BRPI0312288B8 - derivados de amidas - Google Patents
derivados de amidasInfo
- Publication number
- BRPI0312288B8 BRPI0312288B8 BRPI0312288A BR0312288A BRPI0312288B8 BR PI0312288 B8 BRPI0312288 B8 BR PI0312288B8 BR PI0312288 A BRPI0312288 A BR PI0312288A BR 0312288 A BR0312288 A BR 0312288A BR PI0312288 B8 BRPI0312288 B8 BR PI0312288B8
- Authority
- BR
- Brazil
- Prior art keywords
- halogen
- amide derivatives
- alkyl
- present
- formula
- Prior art date
Links
- 150000001408 amides Chemical class 0.000 title abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 229940124290 BCR-ABL tyrosine kinase inhibitor Drugs 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
derivados de amidas. a presente invenção fornece um derivado de amida representado pela seguinte fórmula genérica [1]: onde r^ 1^ representa um grupo amino cíclico saturado, r^ 2^ representa alquila, halogênio ou halo-alquila, r^ 3^ representa hidrogênio ou halogênio, het2 representa piridila ou pirimidinila, e het1 representa um grupo da fórmula [6], ou um seu sal, e uma composição farmacêutica que compreende o mesmo como um ingrediente ativo. o composto da presente invenção é útil como um inibidor de tirosina cinase de bcr-abl.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002189269 | 2002-06-28 | ||
JP2002305146 | 2002-10-18 | ||
JP2002377937 | 2002-12-26 | ||
PCT/JP2003/008192 WO2004002963A1 (ja) | 2002-06-28 | 2003-06-27 | アミド誘導体及び医薬 |
Publications (3)
Publication Number | Publication Date |
---|---|
BR0312288A BR0312288A (pt) | 2005-04-12 |
BRPI0312288B1 BRPI0312288B1 (pt) | 2019-01-02 |
BRPI0312288B8 true BRPI0312288B8 (pt) | 2021-05-25 |
Family
ID=30003594
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0312288A BRPI0312288B8 (pt) | 2002-06-28 | 2003-06-27 | derivados de amidas |
Country Status (15)
Country | Link |
---|---|
US (1) | US7494997B2 (pt) |
EP (1) | EP1533304B1 (pt) |
JP (1) | JP4552650B2 (pt) |
CN (1) | CN100343237C (pt) |
AT (1) | ATE447560T1 (pt) |
AU (1) | AU2003246100A1 (pt) |
BR (1) | BRPI0312288B8 (pt) |
CA (1) | CA2490907C (pt) |
DE (1) | DE60329918D1 (pt) |
DK (1) | DK1533304T3 (pt) |
ES (1) | ES2337995T3 (pt) |
MX (1) | MXPA04012845A (pt) |
PT (1) | PT1533304E (pt) |
RU (1) | RU2315043C2 (pt) |
WO (1) | WO2004002963A1 (pt) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0215676D0 (en) | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
US7375175B2 (en) | 2002-08-19 | 2008-05-20 | National Starch And Chemical Investment Holding Corporation | Dispersions containing living radicals |
AU2004206900B2 (en) * | 2003-01-17 | 2011-03-10 | Wisconsin Alumni Research Foundation | Modified retinoid compounds and their uses |
GB2400101A (en) * | 2003-03-28 | 2004-10-06 | Biofocus Discovery Ltd | Compounds capable of binding to the active site of protein kinases |
CA2529090A1 (en) * | 2003-06-13 | 2004-12-23 | Novartis Ag | 2-aminopyrimidine derivatives as raf kinase inhibitors |
US7365174B2 (en) * | 2003-08-22 | 2008-04-29 | Meiji Seika Kaisha, Ltd. | Azalide and azalactam derivatives and method for producing the same |
CN101456841B (zh) * | 2003-12-25 | 2012-01-25 | 日本新药株式会社 | 酰胺衍生物及医药品 |
US8735415B2 (en) | 2004-09-09 | 2014-05-27 | Natco Pharma Limited | Acid addition salts of (3,5-Bis trifluoromethyl)-N-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide |
MX2007002819A (es) * | 2004-09-09 | 2007-08-14 | Natco Pharma Ltd | Nuevos derivados de fenilaminopirimidina como inhibidores de bcl-abl cinasa. |
GB0512091D0 (en) * | 2005-06-14 | 2005-07-20 | Novartis Ag | Organic compounds |
KR100674813B1 (ko) * | 2005-08-05 | 2007-01-29 | 일양약품주식회사 | N-페닐-2-피리미딘-아민 유도체 및 그의 제조방법 |
WO2008079933A2 (en) * | 2006-12-22 | 2008-07-03 | Novartis Ag | Heteroaryl-heteroaryl compounds as cdk inhibitors for the treatment of cancer, inflammation and viral infections |
EP2166858A4 (en) | 2007-06-07 | 2011-08-03 | Intra Cellular Therapies Inc | NEW HETEROCYCLIC COMPOUNDS AND ITS USE |
JP5559043B2 (ja) | 2007-06-07 | 2014-07-23 | イントラ−セルラー・セラピーズ・インコーポレイテッド | 新規ヘテロ環化合物およびその使用 |
US8415358B2 (en) | 2007-09-17 | 2013-04-09 | Neurosearch A/S | Pyrazine derivatives and their use as potassium channel modulators |
EP2274303B1 (en) * | 2008-03-31 | 2012-08-29 | Teva Pharmaceutical Industries Ltd. | Processes for preparing sunitinib and salts thereof |
CN102341102A (zh) | 2009-03-06 | 2012-02-01 | 诺瓦提斯公司 | 嘧啶基氨基苯甲酰胺衍生物用于治疗由包含亮氨酸拉链和不育α基序的激酶(ZAK)介导的疾病的用途 |
SG10201507362TA (en) | 2009-08-05 | 2015-10-29 | Intra Cellular Therapies Inc | Novel Regulatory Proteins And Inhibitors |
CA2777019A1 (en) | 2009-10-23 | 2011-04-28 | Novartis Ag | Method of treating proliferative disorders and other pathological conditions mediated by bcr-abl, c-kit, ddr1, ddr2 or pdgf-r kinase activity |
JO3634B1 (ar) | 2009-11-17 | 2020-08-27 | Novartis Ag | طريقة لعلاج اضطرابات تكاثرية وحالات مرضية أخرى متوسطة بنشاط كيناز bcr-abl، c-kit، ddr1، ddr2، أو pdgf-r |
EP2825162B1 (en) * | 2012-03-14 | 2018-09-12 | Indiana University Research and Technology Corporation | Compounds and methods for treating leukemia |
CA2892045C (en) | 2012-11-21 | 2022-05-31 | Ptc Therapeutics, Inc. | Substituted reverse pyrimidine bmi-1 inhibitors |
NZ748260A (en) | 2013-08-30 | 2020-01-31 | Ptc Therapeutics Inc | Substituted pyrimidine bmi-1 inhibitors |
US10584115B2 (en) | 2013-11-21 | 2020-03-10 | Ptc Therapeutics, Inc. | Substituted pyridine and pyrazine BMI-1 inhibitors |
US9975878B2 (en) | 2013-11-21 | 2018-05-22 | Ptc Therapeutics, Inc. | Substituted triazine BMI-1 inhibitors |
WO2017156350A1 (en) | 2016-03-09 | 2017-09-14 | K-Gen, Inc. | Methods of cancer treatment |
US11091462B2 (en) | 2017-01-20 | 2021-08-17 | Shenzhen Targetrx, Inc. | (Hetero)arylamide compound for inhibiting protein kinase activity |
JP6778833B2 (ja) * | 2017-01-20 | 2020-11-04 | 深▲チェン▼市塔吉瑞生物医薬有限公司Shenzhen TargetRx, Inc. | キナーゼ活性を抑制するための(ヘテロ)アリールアミド類化合物 |
CN114127065A (zh) * | 2019-03-05 | 2022-03-01 | 鸿仪有限责任公司 | 用于治疗神经退行性疾病和癌症的化合物 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5521184A (en) * | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
TW225528B (pt) * | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
CO4940418A1 (es) | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
GB0022438D0 (en) | 2000-09-13 | 2000-11-01 | Novartis Ag | Organic Compounds |
-
2003
- 2003-06-27 CA CA2490907A patent/CA2490907C/en not_active Expired - Lifetime
- 2003-06-27 AT AT03738555T patent/ATE447560T1/de active
- 2003-06-27 PT PT03738555T patent/PT1533304E/pt unknown
- 2003-06-27 DE DE60329918T patent/DE60329918D1/de not_active Expired - Lifetime
- 2003-06-27 MX MXPA04012845A patent/MXPA04012845A/es active IP Right Grant
- 2003-06-27 JP JP2004517313A patent/JP4552650B2/ja not_active Expired - Lifetime
- 2003-06-27 ES ES03738555T patent/ES2337995T3/es not_active Expired - Lifetime
- 2003-06-27 CN CNB038201461A patent/CN100343237C/zh not_active Expired - Lifetime
- 2003-06-27 US US10/519,722 patent/US7494997B2/en not_active Expired - Lifetime
- 2003-06-27 DK DK03738555.6T patent/DK1533304T3/da active
- 2003-06-27 AU AU2003246100A patent/AU2003246100A1/en not_active Abandoned
- 2003-06-27 WO PCT/JP2003/008192 patent/WO2004002963A1/ja active Application Filing
- 2003-06-27 EP EP03738555A patent/EP1533304B1/en not_active Expired - Lifetime
- 2003-06-27 RU RU2005102098/04A patent/RU2315043C2/ru active
- 2003-06-27 BR BRPI0312288A patent/BRPI0312288B8/pt active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP1533304B1 (en) | 2009-11-04 |
DE60329918D1 (de) | 2009-12-17 |
CN1678590A (zh) | 2005-10-05 |
US20060014742A1 (en) | 2006-01-19 |
EP1533304A4 (en) | 2006-10-18 |
RU2005102098A (ru) | 2005-09-20 |
EP1533304A1 (en) | 2005-05-25 |
WO2004002963A1 (ja) | 2004-01-08 |
BRPI0312288B1 (pt) | 2019-01-02 |
CA2490907A1 (en) | 2004-01-08 |
BR0312288A (pt) | 2005-04-12 |
AU2003246100A1 (en) | 2004-01-19 |
ES2337995T3 (es) | 2010-05-03 |
RU2315043C2 (ru) | 2008-01-20 |
CN100343237C (zh) | 2007-10-17 |
JPWO2004002963A1 (ja) | 2005-10-27 |
PT1533304E (pt) | 2010-02-08 |
CA2490907C (en) | 2010-08-24 |
JP4552650B2 (ja) | 2010-09-29 |
MXPA04012845A (es) | 2005-02-24 |
DK1533304T3 (da) | 2010-03-22 |
US7494997B2 (en) | 2009-02-24 |
ATE447560T1 (de) | 2009-11-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0312288B8 (pt) | derivados de amidas | |
BRPI0418074B8 (pt) | derivado de amida, composição farmacêutica, inibidor da tirosina cinase bcr-abl e agentes terapêuticos | |
BR9803883A (pt) | Derivado de amida. | |
BR112012033770A2 (pt) | novo derivado de nicotinamida ou sal do mesmo | |
BRPI0515446A (pt) | amidas bicìclicas como inibidores de cinases | |
BRPI0510598A (pt) | compostos de amida de aril ou heteroaril substituìdos | |
BR9812095A (pt) | Compostos de indol como inibidores de cox-2 | |
BR0114436A (pt) | Composto com anel de cinco elementos contendo nitrogênio alifático | |
BRPI0512676A (pt) | derivados de indolil alquil amina substituìdos como inibidores de histona desacetilase | |
BR0307606A (pt) | Derivados de piperazinila, piperidinila e morfolinila como inibidores de histona desacetilase | |
BR0113448A (pt) | Composto da fórmula ou um sal ou solvato deste ou um derivado destes fisiologicamente funcional, composição farmacêutica, uso do composto ou de um sal ou solvato deste ou de um derivado destes fisiologicamente funcional, e , métodos para tratar uma condição ou estado de doença mediados pela p38 quinase ou mediados pelas citoquinas, e mediados pela jnk quinase ou mediados pelas citoquinas, e ,para tratar duas ou mais condições ou doenças independentemente mediadas pela atividade da p38 e da jnk quinase | |
BR122017028096B8 (pt) | composto, composição farmacêutica, e, uso do composto | |
BR0207025A (pt) | Derivado de isoxazolina e herbicida contendo o mesmo como o ingrediente ativo | |
BR0108303A (pt) | Derivados do 1h-imidazopiridina | |
BR0210874A (pt) | Derivados de tiazol-benzamida e composições farmacêuticas para a inibição da proliferação celular e métodos para o seu uso | |
BRPI0513863A (pt) | derivados de uréia cìclica substituìda por heterociclo, preparação dos mesmos e uso farmacêutico dos mesmos como inibidores de cinase | |
BRPI0616574A2 (pt) | derivado de sulfonamida tendo atividade antagonìstica de receptor de pgd2 | |
BR0316350A (pt) | Diaminotriazóis úteis como inibidores de proteìna cinases | |
BRPI0616799B8 (pt) | derivado de piridina e derivado de pirimidina, composições farmacêuticas, usos, inibidores de angiogênese, contra receptor de fator de crescimento de hepatócito e contra metástase de câncer, e agente antitumor | |
BRPI0510666A (pt) | compostos de amida de arila ou heteroarila de metila substituìda, composições farmacêuticas compreendendo os mesmos, uso e combinação | |
EA200800781A1 (ru) | АМИДНЫЕ И КАРБАМАТНЫЕ ПРОИЗВОДНЫЕ АЛКИЛЗАМЕЩЕННЫХ N-[4-(4-АМИНО-1Н-ИМИДАЗО[4,5-c]ХИНОЛИН-1-ИЛ)БУТИЛ]МЕТАНСУЛЬФОНАМИДОВ И СПОСОБЫ | |
BR9909666A (pt) | Derivados de amida e antagonistas de nociceptina | |
EA200200942A1 (ru) | Фармацевтические композиции, содержащие производные 3-аминоазетидина, новые производные и способ их получения | |
BR0012697A (pt) | Inibidores da diferenciação de th2 | |
BRPI0515851A (pt) | composto de pirimidona |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 11A ANUIDADE. |
|
B08H | Application fees: decision cancelled [chapter 8.8 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 2261 DE 06/05/2014 |
|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 02/01/2019, OBSERVADAS AS CONDICOES LEGAIS. |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 27/06/2003 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |