BR112015002390A2 - compostos - Google Patents

compostos

Info

Publication number
BR112015002390A2
BR112015002390A2 BR112015002390A BR112015002390A BR112015002390A2 BR 112015002390 A2 BR112015002390 A2 BR 112015002390A2 BR 112015002390 A BR112015002390 A BR 112015002390A BR 112015002390 A BR112015002390 A BR 112015002390A BR 112015002390 A2 BR112015002390 A2 BR 112015002390A2
Authority
BR
Brazil
Prior art keywords
compounds
optionally substituted
hydrogen atom
substituted alkyl
relates
Prior art date
Application number
BR112015002390A
Other languages
English (en)
Other versions
BR112015002390B1 (pt
BR112015002390A8 (pt
Inventor
Godal Aslak
Barry Charnock Colin
Klaveness Jo
Erik Braenden Jon
Olav Nilsen Nils
Original Assignee
Photocure Asa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Photocure Asa filed Critical Photocure Asa
Publication of BR112015002390A2 publication Critical patent/BR112015002390A2/pt
Publication of BR112015002390A8 publication Critical patent/BR112015002390A8/pt
Publication of BR112015002390B1 publication Critical patent/BR112015002390B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Biotechnology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

resumo patente de invenção: "compostos" . a invenção refere-se a novos derivados de ácido 5-aminolevulínico (5-ala) e a seus usos como agentes de fotossensibilização. em particular, refere-se a compostos de fórmula geral i e sais farmaceuticamente aceitáveis do mesmo, a métodos para a preparação desses compostos e a seus usos para fins médicos e cosméticos, por exemplo, em métodos de diagnóstico e terapia fotodinâmica: (i) em que r1 representa um átomo de hidrogênio ou um grupo alquila ou cicloalquila opcionalmente substituído; r2, cada um dos quais pode ser igual ou diferente, representa um átomo de hidrogênio ou um grupo alquila opcionalmente substituído; e x é um grupo de ligação.
BR112015002390-8A 2012-08-03 2013-08-02 Derivados do ácido 5-aminolevulínico (5-ala), sua composição e seu uso como agentes fotossensibilizantes BR112015002390B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12179277.4 2012-08-03
EP12179277 2012-08-03
EP12197305.1 2012-12-14
EP12197305 2012-12-14
PCT/EP2013/066317 WO2014020164A1 (en) 2012-08-03 2013-08-02 Compounds

Publications (3)

Publication Number Publication Date
BR112015002390A2 true BR112015002390A2 (pt) 2017-07-04
BR112015002390A8 BR112015002390A8 (pt) 2019-07-30
BR112015002390B1 BR112015002390B1 (pt) 2020-03-24

Family

ID=48948407

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015002390-8A BR112015002390B1 (pt) 2012-08-03 2013-08-02 Derivados do ácido 5-aminolevulínico (5-ala), sua composição e seu uso como agentes fotossensibilizantes

Country Status (19)

Country Link
US (1) US9249086B2 (pt)
EP (1) EP2880012B1 (pt)
JP (1) JP6280117B2 (pt)
KR (1) KR102180174B1 (pt)
CN (1) CN104661994B (pt)
AU (1) AU2013298525B2 (pt)
BR (1) BR112015002390B1 (pt)
CA (1) CA2880422C (pt)
CL (1) CL2015000233A1 (pt)
ES (1) ES2908080T3 (pt)
HK (1) HK1211283A1 (pt)
IL (1) IL236965B (pt)
IN (1) IN2015DN00837A (pt)
MX (1) MX364940B (pt)
NZ (1) NZ629914A (pt)
RU (1) RU2635563C2 (pt)
SG (1) SG11201500805VA (pt)
WO (1) WO2014020164A1 (pt)
ZA (1) ZA201500778B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015091037A1 (en) 2013-12-20 2015-06-25 Galderma Research & Development Pulse photodynamic treatment of photodamaged skin
ES2930848T3 (es) * 2015-09-23 2022-12-22 Xwpharma Ltd Profármacos de ácido gamma-hidroxibutírico, composiciones y usos de los mismos
JP6995755B2 (ja) * 2015-12-17 2022-01-17 フォトキュア エイエスエイ 膀胱癌に対する光線力学的療法（ｐｄｔ）の方法
GB201522398D0 (en) 2015-12-18 2016-02-03 Photocure As Device for photodynamic therapy
CN106187793A (zh) 2016-01-26 2016-12-07 赵鸣 5‑氨基酮戊酸及其衍生物的盐化合物和应用
ES2965514T3 (es) * 2017-06-21 2024-04-15 Photocure Asa Procedimiento de preparación de una composición farmacéutica líquida y dispositivo para su uso en dicho procedimiento
IL285384B1 (en) 2019-02-13 2024-07-01 Alpheus Medical Inc Non-invasive sonodynamic therapy

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07188133A (ja) 1993-12-27 1995-07-25 Asahi Chem Ind Co Ltd δ−アミノレブリン酸またはその同族体の製造法
US6492420B2 (en) 1995-03-10 2002-12-10 Photocure As Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
CZ291132B6 (cs) * 1995-03-10 2002-12-11 Photocure Asa Estery kyselin 5-aminolevulových a farmaceutický prostředek s jejich obsahem
US7530461B2 (en) 1995-03-10 2009-05-12 Photocure Asa Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
US6992107B1 (en) 1995-03-10 2006-01-31 Photocure Asa Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy
JPH1112197A (ja) 1997-06-18 1999-01-19 Cosmo Sogo Kenkyusho:Kk 悪性腫瘍診断剤及び治療剤
GB0018528D0 (en) 2000-07-27 2000-09-13 Photocure Asa Compounds
DE10202487A1 (de) 2002-01-23 2003-07-31 Photonamic Gmbh & Co Kg Dermales Applikationssystem für Aminolävulinsäure-Derivate
DE10312659A1 (de) 2003-03-21 2004-10-07 Universität Regensburg 5-Aminolävulinsäurederivate und ihre Verwendung
GB0406917D0 (en) 2004-03-26 2004-04-28 Photocure Asa Compounds
ES2355978T3 (es) * 2004-03-30 2011-04-01 Cosmo Oil Co., Ltd. Sal de fosfato de ácido 5-aminolevulinico, proceso para producir la misma y uso de la misma.
JP4417865B2 (ja) 2004-03-30 2010-02-17 コスモ石油株式会社 ５−アミノレブリン酸リン酸塩、その製造方法及びその用途
JP4719483B2 (ja) 2004-03-30 2011-07-06 コスモ石油株式会社 ５−アミノレブリン酸スルホン酸塩の製造方法
GB0424833D0 (en) 2004-11-10 2004-12-15 Photocure Asa Method
JP5404995B2 (ja) 2006-08-10 2014-02-05 コスモ石油株式会社 植物のポリフェノール増量剤
JP5039389B2 (ja) 2007-02-02 2012-10-03 コスモ石油株式会社 ホップのアルファ酸又はホップオイル含量向上剤
EP2130435B8 (en) 2007-03-30 2015-12-16 Cosmo Ala Co., Ltd. Agent for improving alkali resistance of plant and method for improving alkali resistance of plant
JP4705616B2 (ja) 2007-07-20 2011-06-22 コスモ石油株式会社 植物における金属成分の吸収向上剤
GB0724279D0 (en) * 2007-12-12 2008-01-23 Photocure Asa Use
AU2008337067A1 (en) * 2007-12-14 2009-06-25 Photoderma Sa Novel compounds useful in therapeutic and cosmetic methods
JP5472819B2 (ja) 2008-04-22 2014-04-16 Ｓｂｉファーマ株式会社 膀胱がん検出方法
CA2715901C (en) 2008-05-13 2016-05-17 Cosmo Oil Co., Ltd. Agent for improving lawn grass qualities comprising 5-aminolevulinic acid or a derivative thereof and a gibberellin biosynthesis inhibitor
JP5276894B2 (ja) 2008-05-13 2013-08-28 コスモ石油株式会社 イネの健苗育成向上剤
JP5323539B2 (ja) 2009-03-11 2013-10-23 コスモ石油株式会社 農作物の収穫部位の収量向上剤

Also Published As

Publication number Publication date
MX364940B (es) 2019-05-15
JP2015528814A (ja) 2015-10-01
BR112015002390B1 (pt) 2020-03-24
EP2880012A1 (en) 2015-06-10
CA2880422A1 (en) 2014-02-06
NZ629914A (en) 2017-02-24
RU2015104830A (ru) 2016-09-27
IN2015DN00837A (pt) 2015-06-12
CL2015000233A1 (es) 2015-04-24
CN104661994A (zh) 2015-05-27
EP2880012B1 (en) 2021-12-15
WO2014020164A1 (en) 2014-02-06
JP6280117B2 (ja) 2018-02-14
ZA201500778B (en) 2016-04-28
US9249086B2 (en) 2016-02-02
AU2013298525B2 (en) 2017-12-14
SG11201500805VA (en) 2015-02-27
ES2908080T3 (es) 2022-04-27
IL236965B (en) 2019-03-31
MX2015001374A (es) 2015-09-07
KR20150039208A (ko) 2015-04-09
CN104661994B (zh) 2017-08-08
BR112015002390A8 (pt) 2019-07-30
RU2635563C2 (ru) 2017-11-14
HK1211283A1 (en) 2016-05-20
AU2013298525A1 (en) 2015-03-05
US20150191419A1 (en) 2015-07-09
CA2880422C (en) 2021-02-09
KR102180174B1 (ko) 2020-11-19

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/08/2013, OBSERVADAS AS CONDICOES LEGAIS.