BR9812120A - Derivados de 9h-1, 3-dioxolo/4, 5-h// 2,3 /benzodiazepina 8, composição farmacêutica eprocesso para sua preparação - Google Patents
Derivados de 9h-1, 3-dioxolo/4, 5-h// 2,3 /benzodiazepina 8, composição farmacêutica eprocesso para sua preparaçãoInfo
- Publication number
- BR9812120A BR9812120A BR9812120-0A BR9812120A BR9812120A BR 9812120 A BR9812120 A BR 9812120A BR 9812120 A BR9812120 A BR 9812120A BR 9812120 A BR9812120 A BR 9812120A
- Authority
- BR
- Brazil
- Prior art keywords
- benzodiazepine
- derivatives
- dioxolo
- pharmaceutical composition
- preparation
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 title abstract 2
- 229940049706 benzodiazepine Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- UUDAMDVQRQNNHZ-UHFFFAOYSA-N (S)-AMPA Chemical compound CC=1ONC(=O)C=1CC(N)C(O)=O UUDAMDVQRQNNHZ-UHFFFAOYSA-N 0.000 abstract 1
- 102000003678 AMPA Receptors Human genes 0.000 abstract 1
- 108090000078 AMPA Receptors Proteins 0.000 abstract 1
- 102000000079 Kainic Acid Receptors Human genes 0.000 abstract 1
- 108010069902 Kainic Acid Receptors Proteins 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 abstract 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Abstract
"DERIVADOS DE9H-1,3-DIOXOLO/4,5-H//2,3/BENZODIAZEPINA 8,COMPOSIçãO FARMACêUTICA E PROCESSO PAPA SUAPREPAPAçãO". A invenção refere-se a derivados de9H-1,3-dioxolo/4,5-h//2,3/benzodiazepina 8-substituídos, novosda fórmula (I), um processo para preparar estes compostos e acomposições farmacêuticas contendo estas substâncias ativas. Oscompostos (I) inibem receptores Ampa/Kainate.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9701380A HUP9701380A3 (en) | 1997-08-12 | 1997-08-12 | New 8-substituted-9h-1,3-dioxolo-[4,5-h][2,3]-benzodiazepine derivatives, pharmaceutical compositions containing them as active component, and process for producing them |
HU9701381A HUP9701381A3 (en) | 1997-08-12 | 1997-08-12 | New 7,8-dihydro-8,8-disubstituted-9h-1,3-dioxolo-[4,5-h][2,3]-benzodiazepine derivatives, pharmaceutical compositions containing them as active component, and process for producing them |
PCT/HU1998/000075 WO1999007707A1 (en) | 1997-08-12 | 1998-08-07 | 8-SUBSTITUTED-9H-1,3-DIOXOLO/4,5-h//2,3/BENZODIAZEPINE DERIVATIVES, AS AMPA/KAINATE RECEPTOR INHIBITORS |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9812120A true BR9812120A (pt) | 2001-11-20 |
Family
ID=89995497
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9812120-0A BR9812120A (pt) | 1997-08-12 | 1998-08-07 | Derivados de 9h-1, 3-dioxolo/4, 5-h// 2,3 /benzodiazepina 8, composição farmacêutica eprocesso para sua preparação |
Country Status (18)
Country | Link |
---|---|
US (1) | US6562810B1 (pt) |
EP (1) | EP1003749B1 (pt) |
JP (1) | JP2001512730A (pt) |
KR (1) | KR20010022862A (pt) |
CN (1) | CN1109033C (pt) |
AT (1) | ATE252586T1 (pt) |
AU (1) | AU735490B2 (pt) |
BR (1) | BR9812120A (pt) |
CA (1) | CA2300302A1 (pt) |
DE (1) | DE69819166T2 (pt) |
DK (1) | DK1003749T3 (pt) |
NO (1) | NO20000655L (pt) |
NZ (1) | NZ503300A (pt) |
PL (1) | PL338680A1 (pt) |
RU (1) | RU2208013C2 (pt) |
SK (1) | SK1772000A3 (pt) |
UA (1) | UA67749C2 (pt) |
WO (1) | WO1999007707A1 (pt) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP9900354A3 (en) * | 1999-02-15 | 2001-02-28 | Egyt Gyogyszervegyeszeti Gyar | Use of condensed 2,3-benzodiazepine derivatives for the preparation of pharmaceutical compositions treating and preventing diseases related with the inhibition of lipide peroxidation |
HU227128B1 (en) * | 1999-07-07 | 2010-07-28 | Egyt Gyogyszervegyeszeti Gyar | New 2,3-benzodiazepine derivatives |
US6858605B2 (en) | 2003-02-04 | 2005-02-22 | Ivax Drug Research Institute, Ltd. | Substituted 2,3-benzodiazepine derivatives |
CN100558834C (zh) * | 2006-07-21 | 2009-11-11 | 华南理工大学 | 一种环保型干粉涂料及其制备方法 |
FR2972454B1 (fr) * | 2011-03-08 | 2013-03-01 | Servier Lab | Nouveaux derives dihydro-oxazolobenzodiazepinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
HU230684B1 (en) * | 2014-01-21 | 2017-08-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | New dihydro-oxazinobenzodiazepine compounds, a process for their preparation and pharmaceutical compositions containing them |
CN104391999B (zh) * | 2014-12-15 | 2018-02-02 | 北京国双科技有限公司 | 信息推荐方法和装置 |
BR112017028639B1 (pt) * | 2015-07-06 | 2023-03-21 | Public University Corporation Yokohama City University | Composto que liga especificamente ao receptor ampa, composição farmacêutica que o compreende, uso do mesmo e métodos para a produção do referido composto e para a formação de imagem de um receptor ampa |
RU2634594C1 (ru) * | 2016-11-30 | 2017-11-01 | федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) | Ингибиторы образования конечных продуктов гликирования на основе азопроизводных фенилсульфокислот |
WO2023042887A1 (ja) | 2021-09-15 | 2023-03-23 | 国立大学法人 琉球大学 | 認知機能低下、または過体重もしくは肥満症を処置することに用いるための医薬組成物 |
WO2023042888A1 (ja) | 2021-09-15 | 2023-03-23 | 国立大学法人 琉球大学 | 認知機能低下、または過体重もしくは肥満症を処置することに用いるための医薬組成物 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU191702B (en) * | 1984-06-27 | 1987-03-30 | Gyogyszerkutato Intezet | New process for preparing 1-aryl-5 h-2,3-benzodiazepines |
HU191698B (en) * | 1984-07-27 | 1987-03-30 | Gyogyszerkutato Intezet | Process for producing new 1-aryl-5h-2beta-benzodiazepines |
HU198494B (en) * | 1986-08-15 | 1989-10-30 | Gyogyszerkutato Intezet | Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same |
HU219778B (hu) * | 1990-12-21 | 2001-07-30 | Gyógyszerkutató Intézet Közös Vállalat | Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények |
HU206719B (en) * | 1990-12-21 | 1992-12-28 | Gyogyszerkutato Intezet | Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them |
HU219777B (hu) * | 1993-07-02 | 2001-07-30 | Gyógyszerkutató Intézet Kft. | Optikailag aktív 1-(4-nitro-fenil)-4-metil-7,8-metiléndioxi-3,4-dihidro-5H-2,3-benzodiazepin és eljárás előállítására |
DE4428835A1 (de) * | 1994-08-01 | 1996-02-08 | Schering Ag | Neue 3-substituierte 3H-2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel |
TR199501070A2 (tr) * | 1994-08-31 | 1996-06-21 | Lilly Co Eli | Dihidro-2,3-benzodiazepin türevinin kristalli bicimi. |
TR199501071A2 (tr) * | 1994-08-31 | 1996-06-21 | Lilly Co Eli | Dihidro-2,3-benzodiazepin türevlerinin üretilmesi icin stereoselektif islem. |
DE19604919A1 (de) * | 1996-02-01 | 1997-08-07 | Schering Ag | Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel |
-
1998
- 1998-07-08 UA UA2000031380A patent/UA67749C2/uk unknown
- 1998-08-07 CN CN98809765A patent/CN1109033C/zh not_active Expired - Fee Related
- 1998-08-07 US US09/485,391 patent/US6562810B1/en not_active Expired - Fee Related
- 1998-08-07 AT AT98939781T patent/ATE252586T1/de not_active IP Right Cessation
- 1998-08-07 AU AU88181/98A patent/AU735490B2/en not_active Ceased
- 1998-08-07 WO PCT/HU1998/000075 patent/WO1999007707A1/en not_active Application Discontinuation
- 1998-08-07 EP EP98939781A patent/EP1003749B1/en not_active Expired - Lifetime
- 1998-08-07 RU RU2000106060/04A patent/RU2208013C2/ru not_active IP Right Cessation
- 1998-08-07 NZ NZ503300A patent/NZ503300A/en unknown
- 1998-08-07 KR KR1020007001464A patent/KR20010022862A/ko not_active Application Discontinuation
- 1998-08-07 SK SK177-2000A patent/SK1772000A3/sk unknown
- 1998-08-07 CA CA002300302A patent/CA2300302A1/en not_active Abandoned
- 1998-08-07 JP JP2000506210A patent/JP2001512730A/ja active Pending
- 1998-08-07 PL PL98338680A patent/PL338680A1/xx unknown
- 1998-08-07 DE DE69819166T patent/DE69819166T2/de not_active Expired - Fee Related
- 1998-08-07 DK DK98939781T patent/DK1003749T3/da active
- 1998-08-07 BR BR9812120-0A patent/BR9812120A/pt not_active IP Right Cessation
-
2000
- 2000-02-09 NO NO20000655A patent/NO20000655L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PL338680A1 (en) | 2000-11-20 |
KR20010022862A (ko) | 2001-03-26 |
UA67749C2 (uk) | 2004-07-15 |
NO20000655D0 (no) | 2000-02-09 |
EP1003749B1 (en) | 2003-10-22 |
NZ503300A (en) | 2001-06-29 |
CA2300302A1 (en) | 1999-02-18 |
AU8818198A (en) | 1999-03-01 |
EP1003749A1 (en) | 2000-05-31 |
CN1272846A (zh) | 2000-11-08 |
JP2001512730A (ja) | 2001-08-28 |
AU735490B2 (en) | 2001-07-12 |
SK1772000A3 (en) | 2000-10-09 |
WO1999007707A1 (en) | 1999-02-18 |
DK1003749T3 (da) | 2004-03-08 |
DE69819166T2 (de) | 2004-07-22 |
NO20000655L (no) | 2000-04-10 |
DE69819166D1 (de) | 2003-11-27 |
CN1109033C (zh) | 2003-05-21 |
US6562810B1 (en) | 2003-05-13 |
RU2208013C2 (ru) | 2003-07-10 |
ATE252586T1 (de) | 2003-11-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1890 DE 27/03/2007. |