AR029428A1 - DERIVADOS DE FENIL--PIPERIDINA, TETRAHIDROPIRIDINA,-PIPERAZINA,-AZEPAN,-TETRAHIDRO-1H-AZEPINA Y DIAZEPAN SUSTITUIDOS, UNA COMPOSICIoN FARMACEUTICA Y EL USO DE LOS MISMOS PARA LA MANUFACTURA DE UNA PREPARACION FARMACEUTICA - Google Patents

DERIVADOS DE FENIL--PIPERIDINA, TETRAHIDROPIRIDINA,-PIPERAZINA,-AZEPAN,-TETRAHIDRO-1H-AZEPINA Y DIAZEPAN SUSTITUIDOS, UNA COMPOSICIoN FARMACEUTICA Y EL USO DE LOS MISMOS PARA LA MANUFACTURA DE UNA PREPARACION FARMACEUTICA

Info

Publication number
AR029428A1
AR029428A1 ARP000106987A ARP000106987A AR029428A1 AR 029428 A1 AR029428 A1 AR 029428A1 AR P000106987 A ARP000106987 A AR P000106987A AR P000106987 A ARP000106987 A AR P000106987A AR 029428 A1 AR029428 A1 AR 029428A1
Authority
AR
Argentina
Prior art keywords
manufacture
tetrahidropiridina
azepina
piperazina
tetrahidro
Prior art date
Application number
ARP000106987A
Other languages
English (en)
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of AR029428A1 publication Critical patent/AR029428A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Suministra compuestos de la formula 1 en la cual R1 ûR8, X, Y, Z, n y m se definieron en la memoria descriptiva, composiciones farmacéuticas y el uso de los mismos para la fabricacion de preparaciones farmacéuticas para el tratamiento de enfermedades afectivas o neurologicas en humanos causados por trastornos en los humanos, provocados por anormalidades en el sistema de serotonina del sistema nervioso central. Los compuestos de la invencion tienen afinidad por el receptor 5-HT1a.
ARP000106987A 1999-12-30 2000-12-28 DERIVADOS DE FENIL--PIPERIDINA, TETRAHIDROPIRIDINA,-PIPERAZINA,-AZEPAN,-TETRAHIDRO-1H-AZEPINA Y DIAZEPAN SUSTITUIDOS, UNA COMPOSICIoN FARMACEUTICA Y EL USO DE LOS MISMOS PARA LA MANUFACTURA DE UNA PREPARACION FARMACEUTICA AR029428A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA199901885 1999-12-30

Publications (1)

Publication Number Publication Date
AR029428A1 true AR029428A1 (es) 2003-06-25

Family

ID=8108803

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000106987A AR029428A1 (es) 1999-12-30 2000-12-28 DERIVADOS DE FENIL--PIPERIDINA, TETRAHIDROPIRIDINA,-PIPERAZINA,-AZEPAN,-TETRAHIDRO-1H-AZEPINA Y DIAZEPAN SUSTITUIDOS, UNA COMPOSICIoN FARMACEUTICA Y EL USO DE LOS MISMOS PARA LA MANUFACTURA DE UNA PREPARACION FARMACEUTICA

Country Status (28)

Country Link
US (1) US6699864B2 (es)
EP (1) EP1246816B1 (es)
JP (1) JP2003519224A (es)
KR (1) KR100790916B1 (es)
CN (1) CN1230432C (es)
AR (1) AR029428A1 (es)
AT (1) ATE261959T1 (es)
AU (1) AU2152101A (es)
BG (1) BG65262B1 (es)
BR (1) BR0016952A (es)
CA (1) CA2395705C (es)
CZ (1) CZ20022319A3 (es)
DE (1) DE60009155T2 (es)
EA (1) EA006071B1 (es)
ES (1) ES2213634T3 (es)
HU (1) HUP0203722A3 (es)
IL (2) IL150241A0 (es)
IS (1) IS2174B (es)
MX (1) MXPA02006223A (es)
NO (1) NO322666B1 (es)
NZ (1) NZ519647A (es)
PL (1) PL199351B1 (es)
PT (1) PT1246816E (es)
SK (1) SK9442002A3 (es)
TR (2) TR200201683T2 (es)
UA (1) UA72948C2 (es)
WO (1) WO2001049678A1 (es)
ZA (1) ZA200204814B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA81749C2 (uk) * 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
DE10259244A1 (de) * 2002-12-17 2004-07-01 Merck Patent Gmbh N-(Indolethyl-)cycloamin-Verbindungen
UA81300C2 (en) * 2003-04-04 2007-12-25 Lundbeck & Co As H Derivates of 4-(2-fenilsulfanilfenil)-1,2,3,6-tetrahydropiridin as retarding agents of serotonin recapture
EP1626720B1 (en) 2003-04-04 2008-09-03 H. Lundbeck A/S 4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors
BRPI0417858B1 (pt) 2003-12-23 2017-10-10 H. Lundbeck A/S Derivative compounds of aniline and pharmaceutical composition that understand it
SE0400441D0 (sv) 2004-02-25 2004-02-25 Active Biotech Ab Novel Benzofurans and Indols
AR052308A1 (es) 2004-07-16 2007-03-14 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto
AR054393A1 (es) 2005-06-17 2007-06-20 Lundbeck & Co As H Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos.
US7629473B2 (en) 2005-06-17 2009-12-08 H. Lundbeck A/S 2-(1H-indolylsulfanyl)-aryl amine derivatives
BR122020011920A2 (pt) 2006-06-16 2020-08-25 Lundbeck & Co As H composto, composição farmacêutica, método para tratar uma doença, uso de um composto, e processos para a preparação de um composto, e para a fabricação de um composto
EP2209380A4 (en) * 2007-10-09 2011-09-14 Mark T Hamann METHOD OF USE OF COMPOSITIONS WITH ANTIDEPRESSIVE EFFICACY, MOOD EFFICACY AND OTHER NEUROLOGICAL EFFECTIVENESS AND COMPOSITIONS THEREOF
AU2009225025A1 (en) * 2008-03-14 2009-09-17 Merck Patent Gmbh Azaindole compounds for treatment of central nervous system disorders
PL2981520T3 (pl) 2013-04-04 2019-09-30 Lek Pharmaceuticals D.D. Nowy sposób syntezy 1-(2-((2,4-dimetylofenylo)tio)fenylo)piperazyny
CN105085482B (zh) * 2014-05-04 2018-08-10 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
CN105085491B (zh) * 2014-05-05 2019-06-25 广东东阳光药业有限公司 取代的吲哚化合物及其使用方法和用途
CN106243088B (zh) 2015-06-03 2019-01-04 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
CN106795160B (zh) * 2015-07-23 2019-04-19 广东东阳光药业有限公司 取代的吲哚化合物及其使用方法和用途
WO2019062662A1 (en) * 2017-09-29 2019-04-04 Sunshine Lake Pharma Co., Ltd. SUBSTITUTED PYRIMIDINE PIPERAZINE COMPOUND AND USE THEREOF
CN111518012A (zh) * 2020-05-27 2020-08-11 中国药科大学 含苯硫醚结构的化合物或其药学上可接受的盐、制备方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2138865A1 (de) * 1970-08-15 1973-02-22 Sumitomo Chemical Co 3-indolylpiperazine, verfahren zu ihrer herstellung und arzneimittel
GB8830312D0 (en) * 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
WO1994024105A1 (en) * 1993-04-15 1994-10-27 Merck Sharp & Dohme Limited Indole derivatives as dopamine d4 antagonists
FR2712591B1 (fr) * 1993-11-19 1996-02-09 Pf Medicament Nouvelles arylpipérazines dérivées d'indole, leur préparation et leur utilisation thérapeutique.
WO1997019039A1 (en) 1995-11-17 1997-05-29 Novartis Ag Solid phase synthesis of heterocyclic compounds and combinatorial compound library
USH2007H1 (en) * 1996-01-19 2001-12-04 Fmc Corporation Insecticidal N-heterocyclylalkyl-or N-[(polycyclyl)alkyl]-N′substituted piperazines
ES2128266B1 (es) * 1997-07-08 2000-01-16 Vita Invest Sa Compuestos derivados de tiofeno y benzotiofeno y utilizacion y composicion correspondientes.
AU5486600A (en) 1999-06-15 2001-01-02 Aventis Pharmaceuticals Products Inc. Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
AU2351701A (en) * 1999-12-30 2001-07-16 H. Lundbeck A/S A method for the preparation of substituted benzene derivatives

Also Published As

Publication number Publication date
SK9442002A3 (en) 2002-11-06
IL150241A (en) 2008-12-29
ZA200204814B (en) 2003-08-27
NO322666B1 (no) 2006-11-13
NZ519647A (en) 2004-02-27
TR200400645T4 (tr) 2004-06-21
CN1437597A (zh) 2003-08-20
ATE261959T1 (de) 2004-04-15
PT1246816E (pt) 2004-08-31
CZ20022319A3 (cs) 2002-10-16
JP2003519224A (ja) 2003-06-17
WO2001049678A9 (en) 2002-10-10
PL199351B1 (pl) 2008-09-30
DE60009155D1 (de) 2004-04-22
WO2001049678A1 (en) 2001-07-12
DE60009155T2 (de) 2005-01-05
UA72948C2 (uk) 2005-05-16
HUP0203722A2 (hu) 2003-03-28
HUP0203722A3 (en) 2005-03-29
CN1230432C (zh) 2005-12-07
EP1246816A1 (en) 2002-10-09
NO20023146L (no) 2002-06-28
EA200200732A1 (ru) 2003-02-27
CA2395705C (en) 2006-10-17
TR200201683T2 (tr) 2002-12-23
AU2152101A (en) 2001-07-16
BR0016952A (pt) 2002-10-08
KR20020063287A (ko) 2002-08-01
ES2213634T3 (es) 2004-09-01
MXPA02006223A (es) 2002-12-05
BG106930A (en) 2003-04-30
NO20023146D0 (no) 2002-06-28
IS6420A (is) 2002-06-13
PL355539A1 (en) 2004-05-04
CA2395705A1 (en) 2001-07-12
KR100790916B1 (ko) 2008-01-03
US6699864B2 (en) 2004-03-02
EP1246816B1 (en) 2004-03-17
US20030125320A1 (en) 2003-07-03
EA006071B1 (ru) 2005-08-25
IS2174B (is) 2006-11-15
BG65262B1 (bg) 2007-10-31
IL150241A0 (en) 2002-12-01

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