BRPI0809974A2 - Compostos de pirimidina hidrazida como inibidores de pgds - Google Patents
Compostos de pirimidina hidrazida como inibidores de pgdsInfo
- Publication number
- BRPI0809974A2 BRPI0809974A2 BRPI0809974-0A2A BRPI0809974A BRPI0809974A2 BR PI0809974 A2 BRPI0809974 A2 BR PI0809974A2 BR PI0809974 A BRPI0809974 A BR PI0809974A BR PI0809974 A2 BRPI0809974 A2 BR PI0809974A2
- Authority
- BR
- Brazil
- Prior art keywords
- hydrayed
- pyrimidine compounds
- pgds inhibitors
- pgds
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90917107P | 2007-03-30 | 2007-03-30 | |
| PCT/US2008/058347 WO2008121670A1 (en) | 2007-03-30 | 2008-03-27 | Pyrimidine hydrazide compounds as pgds inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0809974A2 true BRPI0809974A2 (pt) | 2014-10-07 |
Family
ID=39494539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0809974-0A2A BRPI0809974A2 (pt) | 2007-03-30 | 2008-03-27 | Compostos de pirimidina hidrazida como inibidores de pgds |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US8258130B2 (pt) |
| EP (1) | EP2142516B1 (pt) |
| JP (1) | JP5427769B2 (pt) |
| KR (1) | KR20090125852A (pt) |
| CN (1) | CN101646656B (pt) |
| AR (1) | AR065874A1 (pt) |
| AU (1) | AU2008232771B2 (pt) |
| BR (1) | BRPI0809974A2 (pt) |
| CA (1) | CA2682629C (pt) |
| CL (1) | CL2008000911A1 (pt) |
| DK (1) | DK2142516T3 (pt) |
| ES (1) | ES2400622T3 (pt) |
| IL (1) | IL200898A (pt) |
| MA (1) | MA31326B1 (pt) |
| MX (1) | MX2009009443A (pt) |
| MY (1) | MY154895A (pt) |
| NZ (1) | NZ579892A (pt) |
| PA (1) | PA8774101A1 (pt) |
| PE (1) | PE20090552A1 (pt) |
| PT (1) | PT2142516E (pt) |
| RU (1) | RU2464262C2 (pt) |
| SG (1) | SG179437A1 (pt) |
| TW (1) | TWI430994B (pt) |
| WO (1) | WO2008121670A1 (pt) |
| ZA (1) | ZA200906082B (pt) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2464262C2 (ru) | 2007-03-30 | 2012-10-20 | Санофи-Авентис | Пиримидингидразидные соединения как ингибиторы pgds |
| WO2009029632A1 (en) * | 2007-08-27 | 2009-03-05 | Helicon Therapeutics, Inc. | Therapeutic isoxazole compounds |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| DK2300013T3 (en) | 2008-05-21 | 2017-12-04 | Ariad Pharma Inc | PHOSPHORUS DERIVATIVES AS KINASE INHIBITORS |
| PE20110843A1 (es) | 2008-09-22 | 2011-12-08 | Cayman Chem Co | Derivados de 5-(1h-imidazol-5-il)-2-fenilpirimidina, como inhibidores de prostaglandina d sintasa hematopoyetica |
| US8912330B2 (en) | 2008-12-12 | 2014-12-16 | Ariad Pharmaceuticals, Inc. | Azaindole derivatives as kinase inhibitors |
| US8703808B2 (en) | 2009-06-23 | 2014-04-22 | Centre National De La Recherche Scientifique | Use of derivatives of indoles for the treatment of cancer |
| EP2266562A1 (en) * | 2009-06-23 | 2010-12-29 | Centre National de la Recherche Scientifique | Use of derivatives of indoles for the treatment of cancer |
| AT509045B1 (de) | 2010-01-29 | 2011-06-15 | Planta Naturstoffe Vertriebsges M B H | Verbindungen zur behandlung von asthma bronchiale |
| AU2011261164A1 (en) * | 2010-06-01 | 2012-12-13 | The University Of Queensland | Haematopoietic-prostaglandin D2 synthase inhibitors |
| CN106943407A (zh) | 2010-07-26 | 2017-07-14 | 赛诺菲 | 苯基噁二唑衍生物在制备治疗变应性或炎性疾病的药物中的用途 |
| AU2012250517B2 (en) | 2011-05-04 | 2016-05-19 | Takeda Pharmaceutical Company Limited | Compounds for inhibiting cell proliferation in EGFR-driven cancers |
| CN104011042B (zh) | 2011-11-29 | 2017-03-29 | 先正达参股股份有限公司 | 杀昆虫三嗪酮衍生物 |
| AU2013204563B2 (en) | 2012-05-05 | 2016-05-19 | Takeda Pharmaceutical Company Limited | Compounds for inhibiting cell proliferation in EGFR-driven cancers |
| US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
| WO2015022546A1 (en) * | 2013-08-14 | 2015-02-19 | Kalvista Pharmaceuticals Limited | Inhibitors of plasma kallikrein |
| TWI636047B (zh) | 2013-08-14 | 2018-09-21 | 英商卡爾維斯塔製藥有限公司 | 雜環衍生物 |
| GB201421085D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | New enzyme inhibitors |
| GB201421083D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | Enzyme inhibitors |
| EP3165093A1 (en) | 2015-11-05 | 2017-05-10 | Basf Se | Substituted oxadiazoles for combating phytopathogenic fungi |
| AU2016370779B2 (en) | 2015-12-17 | 2019-07-25 | Astex Therapeutics Limited | Quinoline-3-carboxamides as H-PGDS inhibitors |
| KR102424709B1 (ko) | 2016-05-31 | 2022-07-22 | 칼비스타 파마슈티컬즈 리미티드 | 혈장 칼리크레인 저해제로서 피라졸 유도체 |
| GB201609603D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide |
| GB201609607D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts |
| JOP20190072A1 (ar) | 2016-10-13 | 2019-04-07 | Glaxosmithkline Ip Dev Ltd | مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم |
| US11149035B2 (en) | 2017-06-13 | 2021-10-19 | Glaxosmithkline Intellectual Property Dfvelopment Limited | Chemical compounds as H—PGDS inhibitors |
| HUE057912T2 (hu) | 2017-11-29 | 2022-06-28 | Kalvista Pharmaceuticals Ltd | Plazma kallikrein inhibitort tartalmazó dózisformák |
| GB201719881D0 (en) | 2017-11-29 | 2018-01-10 | Kalvista Pharmaceuticals Ltd | Solid forms of plasma kallikrein inhibitor and salts thereof |
| WO2019116256A1 (en) | 2017-12-13 | 2019-06-20 | Glaxosmithkline Intellectual Property Development Limited | Fused pyridines which act as inhibitors of h-pgds |
| AR117006A1 (es) | 2018-11-08 | 2021-07-07 | Glaxosmithkline Ip Dev Ltd | Compuesto de 1,3-azol sustituido, composición farmacéutica que lo comprende y su uso para la fabricación de un medicamento |
| EP4010333A1 (en) | 2019-08-09 | 2022-06-15 | Kalvista Pharmaceuticals Limited | Plasma kallikrein inhibitors |
| CN115667259A (zh) | 2020-06-19 | 2023-01-31 | 佐藤制药株式会社 | 抑制h-pgds的稠环化合物 |
| CN112375027B (zh) * | 2020-12-07 | 2023-03-31 | 中国药科大学 | 吲哚磺酰胺类衍生物及其医药用途 |
| WO2023113023A1 (ja) * | 2021-12-17 | 2023-06-22 | 佐藤製薬株式会社 | Ｈ－ｐｇｄｓを阻害するアザインドール誘導体 |
| CN116514769B (zh) * | 2022-01-21 | 2024-02-27 | 中国药科大学 | 4-羟基嘧啶-5-甲酰腙衍生物、制备方法、药物组合物和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6143173A (ja) * | 1984-08-06 | 1986-03-01 | Mitsui Petrochem Ind Ltd | 新規ピリミジン誘導体およびその製法 |
| JPS61140568A (ja) * | 1984-12-14 | 1986-06-27 | Mitsui Petrochem Ind Ltd | キナゾリン誘導体及びそれを有効成分とする血圧降下剤 |
| US5176132A (en) | 1989-05-31 | 1993-01-05 | Fisons Plc | Medicament inhalation device and formulation |
| RU2343148C2 (ru) * | 2002-02-01 | 2009-01-10 | Райджел Фармасьютикалз, Инк | Соединения 2,4-пиримидиндиаминов и их применение |
| JP2006511789A (ja) | 2002-08-16 | 2006-04-06 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | ミクロソームのプロスタグランジンｅ合成酵素または造血系プロスタグランジンｄ合成酵素の活性を低下させる能力に関して化合物または薬剤をアッセイする方法 |
| GB0222023D0 (en) | 2002-09-21 | 2002-10-30 | Aventis Pharma Ltd | Inhaler |
| HN2005000795A (es) * | 2004-10-15 | 2010-08-19 | Aventis Pharma Inc | Pirimidinas como antagonistas del receptor de prostaglandina d2 |
| JP2007051121A (ja) * | 2005-07-22 | 2007-03-01 | Taiho Yakuhin Kogyo Kk | プロスタグランジンｄ合成酵素を阻害するピリミジン化合物 |
| BRPI0718874A2 (pt) * | 2006-12-22 | 2015-06-23 | Novartis Ag | Compostos orgânicos |
| RU2464262C2 (ru) | 2007-03-30 | 2012-10-20 | Санофи-Авентис | Пиримидингидразидные соединения как ингибиторы pgds |
| US8283351B2 (en) * | 2007-04-02 | 2012-10-09 | Institute For Oneworld Health | Cyclic and acyclic hydrazine derivatives compositions including them and uses thereof |
-
2008
- 2008-03-27 RU RU2009140149/04A patent/RU2464262C2/ru not_active IP Right Cessation
- 2008-03-27 EP EP08744426A patent/EP2142516B1/en active Active
- 2008-03-27 ES ES08744426T patent/ES2400622T3/es active Active
- 2008-03-27 DK DK08744426.1T patent/DK2142516T3/da active
- 2008-03-27 NZ NZ579892A patent/NZ579892A/en not_active IP Right Cessation
- 2008-03-27 WO PCT/US2008/058347 patent/WO2008121670A1/en active Application Filing
- 2008-03-27 PE PE2008000555A patent/PE20090552A1/es not_active Application Discontinuation
- 2008-03-27 MY MYPI20093870A patent/MY154895A/en unknown
- 2008-03-27 CN CN2008800100835A patent/CN101646656B/zh active Active
- 2008-03-27 SG SG2012015442A patent/SG179437A1/en unknown
- 2008-03-27 CA CA2682629A patent/CA2682629C/en not_active Expired - Fee Related
- 2008-03-27 PT PT87444261T patent/PT2142516E/pt unknown
- 2008-03-27 JP JP2010501206A patent/JP5427769B2/ja not_active Expired - Fee Related
- 2008-03-27 AU AU2008232771A patent/AU2008232771B2/en not_active Ceased
- 2008-03-27 MX MX2009009443A patent/MX2009009443A/es active IP Right Grant
- 2008-03-27 BR BRPI0809974-0A2A patent/BRPI0809974A2/pt not_active IP Right Cessation
- 2008-03-27 KR KR1020097022868A patent/KR20090125852A/ko not_active Application Discontinuation
- 2008-03-28 TW TW097111155A patent/TWI430994B/zh not_active IP Right Cessation
- 2008-03-28 AR ARP080101297A patent/AR065874A1/es unknown
- 2008-03-28 PA PA20088774101A patent/PA8774101A1/es unknown
- 2008-03-28 CL CL200800911A patent/CL2008000911A1/es unknown
-
2009
- 2009-09-02 ZA ZA200906082A patent/ZA200906082B/xx unknown
- 2009-09-13 IL IL200898A patent/IL200898A/en not_active IP Right Cessation
- 2009-09-30 US US12/570,355 patent/US8258130B2/en active Active
- 2009-10-22 MA MA32299A patent/MA31326B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MY154895A (en) | 2015-08-14 |
| IL200898A (en) | 2013-12-31 |
| RU2009140149A (ru) | 2011-05-10 |
| IL200898A0 (en) | 2010-05-17 |
| PE20090552A1 (es) | 2009-06-01 |
| AU2008232771B2 (en) | 2012-12-20 |
| MA31326B1 (fr) | 2010-04-01 |
| ZA200906082B (en) | 2010-06-30 |
| AR065874A1 (es) | 2009-07-08 |
| EP2142516A1 (en) | 2010-01-13 |
| PT2142516E (pt) | 2013-03-07 |
| CA2682629A1 (en) | 2008-10-09 |
| PA8774101A1 (es) | 2008-11-19 |
| US8258130B2 (en) | 2012-09-04 |
| KR20090125852A (ko) | 2009-12-07 |
| EP2142516B1 (en) | 2012-12-26 |
| WO2008121670A1 (en) | 2008-10-09 |
| ES2400622T3 (es) | 2013-04-11 |
| TW200906802A (en) | 2009-02-16 |
| CL2008000911A1 (es) | 2008-10-03 |
| CN101646656B (zh) | 2013-08-14 |
| RU2464262C2 (ru) | 2012-10-20 |
| JP2010523494A (ja) | 2010-07-15 |
| CN101646656A (zh) | 2010-02-10 |
| NZ579892A (en) | 2012-03-30 |
| CA2682629C (en) | 2013-03-19 |
| JP5427769B2 (ja) | 2014-02-26 |
| DK2142516T3 (da) | 2013-04-15 |
| TWI430994B (zh) | 2014-03-21 |
| MX2009009443A (es) | 2009-09-14 |
| AU2008232771A1 (en) | 2008-10-09 |
| US20100048568A1 (en) | 2010-02-25 |
| SG179437A1 (en) | 2012-04-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0809974A2 (pt) | Compostos de pirimidina hidrazida como inibidores de pgds | |
| BRPI0920135A2 (pt) | imidazopiridazinacarbonitrilos úteis como inibidores de quinase | |
| BRPI0913879A2 (pt) | fenilpirazinonas como inibidores de quinase | |
| BRPI0907435A2 (pt) | Derivados de 5-flúor pirimidina | |
| BRPI0811065A2 (pt) | Indazóis 5-heteroaril substituídos como inibidores de quinase | |
| BRPI0812825A2 (pt) | Derivados ftalazinona como inibidores de parp-1 | |
| BRPI0906838A2 (pt) | Pirimidinas como inibidores de quinase | |
| BRPI0913580A2 (pt) | pirrolopiridinas como inibidores de quinase | |
| BRPI0914544A2 (pt) | derivados de pirimidona substituídos | |
| BRPI0906973A2 (pt) | Compostos e composições como inibidores de cinase. | |
| DK2288375T3 (da) | Pegylerede insulin-lispro-forbindelser | |
| BRPI0920707A2 (pt) | compostos | |
| BRPI0912475A8 (pt) | compostos como inibidores de quinase | |
| SMT201600045B (it) | Composti tetraciclinici c7-fluoro sostituiti | |
| DK2242759T3 (da) | Forbindelser | |
| BRPI0815042A2 (pt) | Compostos de pirazol | |
| BRPI0914652A2 (pt) | compostos e composições como inibidores de quinase | |
| BRPI0916233A2 (pt) | compostos heterocíclicos antivirais | |
| DK2154967T3 (da) | Pyrimidinderivater | |
| BRPI0814426A2 (pt) | Compostos heterocíclicos úteis como inibidores de mk2 | |
| BRPI0922880A2 (pt) | compostos inibidores de quinase | |
| BRPI0920496A2 (pt) | derivados substituídos de pirimidina etriazina | |
| BRPI1013493A2 (pt) | composto de pirimidina | |
| DK2297162T3 (da) | Forbindelser | |
| BRPI0910979A2 (pt) | compostos e composições como inibidores de quinase |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |