GB1548856A - Process for hypotensive 2-(4-substituted piperazin 1-yl)-j-aminopainazolines - Google Patents
Process for hypotensive 2-(4-substituted piperazin 1-yl)-j-aminopainazolinesInfo
- Publication number
- GB1548856A GB1548856A GB24841/77A GB2484177A GB1548856A GB 1548856 A GB1548856 A GB 1548856A GB 24841/77 A GB24841/77 A GB 24841/77A GB 2484177 A GB2484177 A GB 2484177A GB 1548856 A GB1548856 A GB 1548856A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dimethoxyquinazoline
- compounds
- carbon atoms
- amino group
- aminopainazolines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Compounds of the formula <IMAGE> or of a hydrochloric or hydrobromic acid addition salt thereof, in which R1 is hydrogen or methoxy, and R2 denotes benzoyl, furoyl, thienylcarbonyl, alkoxycarbonyl having 2 to 5 carbon atoms or (2-hydroxyalkoxy)carbonyl having 4 or 5 carbon atoms, are prepared in accordance with a novel process. Initially, a 2-chloro-6,7-dimethoxyquinazoline or a 2-bromo-6,7-dimethoxyquinazoline, whose amino group situated in the 4 position is substituted, is reacted, in an inert organic solvent and at 50-200 DEG C, with a corresponding piperazine. In a second reaction step, the substituents of the amino group are removed by hydrogenolysis. The compounds which are obtained can be used as agents for lowering blood pressure.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69620176A | 1976-06-15 | 1976-06-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1548856A true GB1548856A (en) | 1979-07-18 |
Family
ID=24796111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB24841/77A Expired GB1548856A (en) | 1976-06-15 | 1977-06-14 | Process for hypotensive 2-(4-substituted piperazin 1-yl)-j-aminopainazolines |
Country Status (34)
| Country | Link |
|---|---|
| JP (1) | JPS52153985A (en) |
| AR (1) | AR218251A1 (en) |
| AT (1) | AT356115B (en) |
| BE (1) | BE855656A (en) |
| BG (3) | BG35594A3 (en) |
| CA (1) | CA1068698A (en) |
| CH (3) | CH638203A5 (en) |
| CS (1) | CS202069B2 (en) |
| DD (1) | DD131021A5 (en) |
| DE (1) | DE2725019A1 (en) |
| DK (1) | DK146625C (en) |
| EG (1) | EG12922A (en) |
| ES (1) | ES459364A1 (en) |
| FI (1) | FI66853C (en) |
| FR (1) | FR2355015A1 (en) |
| GB (1) | GB1548856A (en) |
| GR (1) | GR72288B (en) |
| HK (1) | HK31481A (en) |
| HU (1) | HU177883B (en) |
| IE (1) | IE45423B1 (en) |
| IL (1) | IL52167A (en) |
| LU (1) | LU77530A1 (en) |
| MY (1) | MY8100270A (en) |
| NL (1) | NL172543C (en) |
| NO (1) | NO147838C (en) |
| NZ (1) | NZ184168A (en) |
| PH (1) | PH22196A (en) |
| PL (3) | PL113012B1 (en) |
| PT (1) | PT66617B (en) |
| RO (3) | RO77308A (en) |
| SE (2) | SE435380B (en) |
| SU (2) | SU1033002A3 (en) |
| YU (1) | YU40164B (en) |
| ZA (1) | ZA773014B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6084095A (en) * | 1994-01-25 | 2000-07-04 | Warner-Lambert Company | Substituted pyrido[3,2-d]pyrimidines capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| EP1018879A1 (en) * | 1996-02-02 | 2000-07-19 | Nitromed, Inc. | Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses |
| US6596726B1 (en) | 1994-01-25 | 2003-07-22 | Warner Lambert Company | Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3346675A1 (en) * | 1983-12-23 | 1985-07-04 | Beiersdorf Ag, 2000 Hamburg | SUBSTITUTED 1- (4-AMINO-6,7-DIALKOXY-CHINAZOLINYL) -4- CYCLOHEXENYL DERIVATIVES OF PIPERAZINE AND HOMOPIPERAZINE, METHODS FOR THE PRODUCTION THEREOF, AND THEIR USE, AND ITS RELATED PRODUCTS |
| AT384218B (en) * | 1985-12-04 | 1987-10-12 | Gerot Pharmazeutika | METHOD FOR PRODUCING NEW CHINAZOLINE DERIVATIVES |
| CA2077252C (en) * | 1992-08-31 | 2001-04-10 | Khashayar Karimian | Methods of making ureas and guanidines, and intermediates therefor |
| US5679683A (en) * | 1994-01-25 | 1997-10-21 | Warner-Lambert Company | Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3511836A (en) | 1967-12-13 | 1970-05-12 | Pfizer & Co C | 2,4,6,7-tetra substituted quinazolines |
| US3669968A (en) | 1970-05-21 | 1972-06-13 | Pfizer | Trialkoxy quinazolines |
| JPS536156B2 (en) * | 1972-10-30 | 1978-03-04 | ||
| US3935213A (en) | 1973-12-05 | 1976-01-27 | Pfizer Inc. | Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives |
| JPS50126682A (en) * | 1974-03-25 | 1975-10-04 |
-
1977
- 1977-05-16 SE SE7705745A patent/SE435380B/en not_active IP Right Cessation
- 1977-05-18 CA CA278,728A patent/CA1068698A/en not_active Expired
- 1977-05-20 ZA ZA00773014A patent/ZA773014B/en unknown
- 1977-05-20 NZ NZ184168A patent/NZ184168A/en unknown
- 1977-05-20 GR GR53521A patent/GR72288B/el unknown
- 1977-05-25 IL IL52167A patent/IL52167A/en unknown
- 1977-05-27 YU YU1326/77A patent/YU40164B/en unknown
- 1977-05-31 PT PT66617A patent/PT66617B/en unknown
- 1977-05-31 DE DE19772725019 patent/DE2725019A1/en active Pending
- 1977-05-31 JP JP6391877A patent/JPS52153985A/en active Granted
- 1977-05-31 NL NLAANVRAGE7705939,A patent/NL172543C/en not_active IP Right Cessation
- 1977-06-01 NO NO771919A patent/NO147838C/en unknown
- 1977-06-01 AT AT386977A patent/AT356115B/en not_active IP Right Cessation
- 1977-06-01 ES ES459364A patent/ES459364A1/en not_active Expired
- 1977-06-01 CH CH673777A patent/CH638203A5/en not_active IP Right Cessation
- 1977-06-01 EG EG338/77A patent/EG12922A/en active
- 1977-06-01 DK DK240877A patent/DK146625C/en not_active IP Right Cessation
- 1977-06-01 FI FI771741A patent/FI66853C/en not_active IP Right Cessation
- 1977-06-02 AR AR267927A patent/AR218251A1/en active
- 1977-06-03 BG BG7736493A patent/BG35594A3/en unknown
- 1977-06-03 BG BG8257396A patent/BG35748A3/en unknown
- 1977-06-03 BG BG8257395A patent/BG35747A3/en unknown
- 1977-06-13 LU LU77530A patent/LU77530A1/en unknown
- 1977-06-14 RO RO7798087A patent/RO77308A/en unknown
- 1977-06-14 SU SU772497901A patent/SU1033002A3/en active
- 1977-06-14 RO RO7790683A patent/RO73050A/en unknown
- 1977-06-14 GB GB24841/77A patent/GB1548856A/en not_active Expired
- 1977-06-14 FR FR7718206A patent/FR2355015A1/en active Granted
- 1977-06-14 IE IE1212/77A patent/IE45423B1/en not_active IP Right Cessation
- 1977-06-14 BE BE178416A patent/BE855656A/en not_active IP Right Cessation
- 1977-06-14 HU HU77PI578A patent/HU177883B/en not_active IP Right Cessation
- 1977-06-14 RO RO7798088A patent/RO77330A/en unknown
- 1977-06-15 PL PL1977211797A patent/PL113012B1/en unknown
- 1977-06-15 PL PL1977198874A patent/PL105558B1/en unknown
- 1977-06-15 DD DD7700199502A patent/DD131021A5/en unknown
- 1977-06-15 PL PL1977211798A patent/PL111221B1/en unknown
- 1977-06-15 CS CS773960A patent/CS202069B2/en unknown
-
1978
- 1978-01-03 PH PH20606A patent/PH22196A/en unknown
- 1978-06-28 SU SU782630798A patent/SU946402A3/en active
-
1981
- 1981-07-02 HK HK314/81A patent/HK31481A/en unknown
- 1981-12-16 SE SE8107554A patent/SE450120B/en not_active IP Right Cessation
- 1981-12-30 MY MY270/81A patent/MY8100270A/en unknown
-
1982
- 1982-04-22 CH CH245682A patent/CH638516A5/en not_active IP Right Cessation
- 1982-04-22 CH CH245782A patent/CH638517A5/en not_active IP Right Cessation
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6084095A (en) * | 1994-01-25 | 2000-07-04 | Warner-Lambert Company | Substituted pyrido[3,2-d]pyrimidines capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| US6265410B1 (en) | 1994-01-25 | 2001-07-24 | Warner-Lambert Company | Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| US6455534B2 (en) | 1994-01-25 | 2002-09-24 | Warner-Lambert Company | Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| US6521620B1 (en) | 1994-01-25 | 2003-02-18 | Warner-Lambert Company | Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| US6596726B1 (en) | 1994-01-25 | 2003-07-22 | Warner Lambert Company | Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| US6713484B2 (en) | 1994-01-25 | 2004-03-30 | Warner-Lambert Company | Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| EP1018879A1 (en) * | 1996-02-02 | 2000-07-19 | Nitromed, Inc. | Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses |
| EP1018879A4 (en) * | 1996-02-02 | 2002-07-24 | Nitromed Inc | Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses |
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19940614 |