BR9911365A - Compostos pirrolo[2,3-d]pirimidina - Google Patents
Compostos pirrolo[2,3-d]pirimidinaInfo
- Publication number
- BR9911365A BR9911365A BR9911365-1A BR9911365A BR9911365A BR 9911365 A BR9911365 A BR 9911365A BR 9911365 A BR9911365 A BR 9911365A BR 9911365 A BR9911365 A BR 9911365A
- Authority
- BR
- Brazil
- Prior art keywords
- diabetes
- disease
- pyrrolo
- pyrimidine compounds
- pyrimidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
Abstract
Patente de Invenção: <B>"COMPOSTOS PIRROLO[2,3-d]PIRIMIDINA"<D>. Composto com a fórmula na qual R¹, R² e R³ são como anteriormente definidos, que são inibidores das enzimas proteína tirosina quinases tal como Janus Kinase 3 e como tal são uma terapia útil como agentes imunossupressivos para transplantes de órgãos, lúpus, esclerose múltipla, artrite reumatóide, psoríase, diabetes do Tipo I e complicações de diabetes, cancêr, asma, dermatite atópica, doenças da tiróide auto-imunes, colite ulcerativa, doença de Crohn, doença de Alzheimer, leucemia e outras doenças auto-imunes.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8986698P | 1998-06-19 | 1998-06-19 | |
US10478798P | 1998-10-19 | 1998-10-19 | |
PCT/IB1999/001100 WO1999065908A1 (en) | 1998-06-19 | 1999-06-14 | PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9911365A true BR9911365A (pt) | 2001-03-13 |
Family
ID=26781018
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9911365-1A BR9911365A (pt) | 1998-06-19 | 1999-06-14 | Compostos pirrolo[2,3-d]pirimidina |
Country Status (41)
Country | Link |
---|---|
US (3) | US6610847B2 (pt) |
EP (1) | EP1087970B1 (pt) |
JP (3) | JP4666762B2 (pt) |
KR (1) | KR100415791B1 (pt) |
CN (1) | CN1128800C (pt) |
AP (1) | AP1021A (pt) |
AR (1) | AR016499A1 (pt) |
AT (1) | ATE265458T1 (pt) |
AU (1) | AU3951899A (pt) |
BG (1) | BG65119B1 (pt) |
BR (1) | BR9911365A (pt) |
CA (1) | CA2335492C (pt) |
CZ (1) | CZ20004727A3 (pt) |
DE (1) | DE69916833T2 (pt) |
DK (1) | DK1087970T3 (pt) |
EA (1) | EA005852B1 (pt) |
ES (1) | ES2219018T3 (pt) |
FR (1) | FR14C0019I2 (pt) |
GE (1) | GEP20074227B (pt) |
GT (1) | GT199900090A (pt) |
HK (1) | HK1036801A1 (pt) |
HR (1) | HRP20000885B1 (pt) |
HU (1) | HUP0102574A3 (pt) |
ID (1) | ID26698A (pt) |
IL (1) | IL139586A0 (pt) |
MA (1) | MA26654A1 (pt) |
MY (1) | MY125916A (pt) |
NO (1) | NO318784B1 (pt) |
NZ (1) | NZ518444A (pt) |
OA (1) | OA11572A (pt) |
PA (1) | PA8476001A1 (pt) |
PE (1) | PE20000698A1 (pt) |
PL (1) | PL198640B1 (pt) |
PT (1) | PT1087970E (pt) |
RS (1) | RS50087B (pt) |
SA (1) | SA99200283B1 (pt) |
SK (1) | SK286640B6 (pt) |
TN (1) | TNSN99126A1 (pt) |
TR (1) | TR200003719T2 (pt) |
TW (1) | TW505646B (pt) |
WO (1) | WO1999065908A1 (pt) |
Families Citing this family (122)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PA8474101A1 (es) | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
HUP0102574A3 (en) * | 1998-06-19 | 2002-01-28 | Pfizer Prod Inc | Pyrrolo[2,3-d]pyrimidine compounds |
JP4078074B2 (ja) | 1999-12-10 | 2008-04-23 | ファイザー・プロダクツ・インク | ピロロ[2,3−d]ピリミジン化合物 |
ATE323704T1 (de) * | 2000-06-26 | 2006-05-15 | Pfizer Prod Inc | Pyrrolo¬2,3-däpyrimidin verbindungen als immunosuppressive wirkstoffe |
PL359920A1 (en) | 2000-09-20 | 2004-09-06 | Merck Patent Gmbh | 4-amino-quinazolines |
US7067550B2 (en) * | 2000-11-03 | 2006-06-27 | Massachusetts Institute Of Technology | Treatments for neurotoxicity in Alzheimer's Disease |
DE10063294A1 (de) * | 2000-12-19 | 2002-07-04 | Aventis Pharma Gmbh | Substituierte Heterocyclo-Norbornylamino-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
US20040102455A1 (en) * | 2001-01-30 | 2004-05-27 | Burns Christopher John | Method of inhibiting kinases |
NZ526961A (en) | 2001-02-12 | 2005-03-24 | F | 6-substituted pyrido-pyrimidines |
US7301023B2 (en) * | 2001-05-31 | 2007-11-27 | Pfizer Inc. | Chiral salt resolution |
GB0115393D0 (en) * | 2001-06-23 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
PT1401413E (pt) | 2001-06-29 | 2007-02-28 | Ab Science | Uso de inibidores da tirosina cinase para tratar doenças alérgicas |
CA2452361A1 (en) * | 2001-06-29 | 2003-01-09 | Ab Science | Use of tyrosine kinase inhibitors for treating autoimmune diseases |
CA2452169A1 (en) | 2001-06-29 | 2003-01-09 | Ab Science | Use of tyrosine kinase inhibitors for treating inflammatory diseases |
US7678805B2 (en) | 2001-06-29 | 2010-03-16 | Ab Science | Use of tyrosine kinase inhibitors for treating inflammatory bowel diseases (IBD) |
ATE376182T1 (de) | 2001-06-29 | 2007-11-15 | Ab Science | C-kit inhibitoren |
GB0119249D0 (en) | 2001-08-07 | 2001-10-03 | Novartis Ag | Organic compounds |
US7323469B2 (en) | 2001-08-07 | 2008-01-29 | Novartis Ag | 7H-pyrrolo[2,3-d]pyrimidine derivatives |
US7829566B2 (en) | 2001-09-17 | 2010-11-09 | Werner Mederski | 4-amino-quinazolines |
GT200200234A (es) | 2001-12-06 | 2003-06-27 | Compuestos cristalinos novedosos | |
JP4505228B2 (ja) * | 2002-01-10 | 2010-07-21 | バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト | Rho−キナーゼ阻害剤 |
WO2003062225A1 (en) | 2002-01-23 | 2003-07-31 | Bayer Pharmaceuticals Corporation | Pyrimidine derivatives as rho-kinase inhibitors |
WO2003062227A1 (en) | 2002-01-23 | 2003-07-31 | Bayer Pharmaceuticals Corporation | Rho-kinase inhibitors |
GB0202679D0 (en) * | 2002-02-05 | 2002-03-20 | Glaxo Group Ltd | Novel compounds |
EP1388541A1 (en) * | 2002-08-09 | 2004-02-11 | Centre National De La Recherche Scientifique (Cnrs) | Pyrrolopyrazines as kinase inhibitors |
CN1717236A (zh) * | 2002-11-26 | 2006-01-04 | 辉瑞产品公司 | 治疗移植排斥的方法 |
CA2543116A1 (en) * | 2003-10-27 | 2005-05-19 | Genelabs Technologies, Inc. | Methods for preparing 7-(2'-substituted-.szlig.-d-ribofuranosyl)-4-(nr2r3)-5-(substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine derivatives |
WO2005051393A1 (en) * | 2003-11-25 | 2005-06-09 | Pfizer Products Inc. | Method of treatment of atherosclerosis |
WO2005095357A2 (en) * | 2004-03-30 | 2005-10-13 | Taisho Pharmaceutical Co., Ltd. | Pyrimidine derivatives and methods of treatment related to the use thereof |
CA2571710A1 (en) | 2004-06-24 | 2006-11-02 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
WO2006004703A2 (en) * | 2004-06-29 | 2006-01-12 | Amgen Inc. | PYRROLO[2,3-d]PYRIMIDINES THAT MODULATE ACK1 AND LCK ACTIVITY |
TW200615268A (en) | 2004-08-02 | 2006-05-16 | Osi Pharm Inc | Aryl-amino substituted pyrrolopyrimidine multi-kinase inhibiting compounds |
MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
AR054416A1 (es) | 2004-12-22 | 2007-06-27 | Incyte Corp | Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas. |
WO2006091450A1 (en) * | 2005-02-18 | 2006-08-31 | Lexicon Genetics Incorporated | 4-piperidin-1-yl-7h-pyrrolo[2,3-d]pyrimidine compounds |
AU2006247757B2 (en) | 2005-05-13 | 2009-08-27 | Irm, Llc | Compounds and compositions as protein kinase inhibitors |
EP2251341A1 (en) | 2005-07-14 | 2010-11-17 | Astellas Pharma Inc. | Heterocyclic Janus kinase 3 inhibitors |
CA2615291A1 (en) | 2005-07-14 | 2007-01-18 | Astellas Pharma Inc. | Heterocyclic janus kinase 3 inhibitors |
CA2621261C (en) | 2005-09-22 | 2014-05-20 | Incyte Corporation | Azepine inhibitors of janus kinases |
ES2401192T3 (es) | 2005-09-30 | 2013-04-17 | Vertex Pharmceuticals Incorporated | Deazapurinas útiles como inhibidores de janus cinasas |
PL2474545T3 (pl) | 2005-12-13 | 2017-04-28 | Incyte Holdings Corporation | Podstawione heteroarylem pirolo[2,3-b]pirydyny i pirolo[2,3-b]pirymidyny jako inhibitory kinazy Janusowej |
EP2007373A4 (en) * | 2006-03-29 | 2012-12-19 | Foldrx Pharmaceuticals Inc | INHIBITION OF ALPHA SYNUCLEINE TOXICITY |
US8796293B2 (en) | 2006-04-25 | 2014-08-05 | Astex Therapeutics Limited | Purine and deazapurine derivatives as pharmaceutical compounds |
US8513270B2 (en) | 2006-12-22 | 2013-08-20 | Incyte Corporation | Substituted heterocycles as Janus kinase inhibitors |
EP2123651A4 (en) | 2007-01-12 | 2011-05-04 | Astellas Pharma Inc | CONDENSED PYRIDINE COMPOUND |
KR20100015353A (ko) * | 2007-04-02 | 2010-02-12 | 팔라우 파르마 에스에이 | Jak3 억제제로서의 피롤로피리미딘 유도체 |
CL2008001709A1 (es) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
HUE043732T2 (hu) | 2007-06-13 | 2019-09-30 | Incyte Holdings Corp | Januskináz gátló hatású (R)-3-(4-(7H pirrolo[2,3-d]pirimidin-4-il)-1H-pirazol-1-il)-3-ciklopentilpropánnitril sók alkalmazása |
DE102007027800A1 (de) | 2007-06-16 | 2008-12-18 | Bayer Healthcare Ag | Substituierte bicyclische Heteroaryl-Verbindungen und ihre Verwendung |
MX2010005116A (es) * | 2007-11-10 | 2010-09-09 | Landmark Graphics Corp | Sistemas y metodos para automatizacion, adaptacion e integracion del flujo de trabajo. |
EP3912973A3 (en) * | 2007-11-28 | 2022-02-16 | Dana-Farber Cancer Institute, Inc. | Small molecule myristate inhibitors of bcr-abl and methods of use |
NZ587271A (en) | 2008-02-06 | 2012-03-30 | Novartis Ag | Pyrrolo[2,3-d]pyrimidines containing a 7h-pyrrolo[2,3-d]pyrimidin-2-yl core and use thereof as tyrosine kinase inhibitors |
PT2247592E (pt) * | 2008-02-25 | 2011-11-03 | Hoffmann La Roche | Inibidores de pirrolpirazina-cinase |
AU2009223640B2 (en) | 2008-03-11 | 2013-07-04 | Incyte Holdings Corporation | Azetidine and cyclobutane derivatives as jak inhibitors |
WO2009115084A2 (de) * | 2008-03-20 | 2009-09-24 | Schebo Biotech Ag | Neue pyrrolopyrimidin-derivate und deren verwendungen |
CA2728559A1 (en) * | 2008-07-03 | 2010-01-07 | Exelixis Inc. | Cdk modulators |
KR20110050654A (ko) * | 2008-08-01 | 2011-05-16 | 바이오크리스트 파마수티컬즈, 인코퍼레이티드 | Jak3 억제제로서의 피페리딘 유도체 |
JP4884570B2 (ja) | 2008-08-20 | 2012-02-29 | ファイザー・インク | ピロロ[2,3−d]ピリミジン化合物 |
US8385364B2 (en) * | 2008-09-24 | 2013-02-26 | Nec Laboratories America, Inc. | Distributed message-passing based resource allocation in wireless systems |
BRPI1007737A2 (pt) | 2009-04-20 | 2015-09-01 | Auspex Pharmaceuticals Llc | "composto da fórmula estrutural i, composição farmacêutica, método de tratamento de um distúbio mediano por janus quinase 3, método de preparação de um composto da fórmula estrutural ii, e método de preparação de um composto da fórmula estrutural xii" |
CA2761954C (en) | 2009-05-22 | 2018-07-31 | Incyte Corporation | 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors |
AU2010249380B2 (en) | 2009-05-22 | 2015-08-20 | Incyte Holdings Corporation | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as Janus kinase inhibitors |
JP5690823B2 (ja) | 2009-07-08 | 2015-03-25 | レオ ファーマ アクティーゼルスカブ | Jak受容体およびタンパク質チロシンキナーゼ阻害薬としての複素環化合物 |
TWI466885B (zh) * | 2009-07-31 | 2015-01-01 | Japan Tobacco Inc | 含氮螺環化合物及其醫藥用途 |
TW201111385A (en) * | 2009-08-27 | 2011-04-01 | Biocryst Pharm Inc | Heterocyclic compounds as janus kinase inhibitors |
TW201113285A (en) | 2009-09-01 | 2011-04-16 | Incyte Corp | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
CN102596960B (zh) | 2009-10-09 | 2016-01-20 | 因西特控股公司 | 3-(4-(7H-吡咯并[2,3-d]嘧啶-4-基)-1H-吡唑-1-基)-3-环戊基丙腈的羟基衍生物、酮基衍生物和葡糖苷酸衍生物 |
JP5629324B2 (ja) | 2009-10-15 | 2014-11-19 | ファイザー・インク | ピロロ[2,3−d]ピリミジン化合物 |
JP5739446B2 (ja) * | 2009-12-18 | 2015-06-24 | ファイザー・インク | ピロロ[2,3−d]ピリミジン化合物 |
CN102822177A (zh) | 2010-02-05 | 2012-12-12 | 美国辉瑞有限公司 | 吡咯并[2,3-d]嘧啶脲化合物 |
EP2360158A1 (en) * | 2010-02-18 | 2011-08-24 | Almirall, S.A. | Pyrazole derivatives as jak inhibitors |
AR081315A1 (es) | 2010-03-10 | 2012-08-08 | Incyte Corp | Derivados heterociclicos de piperidin y pirimidin -4-il-azetidina, una forma cristalina de la sal del acido acetonitriladipico de un derivado pirimidinico, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades relacionadas con la inhibicion de jak-1, t |
TW201204732A (en) * | 2010-07-09 | 2012-02-01 | Leo Pharma As | Novel homopiperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof |
EA026201B1 (ru) | 2010-11-19 | 2017-03-31 | Инсайт Холдингс Корпорейшн | Циклобутилзамещенные производные пирролопиридина и пирролопиримидина как ингибиторы jak |
JP5917544B2 (ja) | 2010-11-19 | 2016-05-18 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Jak阻害剤としての複素環置換ピロロピリジンおよびピロロピリミジン |
CA2823935A1 (en) | 2011-01-07 | 2012-07-12 | Leo Pharma A/S | Novel sulfamide piperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof |
PL2675451T3 (pl) | 2011-02-18 | 2016-05-31 | Novartis Pharma Ag | Terapia skojarzona z inhibitorem mTOR/JAK |
CN103547580B (zh) | 2011-03-22 | 2016-12-07 | 阿迪维纳斯疗法有限公司 | 取代的稠合三环化合物、其组合物及医药用途 |
AU2012255792A1 (en) * | 2011-05-17 | 2013-11-07 | Principia Biopharma Inc. | Azaindole derivatives as tyrosine kinase inhibitors |
AR086983A1 (es) | 2011-06-20 | 2014-02-05 | Incyte Corp | Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de jak |
WO2013023119A1 (en) | 2011-08-10 | 2013-02-14 | Novartis Pharma Ag | JAK P13K/mTOR COMBINATION THERAPY |
TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為jak抑制劑之環己基氮雜環丁烷衍生物 |
UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
WO2013082476A1 (en) | 2011-11-30 | 2013-06-06 | Emory University | Antiviral jak inhibitors useful in treating or preventing retroviral and other viral infections |
EP2796460B1 (en) * | 2011-12-21 | 2018-07-04 | Jiangsu Hengrui Medicine Co. Ltd. | Pyrrole six-membered heteroaryl ring derivative, preparation method therefor, and medicinal uses thereof |
AR091079A1 (es) | 2012-05-18 | 2014-12-30 | Incyte Corp | Derivados de pirrolopirimidina y pirrolopiridina sustituida con piperidinilciclobutilo como inhibidores de jak |
CA2873967A1 (en) | 2012-05-21 | 2013-11-28 | Bayer Pharma Aktiengesellschaft | Substituted benzothienopyrimidines |
EP3255049A1 (en) * | 2012-06-29 | 2017-12-13 | Pfizer Inc | Novel 4-(substituted-amino)-7h-pyrrolo[2,3-d]pyrimidines as lrrk2 inhibitors |
PL2875013T3 (pl) * | 2012-07-17 | 2018-06-29 | Glaxosmithkline Intellectual Property (No. 2) Limited | Indolokarbonitryle jako selektywne modulatory receptora androgenowego |
MX360857B (es) * | 2012-07-20 | 2018-11-20 | Zoetis Llc | Régimen de dosificación para inhibidores de janus quinasa (jak). |
TW201412740A (zh) | 2012-09-20 | 2014-04-01 | Bayer Pharma AG | 經取代之吡咯并嘧啶胺基苯并噻唑酮 |
EP2897962A1 (en) | 2012-09-21 | 2015-07-29 | Advinus Therapeutics Limited | Substituted fused tricyclic compounds, compositions and medicinal applications thereof |
CN102936251A (zh) * | 2012-11-05 | 2013-02-20 | 上海毕得医药科技有限公司 | 一种吡咯并[2,3-d]嘧啶衍生物的制备方法 |
PL2919766T3 (pl) | 2012-11-15 | 2021-10-04 | Incyte Holdings Corporation | Postacie dawkowania ruksolitynibu o przedłużonym uwalnianiu |
KR101683061B1 (ko) * | 2013-02-07 | 2016-12-07 | 한국과학기술연구원 | JAK-3 저해제로 유용한 7H-피롤로[2,3-d]피리미딘-4-싸이올 유도체 |
LT3290421T (lt) * | 2013-02-22 | 2019-02-25 | Pfizer Inc. | Pirolo [2, 3 -d]pirimidino darinių derinys su vienu arba daugiau papildomų agentų, kaip janus kinazės (jak) inhibitorių |
AU2014225938B2 (en) | 2013-03-06 | 2018-07-19 | Incyte Holdings Corporation | Processes and intermediates for making a JAK inhibitor |
EP2970119B1 (en) * | 2013-03-14 | 2021-11-03 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
MX2016001639A (es) | 2013-08-07 | 2016-10-07 | Incyte Corp | Formas de dosificacion de liberacion prolongada para un inhibidor de jak 1 (cinasa de janus 1). |
HUE054560T2 (hu) | 2013-12-05 | 2021-09-28 | Pfizer | Pirrolo[2,3-d]pirimidinil, pirrolo[2,3-b]pirazinil és pirrolo[2,3-d]piridinil akrilamidok |
US9695171B2 (en) | 2013-12-17 | 2017-07-04 | Pfizer Inc. | 3,4-disubstituted-1 H-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7H-pyrrolo[2,3-c]pyridazines as LRRK2 inhibitors |
WO2015184305A1 (en) | 2014-05-30 | 2015-12-03 | Incyte Corporation | TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 |
WO2016024185A1 (en) | 2014-08-12 | 2016-02-18 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidine derivatives useful for inhibiting janus kinase |
EP3288943B1 (en) | 2015-05-01 | 2022-09-28 | Pfizer Inc. | Pyrrolo[2,3-b]pyrazinyl acrylamides and epoxides thereof as inhibitors of janus kinase |
JP6564473B2 (ja) * | 2015-05-29 | 2019-08-21 | 无▲錫▼福祈制▲薬▼有限公司Wuxi Fortune Pharmaceutical Co.,Ltd | Janusキナーゼ阻害剤 |
KR101771219B1 (ko) * | 2015-08-21 | 2017-09-05 | 양지화학 주식회사 | 야누스 키나제 1 선택적 억제제 및 그 의약 용도 |
EP3350178B1 (en) | 2015-09-14 | 2021-10-20 | Pfizer Inc. | Novel imidazo [4,5-c]quinoline and imidazo [4,5-c][1,5]naphthyridine derivatives as lrrk2 inhibitors |
CN106831779B (zh) * | 2015-11-28 | 2019-07-19 | 南昌弘益药业有限公司 | 一类jak激酶抑制剂的新化合物 |
AU2017221193B2 (en) | 2016-02-16 | 2019-03-14 | Zoetis Services Llc | Process for preparing 7H-pyrrolo (2, 3-d) pyrimidine compounds |
CN107098908B (zh) * | 2016-02-23 | 2021-01-08 | 欣凯医药科技(上海)有限公司 | 一种吡咯并嘧啶类化合物的制备方法和应用 |
EP3555074B1 (en) | 2016-12-14 | 2022-07-27 | Intervet International B.V. | Aminopyrazoles as selective janus kinase inhibitors |
JP2022506682A (ja) * | 2018-11-05 | 2022-01-17 | アビスタ ファーマ ソリューションズ,インコーポレーテッド | 化合物 |
TW202043205A (zh) * | 2018-12-31 | 2020-12-01 | 美商拜歐米富士恩有限公司 | Menin-mll相互作用之抑制劑 |
BR112021011578A2 (pt) | 2018-12-31 | 2021-08-31 | Biomea Fusion, Llc | Inibidores irreversíveis de interação menina-mll |
CN113993585A (zh) | 2019-03-27 | 2022-01-28 | 英矽智能科技知识产权有限公司 | 双环jak抑制剂及其用途 |
US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
CN117242080A (zh) | 2020-12-18 | 2023-12-15 | 勃林格殷格翰动物保健美国公司 | 含硼吡唑化合物、包括其的组合物、其方法和用途 |
WO2023029943A1 (zh) * | 2021-09-03 | 2023-03-09 | 星药科技(北京)有限公司 | 一种芳杂环化合物及其制备方法和用途 |
WO2023055731A1 (en) * | 2021-09-28 | 2023-04-06 | Sanford Burnham Prebys Medical Discovery Institute | Inhibitors of serine/threonine protein kinase stk3 or stk4 and uses thereof |
WO2023118555A1 (en) | 2021-12-24 | 2023-06-29 | Intervet International B.V. | Use of aminopyrazole compounds |
GB202215132D0 (en) * | 2022-10-13 | 2022-11-30 | Norwegian Univ Sci & Tech Ntnu | Compound |
GB202215117D0 (en) * | 2022-10-13 | 2022-11-30 | Norwegian Univ Sci & Tech Ntnu | Compound |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3037980A (en) * | 1955-08-18 | 1962-06-05 | Burroughs Wellcome Co | Pyrrolopyrimidine vasodilators and method of making them |
GB915304A (en) | 1958-03-13 | 1963-01-09 | Wellcome Found | Pyrrolo[2,3-d]pyrimidine derivatives |
US6136595A (en) | 1993-07-29 | 2000-10-24 | St. Jude Children's Research Hospital | Jak kinases and regulations of cytokine signal transduction |
US5389509A (en) | 1993-10-04 | 1995-02-14 | Eastman Kodak Company | Ultrathin high chloride tabular grain emulsions |
IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
ES2109796T3 (es) * | 1994-05-03 | 1998-01-16 | Ciba Geigy Ag | Derivados de pirrolopirimidilo con efecto antiproliferante. |
DK0831829T3 (da) * | 1995-06-07 | 2003-12-15 | Pfizer | Heterocykliske, ringkondenserede pyrimidinderivater |
US6066638A (en) | 1995-07-05 | 2000-05-23 | E. I. Du Pont De Nemours And Company | Fungicidal pyrimidinones |
TR199800012T1 (xx) * | 1995-07-06 | 1998-04-21 | Novartis Ag | Piroloprimidinler ve preparasyon i�in tatbikler. |
AR004010A1 (es) | 1995-10-11 | 1998-09-30 | Glaxo Group Ltd | Compuestos heterociclicos |
EA000072B1 (ru) | 1995-11-14 | 1998-06-25 | Фармация Энд Апджон С.П.А. | Бициклическое конденсированное пиримидиновое соединение и его применение в качестве терапевтического агента |
WO1997027199A1 (en) | 1996-01-23 | 1997-07-31 | Novartis Ag | Pyrrolopyrimidines and processes for their preparation |
CH690773A5 (de) | 1996-02-01 | 2001-01-15 | Novartis Ag | Pyrrolo(2,3-d)pyrimide und ihre Verwendung. |
GB9604361D0 (en) * | 1996-02-29 | 1996-05-01 | Pharmacia Spa | 4-Substituted pyrrolopyrimidine compounds as tyrosine kinase inhibitors |
WO1997032879A1 (de) | 1996-03-06 | 1997-09-12 | Novartis Ag | 7-ALKYL-PYRROLO[2,3-d]PYRIMIDINE |
WO1997049706A1 (en) | 1996-06-25 | 1997-12-31 | Novartis Ag | SUBSTITUTED 7-AMINO-PYRROLO[3,2-d]PYRIMIDINES AND THE USE THEREOF |
ID19430A (id) | 1996-07-13 | 1998-07-09 | Glaxo Group Ltd | Senyawa senyawa heterosiklik |
HRP970371A2 (en) | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
DE69738468T2 (de) * | 1996-08-23 | 2009-01-08 | Novartis Ag | Substituierte pyrrolopyrimidine und verfahren zu ihrer herstellung |
KR20000057228A (ko) * | 1996-11-27 | 2000-09-15 | 디. 제이. 우드, 스피겔 알렌 제이 | 축합된 비사이클릭 피리미딘 유도체 |
EP0964864B1 (en) | 1997-02-05 | 2008-04-09 | Warner-Lambert Company LLC | Pyrido 2,3-d pyrimidines and 4-aminopyrimidines as inhibitors of cellular proliferation |
AU6568398A (en) | 1997-03-24 | 1998-10-20 | Pharmacia & Upjohn Company | Method for identifying inhibitors of jak2/cytokine receptor binding |
US6080847A (en) * | 1997-12-04 | 2000-06-27 | Incyte Pharmaceuticals, Inc. | Proteins associated with cell proliferation |
WO1999051599A1 (en) | 1998-04-02 | 1999-10-14 | Neurogen Corporation | Aminoalkyl substituted pyrrolo[2,3-b]pyridine and pyrrolo[2,3-d]pyrimidine derivatives: modulators of crf1 receptors |
EP1082311A1 (en) | 1998-05-28 | 2001-03-14 | Parker Hughes Institute | Quinazolines for treating brain tumor |
HUP0102574A3 (en) * | 1998-06-19 | 2002-01-28 | Pfizer Prod Inc | Pyrrolo[2,3-d]pyrimidine compounds |
EP1091739A1 (en) | 1998-06-30 | 2001-04-18 | Parker Hughes Institute | Method for inhibiting c-jun expression using jak-3 inhibitors |
HUP0103386A3 (en) | 1998-08-21 | 2002-07-29 | Parker Hughes Inst St Paul | Use of quinazoline derivatives for producing pharmaceutical compositions having jak 3-inhibitor effect |
US6080747A (en) | 1999-03-05 | 2000-06-27 | Hughes Institute | JAK-3 inhibitors for treating allergic disorders |
JP4078074B2 (ja) * | 1999-12-10 | 2008-04-23 | ファイザー・プロダクツ・インク | ピロロ[2,3−d]ピリミジン化合物 |
ATE323704T1 (de) * | 2000-06-26 | 2006-05-15 | Pfizer Prod Inc | Pyrrolo¬2,3-däpyrimidin verbindungen als immunosuppressive wirkstoffe |
AU2009100870A4 (en) | 2008-10-01 | 2009-10-22 | Rock Tone Enterprise Co., Ltd. | Drive mechanism for dehydrator |
TWM358618U (en) | 2008-12-26 | 2009-06-11 | Rock Tone Entpr Co Ltd | Combination structure of mop holder and cleaning body |
-
1999
- 1999-06-14 HU HU0102574A patent/HUP0102574A3/hu unknown
- 1999-06-14 EP EP99922454A patent/EP1087970B1/en not_active Expired - Lifetime
- 1999-06-14 EA EA200001203A patent/EA005852B1/ru not_active IP Right Cessation
- 1999-06-14 IL IL13958699A patent/IL139586A0/xx active Protection Beyond IP Right Term
- 1999-06-14 DK DK99922454T patent/DK1087970T3/da active
- 1999-06-14 RS YUP-785/00A patent/RS50087B/sr unknown
- 1999-06-14 PT PT99922454T patent/PT1087970E/pt unknown
- 1999-06-14 PL PL345123A patent/PL198640B1/pl unknown
- 1999-06-14 ID IDW20002644A patent/ID26698A/id unknown
- 1999-06-14 OA OA1200000349A patent/OA11572A/en unknown
- 1999-06-14 DE DE69916833T patent/DE69916833T2/de not_active Expired - Lifetime
- 1999-06-14 CA CA002335492A patent/CA2335492C/en not_active Expired - Lifetime
- 1999-06-14 SK SK1898-2000A patent/SK286640B6/sk not_active IP Right Cessation
- 1999-06-14 ES ES99922454T patent/ES2219018T3/es not_active Expired - Lifetime
- 1999-06-14 WO PCT/IB1999/001100 patent/WO1999065908A1/en active IP Right Grant
- 1999-06-14 AU AU39518/99A patent/AU3951899A/en not_active Abandoned
- 1999-06-14 BR BR9911365-1A patent/BR9911365A/pt not_active Application Discontinuation
- 1999-06-14 JP JP2000554733A patent/JP4666762B2/ja not_active Expired - Lifetime
- 1999-06-14 CN CN99807521A patent/CN1128800C/zh not_active Ceased
- 1999-06-14 TW TW088109926A patent/TW505646B/zh active
- 1999-06-14 AT AT99922454T patent/ATE265458T1/de not_active IP Right Cessation
- 1999-06-14 CZ CZ20004727A patent/CZ20004727A3/cs unknown
- 1999-06-14 TR TR2000/03719T patent/TR200003719T2/xx unknown
- 1999-06-14 KR KR10-2000-7014402A patent/KR100415791B1/ko not_active IP Right Cessation
- 1999-06-16 PA PA19998476001A patent/PA8476001A1/es unknown
- 1999-06-16 PE PE1999000531A patent/PE20000698A1/es not_active Application Discontinuation
- 1999-06-16 TN TNTNSN99126A patent/TNSN99126A1/fr unknown
- 1999-06-16 MA MA25630A patent/MA26654A1/fr unknown
- 1999-06-17 MY MYPI99002502A patent/MY125916A/en unknown
- 1999-06-17 AR ARP990102916A patent/AR016499A1/es active IP Right Grant
- 1999-06-17 AP APAP/P/1999/001584A patent/AP1021A/en active
- 1999-06-18 GT GT199900090A patent/GT199900090A/es unknown
- 1999-06-28 SA SA99200283A patent/SA99200283B1/ar unknown
-
2000
- 2000-11-08 NZ NZ518444A patent/NZ518444A/en not_active Application Discontinuation
- 2000-12-18 NO NO20006453A patent/NO318784B1/no not_active IP Right Cessation
- 2000-12-19 HR HR20000885A patent/HRP20000885B1/xx not_active IP Right Cessation
-
2001
- 2001-01-08 BG BG105129A patent/BG65119B1/bg unknown
- 2001-09-19 US US09/956,645 patent/US6610847B2/en not_active Expired - Lifetime
- 2001-11-06 HK HK01107744A patent/HK1036801A1/xx not_active IP Right Cessation
-
2003
- 2003-05-20 US US10/442,807 patent/US6890929B2/en not_active Expired - Lifetime
-
2005
- 2005-02-23 US US11/064,873 patent/US7687507B2/en not_active Expired - Fee Related
-
2007
- 2007-04-25 GE GEAP200710007A patent/GEP20074227B/en unknown
- 2007-08-06 JP JP2007204429A patent/JP4971068B2/ja not_active Expired - Lifetime
-
2011
- 2011-11-11 JP JP2011247593A patent/JP2012041365A/ja active Pending
-
2014
- 2014-03-07 FR FR14C0019C patent/FR14C0019I2/fr active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR9911365A (pt) | Compostos pirrolo[2,3-d]pirimidina | |
BR9912171A (pt) | Compostos de pirrolo[2,3-d]pirimidina | |
BR0016263A (pt) | Compostos pirrolo[2,3-d]pirimidina | |
YU83302A (sh) | Jedinjenja pirolo (2,3-d) pirimidina kao imunosupresivni agensi | |
BR0215308A (pt) | Pirrolopirimidinas | |
WO2000035906A3 (en) | 4- and 5-alkynyloxindoles and 4- and 5-alkenyloxindoles | |
CO5470282A1 (es) | Union soldada de tubos metalicos, anillo separador para la realizacion de dicha union soldada y uso de dicho anillo separador | |
ECSP992964A (es) | COMPUESTO DE PIRROLO (2,3 -d) PIRIMIDA | |
ECSP993019A (es) | COMPUESTOS DE PIRROLO [2,3-d] PIRIMIDINA | |
HN1999000092A (es) | Compuestos de pirrolo (2,3-d)pirimidina | |
NO20050202L (no) | Pyrrolo(2,3-d)pyrimidinforbindelser | |
UY26791A1 (es) | Compuestos de pirrol (2,3-d) pirimidina |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DE INT.CL: C07D 487/04, C07D 519/00, A61K 31/519, A61P 1/04, A61P 3/10, A61P 5/14, A61P 11/06, A61P 17/00, A61P 17/04, A61P 19/02, A61P 25/00, A61P 25/28, A61P 29/00, A61P 35/00, A61P 35/02, A61P 37/06 Ipc: C07D 487/04 (2009.01), C07D 519/00 (2009.01), A61K |
|
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |