BR112014012521A2 - novos derivados de pirrolidina como inibidores de catepsina - Google Patents
novos derivados de pirrolidina como inibidores de catepsinaInfo
- Publication number
- BR112014012521A2 BR112014012521A2 BR112014012521A BR112014012521A BR112014012521A2 BR 112014012521 A2 BR112014012521 A2 BR 112014012521A2 BR 112014012521 A BR112014012521 A BR 112014012521A BR 112014012521 A BR112014012521 A BR 112014012521A BR 112014012521 A2 BR112014012521 A2 BR 112014012521A2
- Authority
- BR
- Brazil
- Prior art keywords
- pyrrolidine derivatives
- cathepsin inhibitors
- new pyrrolidine
- new
- cathepsin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
resumo novos derivados de pirrolidina como inibidores de catepsina a invenção se refere a um composto da fórmula (i) (i) nnhoor2r3so2r5r6r7r4ar1 em que a e r1 a r7 são definidos como no relatório descritivo e nas reivindicações. o composto da formula (i) pode ser utilizado como um medicamento.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11190756 | 2011-11-25 | ||
PCT/EP2012/073073 WO2013076063A1 (en) | 2011-11-25 | 2012-11-20 | Novel pyrrolidine derivatives as inhibitors of cathepsin |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014012521A2 true BR112014012521A2 (pt) | 2017-06-06 |
Family
ID=47216270
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014012521A BR112014012521A2 (pt) | 2011-11-25 | 2012-11-20 | novos derivados de pirrolidina como inibidores de catepsina |
Country Status (11)
Country | Link |
---|---|
US (1) | US8729061B2 (pt) |
EP (1) | EP2782903B1 (pt) |
JP (1) | JP2014533707A (pt) |
KR (1) | KR20140102253A (pt) |
CN (1) | CN103946213A (pt) |
AR (1) | AR088969A1 (pt) |
BR (1) | BR112014012521A2 (pt) |
CA (1) | CA2854569A1 (pt) |
MX (1) | MX2014006211A (pt) |
RU (1) | RU2014123784A (pt) |
WO (1) | WO2013076063A1 (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6654636B2 (ja) | 2014-12-02 | 2020-02-26 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 新規ピペリジン誘導体 |
CR20180404A (es) * | 2016-02-26 | 2018-10-18 | Hoffmann La Roche | Nuevos derivados pirrolidina |
US10590084B2 (en) | 2016-03-09 | 2020-03-17 | Blade Therapeutics, Inc. | Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof |
US11292801B2 (en) | 2016-07-05 | 2022-04-05 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
MX2019003425A (es) | 2016-09-28 | 2019-08-16 | Blade Therapeutics Inc | Moduladores de calpainas y usos terapeuticos de los mismos. |
WO2023130334A1 (zh) * | 2022-01-07 | 2023-07-13 | 同润生物医药(上海)有限公司 | 一种色烯-4-酮化合物及其中间体的制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE602007013387D1 (de) * | 2006-05-23 | 2011-05-05 | Irm Llc | Verbindungen und zusammensetzungen als kanalaktivierende protease-hemmer |
WO2007137080A2 (en) * | 2006-05-23 | 2007-11-29 | Irm Llc | Compounds and compositions as channel activating protease inhibitors |
MX2009008518A (es) * | 2007-02-09 | 2009-08-20 | Irm Llc | Compuestos y composiciones como inhibidores de la proteasa activadora de canal. |
AU2008214214B2 (en) * | 2007-02-09 | 2011-09-15 | Irm Llc | Compounds and compositions as channel activating protease inhibitors |
WO2009100225A1 (en) | 2008-02-07 | 2009-08-13 | Virobay, Inc. | Inhibitors of cathepsin b |
KR101320790B1 (ko) | 2009-04-20 | 2013-10-22 | 에프. 호프만-라 로슈 아게 | 카텝신 억제제로서의 프롤린 유도체 |
-
2012
- 2012-11-20 KR KR1020147017362A patent/KR20140102253A/ko not_active Application Discontinuation
- 2012-11-20 WO PCT/EP2012/073073 patent/WO2013076063A1/en active Application Filing
- 2012-11-20 MX MX2014006211A patent/MX2014006211A/es not_active Application Discontinuation
- 2012-11-20 EP EP12788530.9A patent/EP2782903B1/en not_active Not-in-force
- 2012-11-20 BR BR112014012521A patent/BR112014012521A2/pt not_active IP Right Cessation
- 2012-11-20 CA CA2854569A patent/CA2854569A1/en not_active Abandoned
- 2012-11-20 US US13/681,470 patent/US8729061B2/en not_active Expired - Fee Related
- 2012-11-20 CN CN201280057430.6A patent/CN103946213A/zh active Pending
- 2012-11-20 JP JP2014542796A patent/JP2014533707A/ja active Pending
- 2012-11-20 RU RU2014123784/04A patent/RU2014123784A/ru not_active Application Discontinuation
- 2012-11-23 AR ARP120104409A patent/AR088969A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US20130137687A1 (en) | 2013-05-30 |
AR088969A1 (es) | 2014-07-23 |
EP2782903A1 (en) | 2014-10-01 |
KR20140102253A (ko) | 2014-08-21 |
CN103946213A (zh) | 2014-07-23 |
JP2014533707A (ja) | 2014-12-15 |
EP2782903B1 (en) | 2016-04-06 |
WO2013076063A1 (en) | 2013-05-30 |
CA2854569A1 (en) | 2013-05-30 |
US8729061B2 (en) | 2014-05-20 |
MX2014006211A (es) | 2014-08-08 |
RU2014123784A (ru) | 2015-12-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |