BRPI0509467A - compostos macrocìclicos como inibidores de replicação viral - Google Patents

compostos macrocìclicos como inibidores de replicação viral

Info

Publication number
BRPI0509467A
BRPI0509467A BRPI0509467-4A BRPI0509467A BRPI0509467A BR PI0509467 A BRPI0509467 A BR PI0509467A BR PI0509467 A BRPI0509467 A BR PI0509467A BR PI0509467 A BRPI0509467 A BR PI0509467A
Authority
BR
Brazil
Prior art keywords
macrocyclic compounds
methods
viral replication
replication inhibitors
exposed
Prior art date
Application number
BRPI0509467-4A
Other languages
English (en)
Inventor
Lawrence M Blatt
Steven M Wenglowsky
Steven W Andrews
Kevin R Condroski
Yutong Jiang
April L Kennedy
George A Doherty
John A Josey
Peter J Stengel
Benjamin T Woodard
Machender R Madduru
Original Assignee
Intermune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intermune Inc filed Critical Intermune Inc
Publication of BRPI0509467A publication Critical patent/BRPI0509467A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

COMPOSTOS MACROCìCLICOS COMO INIBIDORES DE EXPLICAçãO VIRAL As modalidades fornecem compostos macrocíclicos, bem como composições, incluindo composições farmacêuticas, compreendendo um composto exposto. As modalidades fornecem ainda métodos de tratamento, incluindo métodos de tratar infecção flaviviral, incluindo infecção por vírus de hepatite C e métodos de tratar fibrose de fígado, os métodos genericamente envolvendo administrar a um indivíduo necessitando da mesma, uma quantidade eficaz de um composto ou composição exposta.
BRPI0509467-4A 2004-03-30 2005-03-29 compostos macrocìclicos como inibidores de replicação viral BRPI0509467A (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US55816104P 2004-03-30 2004-03-30
US56241804P 2004-04-14 2004-04-14
US61246004P 2004-09-22 2004-09-22
US61238104P 2004-09-22 2004-09-22
PCT/US2005/010494 WO2005095403A2 (en) 2004-03-30 2005-03-29 Macrocyclic compounds as inhibitors of viral replication

Publications (1)

Publication Number Publication Date
BRPI0509467A true BRPI0509467A (pt) 2007-09-11

Family

ID=35005653

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0509467-4A BRPI0509467A (pt) 2004-03-30 2005-03-29 compostos macrocìclicos como inibidores de replicação viral

Country Status (16)

Country Link
EP (1) EP1749007A2 (pt)
JP (1) JP4950026B2 (pt)
AP (1) AP2006003763A0 (pt)
AR (1) AR050321A1 (pt)
AU (1) AU2005228894B9 (pt)
BR (1) BRPI0509467A (pt)
CA (1) CA2560897C (pt)
CU (1) CU23787B7 (pt)
EA (1) EA012389B1 (pt)
EC (1) ECSP066959A (pt)
GE (1) GEP20104926B (pt)
IL (1) IL177917A0 (pt)
MA (1) MA28548B1 (pt)
NO (1) NO20064933L (pt)
NZ (1) NZ549697A (pt)
WO (1) WO2005095403A2 (pt)

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Also Published As

Publication number Publication date
CA2560897A1 (en) 2005-10-13
WO2005095403A3 (en) 2005-12-01
EA200601467A1 (ru) 2007-06-29
AR050321A1 (es) 2006-10-18
AU2005228894B9 (en) 2011-10-13
NZ549697A (en) 2009-12-24
JP2007531749A (ja) 2007-11-08
EA012389B1 (ru) 2009-10-30
AU2005228894B2 (en) 2011-08-25
CU20090209A7 (es) 2011-04-26
WO2005095403A2 (en) 2005-10-13
AP2006003763A0 (en) 2006-10-31
MA28548B1 (fr) 2007-04-03
JP4950026B2 (ja) 2012-06-13
GEP20104926B (en) 2010-03-25
CA2560897C (en) 2012-06-12
ECSP066959A (es) 2006-12-20
AU2005228894A1 (en) 2005-10-13
CU23787B7 (es) 2012-03-15
EP1749007A2 (en) 2007-02-07
NO20064933L (no) 2006-12-15
IL177917A0 (en) 2006-12-31

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014.