BRPI0415373A - ácidos carboxìlicos macrocìclicos e acilsulfonamidas como inibidores de replicação de hcv - Google Patents
ácidos carboxìlicos macrocìclicos e acilsulfonamidas como inibidores de replicação de hcvInfo
- Publication number
- BRPI0415373A BRPI0415373A BRPI0415373-1A BRPI0415373A BRPI0415373A BR PI0415373 A BRPI0415373 A BR PI0415373A BR PI0415373 A BRPI0415373 A BR PI0415373A BR PI0415373 A BRPI0415373 A BR PI0415373A
- Authority
- BR
- Brazil
- Prior art keywords
- carboxylic acids
- methods
- hcv replication
- replication inhibitors
- acylsulfonamides
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
"áCIDOS CARBOXìLICOS MACROCìCLICOS E ACILSULFONAMIDAS COMO INIBIDORES DE REPLICAçãO DE HCV". A presente invenção refere-se a compostos das fórmulas gerais I-IX, bem como composições, incluindo composições farmacêuticas, compreendendo um composto exposto. A presente invenção proporciona ainda métodos de tratamento, incluindo métodos de tratar uma infecção por vírus de hepatite C e métodos de tratar fibrose de fígado, os métodos envolvendo geralmente a administração a um indivíduo necessitando do mesmo de uma quantidade eficaz de uma composição ou composto exposto.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51154103P | 2003-10-14 | 2003-10-14 | |
US61246004P | 2004-09-22 | 2004-09-22 | |
PCT/US2004/033970 WO2005037214A2 (en) | 2003-10-14 | 2004-10-13 | Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of hcv replication |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0415373A true BRPI0415373A (pt) | 2006-12-12 |
Family
ID=34467992
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0415373-1A BRPI0415373A (pt) | 2003-10-14 | 2004-10-13 | ácidos carboxìlicos macrocìclicos e acilsulfonamidas como inibidores de replicação de hcv |
Country Status (30)
Country | Link |
---|---|
EP (2) | EP2407470A3 (pt) |
JP (3) | JP4584260B2 (pt) |
KR (1) | KR100853579B1 (pt) |
CN (2) | CN102020697B (pt) |
AP (2) | AP2287A (pt) |
AR (2) | AR046422A1 (pt) |
AU (1) | AU2004281780B2 (pt) |
BR (1) | BRPI0415373A (pt) |
CA (1) | CA2540858C (pt) |
CY (1) | CY1113809T1 (pt) |
DK (1) | DK1680137T3 (pt) |
EA (1) | EA011857B8 (pt) |
EC (2) | ECSP066570A (pt) |
ES (1) | ES2398912T3 (pt) |
GE (1) | GEP20084560B (pt) |
HK (2) | HK1100164A1 (pt) |
HR (1) | HRP20130098T1 (pt) |
IL (3) | IL174704A (pt) |
IS (1) | IS2876B (pt) |
MA (1) | MA28152A1 (pt) |
MX (1) | MXPA06003963A (pt) |
MY (1) | MY144593A (pt) |
NO (1) | NO343231B1 (pt) |
NZ (1) | NZ546347A (pt) |
OA (1) | OA13315A (pt) |
PL (1) | PL1680137T3 (pt) |
PT (1) | PT1680137E (pt) |
RS (3) | RS20110578A3 (pt) |
TW (2) | TW201245229A (pt) |
WO (1) | WO2005037214A2 (pt) |
Families Citing this family (141)
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