KR900001420B1 (ko) 4-아미노-6,7-디메톡시2-[4-(푸로-2-일)-피페라진-1-일]-퀴나졸린 및 생리적으로 적합한 그염의 제조방법
EP0134096B1 (en) Aminopyrimidinone derivatives as histamine h2-antagonists
RU1838309C (ru) Способ получени производных хиназолина или их формацевтически приемлемых кислотно-аддитивных солей
SU640661A3 (ru) Способ получени арилалкиламинов или их солей
Ciller et al. Synthesis of Heterocyclic Compounds, XXXVIII. Five‐membered Heterocycles by Cyclization of 3‐Benzoyl‐4‐oxobutanenitriles
SU999967A3 (ru) Способ получени 6-N-замещенных 6-амино-3-пиридазинилгидразинов или их солей
US4202977A (en) S-Triazolo [1,5-a] pyridine derivatives
US3767679A (en) 3-substituted chromones
JPS6317828B2 (sv)
EP0199485B1 (en) Intermediates and process
KR810000293B1 (ko) 치환아미노 퀴나졸린 유도체의 제조방법
US4495352A (en) Heterocyclic substituted aryloxy 3-indolyl-tertiary butylaminopropanols
CA1092117A (en) Method for the production of 6,7-dimethoxy-4-amino-2- ¬4-(2-furoyl)-1-piperazinyl| quinazoline having an antihypertensive effect
Fuentes et al. Synthesis of heterocyclic compounds. XXIV. Synthesis of pyridines from β‐substituted α‐phenylacrylonitriles
Schönafinger et al. Synthesis of 7, 8, 9, 10‐tetrahydropyrido [3′, 4′: 4, 5] pyrrolo [2, 3‐c] quinolines