BRPI0518613A2 - compostos, composiÇço farmacÊutica, mÉtodo de preparar uma composiÇço, e, uso de um composto - Google Patents

compostos, composiÇço farmacÊutica, mÉtodo de preparar uma composiÇço, e, uso de um composto

Info

Publication number
BRPI0518613A2
BRPI0518613A2 BRPI0518613-7A BRPI0518613A BRPI0518613A2 BR PI0518613 A2 BRPI0518613 A2 BR PI0518613A2 BR PI0518613 A BRPI0518613 A BR PI0518613A BR PI0518613 A2 BRPI0518613 A2 BR PI0518613A2
Authority
BR
Brazil
Prior art keywords
compounds
composition
compound
preparing
pharmaceutical composition
Prior art date
Application number
BRPI0518613-7A
Other languages
English (en)
Inventor
Roelof W Feenstra
Axel Stoit
Jan-Willem Terpstra
Maria L Pras-Raves
Bernard J Van Vliet
Mayke B Hesselink
Cornelis G Kruse
Andrew C Mccreary
Scharrenburg Gustaaf J M Van
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of BRPI0518613A2 publication Critical patent/BRPI0518613A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

COMPOSTOS, COMPOSIÇçO FARMACÊUTICA, MÉTODO DE PREPARAR UMA COMPOSIÇçO, E, USO DE UM COMPOSTO. A invenção diz respeito a um grupo de novos derivados de ariloxietilamina com um modo duplo de ação inibição da recaptação de serotonina e agonismo parcial em receptores de dopamina-D2. A invenção também diz respeito ao uso de um composto divulgado neste para a fabricação de um medicamento que dá um efeito benéfico. Os compostos têm a fórmula geral (1): Z-T-Ar (1) em que : Z é um fragmento da fórmula geral (2): e em que os outros simbolos tem os significados dados na especificação e os tautôrneros, estereoisômeros e N-óxidos destes, bem como sais, hidratos e solvatos farmaceuticamente aceitáveis dos ditos compostos da fórmula (1) e seus tautômeros, estereoisômeros e N-óxidos.
BRPI0518613-7A 2004-12-08 2005-12-06 compostos, composiÇço farmacÊutica, mÉtodo de preparar uma composiÇço, e, uso de um composto BRPI0518613A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63407404P 2004-12-08 2004-12-08
EP04106394 2004-12-08
PCT/EP2005/056505 WO2006061376A1 (en) 2004-12-08 2005-12-06 Aryloxyethylamine derivatives with a combination of partial d0pamine-d2 receptor agonism and serotonin reuptake inhibition

Publications (1)

Publication Number Publication Date
BRPI0518613A2 true BRPI0518613A2 (pt) 2008-11-25

Family

ID=35744728

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0518613-7A BRPI0518613A2 (pt) 2004-12-08 2005-12-06 compostos, composiÇço farmacÊutica, mÉtodo de preparar uma composiÇço, e, uso de um composto

Country Status (18)

Country Link
EP (4) EP1827427B1 (pt)
JP (4) JP2008523030A (pt)
KR (4) KR20070085988A (pt)
AT (2) ATE413173T1 (pt)
AU (4) AU2005313390A1 (pt)
BR (1) BRPI0518613A2 (pt)
CA (4) CA2587559A1 (pt)
DE (2) DE602005008471D1 (pt)
DK (2) DK1827427T3 (pt)
ES (2) ES2311245T3 (pt)
HR (2) HRP20080538T3 (pt)
IL (4) IL183064A0 (pt)
NO (4) NO20072974L (pt)
PL (2) PL1827427T3 (pt)
PT (2) PT1827427E (pt)
RU (4) RU2007125659A (pt)
SI (2) SI1824479T1 (pt)
WO (4) WO2006061377A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009525304A (ja) * 2006-01-30 2009-07-09 シュペーデル・エクスペリメンタ・アーゲー α，β−不飽和化合物からのアルコールの立体選択的製造方法
US8063062B2 (en) 2006-12-20 2011-11-22 Solvay Pharmaceuticals B.V. Compounds with a combination of cannabinoid-CB1 antagonism and acetylcholinesterase inhibition
EP2111394A1 (en) * 2007-01-10 2009-10-28 Solvay Pharmaceuticals B.V. Compounds with a combination of cannabinoid-cb1 antagonism and serotonin reuptake inhibition
US8138174B2 (en) 2007-01-10 2012-03-20 Solvay Pharmaceuticals B.V. Compounds with a combination of cannabinoid CB1 antagonism and serotonin reuptake inhibition
JP5431305B2 (ja) * 2007-04-23 2014-03-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 高速解離性ドパミン２受容体アンタゴニストとしての４−アルコキシピリダジン誘導体
JP2010525013A (ja) * 2007-04-23 2010-07-22 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 高速解離性ドパミン２受容体アンタゴニストとしてのピリジン誘導体
AU2008240729B2 (en) * 2007-04-23 2012-08-23 Janssen Pharmaceutica N.V. Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists
CN103360342B (zh) * 2012-04-09 2015-12-16 江苏恩华药业股份有限公司 3-氰基苯胺烷基芳基哌嗪衍生物及在制备药物中的应用
CN103570698B (zh) * 2012-08-01 2016-08-03 江苏恩华药业股份有限公司 用于制备维拉佐酮的化合物及其中间体和应用
ITMI20130392A1 (it) * 2013-03-15 2014-09-16 Dipharma Francis Srl Sintesi di un inibitore della ricaptazione della serotonina
CA2914132A1 (en) 2013-06-21 2014-12-24 Lupin Limited Substituted heterocyclic compounds as crac modulators
EP3013810A1 (en) 2013-06-24 2016-05-04 Lupin Limited Chromane and chromene derivatives and their use as crac modulators
US9598401B2 (en) 2013-07-29 2017-03-21 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
EP0900792B1 (en) * 1997-09-02 2003-10-29 Duphar International Research B.V Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists
EP1070050A1 (en) * 1998-04-08 2001-01-24 American Home Products Corporation N-aryloxyethyl-indoly-alkylamines for the treatment of depression (5-ht1a receptor active agents)
AU765317C (en) * 1998-06-19 2004-05-20 H. Lundbeck A/S 4,5,6 and 7-indole and indoline derivatives, their preparation and use
AR022303A1 (es) * 1999-01-22 2002-09-04 Lundbeck & Co As H Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion
SK287018B6 (sk) * 1999-08-23 2009-09-07 Solvay Pharmaceuticals B. V. Deriváty fenylpiperazínov, spôsob ich prípravy, farmaceutická kompozícia s ich obsahom a ich použitie
PL375350A1 (en) * 2002-12-10 2005-11-28 Merck Patent Gmbh Indol derivatives and their use as 5-ht ligands

Also Published As

Publication number Publication date
CA2587357A1 (en) 2006-06-15
NO20072969L (no) 2007-08-31
PT1824479E (pt) 2009-01-30
AU2005313390A1 (en) 2006-06-15
HRP20090015T3 (en) 2009-02-28
NO20072974L (no) 2007-08-23
EP1827426A1 (en) 2007-09-05
DK1824479T3 (da) 2009-03-09
IL183064A0 (en) 2007-09-20
CA2587559A1 (en) 2006-06-15
RU2007125661A (ru) 2009-01-20
EP1827427B1 (en) 2008-07-23
DE602005010902D1 (de) 2008-12-18
WO2006061378A1 (en) 2006-06-15
EP1824479B1 (en) 2008-11-05
JP2008523029A (ja) 2008-07-03
ATE413173T1 (de) 2008-11-15
AU2005313311A1 (en) 2006-06-15
SI1827427T1 (sl) 2008-12-31
ES2311245T3 (es) 2009-02-01
EP1824480A1 (en) 2007-08-29
WO2006061376A1 (en) 2006-06-15
JP2008523031A (ja) 2008-07-03
JP2008523030A (ja) 2008-07-03
DK1827427T3 (da) 2008-11-24
AU2005313391A1 (en) 2006-06-15
HRP20080538T3 (en) 2008-12-31
NO20072981L (no) 2007-09-05
EP1827427A1 (en) 2007-09-05
IL183063A0 (en) 2007-09-20
KR20070085916A (ko) 2007-08-27
AU2005313312A1 (en) 2006-06-15
NO20072977L (no) 2007-09-05
PL1824479T3 (pl) 2009-04-30
SI1824479T1 (sl) 2009-04-30
PT1827427E (pt) 2008-11-03
WO2006061379A1 (en) 2006-06-15
CA2587202A1 (en) 2006-06-15
KR20070085975A (ko) 2007-08-27
RU2007125659A (ru) 2009-01-20
ATE401883T1 (de) 2008-08-15
IL183062A0 (en) 2007-09-20
WO2006061377A1 (en) 2006-06-15
RU2007125658A (ru) 2009-01-20
IL183061A0 (en) 2007-09-20
CA2587381A1 (en) 2006-06-15
EP1824479A1 (en) 2007-08-29
PL1827427T3 (pl) 2009-01-30
RU2007125660A (ru) 2009-01-20
JP2008537725A (ja) 2008-09-25
ES2317335T3 (es) 2009-04-16
KR20070085959A (ko) 2007-08-27
DE602005008471D1 (de) 2008-09-04
KR20070085988A (ko) 2007-08-27

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012.