BR112018002428A2 - “anticorpos, polinucleotídeo, vetor, célula, método de expressar o anticorpo, kit, método para detectar a presença ou o nível de pd-l1 humano ou de macaco em uma amostra, método de identificação de um indivíduo com um distúrbio, método para monitorar a resposta terapêutica, composição farmacêutica,método para tratar uma condição em um sujeito e uso do anticorpo - Google Patents
“anticorpos, polinucleotídeo, vetor, célula, método de expressar o anticorpo, kit, método para detectar a presença ou o nível de pd-l1 humano ou de macaco em uma amostra, método de identificação de um indivíduo com um distúrbio, método para monitorar a resposta terapêutica, composição farmacêutica,método para tratar uma condição em um sujeito e uso do anticorpoInfo
- Publication number
- BR112018002428A2 BR112018002428A2 BR112018002428A BR112018002428A BR112018002428A2 BR 112018002428 A2 BR112018002428 A2 BR 112018002428A2 BR 112018002428 A BR112018002428 A BR 112018002428A BR 112018002428 A BR112018002428 A BR 112018002428A BR 112018002428 A2 BR112018002428 A2 BR 112018002428A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibody
- antibodies
- monkey
- polynucleotide
- disorder
- Prior art date
Links
- 238000000034 method Methods 0.000 title 5
- 241000282693 Cercopithecidae Species 0.000 title 1
- 238000012544 monitoring process Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 102000040430 polynucleotide Human genes 0.000 title 1
- 108091033319 polynucleotide Proteins 0.000 title 1
- 239000002157 polynucleotide Substances 0.000 title 1
- 230000004797 therapeutic response Effects 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 238000003782 apoptosis assay Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000036737 immune function Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000005522 programmed cell death Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Abstract
a presente divulgação provê anticorpos monoclonais contra a proteína 1 ligante de morte celular programada 1 (pd-l1), que pode bloquear a ligação do pd-l1 à pd-1 e, desse modo, bloquear a função inibidora do pd-l1 sobre células t que expressam pd-1. os anticorpos da divulgação fornecem agentes muito potentes para o tratamento de múltiplos cânceres pela modulação da função imune humana.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2015/086216 WO2017020291A1 (en) | 2015-08-06 | 2015-08-06 | Novel anti-pd-l1 antibodies |
| PCT/CN2016/093560 WO2017020858A1 (en) | 2015-08-06 | 2016-08-05 | Novel anti-pd-l1 antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112018002428A2 true BR112018002428A2 (pt) | 2018-09-18 |
Family
ID=57942317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018002428A BR112018002428A2 (pt) | 2015-08-06 | 2016-08-05 | “anticorpos, polinucleotídeo, vetor, célula, método de expressar o anticorpo, kit, método para detectar a presença ou o nível de pd-l1 humano ou de macaco em uma amostra, método de identificação de um indivíduo com um distúrbio, método para monitorar a resposta terapêutica, composição farmacêutica,método para tratar uma condição em um sujeito e uso do anticorpo |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US10981995B2 (pt) |
| EP (1) | EP3332006B1 (pt) |
| JP (2) | JP7066614B2 (pt) |
| KR (1) | KR20180037222A (pt) |
| AU (1) | AU2016301718B2 (pt) |
| BR (1) | BR112018002428A2 (pt) |
| CA (1) | CA2993272A1 (pt) |
| DK (1) | DK3332006T3 (pt) |
| ES (1) | ES2966890T3 (pt) |
| FI (1) | FI3332006T3 (pt) |
| HK (1) | HK1257164A1 (pt) |
| HR (1) | HRP20231664T1 (pt) |
| HU (1) | HUE064563T2 (pt) |
| IL (1) | IL256803B2 (pt) |
| LT (1) | LT3332006T (pt) |
| MX (1) | MX2018001530A (pt) |
| PT (1) | PT3332006T (pt) |
| RS (1) | RS64977B1 (pt) |
| RU (1) | RU2736151C2 (pt) |
| SA (1) | SA518390862B1 (pt) |
| SI (1) | SI3332006T1 (pt) |
| WO (2) | WO2017020291A1 (pt) |
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