BRPI0814294A2 - Agonistas de receptor heterocíclico ligado a n para o tratamento do diabetes e de desordens metabólicas. - Google Patents

Agonistas de receptor heterocíclico ligado a n para o tratamento do diabetes e de desordens metabólicas.

Info

Publication number
BRPI0814294A2
BRPI0814294A2 BRPI0814294-7A2A BRPI0814294A BRPI0814294A2 BR PI0814294 A2 BRPI0814294 A2 BR PI0814294A2 BR PI0814294 A BRPI0814294 A BR PI0814294A BR PI0814294 A2 BRPI0814294 A2 BR PI0814294A2
Authority
BR
Brazil
Prior art keywords
diabetes
treatment
receptor agonists
metabolic disorders
linked heterocyclic
Prior art date
Application number
BRPI0814294-7A2A
Other languages
English (en)
Inventor
Jingyuan Ma
Christopher J Rabbat
Jiangao Song
Xin Chen
Imad Nashashibi
Zuchun Zhao
Aaron Novack
Dong Fang Shi
Peng Cheng
Yan Zhu
Alison Murphy
Original Assignee
Metabolex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolex Inc filed Critical Metabolex Inc
Publication of BRPI0814294A2 publication Critical patent/BRPI0814294A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BRPI0814294-7A2A 2007-07-19 2008-07-10 Agonistas de receptor heterocíclico ligado a n para o tratamento do diabetes e de desordens metabólicas. BRPI0814294A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95085907P 2007-07-19 2007-07-19
PCT/US2008/069714 WO2009014910A2 (en) 2007-07-19 2008-07-10 N-azacyclic substituted pyrrole, pyrazole, imidazole, triazole and tetrazole derivatives as agonists of the rup3 or gpr119 receptor for the treatment of diabetes and metabolic disorders

Publications (1)

Publication Number Publication Date
BRPI0814294A2 true BRPI0814294A2 (pt) 2015-02-03

Family

ID=40194019

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0814294-7A2A BRPI0814294A2 (pt) 2007-07-19 2008-07-10 Agonistas de receptor heterocíclico ligado a n para o tratamento do diabetes e de desordens metabólicas.

Country Status (12)

Country Link
US (2) US8183381B2 (pt)
EP (1) EP2185544B1 (pt)
JP (1) JP5489997B2 (pt)
KR (1) KR20100033419A (pt)
CN (1) CN101754962B (pt)
AR (1) AR067520A1 (pt)
AU (1) AU2008279447A1 (pt)
BR (1) BRPI0814294A2 (pt)
CA (1) CA2693169C (pt)
CL (1) CL2008002042A1 (pt)
TW (1) TW200908972A (pt)
WO (1) WO2009014910A2 (pt)

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US8183381B2 (en) 2012-05-22
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US8846675B2 (en) 2014-09-30
CN101754962B (zh) 2013-12-25
WO2009014910A3 (en) 2009-04-02
KR20100033419A (ko) 2010-03-29
CL2008002042A1 (es) 2009-01-16
AR067520A1 (es) 2009-10-14
AU2008279447A1 (en) 2009-01-29
CA2693169C (en) 2016-01-12
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US20090137590A1 (en) 2009-05-28
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