BR9811022A - Composto, composição farmacêutica, e, processo para preparação de um composto - Google Patents

Composto, composição farmacêutica, e, processo para preparação de um composto

Info

Publication number
BR9811022A
BR9811022A BR9811022-5A BR9811022A BR9811022A BR 9811022 A BR9811022 A BR 9811022A BR 9811022 A BR9811022 A BR 9811022A BR 9811022 A BR9811022 A BR 9811022A
Authority
BR
Brazil
Prior art keywords
compound
pharmaceutical composition
preparing
preparation
triazole
Prior art date
Application number
BR9811022-5A
Other languages
English (en)
Inventor
David Hardern
Brian Springthorpe
Original Assignee
Astra Pharma Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharma Prod filed Critical Astra Pharma Prod
Publication of BR9811022A publication Critical patent/BR9811022A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, E, PROCESSO PARA PREPARAçãO DE UM COMPOSTO" A invenção fornece novos compostos de triazol [4,5-d] pirimidina de fórmula (I): seu uso como medicamentos, composições contendo-os e processos para a sua preparação.
BR9811022-5A 1997-07-22 1998-07-15 Composto, composição farmacêutica, e, processo para preparação de um composto BR9811022A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9702772A SE9702772D0 (sv) 1997-07-22 1997-07-22 Novel compounds
PCT/SE1998/001392 WO1999005142A1 (en) 1997-07-22 1998-07-15 Novel compounds

Publications (1)

Publication Number Publication Date
BR9811022A true BR9811022A (pt) 2000-09-12

Family

ID=20407803

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9811022-5A BR9811022A (pt) 1997-07-22 1998-07-15 Composto, composição farmacêutica, e, processo para preparação de um composto

Country Status (21)

Country Link
US (1) US6156756A (pt)
EP (1) EP0996620B1 (pt)
JP (1) JP2001510841A (pt)
KR (1) KR20010022082A (pt)
CN (1) CN1271359A (pt)
AT (1) ATE216389T1 (pt)
AU (1) AU8370598A (pt)
BR (1) BR9811022A (pt)
CA (1) CA2296648A1 (pt)
DE (1) DE69804964T2 (pt)
EE (1) EE200000042A (pt)
HU (1) HUP0100202A3 (pt)
ID (1) ID24837A (pt)
IL (1) IL134112A0 (pt)
IS (1) IS5351A (pt)
NO (1) NO20000311L (pt)
PL (1) PL338518A1 (pt)
SE (1) SE9702772D0 (pt)
SK (1) SK188099A3 (pt)
TR (1) TR200000151T2 (pt)
WO (1) WO1999005142A1 (pt)

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SE9802574D0 (sv) * 1998-07-17 1998-07-17 Astra Pharma Prod Novel compounds
TWI229674B (en) * 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
SE9904128D0 (sv) * 1999-11-15 1999-11-15 Astra Pharma Prod Novel compounds
SE9904129D0 (sv) * 1999-11-15 1999-11-15 Astra Pharma Prod Novel compounds
US6867199B2 (en) 2000-08-21 2005-03-15 Inspire Pharmaceuticals, Inc. Dinucleoside polyphosphate compositions and their therapeutic use
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US7749981B2 (en) 2003-10-21 2010-07-06 Inspire Pharmaceuticals, Inc. Drug-eluting stents coated with non-nucleotide P2Y12 receptor antagonist compound
US7335648B2 (en) 2003-10-21 2008-02-26 Inspire Pharmaceuticals, Inc. Non-nucleotide composition and method for inhibiting platelet aggregation
US7368438B2 (en) 2003-10-21 2008-05-06 Inspire Pharmaceuticals, Inc. Non-nucleotide compositions and method for inhibiting platelet aggregation
US7932376B2 (en) 2005-05-05 2011-04-26 Inspire Pharmaceuticals, Inc. Pyrimidine-based non-nucleotide composition and method for inhibiting platelet aggregation
US7566722B2 (en) * 2006-10-31 2009-07-28 Janssen Pharmaceutica, N.V. Triazolopyrimidine derivatives as ADP P2Y12 receptor antagonists
WO2008054796A2 (en) 2006-10-31 2008-05-08 Janssen Pharmaceutica, N.V. Triazolopyrimidine derivatives as adp p2y12 receptor antagonists
TWI496776B (zh) * 2007-11-15 2015-08-21 Astrazeneca Ab 製備(3aR,4S,6R,6aS)-6-胺基-2,2-二甲基四氫-3aH-環戊并[d][1,3]二氧雜環戊烯-4-醇之純非對映異構性之二苯甲醯-L-酒石酸鹽之方法
EP2361242B1 (en) 2008-10-17 2018-08-01 Oryzon Genomics, S.A. Oxidase inhibitors and their use
WO2010084160A1 (en) 2009-01-21 2010-07-29 Oryzon Genomics S.A. Phenylcyclopropylamine derivatives and their medical use
EP2459564B1 (en) 2009-07-27 2016-09-07 Auspex Pharmaceuticals, Inc. Cyclopropyl modulators of p2y12 receptor
MX338041B (es) 2009-09-25 2016-03-30 Oryzon Genomics Sa Inhibidores de demetilasa-1 especificos de lisina y su uso.
EP2486002B1 (en) 2009-10-09 2019-03-27 Oryzon Genomics, S.A. Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use
CA2788072A1 (en) 2010-02-16 2011-08-25 Actavis Group Ptc Ehf Improved processes for preparing ticagrelor intermediate, 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine
US9616058B2 (en) 2010-02-24 2017-04-11 Oryzon Genomics, S.A. Potent selective LSD1 inhibitors and dual LSD1/MAO-B inhibitors for antiviral use
US9186337B2 (en) 2010-02-24 2015-11-17 Oryzon Genomics S.A. Lysine demethylase inhibitors for diseases and disorders associated with Hepadnaviridae
KR101794020B1 (ko) 2010-04-19 2017-11-06 오리존 지노믹스 에스.에이. 라이신 특이적 디메틸라아제-1 억제제 및 이의 용도
US9181198B2 (en) 2010-07-29 2015-11-10 Oryzon Genomics S.A. Arylcyclopropylamine based demethylase inhibitors of LSD1 and their medical use
WO2012013727A1 (en) 2010-07-29 2012-02-02 Oryzon Genomics S.A. Cyclopropylamine derivatives useful as lsd1 inhibitors
WO2012045883A1 (en) 2010-10-08 2012-04-12 Oryzon Genomics S.A. Cyclopropylamine inhibitors of oxidases
WO2012063126A2 (en) 2010-11-09 2012-05-18 Actavis Group Ptc Ehf Improved processes for preparing pure (3ar,4s,6r,6as)-6-amino-2,2-dimethyltetrahdro-3ah-cyclopenta[d] [1,3]-dioxol-4-ol and its key starting material
WO2012072713A2 (en) 2010-11-30 2012-06-07 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae
MX2013007115A (es) 2010-12-20 2014-02-10 Actavis Group Ptc Ehf Procesos novedosos para preparar derivados de triazolo[4, 5 - d] pirimidina e intermediarios de los mismos.
EP2712315B1 (en) 2011-02-08 2021-11-24 Oryzon Genomics, S.A. Lysine demethylase inhibitors for myeloproliferative disorders
CZ2011229A3 (cs) 2011-04-19 2012-08-15 Zentiva, K.S. Opticky aktivní soli (3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyklopenta-[d][1,3]dioxol-4-olu a zpusob jejich prípravy
BR112013028936B1 (pt) * 2011-05-13 2021-10-19 Astrazeneca Ab Processo para a preparação de benzil [(3as,4r,6s,6ar)-6-hidróxi-2,2-dimetiltetra-hidro- 3ahciclopenta[d]dioxol]-4-il]carbamato e compostos intermediários no processo
US20140206867A1 (en) 2011-06-15 2014-07-24 Actavis Group Ptc Ehf Process for Preparing Cyclopentylamine Derivatives and Intermediates Thereof
CN102924457A (zh) * 2011-08-12 2013-02-13 上海恒瑞医药有限公司 ***并嘧啶类衍生物、其制备方法及其用途
RS58475B1 (sr) 2011-10-20 2019-04-30 Oryzon Genomics Sa Jedinjenja (hetero)aril ciklopropilamina kao lsd1 inhibitori
CN107266345B (zh) 2011-10-20 2021-08-17 奥瑞泽恩基因组学股份有限公司 作为lsd1抑制剂的(杂)芳基环丙胺化合物
CN102659691B (zh) * 2012-05-23 2014-04-02 山东诚创医药技术开发有限公司 一种4,6-二氯-5-氨基-2-丙硫基嘧啶的制备方法
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WO2014206187A1 (zh) 2013-06-24 2014-12-31 苏州明锐医药科技有限公司 替卡格雷及其中间体的制备方法
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WO2015162630A1 (en) 2014-04-25 2015-10-29 Anlon Chemical Research Organization Novel processes for preparing triazolo [4,5-d]- pyrimidines, including ticagrelor, vianew intermediates and new route of synthesis.
TWI744723B (zh) 2014-06-20 2021-11-01 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
NO2717902T3 (pt) 2014-06-20 2018-06-23
WO2018183965A1 (en) * 2017-03-30 2018-10-04 Corvus Pharmaceuticals, Inc. Processes for making triazolo[4,5d] pyramidine derivatives and intermediates thereof
WO2019016111A1 (en) * 2017-07-18 2019-01-24 Lonza Ltd PROCESS FOR THE PREPARATION OF CHLORINATED S-PROPYLTHIOBARBITURIC ACID
WO2020068583A1 (en) * 2018-09-27 2020-04-02 Corvus Pharmaceuticals, Inc. Processes for making triazolo [4,5d] pyramidine derivatives and intermediates thereof
CN111116592A (zh) * 2019-11-27 2020-05-08 杭州沧海帆医药科技有限公司 嘧啶并三氮唑类化合物及其医药用途
CN115710275B (zh) * 2022-11-21 2024-02-02 河南中医药大学 一种嘧啶-tcp类化合物、制备方法和医药用途

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GB8826205D0 (en) * 1988-11-09 1988-12-14 Wellcome Found Heterocyclic compounds
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Also Published As

Publication number Publication date
ATE216389T1 (de) 2002-05-15
NO20000311D0 (no) 2000-01-21
PL338518A1 (en) 2000-11-06
WO1999005142A1 (en) 1999-02-04
DE69804964D1 (de) 2002-05-23
SK188099A3 (en) 2000-08-14
HUP0100202A3 (en) 2001-10-29
SE9702772D0 (sv) 1997-07-22
TR200000151T2 (tr) 2000-09-21
AU8370598A (en) 1999-02-16
CA2296648A1 (en) 1999-02-04
EE200000042A (et) 2000-10-16
EP0996620B1 (en) 2002-04-17
CN1271359A (zh) 2000-10-25
ID24837A (id) 2000-08-24
DE69804964T2 (de) 2002-11-07
EP0996620A1 (en) 2000-05-03
IS5351A (is) 2000-01-19
HUP0100202A2 (hu) 2001-08-28
JP2001510841A (ja) 2001-08-07
KR20010022082A (ko) 2001-03-15
US6156756A (en) 2000-12-05
NO20000311L (no) 2000-03-21
IL134112A0 (en) 2001-07-24

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 4A, 5A, 6A, 7A, 8A E 9A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO NAO CUMPRIMENTO DO DESPACHO 8.6 NA RPI 1909 DE 07/08/2007.