BR112019011702A2 - tratamento de uma doença do trato gastrointestinal com um inibidor de il-12/il-23 liberado usando um dispositivo ingerível - Google Patents
tratamento de uma doença do trato gastrointestinal com um inibidor de il-12/il-23 liberado usando um dispositivo ingerívelInfo
- Publication number
- BR112019011702A2 BR112019011702A2 BR112019011702A BR112019011702A BR112019011702A2 BR 112019011702 A2 BR112019011702 A2 BR 112019011702A2 BR 112019011702 A BR112019011702 A BR 112019011702A BR 112019011702 A BR112019011702 A BR 112019011702A BR 112019011702 A2 BR112019011702 A2 BR 112019011702A2
- Authority
- BR
- Brazil
- Prior art keywords
- gastrointestinal tract
- treating
- ingestible device
- tract disease
- inhibitor released
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 210000001035 gastrointestinal tract Anatomy 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
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- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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- A61K9/0097—Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips
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- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/555—Interferons [IFN]
- G01N2333/57—IFN-gamma
Abstract
a presente invenção refere-se a métodos e composições para o tratamento de doenças do trato gastrointestinal com um inibidor de il-12/il-23. em particular, os medicamentos são administrados em proximidade dos sítios de doenças usando dispositivos ingeríveis que podem liberar os fármacos em um modo controlado.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662434348P | 2016-12-14 | 2016-12-14 | |
US201762478744P | 2017-03-30 | 2017-03-30 | |
US201762545188P | 2017-08-14 | 2017-08-14 | |
US201762583797P | 2017-11-09 | 2017-11-09 | |
PCT/US2017/066474 WO2018112232A1 (en) | 2016-12-14 | 2017-12-14 | Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor released using an ingestible device |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112019011702A2 true BR112019011702A2 (pt) | 2019-10-22 |
Family
ID=60953956
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112019011702A BR112019011702A2 (pt) | 2016-12-14 | 2017-12-14 | tratamento de uma doença do trato gastrointestinal com um inibidor de il-12/il-23 liberado usando um dispositivo ingerível |
Country Status (10)
Country | Link |
---|---|
US (1) | US11597762B2 (pt) |
EP (1) | EP3554540B1 (pt) |
JP (2) | JP7237834B2 (pt) |
KR (1) | KR20190095931A (pt) |
CN (2) | CN117045784A (pt) |
AU (1) | AU2017376807A1 (pt) |
BR (1) | BR112019011702A2 (pt) |
CA (1) | CA3045475A1 (pt) |
MX (1) | MX2019006823A (pt) |
WO (1) | WO2018112232A1 (pt) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
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US20220135666A1 (en) * | 2017-12-14 | 2022-05-05 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a s1p modulator |
JP6611833B2 (ja) * | 2018-01-16 | 2019-11-27 | キヤノン株式会社 | 放射線撮影システム、並びに、カメラ制御装置及びその制御方法 |
US20210363233A1 (en) * | 2018-06-20 | 2021-11-25 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor |
AU2019346134B2 (en) * | 2018-09-24 | 2023-01-12 | Janssen Biotech, Inc. | Safe and effective method of treating ulcerative colitis with anti-il12/il23 antibody |
CA3119294A1 (en) * | 2018-11-15 | 2020-05-22 | Janssen Biotech, Inc. | Methods and compositions for prediction of response to a therapy of inflammatory bowel disease |
CN109350599A (zh) * | 2018-12-12 | 2019-02-19 | 辽宁新高制药有限公司 | 一种用于皮肤念球菌病治疗的喷雾剂 |
AU2020279987A1 (en) | 2019-05-23 | 2021-11-18 | Janssen Biotech, Inc. | Method of treating inflammatory bowel disease with a combination therapy of antibodies to IL-23 and TNF alpha |
WO2021074897A2 (en) * | 2019-10-18 | 2021-04-22 | Janssen Biotech, Inc. | Safe and effective method of treating ulcerative colitis with anti-il12/il23 antibody |
KR102391865B1 (ko) * | 2020-04-03 | 2022-04-27 | 재단법인대구경북과학기술원 | 약물 전달 디바이스 |
CN112731954A (zh) * | 2020-12-25 | 2021-04-30 | 深圳市优必选科技股份有限公司 | 机器人的运动控制方法、装置、机器人及存储介质 |
DK180991B1 (en) * | 2021-01-29 | 2022-09-06 | Biograil ApS | Drug delivery device with carrier and insert |
EP4284483A1 (en) * | 2021-01-29 | 2023-12-06 | Biograil APS | Drug delivery device with releasable attachment part |
CA3202633A1 (en) * | 2021-01-29 | 2022-08-04 | Nikolaj Skak | Single attachment part drug delivery device |
WO2023073168A1 (en) * | 2021-10-28 | 2023-05-04 | Biograil ApS | High-dose drug delivery device |
WO2024086013A1 (en) * | 2022-10-17 | 2024-04-25 | Rani Therapeutics, Llc | Ustekinumab dosage forms and methods |
CN116027048A (zh) * | 2023-02-06 | 2023-04-28 | 山东中鸿特检生物科技有限公司 | 一种细胞因子风暴综合征诊断试剂盒及其应用 |
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-
2017
- 2017-12-14 EP EP17826641.7A patent/EP3554540B1/en active Active
- 2017-12-14 CN CN202310488599.7A patent/CN117045784A/zh active Pending
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JP2020501699A (ja) | 2020-01-23 |
JP2023071838A (ja) | 2023-05-23 |
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MX2019006823A (es) | 2019-10-21 |
CN110072551A (zh) | 2019-07-30 |
EP3554540C0 (en) | 2023-08-02 |
WO2018112232A1 (en) | 2018-06-21 |
KR20190095931A (ko) | 2019-08-16 |
AU2017376807A1 (en) | 2019-06-13 |
JP7237834B2 (ja) | 2023-03-13 |
CA3045475A1 (en) | 2018-06-21 |
CN110072551B (zh) | 2023-05-23 |
CN117045784A (zh) | 2023-11-14 |
US20200262908A1 (en) | 2020-08-20 |
EP3554540B1 (en) | 2023-08-02 |
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