BR9901095A - Pirazopirimidinas e pirazoltriazinas. - Google Patents

Pirazopirimidinas e pirazoltriazinas.

Info

Publication number
BR9901095A
BR9901095A BR9901095-0A BR9901095A BR9901095A BR 9901095 A BR9901095 A BR 9901095A BR 9901095 A BR9901095 A BR 9901095A BR 9901095 A BR9901095 A BR 9901095A
Authority
BR
Brazil
Prior art keywords
disorders
pyrazoltriazines
disease
depressions
pyrazopyrimidines
Prior art date
Application number
BR9901095-0A
Other languages
English (en)
Inventor
Michael Boes
Claus Riemer
Heinz Stadler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR9901095A publication Critical patent/BR9901095A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Patente de Invenção: <B>"PIRAZOLPIRIMIDINAS E PIRAZOLTRIAZINAS"<D>. A presente invenção refere-se a pirazolpirimidinas e pirazoltriazinas das fórmulas gerais e seus sais farmaceuticamente aceitáveis. Surpreendentemente, estes compostos têm uma afinidade seletiva com receptores de 5HT-6. Eles são por conseguinte adequados para o tratamento e prevenção de distúrbios do sistema nervoso central tais como psicoses, esquizofrenia, depressões maníacas, depressões, distúrbios neurológicos, distúrbios da memória, mal de Parkinson, esclerose lateral amiotrófica, mal de Alzheimer e coréia de Huntington.
BR9901095-0A 1998-03-11 1999-03-10 Pirazopirimidinas e pirazoltriazinas. BR9901095A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98104346 1998-03-11

Publications (1)

Publication Number Publication Date
BR9901095A true BR9901095A (pt) 2000-05-02

Family

ID=8231568

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9901095-0A BR9901095A (pt) 1998-03-11 1999-03-10 Pirazopirimidinas e pirazoltriazinas.

Country Status (34)

Country Link
US (1) US6194410B1 (pt)
EP (1) EP0941994B1 (pt)
JP (1) JP3231288B2 (pt)
KR (1) KR100313181B1 (pt)
CN (1) CN1118468C (pt)
AR (1) AR016453A1 (pt)
AT (1) ATE240332T1 (pt)
AU (1) AU752408B2 (pt)
BR (1) BR9901095A (pt)
CA (1) CA2265095C (pt)
CZ (1) CZ291514B6 (pt)
DE (1) DE69907784T2 (pt)
DK (1) DK0941994T3 (pt)
ES (1) ES2198095T3 (pt)
HK (1) HK1023343A1 (pt)
HR (1) HRP990077B1 (pt)
HU (1) HUP9900589A1 (pt)
ID (1) ID23575A (pt)
IL (1) IL128869A (pt)
MA (1) MA26612A1 (pt)
MY (1) MY119536A (pt)
NO (1) NO312297B1 (pt)
NZ (1) NZ334526A (pt)
PE (1) PE20000337A1 (pt)
PL (1) PL331875A1 (pt)
PT (1) PT941994E (pt)
RU (1) RU2218340C2 (pt)
SG (1) SG78336A1 (pt)
SI (1) SI0941994T1 (pt)
TR (1) TR199900531A3 (pt)
TW (1) TW585865B (pt)
UY (1) UY25419A1 (pt)
YU (1) YU12099A (pt)
ZA (1) ZA991946B (pt)

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WO2000059907A2 (en) 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolotriazines as crf antagonists
DE19956791A1 (de) * 1999-11-25 2001-05-31 Merck Patent Gmbh Neue Sulfonyloxazolamine
PE20020394A1 (es) 2000-08-18 2002-06-21 Agouron Pharma Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
EP1368094B1 (en) * 2001-03-13 2007-02-28 Bristol-Myers Squibb Pharma Company 4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl) pyrazolo- 1,5-a|-1,3,5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligands
CA2449874C (en) 2001-06-07 2009-06-23 F. Hoffmann-La Roche Ag New indole derivatives with 5-ht6 receptor affinity
EP1401812B1 (en) 2001-06-15 2006-06-28 F. Hoffmann-La Roche Ag 4-piperazinylindole derivatives with 5-ht6 receptor affinity
JP2005527463A (ja) * 2001-08-07 2005-09-15 スミスクライン　ビーチャム　パブリック　リミテッド　カンパニー Ｃｎｓ疾患を治療するための５−ｈｔ６受容体アフィニティーを有する３−アリールスルホニル−７−ピペラジニル−インドール、−ベンゾフランおよび−ベンゾチオフェン
UA78536C2 (en) * 2001-12-20 2007-04-10 Wyeth Corp Indolylalkylamine derivatives as ligands of 5-hydroxytryptamine-6, method of production (variants), pharmaceutical composition
US6642381B2 (en) * 2001-12-27 2003-11-04 Hoffman-La Roche Inc. Pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds as protein tyrosine phosphatase inhibitors
GB0202679D0 (en) * 2002-02-05 2002-03-20 Glaxo Group Ltd Novel compounds
UA78999C2 (en) * 2002-06-04 2007-05-10 Wyeth Corp 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6
US6875771B2 (en) 2002-07-26 2005-04-05 Bristol-Myers Squibb Company Pyridopyrimidine derivatives as 5-HT6 antagonists
US7329658B2 (en) * 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
TW200418830A (en) * 2003-02-14 2004-10-01 Wyeth Corp Heterocyclyl-3-sulfonylazaindole or-azaindazole derivatives as 5-hydroxytryptamine-6 ligands
MXPA05008955A (es) 2003-02-28 2006-02-22 Teijin Pharma Ltd Derivados de pirazolo [1,5-a] pirimidina.
GB0305559D0 (en) * 2003-03-11 2003-04-16 Teijin Ltd Compounds
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RU2369600C1 (ru) * 2008-01-24 2009-10-10 Андрей Александрович Иващенко ЗАМЕЩЕННЫЕ 4-СУЛЬФОНИЛ-ПИРАЗОЛЫ И 3-СУЛЬФОНИЛ-ПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ5-HT6 РЕЦЕПТОРОВ, АКТИВНЫЙ КОМПОНЕНТ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ЛЕКАРСТВЕННОЕ СРЕДСТВО И СПОСОБЫ ИХ ПОЛУЧЕНИЯ
JP5584627B2 (ja) * 2008-01-24 2014-09-03 アンドレイ・アレクサンドロビッチ・イワシェンコ 置換されたシクロアルキル［ｅ又はｄ］ピラゾロ［１，５−ａ］ピリミジン−セロトニン５−ＨＴ６受容体のアンタゴニスト、その調製の方法及び使用
EA017968B1 (ru) * 2008-01-24 2013-04-30 Андрей Александрович ИВАЩЕНКО ЗАМЕЩЕННЫЕ 2-АМИНО-3-СУЛЬФОНИЛПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ-АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-НТРЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
US8471009B2 (en) 2008-01-24 2013-06-25 Andrey Alexandrovich Ivashchenko (EN) 2-alkylamino-3-arylsulfonyl-cycloalcano [e OR d] pyrazolo [1,5-A]pyrimidines / antagonists of serotonin 5-HT6 receptors, methods for the production and the use thereof
RU2384581C2 (ru) 2008-05-07 2010-03-20 Андрей Александрович Иващенко ЗАМЕЩЕННЫЕ 2-АМИНО-3-СУЛЬФОНИЛ-ТЕТРАГИДРО-ПИРАЗОЛО[1,5-a]ПИРИДО-ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-HT6 РЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
JP2012504663A (ja) * 2008-10-06 2012-02-23 アンドレイ・アレクサンドロビッチ・イワシェンコ 置換された３−アリールスルホニル−ピラゾロ［１，５−ａ］ピリミジン、セロトニン５−ＨＴ６受容体アンタゴニスト、その調製のための方法及び使用
CA2743241A1 (en) 2008-11-27 2010-06-03 Boehringer Ingelheim International Gmbh 6,7,8,9-tetrahydro-5h-1,4,7,10a-tetraaza-cyclohept[f]indene derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
CA2817165A1 (en) 2010-11-15 2012-05-24 Patrick Chaltin Novel antiviral compounds
RU2443697C1 (ru) 2010-12-21 2012-02-27 Александр Васильевич Иващенко Замещенные метил-амины, антагонисты серотониновых 5-ht6 рецепторов, способы получения и применения
BR112014007654A8 (pt) 2011-09-30 2018-06-12 Ipsen Pharma Inibidores de lrrk2 quinase macrocíclicos.
IN2014DN07384A (pt) 2012-03-09 2015-04-24 Lexicon Pharmaceuticals Inc
TW201542550A (zh) * 2013-09-06 2015-11-16 Lexicon Pharmaceuticals Inc 吡唑并［１，５－ａ］嘧啶基化合物、包含彼之組合物以及使用彼之方法
TW201620911A (zh) * 2014-03-17 2016-06-16 雷西肯製藥股份有限公司 銜接子關聯激酶１之抑制劑、包含其之組成物、及其使用方法
AU2015316801B2 (en) 2014-09-17 2019-03-07 Oncodesign S.A. Macrocyclic LRRK2 kinase inhibitors
JP6789962B2 (ja) * 2015-03-09 2020-11-25 オーリジーン ディスカバリー テクノロジーズ リミテッドＡｕｒｉｇｅｎｅ Ｄｉｓｃｏｖｅｒｙ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｉｍｉｔｅｄ ＣＤＫ阻害剤としてのピラゾロ［１，５−ａ］［１，３，５］トリアジンとピラゾロ［１，５−ａ］ピリミジン誘導体
WO2017052394A1 (en) * 2015-09-23 2017-03-30 Uniwersytet Jagielloński Imidazopyridine compounds and their use as 5-ht6 receptor ligands
AU2016348549B2 (en) 2015-11-02 2020-07-23 Janssen Pharmaceutica Nv [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compound
MY193511A (en) 2016-11-02 2022-10-17 Janssen Pharmaceutica Nv [1,2,4]triazolo[1,5-a]pyrimidine derivatives as pde2 inhibitors
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Also Published As

Publication number Publication date
CN1236780A (zh) 1999-12-01
EP0941994A1 (en) 1999-09-15
TW585865B (en) 2004-05-01
TR199900531A2 (xx) 1999-10-21
HU9900589D0 (en) 1999-05-28
JP3231288B2 (ja) 2001-11-19
JP2000186090A (ja) 2000-07-04
EP0941994B1 (en) 2003-05-14
UY25419A1 (es) 2001-11-30
TR199900531A3 (tr) 1999-10-21
HUP9900589A1 (hu) 2000-03-28
CN1118468C (zh) 2003-08-20
CA2265095C (en) 2008-07-22
PE20000337A1 (es) 2000-05-13
ID23575A (id) 2000-05-04
AU2038399A (en) 1999-09-23
YU12099A (sh) 2000-10-30
ATE240332T1 (de) 2003-05-15
DE69907784D1 (de) 2003-06-18
CA2265095A1 (en) 1999-09-11
NO312297B1 (no) 2002-04-22
ZA991946B (en) 1999-09-13
HRP990077B1 (en) 2003-08-31
CZ82599A3 (cs) 1999-09-15
DK0941994T3 (da) 2003-09-08
NO991150L (no) 1999-09-13
NZ334526A (en) 2000-07-28
NO991150D0 (no) 1999-03-10
US6194410B1 (en) 2001-02-27
HK1023343A1 (en) 2000-09-08
IL128869A0 (en) 2000-01-31
SI0941994T1 (en) 2003-10-31
CZ291514B6 (cs) 2003-03-12
MA26612A1 (fr) 2004-12-20
KR100313181B1 (ko) 2001-11-05
DE69907784T2 (de) 2004-03-25
AR016453A1 (es) 2001-07-04
ES2198095T3 (es) 2004-01-16
KR19990077741A (ko) 1999-10-25
SG78336A1 (en) 2001-02-20
MY119536A (en) 2005-06-30
HRP990077A2 (en) 2000-02-29
AU752408B2 (en) 2002-09-19
PT941994E (pt) 2003-09-30
IL128869A (en) 2003-09-17
PL331875A1 (en) 1999-09-13
RU2218340C2 (ru) 2003-12-10

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Legal Events

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B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements