BR112015024109A2 - derivados de ureia e seu uso como inibidores de proteína de ligação de ácidos graxos (fabp) - Google Patents

derivados de ureia e seu uso como inibidores de proteína de ligação de ácidos graxos (fabp)

Info

Publication number
BR112015024109A2
BR112015024109A2 BR112015024109A BR112015024109A BR112015024109A2 BR 112015024109 A2 BR112015024109 A2 BR 112015024109A2 BR 112015024109 A BR112015024109 A BR 112015024109A BR 112015024109 A BR112015024109 A BR 112015024109A BR 112015024109 A2 BR112015024109 A2 BR 112015024109A2
Authority
BR
Brazil
Prior art keywords
fabp
inhibitors
fatty acid
binding protein
acid binding
Prior art date
Application number
BR112015024109A
Other languages
English (en)
Inventor
Conte Aurelia
Buettelmann Bernd
Kuhn Bernd
Richter Hans
Kuehne Holger
M Ceccarelli Simona
Obst Sander Ulrike
Neidhart Werner
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112015024109A2 publication Critical patent/BR112015024109A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1854—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas by reactions not involving the formation of the N-C(O)-N- moiety
    • C07C273/1863—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas by reactions not involving the formation of the N-C(O)-N- moiety from urea
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • G01N33/5304—Reaction vessels, e.g. agglutination plates

Abstract

1/1 resumo "derivados de ureia e seu uso como inibidores de proteína de ligação de ácidos graxos (fabp)" a invenção proporciona novos compostos que possuem a fórmula geral (i) em que r1, r2, r3, r4, w, a e b são tal como descrito no presente documento, composições incluindo os compostos e métodos de utilização dos compostos.
BR112015024109A 2013-03-20 2014-03-17 derivados de ureia e seu uso como inibidores de proteína de ligação de ácidos graxos (fabp) BR112015024109A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13160088 2013-03-20
PCT/EP2014/055224 WO2014146995A1 (en) 2013-03-20 2014-03-17 Urea derivatives and their use as fatty-acid binding protein (fabp) inhibitors

Publications (1)

Publication Number Publication Date
BR112015024109A2 true BR112015024109A2 (pt) 2017-07-18

Family

ID=47900931

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015024109A BR112015024109A2 (pt) 2013-03-20 2014-03-17 derivados de ureia e seu uso como inibidores de proteína de ligação de ácidos graxos (fabp)

Country Status (13)

Country Link
US (1) US9278918B2 (pt)
EP (1) EP2991967A1 (pt)
JP (1) JP6235048B2 (pt)
KR (1) KR101804650B1 (pt)
CN (1) CN105308020B (pt)
AR (1) AR095570A1 (pt)
BR (1) BR112015024109A2 (pt)
CA (1) CA2898534C (pt)
HK (1) HK1214238A1 (pt)
MX (1) MX2015013365A (pt)
RU (1) RU2642454C2 (pt)
TW (1) TWI629258B (pt)
WO (1) WO2014146995A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3319959T (lt) 2015-07-06 2021-12-27 Alkermes, Inc. Histono deacetilazės hetero-halogeno inhibitoriai
WO2017007755A1 (en) 2015-07-06 2017-01-12 Rodin Therapeutics, Inc. Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase
WO2018066646A1 (ja) 2016-10-06 2018-04-12 第一三共株式会社 尿素誘導体
SG11201906164RA (en) 2017-01-11 2019-08-27 Rodin Therapeutics Inc Bicyclic inhibitors of histone deacetylase
JP7152471B2 (ja) 2017-08-07 2022-10-12 ロダン・セラピューティクス，インコーポレーテッド ヒストン脱アセチル化酵素の二環阻害剤
CN113401281B (zh) * 2021-08-17 2021-11-02 南通御美津精密工业有限公司 一种船体锚穴外板开口用的关闭装置
AU2022345018A1 (en) * 2021-09-15 2024-03-28 Celloram, Inc. Fabp4/5 inhibitors, methods of use and methods of making

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0091596B1 (de) * 1982-04-08 1991-09-11 Shell Internationale Researchmaatschappij B.V. Neue Hydantoine, ihre Herstellung und Verwendung
HUP0102101A3 (en) * 1997-11-10 2002-11-28 Bristol Myers Squibb Co Protein tyrosine kinase inhibitor benzothiazole derivatives and pharmaceutical compositions containing them
US6727247B2 (en) * 2001-12-10 2004-04-27 Hoffman-La Roche Inc. Substituted benzothiazole amide derivatives
ATE430728T1 (de) * 2002-10-21 2009-05-15 Janssen Pharmaceutica Nv Substituierte tetraline und indane und ihre verwendung
US7202269B2 (en) 2003-10-30 2007-04-10 Janssen Pharmaceutica N.V. GlyT2 modulators
FR2869903B1 (fr) * 2004-05-06 2006-06-23 Galderma Res & Dev Nouveaux composes bi-aromatiques activateurs des recepteurs de type ppary, leur procede de preparation et leur utilisation dans les compositions cosmetiques ou pharmaceutiques
JP4047365B2 (ja) * 2006-01-11 2008-02-13 生化学工業株式会社 シクロアルカンカルボキサミド誘導体及びその製造方法
WO2008000407A1 (en) * 2006-06-28 2008-01-03 Sanofi-Aventis Inhibitors of cxcr2
JP2010517964A (ja) * 2007-02-01 2010-05-27 グラクソ グループ リミテッド ＧｌｙＴ１トランスポーター阻害薬および神経学的および神経精神病学的障害の治療におけるその使用
WO2009034062A1 (en) * 2007-09-11 2009-03-19 Glaxo Group Limited Compounds which inhibit the glycine transporter and uses thereof in medicine
US8815875B2 (en) * 2008-11-12 2014-08-26 Merck Sharp & Dohme Corp. Inhibitors of fatty acid binding protein (FABP)

Also Published As

Publication number Publication date
AR095570A1 (es) 2015-10-28
US20160002152A1 (en) 2016-01-07
KR101804650B1 (ko) 2018-01-10
EP2991967A1 (en) 2016-03-09
CA2898534A1 (en) 2014-09-25
KR20150119357A (ko) 2015-10-23
RU2015140599A (ru) 2017-04-26
TWI629258B (zh) 2018-07-11
JP2016514106A (ja) 2016-05-19
CN105308020A (zh) 2016-02-03
WO2014146995A1 (en) 2014-09-25
MX2015013365A (es) 2016-01-08
US9278918B2 (en) 2016-03-08
RU2642454C2 (ru) 2018-01-25
JP6235048B2 (ja) 2017-11-22
HK1214238A1 (zh) 2016-07-22
CN105308020B (zh) 2018-01-26
TW201514138A (zh) 2015-04-16
CA2898534C (en) 2017-09-19

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements