CA2274055A1

CA2274055A1 - N-piperazin-1-ylphenyl-benzamide derivatives

Info

Publication number: CA2274055A1
Application number: CA002274055A
Authority: CA
Inventors: Steven Mark Bromidge; Francis David King; Paul Adrian Wyman
Original assignee: Individual
Current assignee: SmithKline Beecham Ltd
Priority date: 1996-12-19
Filing date: 1997-12-15
Publication date: 1998-06-25
Also published as: WO1998027058A3; WO1998027058A2; EP0946551A2; JP2001506995A

Abstract

Novel carboxamide derivatives having CNS activity, processes for their preparation and their use as medicaments.

Description

NOVEL COMPOUNDS
This invention relates to compounds having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the S treatment of CNS disorders.
EPA 0 021 580 and EPA 0 076 072 describe sulphonamide derivatives which are disclosed as having antiarrhythmic activity. A structurally distinct class of compounds has now been discovered, which have been found to have SHT6 receptor antagonist activity. SHT6 receptor antagonists are believed to be of potential use in the treatment of certain CNS disorders such as anxiety, depression, epilepsy, obsessive compulsive disorders, migraine, Alzheimers disease (enhancement of cognitive memory), sleep disorders, feeding disorders such as anorexia and bulimia, panic attacks, withdrawal from drug abuse such as ***e, ethanol, nicotine and benzodiazepines, schizophrenia) and also disorders associated with spinal trauma and/or head injury such as hydrocephalus. Compounds of the invention are also expected to be of use in the treatment of certain GI (gastrointestinal) disorders such as IBS (Irritable Bowel Syndrome).
The present invention therefore provides, in a first aspect, a compound of formula (I) or a salt thereof:
O RZ _ R4 C
~R~~ ~n Rs Re (I) wherein:
P is phenyl, naphthyl, a bicyclic heterocyclic ring or is a 5 to 7-membered heterocyclic ring each containing 1 to 4 heteroatoms selected from oxygen, nitrogen or sulphur;
A is a single bond, a C 1 _6alkylene or a C 1 _6alkenylene group;
R 1 is halogen, C 1 _6alkyl optionally substituted by one or more halogen atoms, C3_6cycloalkyl, COC 1 _6alkyl, C 1 _6alkoxy, OCF3, hydroxy, hydroxyC 1 _6alkyl, hydroxyC 1 _6alkoxy, C 1 _6alkoxyC 1 _6alkoxy, C 1 _6alkanoyl, nitro, amino, C
1 _ 6alkylamino or diC 1 _6alkylamino, cyano or R 1 is phenyl, naphthyl, a bicyclic heterocyclic ring or is a S to 7-membered heterocyclic ring each containing 1 to 4 heteroatoms selected from oxygen, nitrogen or sulphur;

n is 0, 1, 2, 3, 4, 5 or b:
R2 is C 1 _6 alkyl or aryl C 1 _6 alkyl;
R3 is a group RS or together with RS forms a group (CH2)20 or (CH2)30 or R3 is linked to R2 to form a group (CH2)2 or (CH2)3;
S R4 is -X(CH2)p-R6 where X is a single bond, CH2, O, NH or N-C 1 _6alkyl and p is 0 to 6 and R6 is an optionally substituted S- to 7-membered heterocyclic ring containing 1 to 3 heteroatoms selected from nitrogen, sulphur or oxygen, or R6 is NR~R8 where R~ and R8 are independently hydrogen, C 1 _6 alkyl or aryl C 1 _6 alkyl; and RS is hydrogen, halogen, C 1 _6alkyl, C3_6cycloalkyl, COC 1 _6alkyl, C 1 _6alkoxy, hydroxy, hydroxyC 1 _6alkyl, hydroxyC 1 _6alkoxy, C 1 _6alkoxyC 1 _6alkoxy, C
1 _ 6alkanoyl, nitro, trifluoromethyl, cyano or aryl.
C 1-6 Alkyl groups, whether alone or as part of another group, may be straight chain or branched. As used herein the term aryl includes phenyl and naphthyl.
When P is a bicyclic heterocyclic ring suitable examples include I S benzothiophene, quinoline or isoquinoline. Suitable S to 7-membered heterocyclic rings include thienyl, furyl, pyrrolyl, triazolyl, diazolyl, imidazolyl, oxazolyl, thiazolyl, oxadiazolyl, isothiazolyl, isoxazolyl, thiadiazolyl, pyridyl, pyrimidyl, pyrrolidinyl and pyrazinyl. The heterocyclic rings can be linked to the remainder of the molecule via any suitable carbon atom or, when present, a nitrogen atom.
Suitable substituents for these rings include RS groups as defined above.
Preferably P is phenyl, thiophene, benzothiophene or naphthyl.
Preferably A is a single bond, an ethyl or -CH=CH- group. Most preferably A
is a single bond.
When RI is a S-7 membered heterocyclic or bicyclic hetcrocyclic ring suitable 2S examples include those given within the description of group P. Preferably RI is halogen or C 1 _4 alkyl optionally substituted by one or more halogens, for example methyl or CF3.
Preferably n is 0, 1, 2 or 3, particularly 1 or 2.
Preferably R2 is C 1 _6 alkyl, in particular methyl or ethyl.
Suitably R3 is a group RS or together with RS forms a group (CH2)20 or (CH2)30 or R3 is linked to R2 to form a group (CH2)2 or (CH2)3. It will be appreciated that when R3/RS groups are linked together the two groups must be attached to adjacent carbon atoms of the phenyl ring. Preferably R3 is a group RS in particular hydrogen.
3S Preferably R4 is meta with respect to the carboxamide linkage. Preferably X
is a bond, p is 0 and R6 is an optionally substituted S- to 7-membered heterocyclic ring. The heterocyclic rings can be linked to the remainder of the molecule via a carbon atom or, when present, a nitrogen atom. Optional substituents for these rings, which can be present on carbon and/or nitrogen atoms, include C1-6alkyl, in particular methyl. More preferably R4 is an optionally substituted piperazine. Most preferably R4 is N-methylpiperazine or piperazine.
Preferably RS is C1-6alkoxy, most preferably methoxy. Preferably RS is para with respect to the amide group.
Particular compounds of the invention include:
N-[4-Methoxy-3-(4-methylpiperazin-1-yl)phenyl]-N-methyl-4-phenylbenzamide, 4-Bromo-N-ethyl-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3-methylbenzamide, 4-Bromo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3-methyl-N-propylbenzamide, 4-Bromo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3,N-d imethylbenzamide, Naphthalene-2-carboxylic acid N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)-N
methyl amide, 3-Chlorobenzo[b]thiophene-2-carboxylic acid-N-[4-methoxy-3-(4-methylpiperazin-yl)phenyl]-N-methyl amide, 3-Bromo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-N-methylbenzamide, 3,4-Dichloro-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)-N-methylbenzamide, 3-Bromothiophene-2-carboxylic acid-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-N-methyl amide, 4-tert Butyl-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)-N-methylbenzamide, 4-Bromo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-N-methylbenzamide, 3,4-Dichloro-N-(4-methoxy-3-piperazin-1-ylphenyl)-N-methylbenzamide, 3-Chlorobenzo[b]thiophene-2-carboxylic acid N-(4-methoxy-3-piperazin-1-ylphenyl)-N-methyl amide and pharmaceutically acceptable salts thereof.
The compounds of the formula (I) can form acid addition salts with acids, such as conventional pharmaceutically acceptable acids, for example malefic, hydrochloric, hydrobromic, phosphoric, acetic, fumaric, salicylic, citric, lactic, mandelic, tartaric and methanesulphonic.
Compounds of formula (I) may also form solvates such as hydrates, and the invention also extends to these forms. When referred to herein, it is understood that the term 'compound of formula (I)' also includes these forms.
Certain compounds of formula (I) are capable of existing in stereoisomeric forms including diastereomers and enantiomers and the invention extends to each of these stereoisomeric forms and to mixtures thereof including racemates. The different stereoisomeric forms may be separated one from the other by the usual methods, or any given isomer may be obtained by stereospecific or asymmetric synthesis.
The invention also extends to any tautomeric forms and mixtures thereof.
The present invention also provides a process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof, which process comprises the coupling of a compound of formula (II):
~A-COL
~R~ ~ ~n (II) in which R1, n, P, and A are as defined in formula (I) or protected derivatives thereof and L is a leaving group with a compound of formula (III):
R2 Ra I -N
H
R3 Rs (nI) in which R2, R3, R4 and RS are as defined in formula (I) or protected derivatives thereof and optionally thereafter:
~ removing any protecting groups, ~ forming a pharmaceutically acceptable salt.
Suitable leaving groups include halogen, in particular chloro. The reaction of a compounds of formulae (II) and (III) is carried out by mixing the two reagents together, optionally in an inert solvent such as dichloromethane.
Those skilled in the art will appreciate that it may be necesary to protect certain groups. Suitable protecting groups and methods for their attachment and removal are conventional in the art of organic chemistry, such as those described in Greene T. W. 'Protective groups in organic synthesis' New York, Wiley ( 1981 ).
Compounds of formulae (II) and (III) are commercially available or may be prepared according to known methods or analogous to known methods.
Pharmaceutically acceptable salts may be prepared conventionally by reaction with the appropriate acid or acid derivative.
Compounds of formula (I) and their pharmaceutically acceptable salts have SHT6 receptor antagonists are believed to be of potential use in the treatment of certain CNS disorders such as anxiety, depression, epilepsy, obsessive compulsive disorders, migraine, Alzheimers disease and enhancement of cognitive memory, sleep disorders (including disturbances of Circadian Rhythym), feeding disorders such as anorexia and bulimia, panic attacks, withdrawal from drug abuse such as ***e, ethanol, nicotine and benzodiazepines, schizophrenia, and also disorders associated with spinal trauma and/or head injury such as hydrocephalus. Compounds of the invention are also expected to be of use in the treatment of certain GI
disorders such as IBS
Thus the invention also provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, for use as a therapeutic substance, in particular in the treatment or prophylaxis of the above disorders.
The invention further provides a method of treatment or prophylaxis of the above disorders, in mammals including humans, which comprises administering to the sufferer a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof.
In another aspect, the invention provides the use of a compound of formula (I} or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for the treatment or prophylaxis of the above disorders.
The present invention also provides a pharmaceutical composition, which comprises a compound of formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
A pharmaceutical composition of the invention, which may be prepared by admixture, suitably at ambient temperature and atmospheric pressure, is usually adapted for oral, parenteral or rectal administration and, as such, may be in the form of tablets, capsules, oral liquid preparations, powders, granules, lozenges, reconstitutable powders, injectable or infusable solutions or suspensions or suppositories. Orally administrable compositions are generally preferred.
Tablets and capsules for oral administration may be in unit dose form, and may contain conventional excipients, such as binding agents, fillers, tabletting lubricants, disintegrants and acceptable wetting agents. The tablets may be coated according to methods well known in normal pharmaceutical practice.
Oral liquid preparations may be in the form of, for example, aqueous or oily suspension, solutions, emulsions, syrups or elixirs, or may be in the form of a dry product for reconstitution with water or other suitable vehicle before use.
Such liquid preparations may contain conventional additives such as suspending agents, emulsifying agents, non-aqueous vehicles (which may include edible oils), preservatives, and, if desired, conventional flavourings or colourants.
For parenteral administration, fluid unit dosage forms are prepared utilising a compound of the invention or pharmaceutically acceptable salt thereof and a sterile vehicle. The compound, depending on the vehicle and concentration used, can be either suspended or dissolved in the vehicle. In preparing solutions, the compound can be dissolved for injection and filter sterilised before filling into a suitable vial or ampoule and sealing. Advantageously, adjuvants such as a local anaesthetic, preservatives and buffering agents are dissolved in the vehicle. To enhance the stability, the composition can be frozen after filling into the vial and the water removed under vacuum. Parenteral suspensions are prepared in substantially the same manner, except that the compound is suspended in the vehicle instead of being dissolved, and sterilization cannot be accomplished by filtration. The compound can be sterilised by exposure to ethylene oxide before suspension in a sterile vehicle.
Advantageously, a surfactant or wetting agent is included in the composition to facilitate uniform distribution of the compound.
The composition may contain from 0.1 % to 99% by weight, preferably from 10 to 60% by weight, of the active material, depending on the method of administration.
The dose of the compound used in the treatment of the aforementioned disorders will vary in the usual way with the seriousness of the disorders, the weight of the sufferer, and other similar factors. However, as a general guide suitable unit doses may be 0.05 to 1000 mg, more suitably 0.05 to 20.0 mg, for example 0.2 to 5 mg; and such unit doses may be administered more than once a day, for example two or three a day, so that the total daily dosage is in the range of about 0.5 to 100 mg; and such therapy may extend for a number of weeks or months.
When administered in accordance with the invention, no unacceptable toxicological effects are expected with the compounds of the invention.
The following Examples illustrate the preparation of compounds of the invention.
Example 1 N-[4-Methoxy-3-(4-methylpiperazin-1-yl)phenyl]-N-methyl-4-phenylbenzamide A solution of biphenyl-4-carboxylic acid chloride in acetone (2ml) was added to a solution of N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-N-methylamine (1 equivalent) in acetone and the mixture stood overnight at room temperature.
The resultant crystalline solid was filtered off and washed with acetone, then diethyl ether, to afford the title compound as the hydrochloride salt. MS: m/z = 416 (MH+).
The following compounds were prepared in a similar manner from an N-alkyl-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]amine and the appropriate carboxylic acid chloride:

MS (MH+) 4-Bromo-N-ethyl-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3-446/448 methylbenzamide (E2) 4-Bromo-N-(4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3-methyl-460/462 N-propylbenzamide (E3) 4-Bromo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3,N-432/434 dimethylbenzamide (E4) Naphthalene-2-carboxylic acid N-[4-methoxy-3-(4-methylpiperazin-1-390 yl)phenyl]-N-methyl amide (ES) 3-Chlorobenzo[b]thiophene-2-carboxylic acid N-[4-methoxy-3-(4-430/432 methylpiperazin-1-yl)phenyl]-N-methyl amide (E6) 3-Bromo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-N-418/420 methylbenzamide (E7) 3,4-Dichloro-N-[4-methoxy-3-{4-methylpiperazin-1-yl)phenyl]-N-408/410 methylbenzamide (E8) 3-Bromothiophene-2-carboxylic acid N-[4-methoxy-3-(4-424/426 methylpiperazin-1-yl)phenyl]-N-methyl amide (E9) 4-tert Butyl-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-N-396 methylbenzamide (E10) 4-Bromo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-N-418/420 methylbenzamide (E11) Example 12 3,4-Dichloro-N-(4-methoxy-3-piperazin-1-ylphenyl)-N-methylbenzamide (E12) S A solution of 1-chloroethylchloroformate (1.12mmol), 3,4-dichloro-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-N-methylbenzamide (E8) (0.22mmol) and diisopropylethylamine (1.14mmo1) in 1,2-dichloroethane (2m1) was refluxed for 12h.
The solution was concentrated to a residue which was re-dissolved in methanol and refluxed for 6h. The mixture was concentrated, and the residue partitioned between dichloromethane and aqueous sodium bicarbonate solution. The organic layer was dried, concentrated to a residue and purified by column chromatography on silica gel using a methanol/dichloromethane solvent gradient. The hydrochloride salt of the title compound (E12) was prepared by dissolving the pure material from chromatography in acetone/dichloromethane and acidifying with ethereal HC1.
MH+ 393/395/397.
Example 13 3-Chlorobenzo[b[thiophene-2-carboxylic acid N-(4-methoxy-3-piperazin-1-ylphenyl)-N-methyl amide (E13) The title compound was prepared from 3-chlorobenzo[b]thiophene-2-carboxylic acid [4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]methyl amide (E6) according to the method described for Example 12. MH+ 415/417.
Method for assay of 5-HT6 antagonistic activity:
The test compounds were dissolved in polyethylene glycol:dimethyl sulphoxide ( 1:1 ) at 1 or IOmM and diluted to O.lmM using SmM tris buffer (pH 7.7 @
25°C).
Dissolution was assisted by addition of 0.02m1 SM HCl plus heating to 40°C and sonication for 10 minutes. Serial dilutions of drugs in the same buffer were carried out using either a TECAN 5052 or Biomek 2000 Workstation. Samples of the diluted test compounds (O.OSmI) were mixed with O.OSml of radio-ligand [3H]-LSD
prepared in the incubation buffer, and 0.4m1 of a suspension of a preparation of the washed membranes of HeLa_SHT6 cells {acquired from Dr. D. Sibley, NIH, Bethesda, see Ref 1 )(see Table 1 ), also in the incubation buffer. The details of the incubation conditions for each assay are shown in Table 2. The incubation buffer was SOmM
Trizma (Sigma, UK) pH7.7 @ 25°C, 4mM MgCl2.
After incubation at 37°C, the mixtures were filtered using a Packard Fiitermate in Packard TopCount format. Filters were washed with 4 x Iml aliquots of ice-cold incubation buffer. Filters were dried and impregnated with 0.04m1 of Microscint 20 (Packard). IC50 values were estimated from the counts per minute using a four parameter logistic curve fit within EXCEL (2). Ki values were calculated using the method of Cheng and Prusoff (3). pICSp and pKi are the negative 1og10 of the molar ICSO and Ki respectively.
Table 1 Details of the methods used to prepare membranes for binding assays 1st spin / resuspensionIncubation protein conc.cells /ml 1, 2 ,3 in in stored resuspension before finalstored aliquotsaliquots cells/ml spin 7 x 10 Yes 20min at 4mg/ml ~ 1.0 x 37C 10~

Table 2 Summary of receptor binding assay conditions proteinradio-ligand Specific Non-SpecificKd (nM) [vH]-LSD Activity (ug/ (nM) (Ci/mmol) Definition sample) 40 2.0 83 Methiothepin3.1 References 1. MONSMA, F.J., SHEN, Y., WARD, R.P., HAMBLIN, M.W., SIBLEY, D.R..
1993. Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol. Pharmacol., 43, 320-327.

2. BOWEN, W.P., JERMAN, J.C.. 1995. Nonlinear regression using spreadsheets.
Trends in Pharmacol. Sci., 16, 413-417.
3. CHENG, Y.C., PRUSSOF, W.H.. 1973. Relationship between inhibition constant (Ki) and the concentration of inhibitor which causes 50% inhibition (IC50) of an enzymatic reaction. Biochem. Pharmacol., 92, 881-894.
The compounds of Examples all showed good selective 5-HT6 receptor antagonist activity, having pKi values above 7.0 at human cloned 5-HT6 receptors.

Claims

Claims:

1. A compound of formula (I) or a salt thereof:

wherein:
P is phenyl, naphthyl, a bicyclic heterocycle selected from the group consisting of benzothiophene, quinoline or isoquinoline or P is a 5 to 7-membered heterocyclic ring each containing 1 to 4 heteroatoms selected from oxygen, nitrogen or sulphur;
A is a single bond, a C1-6alkylene or a C1-6alkenylene group;
R1 is halogen, C1-6alkyl optionally substituted by one or more halogen atoms, C3-6cycloalkyl, C1-6alkoxy, OCF3, hydroxy, hydroxyC1-6alkyl, hydroxyC1-6alkoxy, C1-6alkoxyC1-6alkoxy, C1-6alkanoyl, nitro, amino, C1-6alkylamino or di C1-6alkylamino, cyano or R1 is phenyl, naphthyl, a bicyclic heterocycle selected from the group consisting of benzothiophene, quinoline or isoquinoline or P is a 5 to 7-membered heterocyclic ring each containing 1 to 4 heteroatoms selected from oxygen, nitrogen or sulphur;
n is 0, 1, 2, 3, 4, 5 or 6:
R2 is C1-6 alkyl or aryl C1-6alkyl;
R3 is a group R5 or together with R5 forms a group (CH2)2O or (CH2)3O or R3 is linked to R2 to form a group (CH2)2 or (CH2)3;
R4 is -X(CH2)p-R6 where X is a single bond, CH2, O, NH or N-C1-6alkyl and p is to 6 and R6 is an optionally substituted 5- to 7-membered heterocyclic ring containing 1 to 3 heteroatoms selected from nitrogen, sulphur or oxygen, or R6 is NR7R8 where R7 and R8 are independently hydrogen, C1-6 alkyl or aryl C1-6 alkyl; and R5 is hydrogen, halogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkoxy, hydroxy, hydroxyC1-6alkyl, hydroxyC1-6alkoxy, C1-6alkoxyC1-6alkoxy, C1-6alkanoyl, nitro, trifluoromethyl, cyano or aryl;
subject to the proviso that when P is naphthyl and A is a single bond then R1 is not a 5-7 membered heterocyclic ring.

2. A compound according to claim 1 in which P is phenyl.

3 A compound according to any one of claims 1 to 2 in which R2 is C1-6alkyl.

4 A compound according to any one of claims 1 to 3 in which R4 is an optionally substituted piperazine ring.

5. A compound according to any one of claims 1 to 4 in which R5 is C1-6alkoxy.

6. A compound according to any one of claims 1 to 5 in which n is 1 or 2.

7. A compound according to claim 1 which is:
N-[4-Methoxy-3-(4-methylpiperazin-1-yl)phenyl]-N-methyl-4-phenylbenzamide, 4-Bromo-N-ethyl-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3-methylbenzamide, 4-Bromo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3-methyl-N-propylbenzamide, 4-Bromo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3,N-dimethylbenzamide, Naphthalene-2-carboxylic acid N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-N-methyl amide, 3-Chlorobenzo[b]thiophene-2-carboxylic acid-N-[4-methoxy-3-(4-methylpiperazin-yl)phenyl]-N-methyl amide, 3-Bromo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-N-methylbenzamide, 3,4-Dichloro-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-N-methylbenzamide, 3-Bromothiophene-2-carboxylic acid-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-N-methyl amide, 4-tert Butyl-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-N-methylbenzamide, 4-Bromo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-N-methylbenzamide, 3,4-Dichloro-N-(4-methoxy-3-piperazin-1-ylphenyl)-N-methylbenzamide, or 3-Chlorobenzo[b]thiophene-2-carboxylic acid N-(4-methoxy-3-piperazin-1-ylphenyl)-N-methyl amide, and pharmaceutically acceptable salts thereof.

8. A compound according to any one of claims 1 to 7 for use in therapy.

9. A compound according to any one of claims 1 to 7 for use in therapy, in which the beneficial activity is effected by antagonism of 5-HT6 receptors.

10. A compound according to any one of claims 1 to 7 for use in the treatment of schizophrenia, Alzheimer's disease and/or depression.

11. A pharmaceutical composition which comprises a compound according to any one of claims 1 to 7 and a pharmaceutically acceptable carrier or excipient.

12. A process for the preparation of a compound of formula (I) or a salt thereof wherein:
P is phenyl, naphthyl, a bicyclic heterocyclic ring or is a 5 to 7-membered heterocyclic ring each containing 1 to 4 heteroatoms selected from oxygen, nitrogen or sulphur;
A is a single bond, a C1-6alkylene or a C1-alkenylene group;
R1 is halogen, C1-6alkyl optionally substituted by one or more halogen atoms, C3-6cycloalkyl, COC1-6lkyl, C1-6-koxy, OCF3, hydroxy, hydroxyC1-6alkyl, hydroxyC1-6alkoxy, C1-6alkoxyC1-6alkoxy, C1-6alkanoyl, nitro, amino, alkylamino or dialkylamino, cyano or R1 is phenyl, naphthyl, a bicyclic heterocyclic ring or is a 5 to 7-membered heterocyclic ring each containing 1 to 4 heteroatoms selected from oxygen, nitrogen or sulphur;
n is 0, 1, 2, 3, 4, 5 or 6:
R2 is hydrogen, C1-6 alkyl or aryl C1-6 alkyl;
R3 is a group R6 or together with R5 forms a group (CH2)2O or (CH2)3O or R3 is linked to R2 to form a group (CH2)2 or (CH2)3;
R4 is -X(CH2)p-R6 where X is a single bond, CH2, O, NH or N-C1-6alkyl and p is to 6 and R6 is an optionally substituted 5- to 7-membered heterocyclic ring containing 1 to 3 heteroatoms selected from nitrogen, sulphur or oxygen, or R6 is NR7R8 where R7 and R8 are independently hydrogen, C1-6alkyl or aryl C1-6 alkyl; and R5 is hydrogen, halogen, C1-6alkyl, C3-6-cloalkyl, COC1-6alkyl, C1-6lkoxy, hydroxy, hydroxyC1-6alkyl, hydroxyC1-6alkoxy, C1-6alkoxyC1-6alkoxy, C1-6alkanoyl, nitro, trifluoromethyl, cyano or aryl;
which process comprises the coupling of a compound of formula (II):

in which R1, n, P, and A are as defined in formula (I) or protected derivatives thereof and L is a leaving group with a compound of formula (III):

in which R2, R3, R4 and R5 are as defined in formula (I) or protected derivatives thereof and optionally thereafter:
~ removing any protecting groups, ~ forming a pharmaceutically acceptable salt.