SG11201903795WA - Salts of indazole derivative and crystals thereof - Google Patents
Salts of indazole derivative and crystals thereofInfo
- Publication number
- SG11201903795WA SG11201903795WA SG11201903795WA SG11201903795WA SG11201903795WA SG 11201903795W A SG11201903795W A SG 11201903795WA SG 11201903795W A SG11201903795W A SG 11201903795WA SG 11201903795W A SG11201903795W A SG 11201903795WA SG 11201903795W A SG11201903795W A SG 11201903795WA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- crystals
- pct
- salts
- eisai
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 31 May 2018 (31.05.2018) WIPO I PCT ill~~~~~~~~ 011101010VIIIOH olo omoimo im million° ow (10) International Publication Number WO 2018/097273 Al (51) International Patent Classification: C07D 401/10 (2006.01) (21) International Application Number: PCT/JP2017/042335 EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) (22) International Filing Date: 27 November 2017 (27.11.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 2016-229635 28 November 2016 (28.11.2016) JP (71) Applicant: EISAI R&D MANAGEMENT CO., LTD. [JP/JP]; 4-6-10 Koishikawa, Bunkyo-ku, Tokyo, 1128088 (JP). (72) Inventor: ONUMA Keiko; C/O Eisai Co., Ltd. Tsukuba Research Laboratories, 5-1-3 Tokodai, Tsukuba-shi, Ibara- ki, 3002635 (JP). (74) Agent: HASEGAWA Yoshiki et al.; SOEI PATENT AND LAW FIRM, Marunouchi MY PLAZA (Meiji Yasuda Life Bldg.) 9th fl., 1-1, Marunouchi 2-chome, Chiyoda-ku, Tokyo, 1000005 (JP). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (54) Title: SALTS OF INDAZOLE DERIVATIVE AND CRYSTALS THEREOF 0 H (I) (57) : The present invention provides salts of (E)-N,N-dimethy1-44245-((Z)-4,4,4-trifluoro-1-(3-fluoro-1H-indazol-5-y1)-2- phenylbut-1-en-l-yppyridin-2-yl)oxy)ethyl)amino)but-2-enamide represented by the formula I and acids, and crystals thereof, possess- ing a potential to be used as drug substance in pharmaceuticals.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2016229635 | 2016-11-28 | ||
PCT/JP2017/042335 WO2018097273A1 (en) | 2016-11-28 | 2017-11-27 | Salts of indazole derivative and crystals thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201903795WA true SG11201903795WA (en) | 2019-05-30 |
Family
ID=62195940
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201903795WA SG11201903795WA (en) | 2016-11-28 | 2017-11-27 | Salts of indazole derivative and crystals thereof |
Country Status (14)
Country | Link |
---|---|
US (1) | US10640483B2 (en) |
EP (1) | EP3544967B1 (en) |
JP (1) | JP6346368B1 (en) |
KR (1) | KR102425785B1 (en) |
CN (1) | CN109790141B (en) |
AU (1) | AU2017363699B2 (en) |
BR (1) | BR112019008489A2 (en) |
CA (1) | CA3041986A1 (en) |
ES (1) | ES2954879T3 (en) |
IL (1) | IL266003B (en) |
MX (1) | MX2019004967A (en) |
RU (1) | RU2747399C2 (en) |
SG (1) | SG11201903795WA (en) |
WO (1) | WO2018097273A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6346368B1 (en) | 2016-11-28 | 2018-06-20 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Salts and crystals of indazole derivatives |
WO2019225552A1 (en) * | 2018-05-22 | 2019-11-28 | Eisai R&D Management Co., Ltd. | Salts of indazole derivative and crystals thereof |
JP6928301B2 (en) | 2018-06-06 | 2021-09-01 | 日本電信電話株式会社 | Subscriber line end station equipment and band allocation method |
CN114340625A (en) | 2019-05-24 | 2022-04-12 | 卫材R&D管理有限公司 | Method of treating cancer with oral dosage forms of estrogen receptor-alpha inhibitors |
KR20230104158A (en) * | 2020-11-06 | 2023-07-07 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | How to treat breast cancer |
Family Cites Families (27)
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DE3907290A1 (en) | 1989-03-07 | 1990-09-13 | Gerhard Prof Dr Eisenbrand | STEROID HORMONE RECEPTOR AFFINES ANTITUARY ACTIVE SUBSTANCES |
US5552412A (en) | 1995-01-09 | 1996-09-03 | Pfizer Inc | 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis |
TW397821B (en) | 1996-04-19 | 2000-07-11 | American Home Produits Corp | 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof |
US6897231B2 (en) | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
WO2007058626A1 (en) | 2005-11-16 | 2007-05-24 | S*Bio Pte Ltd | Indazole compounds |
WO2009120999A2 (en) | 2008-03-28 | 2009-10-01 | Olema Pharmaceuticals, Inc. | Use of an endoxifen prodrug for treatment of breast cancer |
US8063249B1 (en) | 2008-04-25 | 2011-11-22 | Olema Pharmaceuticals, Inc. | Substituted triphenyl butenes |
WO2011046596A2 (en) | 2009-10-13 | 2011-04-21 | Duquesne University Of The Holy Spirit, A Nonprofit Corporation Organized Under The Laws Of The Commonwealth Of Pennsylvania | Anti-cancer tamoxifen-melatonin hybrid ligand |
WO2011068211A1 (en) * | 2009-12-04 | 2011-06-09 | 大正製薬株式会社 | 2-pyridone compounds |
US8222416B2 (en) | 2009-12-14 | 2012-07-17 | Hoffmann-La Roche Inc. | Azaindole glucokinase activators |
WO2011129837A1 (en) | 2010-04-16 | 2011-10-20 | Olema Pharmaceuticals, Inc. | Use of a 4-hydroxytoremifene prodrug for treatment of breast cancer |
GB2483736B (en) * | 2010-09-16 | 2012-08-29 | Aragon Pharmaceuticals Inc | Estrogen receptor modulators and uses thereof |
CA3027814A1 (en) * | 2010-12-13 | 2012-06-21 | Array Biopharma Inc. | Substituted n-(1h-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide compounds as intermediates for type iii receptor tyrosine kinase inhibitors |
WO2013056178A2 (en) | 2011-10-14 | 2013-04-18 | Foundation Medicine, Inc. | Novel estrogen receptor mutations and uses thereof |
US9499538B2 (en) | 2012-03-20 | 2016-11-22 | Seragon Pharmaceuticals, Inc. | Estrogen receptor modulators and uses thereof |
US9365510B2 (en) | 2012-04-16 | 2016-06-14 | British Columbia Cancer Agency Branch | Aziridine bisphenol ethers and related compounds and methods for their use |
JOP20200097A1 (en) | 2013-01-15 | 2017-06-16 | Aragon Pharmaceuticals Inc | Androgen receptor modulator and uses thereof |
BR112015030595A2 (en) | 2013-06-19 | 2017-07-25 | Seragon Pharmaceuticals Inc | azetidine estrogen receptor modulators and uses thereof |
CA2912853A1 (en) | 2013-06-19 | 2014-12-24 | Seragon Pharmaceuticals, Inc. | Estrogen receptor modulator and uses thereof |
GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
MA39741A (en) | 2014-03-13 | 2017-01-18 | Hoffmann La Roche | Therapeutic combinations with estrogen receptor modulators |
WO2016055982A1 (en) * | 2014-10-10 | 2016-04-14 | Acerta Pharma B.V. | Quinoline and quinazoline compounds |
US9845291B2 (en) | 2014-12-18 | 2017-12-19 | Genentech, Inc. | Estrogen receptor modulators and uses thereof |
EP3981766A1 (en) * | 2015-05-29 | 2022-04-13 | Eisai R&D Management Co., Ltd. | Indazole derivatives useful in the treatment of cancer |
WO2018098305A1 (en) | 2016-11-24 | 2018-05-31 | Eisai R&D Management Co., Ltd. | Tetrasubstituted alkene compounds and their use for the treatment of breast cancer |
JP6346368B1 (en) | 2016-11-28 | 2018-06-20 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Salts and crystals of indazole derivatives |
US11083722B2 (en) * | 2017-03-16 | 2021-08-10 | Eisai R&D Management Co., Ltd. | Combination therapies for the treatment of breast cancer |
-
2017
- 2017-11-27 JP JP2017226501A patent/JP6346368B1/en active Active
- 2017-11-27 KR KR1020197009419A patent/KR102425785B1/en active IP Right Grant
- 2017-11-27 IL IL266003A patent/IL266003B/en unknown
- 2017-11-27 RU RU2019112080A patent/RU2747399C2/en active
- 2017-11-27 CN CN201780057482.6A patent/CN109790141B/en active Active
- 2017-11-27 ES ES17873875T patent/ES2954879T3/en active Active
- 2017-11-27 BR BR112019008489A patent/BR112019008489A2/en unknown
- 2017-11-27 US US16/096,136 patent/US10640483B2/en active Active
- 2017-11-27 WO PCT/JP2017/042335 patent/WO2018097273A1/en active Application Filing
- 2017-11-27 MX MX2019004967A patent/MX2019004967A/en unknown
- 2017-11-27 EP EP17873875.3A patent/EP3544967B1/en active Active
- 2017-11-27 SG SG11201903795WA patent/SG11201903795WA/en unknown
- 2017-11-27 CA CA3041986A patent/CA3041986A1/en active Pending
- 2017-11-27 AU AU2017363699A patent/AU2017363699B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
RU2747399C2 (en) | 2021-05-04 |
WO2018097273A1 (en) | 2018-05-31 |
JP2018108981A (en) | 2018-07-12 |
IL266003A (en) | 2019-06-30 |
RU2019112080A (en) | 2020-12-28 |
BR112019008489A2 (en) | 2019-09-10 |
US20190144419A1 (en) | 2019-05-16 |
AU2017363699B2 (en) | 2021-02-18 |
CN109790141B (en) | 2021-06-11 |
MX2019004967A (en) | 2019-08-22 |
JP6346368B1 (en) | 2018-06-20 |
US10640483B2 (en) | 2020-05-05 |
IL266003B (en) | 2022-08-01 |
AU2017363699A1 (en) | 2019-04-18 |
KR102425785B1 (en) | 2022-07-28 |
KR20190084941A (en) | 2019-07-17 |
EP3544967B1 (en) | 2023-06-28 |
RU2019112080A3 (en) | 2020-12-28 |
EP3544967A4 (en) | 2020-05-20 |
CA3041986A1 (en) | 2018-05-31 |
ES2954879T3 (en) | 2023-11-27 |
EP3544967A1 (en) | 2019-10-02 |
CN109790141A (en) | 2019-05-21 |
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