BRPI0512790A - derivados de 2-alquil quinazolinona substituìdos como inibidores de parp - Google Patents

derivados de 2-alquil quinazolinona substituìdos como inibidores de parp

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Publication number
BRPI0512790A
BRPI0512790A BRPI0512790-4A BRPI0512790A BRPI0512790A BR PI0512790 A BRPI0512790 A BR PI0512790A BR PI0512790 A BRPI0512790 A BR PI0512790A BR PI0512790 A BRPI0512790 A BR PI0512790A
Authority
BR
Brazil
Prior art keywords
parp inhibitors
substituted
quinazolinone derivatives
alkyl
alkyl quinazolinone
Prior art date
Application number
BRPI0512790-4A
Other languages
English (en)
Inventor
Marcel Jozef Maria Van Der Aa
Albertus Henricus Mari Heertum
Jacobus Alphonsus Josephus Dun
Maria Victorina Francis Somers
Walter Boudewijn Leopo Wouters
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BRPI0512790A publication Critical patent/BRPI0512790A/pt

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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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Abstract

DERIVADOS DE 2-ALQUIL QUINAZOLINONA SUBSTITUìDOS COMO INIBIDORES DE PARP. A presente invenção proporciona compostos da fórmula (I), seu uso como inibidores de PARP bem como composições farmacêuticas compreendendo os referidos compostos da fórmula (I) em que R¬ 1¬, R¬ 3¬, L, X, Y e Z têm os significados definidos.
BRPI0512790-4A 2004-06-30 2005-06-28 derivados de 2-alquil quinazolinona substituìdos como inibidores de parp BRPI0512790A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04076887 2004-06-30
PCT/EP2005/053034 WO2006003150A1 (en) 2004-06-30 2005-06-28 Substituted 2-alkyl quinazolinone derivatives as parp inhibitors

Publications (1)

Publication Number Publication Date
BRPI0512790A true BRPI0512790A (pt) 2008-04-08

Family

ID=34928320

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0512790-4A BRPI0512790A (pt) 2004-06-30 2005-06-28 derivados de 2-alquil quinazolinona substituìdos como inibidores de parp
BRPI0512797-1A BRPI0512797A (pt) 2004-06-30 2005-06-28 derivados de quinazolinona como inibidores de parp

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0512797-1A BRPI0512797A (pt) 2004-06-30 2005-06-28 derivados de quinazolinona como inibidores de parp

Country Status (24)

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US (5) US7875621B2 (pt)
EP (2) EP1763518B1 (pt)
JP (2) JP4969443B2 (pt)
KR (2) KR101184036B1 (pt)
CN (2) CN1976906B (pt)
AR (2) AR049656A1 (pt)
AT (2) ATE498613T1 (pt)
AU (2) AU2005259192C1 (pt)
BR (2) BRPI0512790A (pt)
CA (2) CA2569826C (pt)
DE (1) DE602005026391D1 (pt)
EA (2) EA012837B1 (pt)
ES (2) ES2380702T3 (pt)
HK (2) HK1105631A1 (pt)
IL (2) IL180382A (pt)
MX (2) MXPA06014543A (pt)
MY (2) MY148322A (pt)
NO (2) NO339883B1 (pt)
NZ (2) NZ551680A (pt)
SG (2) SG154434A1 (pt)
TW (2) TWI361689B (pt)
UA (2) UA86237C2 (pt)
WO (2) WO2006003146A1 (pt)
ZA (2) ZA200610772B (pt)

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ES2563954T3 (es) 2004-06-30 2016-03-16 Janssen Pharmaceutica Nv Derivados de ftalazina como inhibidores de PARP
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CA2569827C (en) 2004-06-30 2013-04-09 Janssen Pharmaceutica N.V. Quinazolinedione derivatives as parp inhibitors
WO2006047022A1 (en) 2004-10-25 2006-05-04 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis
ZA200800907B (en) 2005-07-18 2010-04-28 Bipar Sciences Inc Treatment of cancer
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KR101591656B1 (ko) * 2007-01-10 2016-02-19 엠에스디 이탈리아 에스.알.엘. 폴리(ａｄｐ-리보오스) 폴리머라아제(ｐａｒｐ) 억제제로서의 아미드 치환된 인다졸
ES2381446T3 (es) 2007-03-08 2012-05-28 Janssen Pharmaceutica, N.V. Derivado de quinolinona como inhibidores de PARP y TANK
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EP2217227B1 (en) 2007-11-12 2013-08-21 BiPar Sciences, Inc. Treatment of breast cancer with 4-iodo-3-nitrobenzamide in combination with anti-tumor agents
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