FR2355015A1 - Procede et composes intermediaires pour la preparation de certaines 2-(piperazin-1-yle 4-substitue)-4-amino-quinazolines - Google Patents

Procede et composes intermediaires pour la preparation de certaines 2-(piperazin-1-yle 4-substitue)-4-amino-quinazolines

Info

Publication number
FR2355015A1
FR2355015A1 FR7718206A FR7718206A FR2355015A1 FR 2355015 A1 FR2355015 A1 FR 2355015A1 FR 7718206 A FR7718206 A FR 7718206A FR 7718206 A FR7718206 A FR 7718206A FR 2355015 A1 FR2355015 A1 FR 2355015A1
Authority
FR
France
Prior art keywords
amino
piperazin
quinazolines
preparation
certain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7718206A
Other languages
English (en)
Other versions
FR2355015B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of FR2355015A1 publication Critical patent/FR2355015A1/fr
Application granted granted Critical
Publication of FR2355015B1 publication Critical patent/FR2355015B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

L'invention concerne la préparation de 2-(pipérazin-1-yle 4-substitué)-4-amino-6,7-dimethoxy ou 6,7-8-triméthoxyquinazolines. Certaines 2-chloro (ou bromo)-4-amino substitué quinazolines sont amenées à réagir avec la pipérazine 1-substituée correspondante pour former directement les composés désirés ou une 2-(pipérazin-1-yle substitué)-4-(amino substitué)-quinazoline; dans ce dernier cas le substituant du groupe 4 amino de la quinazoline est éliminé sélectivement pour former les composes désirés. Les produits obtenus sont des agents hypotensifs connus. Certains intermédiaires sont nouveaux.
FR7718206A 1976-06-15 1977-06-14 Procede et composes intermediaires pour la preparation de certaines 2-(piperazin-1-yle 4-substitue)-4-amino-quinazolines Granted FR2355015A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69620176A 1976-06-15 1976-06-15

Publications (2)

Publication Number Publication Date
FR2355015A1 true FR2355015A1 (fr) 1978-01-13
FR2355015B1 FR2355015B1 (fr) 1981-07-24

Family

ID=24796111

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7718206A Granted FR2355015A1 (fr) 1976-06-15 1977-06-14 Procede et composes intermediaires pour la preparation de certaines 2-(piperazin-1-yle 4-substitue)-4-amino-quinazolines

Country Status (34)

Country Link
JP (1) JPS52153985A (fr)
AR (1) AR218251A1 (fr)
AT (1) AT356115B (fr)
BE (1) BE855656A (fr)
BG (3) BG35594A3 (fr)
CA (1) CA1068698A (fr)
CH (3) CH638203A5 (fr)
CS (1) CS202069B2 (fr)
DD (1) DD131021A5 (fr)
DE (1) DE2725019A1 (fr)
DK (1) DK146625C (fr)
EG (1) EG12922A (fr)
ES (1) ES459364A1 (fr)
FI (1) FI66853C (fr)
FR (1) FR2355015A1 (fr)
GB (1) GB1548856A (fr)
GR (1) GR72288B (fr)
HK (1) HK31481A (fr)
HU (1) HU177883B (fr)
IE (1) IE45423B1 (fr)
IL (1) IL52167A (fr)
LU (1) LU77530A1 (fr)
MY (1) MY8100270A (fr)
NL (1) NL172543C (fr)
NO (1) NO147838C (fr)
NZ (1) NZ184168A (fr)
PH (1) PH22196A (fr)
PL (3) PL113012B1 (fr)
PT (1) PT66617B (fr)
RO (3) RO77308A (fr)
SE (2) SE435380B (fr)
SU (2) SU1033002A3 (fr)
YU (1) YU40164B (fr)
ZA (1) ZA773014B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3346675A1 (de) * 1983-12-23 1985-07-04 Beiersdorf Ag, 2000 Hamburg Substituierte 1-(4-amino-6,7-dialkoxy-chinazolinyl)-4- cyclohexenyl-derivate des piperazins und homopiperazins, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen und zwischenprodukte
AT384218B (de) * 1985-12-04 1987-10-12 Gerot Pharmazeutika Verfahren zur herstellung von neuen chinazolin-derivaten
CA2077252C (fr) * 1992-08-31 2001-04-10 Khashayar Karimian Methodes de fabrication d'urees et de guanidines et composes intermediaires servant a ces syntheses
IL112248A0 (en) 1994-01-25 1995-03-30 Warner Lambert Co Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
IL112249A (en) * 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
US5679683A (en) * 1994-01-25 1997-10-21 Warner-Lambert Company Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
US5932538A (en) * 1996-02-02 1999-08-03 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3511836A (en) 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines
US3669968A (en) 1970-05-21 1972-06-13 Pfizer Trialkoxy quinazolines
JPS536156B2 (fr) * 1972-10-30 1978-03-04
US3935213A (en) 1973-12-05 1976-01-27 Pfizer Inc. Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives
JPS50126682A (fr) * 1974-03-25 1975-10-04

Also Published As

Publication number Publication date
SU946402A3 (ru) 1982-07-23
DK240877A (da) 1977-12-16
ZA773014B (en) 1978-04-26
EG12922A (en) 1980-03-31
BG35594A3 (en) 1984-05-15
NO771919L (no) 1977-12-16
SE435380B (sv) 1984-09-24
DK146625B (da) 1983-11-21
FI66853B (fi) 1984-08-31
NL172543B (nl) 1983-04-18
RO77308A (fr) 1981-08-17
FI66853C (fi) 1984-12-10
NL172543C (nl) 1983-09-16
AU2558377A (en) 1978-09-07
HU177883B (en) 1982-01-28
DE2725019A1 (de) 1977-12-22
PT66617B (en) 1978-10-27
SU1033002A3 (ru) 1983-07-30
FI771741A (fr) 1977-12-16
PT66617A (en) 1977-06-01
PH22196A (en) 1988-06-28
SE7705745L (sv) 1977-12-16
YU132677A (en) 1982-08-31
BE855656A (fr) 1977-12-14
PL105558B1 (pl) 1979-10-31
GR72288B (fr) 1983-10-17
FR2355015B1 (fr) 1981-07-24
PL111221B1 (en) 1980-08-30
CS202069B2 (en) 1980-12-31
DK146625C (da) 1984-06-04
IL52167A (en) 1981-01-30
NO147838B (no) 1983-03-14
NO147838C (no) 1983-06-22
DD131021A5 (de) 1978-05-24
CH638203A5 (en) 1983-09-15
ATA386977A (de) 1979-09-15
JPS5543465B2 (fr) 1980-11-06
SE8107554L (sv) 1981-12-16
LU77530A1 (fr) 1979-03-26
CA1068698A (fr) 1979-12-25
PL113012B1 (en) 1980-11-29
PL198874A1 (pl) 1978-04-10
BG35747A3 (en) 1984-06-15
AR218251A1 (es) 1980-05-30
ES459364A1 (es) 1978-03-16
CH638516A5 (en) 1983-09-30
NZ184168A (en) 1979-08-31
BG35748A3 (en) 1984-06-15
JPS52153985A (en) 1977-12-21
SE450120B (sv) 1987-06-09
GB1548856A (en) 1979-07-18
IE45423L (en) 1977-12-15
AT356115B (de) 1980-04-10
RO73050A (fr) 1981-08-30
IL52167A0 (en) 1977-07-31
RO77330A (fr) 1981-06-22
IE45423B1 (en) 1982-08-25
CH638517A5 (en) 1983-09-30
HK31481A (en) 1981-07-10
MY8100270A (en) 1981-12-31
NL7705939A (nl) 1977-12-19
YU40164B (en) 1985-08-31

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Legal Events

Date Code Title Description
ST Notification of lapse