BRPI0413565B8 - análogos de quinazolina como inibidores de receptor de erbb2, seu uso e sua composição farmacêutica - Google Patents
análogos de quinazolina como inibidores de receptor de erbb2, seu uso e sua composição farmacêuticaInfo
- Publication number
- BRPI0413565B8 BRPI0413565B8 BRPI0413565A BRPI0413565A BRPI0413565B8 BR PI0413565 B8 BRPI0413565 B8 BR PI0413565B8 BR PI0413565 A BRPI0413565 A BR PI0413565A BR PI0413565 A BRPI0413565 A BR PI0413565A BR PI0413565 B8 BRPI0413565 B8 BR PI0413565B8
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- receptor inhibitors
- erbb2 receptor
- quinazoline analogues
- analogues
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Abstract
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/642,440 US7501427B2 (en) | 2003-08-14 | 2003-08-14 | Quinazoline analogs as receptor tyrosine kinase inhibitors |
US10/642.440 | 2003-08-14 | ||
US55171804P | 2004-03-10 | 2004-03-10 | |
US60/551.718 | 2004-03-10 | ||
PCT/US2004/026235 WO2005016346A1 (en) | 2003-08-14 | 2004-08-10 | Quinazoline analogs as receptor tyrosine kinase inhibitors |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0413565A BRPI0413565A (pt) | 2006-10-17 |
BRPI0413565B1 BRPI0413565B1 (pt) | 2019-10-01 |
BRPI0413565B8 true BRPI0413565B8 (pt) | 2021-05-25 |
Family
ID=34198338
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0413565A BRPI0413565B8 (pt) | 2003-08-14 | 2004-08-10 | análogos de quinazolina como inibidores de receptor de erbb2, seu uso e sua composição farmacêutica |
Country Status (24)
Country | Link |
---|---|
US (2) | US7452895B2 (pt) |
EP (1) | EP1660090B1 (pt) |
JP (1) | JP4828421B2 (pt) |
KR (2) | KR101028952B1 (pt) |
CN (3) | CN103664802B (pt) |
AR (1) | AR045378A1 (pt) |
AU (1) | AU2004264937B2 (pt) |
BR (1) | BRPI0413565B8 (pt) |
CA (1) | CA2535614C (pt) |
CL (1) | CL2004002066A1 (pt) |
CY (1) | CY1113992T1 (pt) |
DK (1) | DK1660090T3 (pt) |
ES (1) | ES2399427T3 (pt) |
HK (1) | HK1085400A1 (pt) |
IL (1) | IL173593A (pt) |
IS (1) | IS8288A (pt) |
MX (1) | MXPA06001767A (pt) |
NO (1) | NO336275B1 (pt) |
NZ (1) | NZ545459A (pt) |
PL (1) | PL1660090T3 (pt) |
PT (1) | PT1660090E (pt) |
RU (1) | RU2350605C2 (pt) |
TW (1) | TWI353982B (pt) |
WO (1) | WO2005016346A1 (pt) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
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US7488823B2 (en) * | 2003-11-10 | 2009-02-10 | Array Biopharma, Inc. | Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors |
CN103664802B (zh) * | 2003-08-14 | 2015-08-05 | 阿雷生物药品公司 | 作为受体酪氨酸激酶抑制剂的喹唑啉类似物 |
US7501427B2 (en) | 2003-08-14 | 2009-03-10 | Array Biopharma, Inc. | Quinazoline analogs as receptor tyrosine kinase inhibitors |
ES2335535T3 (es) * | 2005-11-15 | 2010-03-29 | Array Biopharma Inc. | Derivados de n4-fenil-quinazolin-4-amina ycompuestos afines como inhibidores de la tirosina quinasa receptora erbb tipo i para el tratamiento de enfermedades hiperproliferativas. |
CN104011047A (zh) | 2011-10-14 | 2014-08-27 | 阵列生物制药公司 | 选择性herb2抑制剂arry-380的多晶型物和含有它们的药物组合物 |
HUE035247T2 (hu) | 2011-10-14 | 2018-05-02 | Array Biopharma Inc | Szilárd diszperzió |
JP2015514075A (ja) | 2012-03-23 | 2015-05-18 | アレイ バイオファーマ、インコーポレイテッド | 脳癌の治療 |
JP2018535923A (ja) * | 2015-09-04 | 2018-12-06 | アスラン ファーマシューティカルズ ピーティーイー リミテッド | 胆道癌の治療 |
US20190134034A1 (en) * | 2016-04-21 | 2019-05-09 | Aslan Pharmaceuticals Pte. Ltd. | Method of Treating Liver Cancer |
GB201611580D0 (en) * | 2016-07-01 | 2016-08-17 | Aslan Pharmaceuticals Pte Ltd | Method |
CN106317040A (zh) * | 2016-08-09 | 2017-01-11 | 浙江医药高等专科学校 | 含噻吩磺酰胺结构的苯并喹唑啉类酪氨酸激酶抑制剂、制备方法及用途 |
CN106349230A (zh) * | 2016-08-09 | 2017-01-25 | 浙江医药高等专科学校 | 一种含硝基噻吩磺酰胺结构的苯并喹唑啉类酪氨酸激酶抑制剂及用途 |
CN106349231A (zh) * | 2016-08-09 | 2017-01-25 | 浙江医药高等专科学校 | 一类含卤代噻吩磺酰胺结构的苯并喹唑啉类酪氨酸激酶抑制剂 |
CN106317039A (zh) * | 2016-08-09 | 2017-01-11 | 浙江医药高等专科学校 | 一种含噻吩磺酰胺结构的乙氧苯并喹唑啉类酪氨酸激酶抑制剂、制备方法及用途 |
CN106279135A (zh) * | 2016-08-09 | 2017-01-04 | 浙江医药高等专科学校 | 一种噻吩磺酰胺结构的苯并喹唑啉类酪氨酸激酶抑制剂 |
SG10201913858WA (en) | 2016-08-26 | 2020-03-30 | Agency Science Tech & Res | Macrophage stimulating protein receptor (or ron - recepteur d' origine nantais) antibodies and uses thereof |
EP3589286B1 (en) | 2017-03-02 | 2022-08-03 | ASLAN Pharmaceuticals Pte Ltd | Dhodh inhibitor for treating haematological cancer |
EP3615067A1 (en) | 2017-04-28 | 2020-03-04 | Seattle Genetics, Inc. | Treatment of her2 positive cancers |
WO2018222135A1 (en) | 2017-06-02 | 2018-12-06 | Aslan Pharmaceuticals Pte Ltd | Cancer therapy |
WO2018222134A1 (en) | 2017-06-02 | 2018-12-06 | Aslan Pharmaceuticals Pte Ltd | Cancer therapy |
PT3853220T (pt) | 2018-09-18 | 2024-02-22 | Hoffmann La Roche | Derivados de quinazolina enquanto agentes antitumorais |
CN112969699A (zh) * | 2018-10-09 | 2021-06-15 | 亚狮康私人有限公司 | 瓦利替尼的丙二酸盐 |
CN111499622B (zh) * | 2019-07-08 | 2023-06-06 | 山东省科学院菏泽分院 | 一种治疗胆管癌的药物的制备方法 |
TW202214641A (zh) | 2020-06-30 | 2022-04-16 | 美商艾瑞生藥股份有限公司 | Her2突變抑制劑 |
TW202345816A (zh) * | 2022-03-28 | 2023-12-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 含氮雜環類化合物、其製備方法及其在醫藥上的應用 |
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US7488823B2 (en) | 2003-11-10 | 2009-02-10 | Array Biopharma, Inc. | Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors |
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CA2527017A1 (en) | 2003-05-27 | 2004-12-09 | Pfizer Products Inc. | Quinazolines and pyrido [3,4-d] pyrimidines as receptor tyrosine kinase inhibitors |
US7501427B2 (en) * | 2003-08-14 | 2009-03-10 | Array Biopharma, Inc. | Quinazoline analogs as receptor tyrosine kinase inhibitors |
CN103664802B (zh) | 2003-08-14 | 2015-08-05 | 阿雷生物药品公司 | 作为受体酪氨酸激酶抑制剂的喹唑啉类似物 |
EP1658080A1 (en) | 2003-08-18 | 2006-05-24 | Pfizer Products Inc. | Dosing schedule for a erbb2 anticancer agents |
MXPA06005024A (es) | 2003-11-06 | 2006-07-06 | Pfizer Prod Inc | Combinaciones de inhibidor de erbb2 selectivo/anticuerpos anti-erbb en el tratamiento del cancer. |
KR100735639B1 (ko) | 2004-12-29 | 2007-07-04 | 한미약품 주식회사 | 암세포 성장 억제 효과를 갖는 퀴나졸린 유도체 및 이의제조방법 |
ES2335535T3 (es) | 2005-11-15 | 2010-03-29 | Array Biopharma Inc. | Derivados de n4-fenil-quinazolin-4-amina ycompuestos afines como inhibidores de la tirosina quinasa receptora erbb tipo i para el tratamiento de enfermedades hiperproliferativas. |
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2004
- 2004-08-10 CN CN201310428856.4A patent/CN103664802B/zh active Active
- 2004-08-10 US US10/914,974 patent/US7452895B2/en active Active
- 2004-08-10 JP JP2006523384A patent/JP4828421B2/ja active Active
- 2004-08-10 CA CA002535614A patent/CA2535614C/en active Active
- 2004-08-10 MX MXPA06001767A patent/MXPA06001767A/es active IP Right Grant
- 2004-08-10 PT PT47809900T patent/PT1660090E/pt unknown
- 2004-08-10 ES ES04780990T patent/ES2399427T3/es active Active
- 2004-08-10 KR KR1020107000942A patent/KR101028952B1/ko active IP Right Grant
- 2004-08-10 WO PCT/US2004/026235 patent/WO2005016346A1/en active Application Filing
- 2004-08-10 PL PL04780990T patent/PL1660090T3/pl unknown
- 2004-08-10 KR KR1020067003060A patent/KR100953246B1/ko active IP Right Grant
- 2004-08-10 CN CN201310581100.3A patent/CN103772373B/zh active Active
- 2004-08-10 DK DK04780990.0T patent/DK1660090T3/da active
- 2004-08-10 EP EP04780990A patent/EP1660090B1/en active Active
- 2004-08-10 RU RU2006103493/04A patent/RU2350605C2/ru active
- 2004-08-10 BR BRPI0413565A patent/BRPI0413565B8/pt active IP Right Grant
- 2004-08-10 AU AU2004264937A patent/AU2004264937B2/en active Active
- 2004-08-10 CN CN201110283526.1A patent/CN102432552B/zh active Active
- 2004-08-10 NZ NZ545459A patent/NZ545459A/en unknown
- 2004-08-13 CL CL200402066A patent/CL2004002066A1/es unknown
- 2004-08-13 TW TW093124336A patent/TWI353982B/zh active
- 2004-08-13 AR ARP040102929A patent/AR045378A1/es active IP Right Grant
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2006
- 2006-02-07 IS IS8288A patent/IS8288A/is unknown
- 2006-02-07 IL IL173593A patent/IL173593A/en active IP Right Grant
- 2006-03-13 NO NO20061171A patent/NO336275B1/no unknown
- 2006-06-05 HK HK06106407.8A patent/HK1085400A1/xx unknown
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2008
- 2008-10-10 US US12/249,421 patent/US8278314B2/en active Active
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2013
- 2013-02-08 CY CY20131100122T patent/CY1113992T1/el unknown
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