BR112016013960A2 - anticorpos, ácido nucleico, célula hospedeira, método de produção de um anticorpo, formulação farmacêutica, uso do anticorpo, método de tratamento e método de ativação de um complexo - Google Patents

anticorpos, ácido nucleico, célula hospedeira, método de produção de um anticorpo, formulação farmacêutica, uso do anticorpo, método de tratamento e método de ativação de um complexo

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Publication number
BR112016013960A2
BR112016013960A2 BR112016013960-7A BR112016013960A BR112016013960A2 BR 112016013960 A2 BR112016013960 A2 BR 112016013960A2 BR 112016013960 A BR112016013960 A BR 112016013960A BR 112016013960 A2 BR112016013960 A2 BR 112016013960A2
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BR
Brazil
Prior art keywords
antibody
antibodies
complex
nucleic acid
host cell
Prior art date
Application number
BR112016013960-7A
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English (en)
Other versions
BR112016013960B1 (pt
Inventor
Chen Yongmei
Ernst James
Seon Kim Hok
Sonoda Junichiro
Spiess Christoph
Stawicki Scott
Wu Yan
Original Assignee
Genentech, Inc.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52347471&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112016013960(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech, Inc. filed Critical Genentech, Inc.
Publication of BR112016013960A2 publication Critical patent/BR112016013960A2/pt
Publication of BR112016013960B1 publication Critical patent/BR112016013960B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/55—Fab or Fab'
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

a matéria em questão atualmente divulgada fornece anticorpos que se ligam a klb e fgfr1, e métodos de uso dos mesmos. em certas realizações, um anticorpo da presente divulgação inclui um anticorpo biespecífico que se liga a um epítopo presente no fgfr1 e se liga a um epítopo presente em klb.
BR112016013960-7A 2013-12-23 2014-12-23 Anticorpo biespecífico isolado ou uma porção de ligação ao antígeno do mesmo, formulação farmacêutica e uso do anticorpo biespecífico isolado ou uma porção de ligação ao antígeno do mesmo BR112016013960B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361920396P 2013-12-23 2013-12-23
US61/920,396 2013-12-23
US201462081435P 2014-11-18 2014-11-18
US62/081,435 2014-11-18
PCT/US2014/072245 WO2015100366A1 (en) 2013-12-23 2014-12-23 Antibodies and methods of use

Publications (2)

Publication Number Publication Date
BR112016013960A2 true BR112016013960A2 (pt) 2018-01-09
BR112016013960B1 BR112016013960B1 (pt) 2023-03-14

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BR112016013960-7A BR112016013960B1 (pt) 2013-12-23 2014-12-23 Anticorpo biespecífico isolado ou uma porção de ligação ao antígeno do mesmo, formulação farmacêutica e uso do anticorpo biespecífico isolado ou uma porção de ligação ao antígeno do mesmo

Country Status (30)

Country Link
US (6) US9873748B2 (pt)
EP (2) EP3086807B1 (pt)
JP (3) JP6687533B2 (pt)
KR (3) KR102329693B1 (pt)
CN (2) CN105939727B (pt)
AU (4) AU2014369872B2 (pt)
BR (1) BR112016013960B1 (pt)
CA (1) CA2929868C (pt)
CL (1) CL2016001592A1 (pt)
CR (1) CR20160338A (pt)
DK (1) DK3086807T3 (pt)
EA (1) EA036107B1 (pt)
ES (1) ES2926375T3 (pt)
HR (1) HRP20221088T1 (pt)
HU (1) HUE059701T2 (pt)
IL (3) IL245493B (pt)
LT (1) LT3086807T (pt)
MX (2) MX2016008196A (pt)
MY (1) MY194936A (pt)
NZ (1) NZ720765A (pt)
PE (1) PE20161152A1 (pt)
PH (1) PH12016500927A1 (pt)
PL (1) PL3086807T3 (pt)
PT (1) PT3086807T (pt)
RS (1) RS63565B1 (pt)
SG (2) SG11201605071XA (pt)
SI (1) SI3086807T1 (pt)
TW (2) TWI728373B (pt)
UA (1) UA120357C2 (pt)
WO (1) WO2015100366A1 (pt)

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JP6998869B2 (ja) * 2015-11-08 2022-02-04 ジェネンテック， インコーポレイテッド 多重特異性抗体のスクリーニング方法
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CN107966525B (zh) * 2017-11-06 2023-10-20 中国矿业大学(北京) 一种13co2量化脉冲标记植物的方法
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