IN2015DN00837A - - Google Patents

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Publication number
IN2015DN00837A
IN2015DN00837A IN837DEN2015A IN2015DN00837A IN 2015DN00837 A IN2015DN00837 A IN 2015DN00837A IN 837DEN2015 A IN837DEN2015 A IN 837DEN2015A IN 2015DN00837 A IN2015DN00837 A IN 2015DN00837A
Authority
IN
India
Prior art keywords
compounds
optionally substituted
hydrogen atom
methods
substituted alkyl
Prior art date
Application number
Inventor
Jon Erik Braenden
Colin Barry Charnock
Aslak Godal
Jo Klaveness
Nils Olav Nilsen
Original Assignee
Photocure Asa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Photocure Asa filed Critical Photocure Asa
Publication of IN2015DN00837A publication Critical patent/IN2015DN00837A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Biotechnology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to new derivatives of 5-aminolevulinic acid (5-ALA) and their use as photosensitizing agents. In particular, it relates to compounds of general formula I and their pharmaceutically acceptable salts, to methods for preparing such compounds and their medical and cosmetic use, for example in methods of photodynamic therapy and diagnosis: wherein R 1 represents a hydrogen atom or an optionally substituted alkyl or cycloalkyl group; R2, each of which may be the same or different, represents a hydrogen atom or an optionally substituted alkyl group; and X is a linking group.
IN837DEN2015 2012-08-03 2013-08-02 IN2015DN00837A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12179277 2012-08-03
EP12197305 2012-12-14
PCT/EP2013/066317 WO2014020164A1 (en) 2012-08-03 2013-08-02 Compounds

Publications (1)

Publication Number Publication Date
IN2015DN00837A true IN2015DN00837A (en) 2015-06-12

Family

ID=48948407

Family Applications (1)

Application Number Title Priority Date Filing Date
IN837DEN2015 IN2015DN00837A (en) 2012-08-03 2013-08-02

Country Status (19)

Country Link
US (1) US9249086B2 (en)
EP (1) EP2880012B1 (en)
JP (1) JP6280117B2 (en)
KR (1) KR102180174B1 (en)
CN (1) CN104661994B (en)
AU (1) AU2013298525B2 (en)
BR (1) BR112015002390B1 (en)
CA (1) CA2880422C (en)
CL (1) CL2015000233A1 (en)
ES (1) ES2908080T3 (en)
HK (1) HK1211283A1 (en)
IL (1) IL236965B (en)
IN (1) IN2015DN00837A (en)
MX (1) MX364940B (en)
NZ (1) NZ629914A (en)
RU (1) RU2635563C2 (en)
SG (1) SG11201500805VA (en)
WO (1) WO2014020164A1 (en)
ZA (1) ZA201500778B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015091037A1 (en) 2013-12-20 2015-06-25 Galderma Research & Development Pulse photodynamic treatment of photodamaged skin
ES2930848T3 (en) * 2015-09-23 2022-12-22 Xwpharma Ltd Gamma-hydroxybutyric acid prodrugs, compositions and uses thereof
JP6995755B2 (en) * 2015-12-17 2022-01-17 フォトキュア エイエスエイ Method of photodynamic therapy (PDT) for bladder cancer
GB201522398D0 (en) 2015-12-18 2016-02-03 Photocure As Device for photodynamic therapy
CN106187793A (en) 2016-01-26 2016-12-07 赵鸣 5 aminolevulinic acids and the salt compound of derivant thereof and application
ES2965514T3 (en) * 2017-06-21 2024-04-15 Photocure Asa Procedure for preparing a liquid pharmaceutical composition and device for use in said procedure
IL285384B1 (en) 2019-02-13 2024-07-01 Alpheus Medical Inc Non-invasive sonodynamic therapy

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07188133A (en) 1993-12-27 1995-07-25 Asahi Chem Ind Co Ltd Production of delta-aminolevulinic acid or its homologue
US6492420B2 (en) 1995-03-10 2002-12-10 Photocure As Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
CZ291132B6 (en) * 1995-03-10 2002-12-11 Photocure Asa Esters of 5-aminolevullinic acids and pharmaceutical preparation in which the esters are comprised
US7530461B2 (en) 1995-03-10 2009-05-12 Photocure Asa Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
US6992107B1 (en) 1995-03-10 2006-01-31 Photocure Asa Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy
JPH1112197A (en) 1997-06-18 1999-01-19 Cosmo Sogo Kenkyusho:Kk Malignant tumor diagnostic agent and therapeutic agent
GB0018528D0 (en) 2000-07-27 2000-09-13 Photocure Asa Compounds
DE10202487A1 (en) 2002-01-23 2003-07-31 Photonamic Gmbh & Co Kg Dermal application system for aminolevulinic acid derivatives
DE10312659A1 (en) 2003-03-21 2004-10-07 Universität Regensburg New 5-aminolevulinic acid derivatives useful for photodynamic tumor therapy and/or diagnosis
GB0406917D0 (en) 2004-03-26 2004-04-28 Photocure Asa Compounds
ES2355978T3 (en) * 2004-03-30 2011-04-01 Cosmo Oil Co., Ltd. 5-AMINOLEVULINIC ACID PHOSPHATE SALT, PROCESS TO PRODUCE THE SAME AND USE OF THE SAME.
JP4417865B2 (en) 2004-03-30 2010-02-17 コスモ石油株式会社 5-Aminolevulinic acid phosphate, method for producing the same, and use thereof
JP4719483B2 (en) 2004-03-30 2011-07-06 コスモ石油株式会社 Process for producing 5-aminolevulinic acid sulfonate
GB0424833D0 (en) 2004-11-10 2004-12-15 Photocure Asa Method
JP5404995B2 (en) 2006-08-10 2014-02-05 コスモ石油株式会社 Plant polyphenol extender
JP5039389B2 (en) 2007-02-02 2012-10-03 コスモ石油株式会社 Hop alpha acid or hop oil content improver
EP2130435B8 (en) 2007-03-30 2015-12-16 Cosmo Ala Co., Ltd. Agent for improving alkali resistance of plant and method for improving alkali resistance of plant
JP4705616B2 (en) 2007-07-20 2011-06-22 コスモ石油株式会社 Absorption enhancer of metal components in plants
GB0724279D0 (en) * 2007-12-12 2008-01-23 Photocure Asa Use
AU2008337067A1 (en) * 2007-12-14 2009-06-25 Photoderma Sa Novel compounds useful in therapeutic and cosmetic methods
JP5472819B2 (en) 2008-04-22 2014-04-16 Ｓｂｉファーマ株式会社 Bladder cancer detection method
CA2715901C (en) 2008-05-13 2016-05-17 Cosmo Oil Co., Ltd. Agent for improving lawn grass qualities comprising 5-aminolevulinic acid or a derivative thereof and a gibberellin biosynthesis inhibitor
JP5276894B2 (en) 2008-05-13 2013-08-28 コスモ石油株式会社 Rice seedling raising improver
JP5323539B2 (en) 2009-03-11 2013-10-23 コスモ石油株式会社 Yield improver for crop crops

Also Published As

Publication number Publication date
MX364940B (en) 2019-05-15
JP2015528814A (en) 2015-10-01
BR112015002390B1 (en) 2020-03-24
EP2880012A1 (en) 2015-06-10
CA2880422A1 (en) 2014-02-06
NZ629914A (en) 2017-02-24
BR112015002390A2 (en) 2017-07-04
RU2015104830A (en) 2016-09-27
CL2015000233A1 (en) 2015-04-24
CN104661994A (en) 2015-05-27
EP2880012B1 (en) 2021-12-15
WO2014020164A1 (en) 2014-02-06
JP6280117B2 (en) 2018-02-14
ZA201500778B (en) 2016-04-28
US9249086B2 (en) 2016-02-02
AU2013298525B2 (en) 2017-12-14
SG11201500805VA (en) 2015-02-27
ES2908080T3 (en) 2022-04-27
IL236965B (en) 2019-03-31
MX2015001374A (en) 2015-09-07
KR20150039208A (en) 2015-04-09
CN104661994B (en) 2017-08-08
BR112015002390A8 (en) 2019-07-30
RU2635563C2 (en) 2017-11-14
HK1211283A1 (en) 2016-05-20
AU2013298525A1 (en) 2015-03-05
US20150191419A1 (en) 2015-07-09
CA2880422C (en) 2021-02-09
KR102180174B1 (en) 2020-11-19

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