BRPI0815708B8 - composto, éster de pró-droga, composição farmacêutica, e, método para tratar uma doença ou condição - Google Patents
composto, éster de pró-droga, composição farmacêutica, e, método para tratar uma doença ou condiçãoInfo
- Publication number
- BRPI0815708B8 BRPI0815708B8 BRPI0815708A BRPI0815708A BRPI0815708B8 BR PI0815708 B8 BRPI0815708 B8 BR PI0815708B8 BR PI0815708 A BRPI0815708 A BR PI0815708A BR PI0815708 A BRPI0815708 A BR PI0815708A BR PI0815708 B8 BRPI0815708 B8 BR PI0815708B8
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- pharmaceutical composition
- disease
- treating
- prodrug ester
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/04—Carbocyclic radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
composto, éster de pró-droga, composição farmacêutica, e, uso de um composto fornecidos são compostos tendo um efeito inibitório sobre o cotransportador de glicose dependente de sódio sglt. a invenção também fornece composições farmacêuticas, métodos de preparar os compostos, intermediários sintéticos, e métodos de usar os compostos, independentemente ou em combinação com outros agentes terapêuticos, para tratar doenças e condições que são afetadas pela inibição de sglt.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95762507P | 2007-08-23 | 2007-08-23 | |
US60/957625 | 2007-08-23 | ||
PCT/US2008/074058 WO2009026537A1 (en) | 2007-08-23 | 2008-08-22 | Benzylbenzene derivatives and methods of use |
Publications (4)
Publication Number | Publication Date |
---|---|
BRPI0815708A2 BRPI0815708A2 (pt) | 2014-09-30 |
BRPI0815708A8 BRPI0815708A8 (pt) | 2019-04-09 |
BRPI0815708B1 BRPI0815708B1 (pt) | 2019-07-02 |
BRPI0815708B8 true BRPI0815708B8 (pt) | 2021-05-25 |
Family
ID=40378694
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0815708A BRPI0815708B8 (pt) | 2007-08-23 | 2008-08-22 | composto, éster de pró-droga, composição farmacêutica, e, método para tratar uma doença ou condição |
Country Status (30)
Country | Link |
---|---|
US (4) | US7838499B2 (pt) |
EP (2) | EP2187742B1 (pt) |
JP (1) | JP4809931B2 (pt) |
KR (1) | KR101107425B1 (pt) |
CN (1) | CN101790311B (pt) |
AR (2) | AR068016A1 (pt) |
AU (1) | AU2008288770B2 (pt) |
BR (1) | BRPI0815708B8 (pt) |
CA (1) | CA2697349C (pt) |
CY (1) | CY1119810T1 (pt) |
DK (1) | DK2187742T3 (pt) |
ES (1) | ES2654894T3 (pt) |
HK (1) | HK1254895A1 (pt) |
HR (1) | HRP20180127T1 (pt) |
HU (1) | HUE035947T2 (pt) |
IL (1) | IL203915A (pt) |
LT (1) | LT2187742T (pt) |
MX (1) | MX2010002027A (pt) |
NO (1) | NO2187742T3 (pt) |
NZ (1) | NZ583369A (pt) |
PL (1) | PL2187742T3 (pt) |
PT (1) | PT2187742T (pt) |
RS (1) | RS56822B1 (pt) |
RU (1) | RU2497526C2 (pt) |
SG (1) | SG188800A1 (pt) |
SI (1) | SI2187742T1 (pt) |
TW (1) | TWI434691B (pt) |
UA (1) | UA99924C2 (pt) |
WO (1) | WO2009026537A1 (pt) |
ZA (1) | ZA201001051B (pt) |
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HUE035130T2 (en) | 2007-09-10 | 2018-05-02 | Janssen Pharmaceutica Nv | A method for preparing compounds useful as SGLT inhibitors |
UA101004C2 (en) | 2007-12-13 | 2013-02-25 | Теракос, Инк. | Derivatives of benzylphenylcyclohexane and use thereof |
TWI523652B (zh) | 2008-07-15 | 2016-03-01 | 泰瑞克公司 | 氘化苄基苯衍生物及使用方法 |
AR073118A1 (es) * | 2008-08-22 | 2010-10-13 | Theracos Inc | Procesos para la preparacion de inhibidores de sglt2 y formas cristalinas del mismo. |
AU2014201286B2 (en) * | 2008-08-22 | 2015-07-02 | Theracosbio, Llc | Processes for the preparation of SGLT2 inhibitors |
BRPI0918841B8 (pt) | 2008-08-28 | 2021-05-25 | Pfizer | derivados de dioxa-biciclo[3.2.1]octano-2,3,4-triol, seus cristais, composições farmacêuticas e usos |
US9056850B2 (en) | 2008-10-17 | 2015-06-16 | Janssen Pharmaceutica N.V. | Process for the preparation of compounds useful as inhibitors of SGLT |
EP2367554A4 (en) * | 2008-11-26 | 2020-03-25 | Satiogen Pharmaceuticals, Inc. | BILIARY ACID RECYCLING INHIBITORS FOR THE TREATMENT OF OBESITY AND DIABETES |
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US8163704B2 (en) | 2009-10-20 | 2012-04-24 | Novartis Ag | Glycoside derivatives and uses thereof |
SI2496583T1 (sl) | 2009-11-02 | 2015-02-27 | Pfizer Inc. | Derivati dioksa-biciklo(3.2.1)oktan-2,3,4-triola |
AR079438A1 (es) | 2009-12-09 | 2012-01-25 | Panacea Biotec Ltd | Derivados de azucar, composiciones farmaceuticas y sus usos |
CN102134226B (zh) * | 2010-01-26 | 2013-06-12 | 天津药物研究院 | 一类苯基c-葡萄糖苷衍生物、其制备方法和用途 |
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