BR9710453A - Inhibidor de produ-Æo de citocina composto de triazepina e intermedi rio para o mesmo - Google Patents
Inhibidor de produ-Æo de citocina composto de triazepina e intermedi rio para o mesmoInfo
- Publication number
- BR9710453A BR9710453A BR9710453A BR9710453A BR9710453A BR 9710453 A BR9710453 A BR 9710453A BR 9710453 A BR9710453 A BR 9710453A BR 9710453 A BR9710453 A BR 9710453A BR 9710453 A BR9710453 A BR 9710453A
- Authority
- BR
- Brazil
- Prior art keywords
- triazepine
- same
- cytokine production
- production inhibitor
- inhibitor composed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/04—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17426896 | 1996-06-12 | ||
| JP9523797 | 1997-03-28 | ||
| PCT/JP1997/002016 WO1997047622A1 (fr) | 1996-06-12 | 1997-06-11 | Inhibiteurs de production de cytokines, composes triazepine et intermediaires correspondants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9710453A true BR9710453A (pt) | 1999-08-17 |
Family
ID=26436510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9710453A BR9710453A (pt) | 1996-06-12 | 1997-06-11 | Inhibidor de produ-Æo de citocina composto de triazepina e intermedi rio para o mesmo |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0934940A1 (pt) |
| CN (1) | CN1227555A (pt) |
| AU (1) | AU3106197A (pt) |
| BR (1) | BR9710453A (pt) |
| CA (1) | CA2258053A1 (pt) |
| IL (1) | IL127516A0 (pt) |
| NO (1) | NO985820L (pt) |
| PL (1) | PL330635A1 (pt) |
| WO (1) | WO1997047622A1 (pt) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1375465A4 (en) * | 2001-04-03 | 2006-01-11 | Eisai Co Ltd | CYCLOOCTANON DERIVATIVE AND CYCLODECANON DERIVATIVE AND THEIR USE |
| WO2005089800A1 (ja) * | 2004-03-17 | 2005-09-29 | Locomogene, Inc. | hsHRD3を含む医薬組成物 |
| PT2722334E (pt) * | 2009-11-05 | 2016-03-11 | Glaxosmithkline Llc | Inibidor do bromodomínio da benzodiazepina |
| GB0919426D0 (en) * | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| DK2496582T3 (en) * | 2009-11-05 | 2016-03-21 | Glaxosmithkline Llc | Benzodiazepine-BROMDOMAeNEINHIBITOR. |
| AU2015203454B2 (en) * | 2009-11-05 | 2017-02-23 | Glaxosmithkline Llc | Benzodiazepine bromodomain inhibitor |
| ES2539964T3 (es) * | 2009-11-05 | 2015-07-07 | Glaxosmithkline Llc | Procedimiento novedoso |
| EP2571503B1 (en) * | 2010-05-14 | 2015-01-07 | Dana-Farber Cancer Institute, Inc. | Compositions and their use in treating neoplasia, inflammatory disease and other disorders |
| AU2015201727B2 (en) * | 2010-05-14 | 2018-03-08 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating neoplasia, inflammatory disease and other disorders |
| JP6022442B2 (ja) | 2010-05-14 | 2016-11-09 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | 男性用避妊組成物および使用方法 |
| CA2799403C (en) | 2010-05-14 | 2020-01-21 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating leukemia |
| JP5715241B2 (ja) * | 2010-05-14 | 2015-05-07 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | 新生物、炎症性疾患、およびその他の障害を治療するための組成物および方法 |
| ES2526671T3 (es) | 2010-06-22 | 2015-01-14 | Glaxosmithkline Llc | Compuestos de benzotriazoldiazepina inhibidores de bromodominios |
| TWI549955B (zh) * | 2010-08-04 | 2016-09-21 | 達納 法柏癌症學院有限公司 | 治療腫瘤形成、發炎疾病及其他病症之組成物及方法 |
| AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| WO2012075456A1 (en) | 2010-12-02 | 2012-06-07 | Constellation Pharmaceuticals | Bromodomain inhibitors and uses thereof |
| EP2705039B1 (en) | 2011-05-04 | 2017-07-26 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| WO2012174487A2 (en) | 2011-06-17 | 2012-12-20 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| DE102011082013A1 (de) | 2011-09-01 | 2013-03-07 | Bayer Pharma AG | 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine |
| CN102603743B (zh) | 2012-02-24 | 2014-05-28 | 南京天易生物科技有限公司 | 抗肿瘤的氮杂苯并[f]薁衍生物其制备方法及其用途 |
| EP2864336B1 (en) | 2012-06-06 | 2016-11-23 | Constellation Pharmaceuticals, Inc. | Benzo[b]isoxazoloazepine bromodomain inhibitors and uses thereof |
| TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
| MX2015001880A (es) | 2012-08-16 | 2015-05-11 | Bayer Pharma AG | 2,3-benzodiacepinas. |
| EP2900672B1 (de) | 2012-09-28 | 2017-02-22 | Bayer Pharma Aktiengesellschaft | Bet-proteininhibitorische 5-aryl-triazolo-azepine |
| AU2014292888B2 (en) | 2013-07-25 | 2018-03-22 | Dana-Farber Cancer Institute, Inc. | Inhibitors of transcription factors and uses thereof |
| CN105849110B (zh) | 2013-11-08 | 2019-08-02 | 达纳-法伯癌症研究所有限公司 | 使用溴结构域和额外终端(bet)蛋白抑制剂的用于癌症的组合疗法 |
| CA2936865A1 (en) | 2014-01-31 | 2015-08-06 | Dana-Farber Cancer Institute, Inc. | Diaminopyrimidine benzenesulfone derivatives and uses thereof |
| EP3099693A4 (en) | 2014-01-31 | 2017-08-16 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
| SG11201607108XA (en) | 2014-02-28 | 2016-09-29 | Tensha Therapeutics Inc | Treatment of conditions associated with hyperinsulinaemia |
| US9969747B2 (en) | 2014-06-20 | 2018-05-15 | Constellation Pharmaceuticals, Inc. | Crystalline forms of 2-((4S)-6-(4-chlorophenyl)-1-methyl-4H-benzo[C]isoxazolo[4,5-e]azepin-4-yl)acetamide |
| CN106793775B (zh) | 2014-08-08 | 2020-06-02 | 达纳-法伯癌症研究所股份有限公司 | 二氢碟啶酮衍生物及其用途 |
| CA2955074A1 (en) | 2014-08-08 | 2016-02-11 | Dana-Farber Cancer Institute, Inc. | Diazepane derivatives and uses thereof |
| US9975901B2 (en) * | 2014-10-02 | 2018-05-22 | Glaxosmithkline Intellectual Property (No. 2) Limited | Crystalline solid state form of the benzene sulphonic acid salt of 2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide |
| UA122130C2 (uk) | 2014-10-27 | 2020-09-25 | Тенша Терапеутікс, Інк. | Інгібітори бромодомену |
| WO2016201370A1 (en) | 2015-06-12 | 2016-12-15 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
| CN108472299A (zh) | 2015-09-11 | 2018-08-31 | 达纳-法伯癌症研究所股份有限公司 | 乙酰胺噻吩并***并二氮杂环庚三烯及其用途 |
| KR20180049058A (ko) | 2015-09-11 | 2018-05-10 | 다나-파버 캔서 인스티튜트 인크. | 시아노 티에노트리아졸로디아제핀 및 그의 용도 |
| SG11201803210YA (en) | 2015-11-25 | 2018-05-30 | Dana Farber Cancer Inst Inc | Bivalent bromodomain inhibitors and uses thereof |
| EP3518898A4 (en) * | 2016-10-03 | 2020-06-17 | The Children's Medical Center Corporation | PREVENTION AND TREATMENT OF DIABETIC NEPHROPATHY |
| EP3640253A4 (en) * | 2017-05-31 | 2021-01-13 | AYUMI Pharmaceutical Corporation | 6H-THIEN [2,3-E] [1,2,4] TRIAZOLE [3,4-C] [1,2,4] TRIAZEPINE DERIVATIVE |
| BR112020025003A2 (pt) | 2018-06-13 | 2021-03-23 | Dybly Ag | preparação de derivados de triazepina condensados e uso dos mesmos como inibidores de bet |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1489980A (en) * | 1975-01-20 | 1977-10-26 | Upjohn Co | Reaction products of 3-amino-3,4-dihydro-4-hydroxy-4-phenylquinazolines |
| US4144233A (en) * | 1977-02-16 | 1979-03-13 | The Dow Chemical Company | Method for preparing benzo-(1,3,4)-benzotriazepines |
| HUT77349A (hu) * | 1994-11-18 | 1998-03-30 | Japan Tobacco Inc. | Eljárás csontritkulás kezelésére alkalmas kondenzált triazepinszármazékokat tartalmazó gyógyszerkészítmények előállítására, valamint új kondenzált triazepinszármazékok és intermedierjeik |
| JP2622673B2 (ja) * | 1994-11-18 | 1997-06-18 | 日本たばこ産業株式会社 | 骨粗鬆症治療薬およびトリアゼピン化合物 |
-
1997
- 1997-06-11 CN CN97197090.4A patent/CN1227555A/zh active Pending
- 1997-06-11 IL IL12751697A patent/IL127516A0/xx unknown
- 1997-06-11 BR BR9710453A patent/BR9710453A/pt unknown
- 1997-06-11 PL PL97330635A patent/PL330635A1/xx unknown
- 1997-06-11 AU AU31061/97A patent/AU3106197A/en not_active Abandoned
- 1997-06-11 WO PCT/JP1997/002016 patent/WO1997047622A1/ja not_active Application Discontinuation
- 1997-06-11 CA CA002258053A patent/CA2258053A1/en not_active Abandoned
- 1997-06-11 EP EP97926224A patent/EP0934940A1/en not_active Withdrawn
-
1998
- 1998-12-11 NO NO985820A patent/NO985820L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997047622A1 (fr) | 1997-12-18 |
| IL127516A0 (en) | 1999-10-28 |
| AU3106197A (en) | 1998-01-07 |
| NO985820L (no) | 1999-02-01 |
| CN1227555A (zh) | 1999-09-01 |
| EP0934940A1 (en) | 1999-08-11 |
| PL330635A1 (en) | 1999-05-24 |
| NO985820D0 (no) | 1998-12-11 |
| CA2258053A1 (en) | 1997-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENETA A 4A,5A,6A,7A E 8A ANUIDADES. |