PE20160157A1 - Moduladores de los receptores de estrogeno y sus usos - Google Patents
Moduladores de los receptores de estrogeno y sus usosInfo
- Publication number
- PE20160157A1 PE20160157A1 PE2015002634A PE2015002634A PE20160157A1 PE 20160157 A1 PE20160157 A1 PE 20160157A1 PE 2015002634 A PE2015002634 A PE 2015002634A PE 2015002634 A PE2015002634 A PE 2015002634A PE 20160157 A1 PE20160157 A1 PE 20160157A1
- Authority
- PE
- Peru
- Prior art keywords
- cancer
- modulators
- estrogen receptors
- formula
- azethyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
SE REFIERE AL COMPUESTO (±)-2-(4-(2-(3-(FLUOROMETIL)AZETIDIN-1-IL)ETOXI)FENIL)-3-(3-HIDROXIFENIL)-4-METIL-2H-CROMEN-6-OL, ASI COMO A SUS ENANTIOMEROS (R) DE FORMULA (II) Y (S) DE FORMULA (III), Y SALES Y SOLVATOS DE LOS MISMOS. DICHOS COMPUESTOS SON MODULADORES DE LOS RECEPTORES DE ESTROGENO, POR LO CUAL SON UTILES EN EL TRATAMIENTO DE CANCER DE MAMA, CANCER DE OVARIO, CANCER DE ENDOMETRIO, CANCER DE PROSTATA, CANCER DE PULMON Y CANCER DE UTERO, ENTRE OTROS
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361836901P | 2013-06-19 | 2013-06-19 | |
US201461952430P | 2014-03-13 | 2014-03-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20160157A1 true PE20160157A1 (es) | 2016-03-18 |
Family
ID=52105249
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2015002634A PE20160157A1 (es) | 2013-06-19 | 2014-06-18 | Moduladores de los receptores de estrogeno y sus usos |
Country Status (20)
Country | Link |
---|---|
US (2) | US9873684B2 (es) |
EP (1) | EP3010501B1 (es) |
JP (2) | JP6576916B2 (es) |
KR (1) | KR20160021277A (es) |
CN (1) | CN105324115B (es) |
AU (1) | AU2014281511A1 (es) |
BR (1) | BR112015031903A8 (es) |
CA (1) | CA2912853A1 (es) |
CL (1) | CL2015003456A1 (es) |
CR (1) | CR20150664A (es) |
EA (1) | EA031077B1 (es) |
HK (1) | HK1214532A1 (es) |
IL (1) | IL242611B (es) |
MX (1) | MX2015017655A (es) |
PE (1) | PE20160157A1 (es) |
PH (1) | PH12015502621A1 (es) |
SG (1) | SG11201509508YA (es) |
TW (1) | TW201501710A (es) |
UA (1) | UA117249C2 (es) |
WO (1) | WO2014205138A1 (es) |
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CA2915534A1 (en) | 2013-06-19 | 2014-12-24 | Seragon Pharmaceuticals, Inc. | Azetidine estrogen receptor modulators and uses thereof |
SG11201509508YA (en) * | 2013-06-19 | 2015-12-30 | Seragon Pharmaceuticals Inc | Estrogen receptor modulator and uses thereof |
EP2862880A1 (en) | 2013-10-16 | 2015-04-22 | Solvay Acetow GmbH | Acylation process |
WO2015138895A1 (en) | 2014-03-13 | 2015-09-17 | Indiana University Research And Technology Corporation | Hepatitis b core protein allosteric modulators |
MA39741A (fr) * | 2014-03-13 | 2017-01-18 | Hoffmann La Roche | Combinaisons thérapeutiques avec des modulateurs du récepteur des œstrogènes |
RU2016137150A (ru) | 2014-03-13 | 2018-04-18 | Ф. Хоффманн-Ля Рош Аг | Способы и композиции для модулирования мутантов эстрогеновых рецепторов |
CN107406424B (zh) | 2014-12-18 | 2020-08-25 | 豪夫迈·罗氏有限公司 | ***受体调节剂及其用途 |
JP2017538727A (ja) * | 2014-12-18 | 2017-12-28 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 癌の治療に有用な2,3−ジフェニルクロメンの誘導体 |
EA032311B1 (ru) | 2014-12-18 | 2019-05-31 | Ф. Хоффманн-Ля Рош Аг | Тетрагидро-пиридо[3,4-b]индоловые модуляторы эстрогеновых рецепторов и их применение |
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TWI721016B (zh) | 2015-09-15 | 2021-03-11 | 美商艾森伯利生物科學公司 | B型肝炎核心蛋白質調節劑 |
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TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
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RU2016137150A (ru) | 2014-03-13 | 2018-04-18 | Ф. Хоффманн-Ля Рош Аг | Способы и композиции для модулирования мутантов эстрогеновых рецепторов |
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JP2017538727A (ja) | 2014-12-18 | 2017-12-28 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 癌の治療に有用な2,3−ジフェニルクロメンの誘導体 |
CN107406424B (zh) | 2014-12-18 | 2020-08-25 | 豪夫迈·罗氏有限公司 | ***受体调节剂及其用途 |
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2014
- 2014-06-18 SG SG11201509508YA patent/SG11201509508YA/en unknown
- 2014-06-18 CA CA2912853A patent/CA2912853A1/en not_active Abandoned
- 2014-06-18 PE PE2015002634A patent/PE20160157A1/es unknown
- 2014-06-18 CN CN201480035316.2A patent/CN105324115B/zh active Active
- 2014-06-18 MX MX2015017655A patent/MX2015017655A/es unknown
- 2014-06-18 KR KR1020167001338A patent/KR20160021277A/ko not_active Application Discontinuation
- 2014-06-18 JP JP2016521557A patent/JP6576916B2/ja active Active
- 2014-06-18 WO PCT/US2014/043040 patent/WO2014205138A1/en active Application Filing
- 2014-06-18 EP EP14812952.1A patent/EP3010501B1/en active Active
- 2014-06-18 AU AU2014281511A patent/AU2014281511A1/en not_active Abandoned
- 2014-06-18 EA EA201592214A patent/EA031077B1/ru not_active IP Right Cessation
- 2014-06-18 UA UAA201600246A patent/UA117249C2/uk unknown
- 2014-06-18 BR BR112015031903A patent/BR112015031903A8/pt not_active Application Discontinuation
- 2014-06-19 TW TW103121277A patent/TW201501710A/zh unknown
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2015
- 2015-11-16 IL IL242611A patent/IL242611B/en not_active IP Right Cessation
- 2015-11-24 CL CL2015003456A patent/CL2015003456A1/es unknown
- 2015-11-24 PH PH12015502621A patent/PH12015502621A1/en unknown
- 2015-12-09 US US14/963,658 patent/US9873684B2/en active Active
- 2015-12-16 CR CR20150664A patent/CR20150664A/es unknown
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2016
- 2016-03-08 HK HK16102620.6A patent/HK1214532A1/zh unknown
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2017
- 2017-06-12 US US15/620,304 patent/US10227334B2/en active Active
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2019
- 2019-03-13 JP JP2019045520A patent/JP2019142871A/ja active Pending
Also Published As
Publication number | Publication date |
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US20160090378A1 (en) | 2016-03-31 |
CN105324115A (zh) | 2016-02-10 |
JP2019142871A (ja) | 2019-08-29 |
UA117249C2 (uk) | 2018-07-10 |
PH12015502621A1 (en) | 2016-03-07 |
MX2015017655A (es) | 2016-04-15 |
EP3010501A4 (en) | 2017-02-01 |
EP3010501A1 (en) | 2016-04-27 |
HK1214532A1 (zh) | 2016-07-29 |
KR20160021277A (ko) | 2016-02-24 |
AU2014281511A1 (en) | 2015-12-03 |
JP2016523253A (ja) | 2016-08-08 |
BR112015031903A2 (pt) | 2017-07-25 |
JP6576916B2 (ja) | 2019-09-18 |
CA2912853A1 (en) | 2014-12-24 |
WO2014205138A1 (en) | 2014-12-24 |
IL242611B (en) | 2018-10-31 |
TW201501710A (zh) | 2015-01-16 |
CR20150664A (es) | 2016-01-29 |
US10227334B2 (en) | 2019-03-12 |
EA031077B1 (ru) | 2018-11-30 |
EA201592214A1 (ru) | 2016-06-30 |
EP3010501B1 (en) | 2021-11-03 |
CL2015003456A1 (es) | 2016-07-29 |
BR112015031903A8 (pt) | 2019-12-31 |
US9873684B2 (en) | 2018-01-23 |
CN105324115B (zh) | 2019-01-04 |
US20170275273A1 (en) | 2017-09-28 |
SG11201509508YA (en) | 2015-12-30 |
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