BR112015027951A8 - arilquinazolinas, seus usos, medicamento, composição farmacêutica, e kit - Google Patents

arilquinazolinas, seus usos, medicamento, composição farmacêutica, e kit Download PDF

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Publication number
BR112015027951A8
BR112015027951A8 BR112015027951A BR112015027951A BR112015027951A8 BR 112015027951 A8 BR112015027951 A8 BR 112015027951A8 BR 112015027951 A BR112015027951 A BR 112015027951A BR 112015027951 A BR112015027951 A BR 112015027951A BR 112015027951 A8 BR112015027951 A8 BR 112015027951A8
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arylquinazolines
medication
kit
pharmaceutical composition
threonine
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BR112015027951A
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BR112015027951A2 (pt
BR112015027951B1 (pt
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Buchstaller Hans-Peter
Fuchss Thomas
Emde Ulrich
Mederski Werner
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Merck Patent Gmbh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
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    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D491/04—Ortho-condensed systems
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

resumo patente de invenção: "arilquinazolinas". a presente invenção refere-se a novos compostos da fórmula (i), que podem ser usados para inibição de quinase de serina, treonina, proteína, bem como para sensibilização de células cancerígenas em relação a agentes anticancerígenos e/ou à radiação ionizante.
BR112015027951-1A 2013-05-11 2014-05-08 Arilquinazolinas, seu uso e seu processo de produção, e composição farmacêutica BR112015027951B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102013008118.1 2013-05-11
DE102013008118.1A DE102013008118A1 (de) 2013-05-11 2013-05-11 Arylchinazoline
PCT/EP2014/001236 WO2014183850A1 (de) 2013-05-11 2014-05-08 Arylchinazoline

Publications (3)

Publication Number Publication Date
BR112015027951A2 BR112015027951A2 (pt) 2017-07-25
BR112015027951A8 true BR112015027951A8 (pt) 2019-12-24
BR112015027951B1 BR112015027951B1 (pt) 2022-05-31

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BR112015027951-1A BR112015027951B1 (pt) 2013-05-11 2014-05-08 Arilquinazolinas, seu uso e seu processo de produção, e composição farmacêutica

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US (5) US9732094B2 (pt)
EP (1) EP2994467B1 (pt)
JP (1) JP6562903B2 (pt)
KR (1) KR102292811B1 (pt)
CN (1) CN105358552B (pt)
AR (2) AR096235A1 (pt)
AU (1) AU2014267723B2 (pt)
BR (1) BR112015027951B1 (pt)
CA (1) CA2911668C (pt)
CL (1) CL2015003285A1 (pt)
DE (1) DE102013008118A1 (pt)
DK (1) DK2994467T3 (pt)
ES (1) ES2693774T3 (pt)
HK (1) HK1221719A1 (pt)
HR (1) HRP20181775T1 (pt)
HU (1) HUE041397T2 (pt)
IL (2) IL242348B (pt)
LT (1) LT2994467T (pt)
MX (1) MX362183B (pt)
MY (1) MY173126A (pt)
NZ (1) NZ713362A (pt)
PE (1) PE20152001A1 (pt)
PH (1) PH12015502339B1 (pt)
PL (1) PL2994467T3 (pt)
PT (1) PT2994467T (pt)
RS (1) RS57838B1 (pt)
RU (1) RU2701193C2 (pt)
SG (1) SG11201509268YA (pt)
SI (1) SI2994467T1 (pt)
TR (1) TR201816069T4 (pt)
UA (1) UA116020C2 (pt)
WO (1) WO2014183850A1 (pt)

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BR112019006504A2 (pt) 2016-10-06 2019-06-25 Merck Patent Gmbh regime de dosagem de avelumabe para o tratamento de câncer
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