BR112015001213A2 - pirimidinas fundidas como inibidores de complexo p97 - Google Patents
pirimidinas fundidas como inibidores de complexo p97Info
- Publication number
- BR112015001213A2 BR112015001213A2 BR112015001213A BR112015001213A BR112015001213A2 BR 112015001213 A2 BR112015001213 A2 BR 112015001213A2 BR 112015001213 A BR112015001213 A BR 112015001213A BR 112015001213 A BR112015001213 A BR 112015001213A BR 112015001213 A2 BR112015001213 A2 BR 112015001213A2
- Authority
- BR
- Brazil
- Prior art keywords
- complex inhibitors
- fused pyrimidines
- pyrimidines
- fused
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261674144P | 2012-07-20 | 2012-07-20 | |
US201261737666P | 2012-12-14 | 2012-12-14 | |
PCT/US2013/051358 WO2014015291A1 (en) | 2012-07-20 | 2013-07-19 | FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015001213A2 true BR112015001213A2 (pt) | 2018-05-22 |
Family
ID=48948500
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015001213A BR112015001213A2 (pt) | 2012-07-20 | 2013-07-19 | pirimidinas fundidas como inibidores de complexo p97 |
Country Status (19)
Country | Link |
---|---|
US (3) | US9062026B2 (pt) |
EP (2) | EP2875018B1 (pt) |
JP (2) | JP6109937B2 (pt) |
KR (1) | KR101862912B1 (pt) |
CN (2) | CN104768946B (pt) |
AU (1) | AU2013292309B2 (pt) |
BR (1) | BR112015001213A2 (pt) |
CA (1) | CA2879789C (pt) |
CL (1) | CL2015000132A1 (pt) |
EA (1) | EA030687B1 (pt) |
ES (1) | ES2667726T3 (pt) |
HK (1) | HK1210140A1 (pt) |
HU (1) | HUE037190T2 (pt) |
IL (1) | IL236812B (pt) |
MX (1) | MX2015000908A (pt) |
NZ (1) | NZ705040A (pt) |
TW (1) | TWI614246B (pt) |
WO (1) | WO2014015291A1 (pt) |
ZA (1) | ZA201500953B (pt) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014015291A1 (en) | 2012-07-20 | 2014-01-23 | Han-Jie Zhou | FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX |
JP6669499B2 (ja) | 2013-02-15 | 2020-03-18 | カラ ファーマシューティカルズ インコーポレイテッド | 治療用化合物 |
US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
EP2958895B1 (en) | 2013-02-20 | 2020-08-19 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
JPWO2015005491A1 (ja) | 2013-07-12 | 2017-03-02 | 国立大学法人京都大学 | 疾病の発症又は進行の一因となる異常スプライシングを抑制できる物質のスクリーニング方法 |
WO2015033981A1 (ja) | 2013-09-04 | 2015-03-12 | 国立大学法人京都大学 | レプチン抵抗性を改善する医薬組成物 |
MX355330B (es) | 2013-11-01 | 2018-04-16 | Kala Pharmaceuticals Inc | Formas cristalinas de compuestos terapeuticos y sus usos. |
US9890173B2 (en) | 2013-11-01 | 2018-02-13 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
WO2015089218A1 (en) | 2013-12-10 | 2015-06-18 | David Wustrow | Monocyclic pyrimidine/pyridine compounds as inhibitors of p97 complex |
SG11201605699QA (en) * | 2014-01-20 | 2016-08-30 | Cleave Biosciences Inc | FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX |
US20170159101A1 (en) * | 2014-07-09 | 2017-06-08 | Cleave Biosciences, Inc. | Drug-resistant p97 atpase mutations |
TW201617368A (zh) * | 2014-09-05 | 2016-05-16 | 史坦森特瑞斯公司 | 新穎抗mfi2抗體及使用方法 |
WO2016154110A1 (en) * | 2015-03-20 | 2016-09-29 | Cleave Biosciences, Inc. | Companion diagnostic for p97 inhibitor therapy and methods of use thereof |
WO2016200840A1 (en) * | 2015-06-08 | 2016-12-15 | Cleave Biosciences, Inc. | Mono and bicyclic ring boronic acid, ester and salt compounds as inhibitors of p97 complex |
CN108135906A (zh) * | 2015-07-24 | 2018-06-08 | 路易斯维尔大学研究基金会有限公司 | 治病化合物、组合物、方法、及化合物制备方法 |
CA3000565C (en) * | 2015-10-02 | 2023-09-26 | Sentinel Oncology Limited | 2-aminoquinazoline derivatives as p70s6 kinase inhibitors |
WO2017070320A1 (en) | 2015-10-21 | 2017-04-27 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Phenyl indole allosteric inhibitors of p97 atpase |
IT201600070952A1 (it) * | 2016-07-07 | 2018-01-07 | Univ Degli Studi Di Ferrara | NUOVI TIAZOLO[5,4-d]PIRIMIDIN DERIVATI QUALI AGONISTI INVERSI DEI RECETTORI A2A DELL’ADENOSINA |
US10392399B2 (en) | 2016-09-08 | 2019-08-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
MX2019002629A (es) | 2016-09-08 | 2019-10-07 | Kala Pharmaceuticals Inc | Formas cristalinas de compuestos terapéuticos y usos de los mismos. |
US10253036B2 (en) | 2016-09-08 | 2019-04-09 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
IT201600130706A1 (it) | 2016-12-23 | 2018-06-23 | Fondazione St Italiano Tecnologia | 4 amino-2-pirido-biciclo pirimidine e lo uso come medicamenti |
US11845742B2 (en) * | 2017-11-14 | 2023-12-19 | Rutgers, The State University Of New Jersey | Therapeutic compounds and methods to treat infection |
US20230133165A1 (en) * | 2017-11-16 | 2023-05-04 | Principia Biopharma Inc. | Immunoproteasome inhibitors |
US20200360386A1 (en) * | 2017-12-30 | 2020-11-19 | Unity Biotechnology, Inc. | Inhibitors of HSP90, PI3-Kinase, Proteasome, HDAC, and P97 Pathways for Selective Removal of Senescent Cells in the Treatment of Age Related Conditions |
TW201942116A (zh) * | 2018-02-09 | 2019-11-01 | 美商輝瑞股份有限公司 | 作為抗癌劑之四氫喹唑啉衍生物 |
KR20210146288A (ko) * | 2019-03-01 | 2021-12-03 | 레볼루션 메디슨즈, 인크. | 이환식 헤테로사이클릴 화합물 및 이의 용도 |
CN110339828B (zh) * | 2019-07-19 | 2020-08-11 | 浙江大学 | 以苯并噻唑基硫代羧酸为功能配基的层析介质及其制备方法 |
MX2022005525A (es) | 2019-11-08 | 2022-06-08 | Revolution Medicines Inc | Compuestos de heteroarilo bicíclicos y usos de estos. |
JP2022170472A (ja) * | 2021-04-28 | 2022-11-10 | 国立大学法人京都大学 | 皮膚組織の異常を改善するための組成物 |
GB202111193D0 (en) | 2021-08-03 | 2021-09-15 | Phoremost Ltd | Pharmaceutical compounds |
CN114105887B (zh) * | 2021-09-16 | 2023-12-01 | 沈阳药科大学 | 一种氨基嘧啶衍生物及其制备方法和用途 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998010779A1 (en) | 1996-09-13 | 1998-03-19 | New York University | Method for treating parasitic diseases with proteasome inhibitors |
ES2290743T3 (es) * | 2003-04-30 | 2008-02-16 | The Institutes For Pharmaceutical Discovery, Llc | Heteroarilos sustituidos como inhibidores de las proteina-tirosina fosfatasas. |
EP1885744B1 (en) | 2005-05-27 | 2010-10-06 | Proteolix, Inc. | Substrate for rpn 11 enzymatic activity |
WO2007041282A2 (en) * | 2005-09-29 | 2007-04-12 | The Johns Hopkins University | Methods and compositions for treatment of cystic fibrosis |
WO2008152390A1 (en) | 2007-06-12 | 2008-12-18 | F.Hoffmann-La Roche Ag | Thiazoliopyrimidines and their use as inhibitors of phosphatidylinositol-3 kinase |
WO2009011910A2 (en) * | 2007-07-18 | 2009-01-22 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Serices | Imidazolidinone compounds, methods to inhibit deubiquitination and methods of treatment |
EP2445346A4 (en) | 2009-06-24 | 2012-12-05 | Genentech Inc | OXOHETEROCYCLIC FUSIONED PYRIMIDINE COMPOUNDS AND COMPOSITIONS AND METHOD FOR THEIR USE |
AU2010283769B2 (en) * | 2009-08-10 | 2015-09-17 | F. Hoffmann-La Roche Ag | Inhibitors of JNK |
AU2011249859B2 (en) * | 2010-05-07 | 2014-07-03 | California Institute Of Technology | Methods and compositions for inhibition of the transitional endoplasmic reticulum ATPase |
JP2013166700A (ja) | 2010-06-02 | 2013-08-29 | Dainippon Sumitomo Pharma Co Ltd | 新規4,5−縮環ピリミジン誘導体 |
WO2014015291A1 (en) | 2012-07-20 | 2014-01-23 | Han-Jie Zhou | FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX |
-
2013
- 2013-07-19 WO PCT/US2013/051358 patent/WO2014015291A1/en active Application Filing
- 2013-07-19 CN CN201380048509.7A patent/CN104768946B/zh active Active
- 2013-07-19 US US13/946,795 patent/US9062026B2/en active Active
- 2013-07-19 US US14/416,033 patent/US9475824B2/en active Active
- 2013-07-19 HU HUE13745937A patent/HUE037190T2/hu unknown
- 2013-07-19 EA EA201590255A patent/EA030687B1/ru not_active IP Right Cessation
- 2013-07-19 CA CA2879789A patent/CA2879789C/en active Active
- 2013-07-19 CN CN201710222449.6A patent/CN107459508A/zh active Pending
- 2013-07-19 ES ES13745937.6T patent/ES2667726T3/es active Active
- 2013-07-19 EP EP13745937.6A patent/EP2875018B1/en active Active
- 2013-07-19 MX MX2015000908A patent/MX2015000908A/es unknown
- 2013-07-19 AU AU2013292309A patent/AU2013292309B2/en active Active
- 2013-07-19 BR BR112015001213A patent/BR112015001213A2/pt not_active IP Right Cessation
- 2013-07-19 EP EP16200986.4A patent/EP3208270A1/en not_active Withdrawn
- 2013-07-19 KR KR1020157004477A patent/KR101862912B1/ko active IP Right Grant
- 2013-07-19 JP JP2015523293A patent/JP6109937B2/ja active Active
- 2013-07-19 NZ NZ705040A patent/NZ705040A/en not_active IP Right Cessation
- 2013-07-22 TW TW102126210A patent/TWI614246B/zh active
-
2015
- 2015-01-20 IL IL236812A patent/IL236812B/en active IP Right Grant
- 2015-01-20 CL CL2015000132A patent/CL2015000132A1/es unknown
- 2015-02-10 ZA ZA2015/00953A patent/ZA201500953B/en unknown
- 2015-10-29 HK HK15110723.6A patent/HK1210140A1/xx unknown
-
2016
- 2016-09-13 US US15/264,007 patent/US10010554B2/en active Active
-
2017
- 2017-03-08 JP JP2017043608A patent/JP2017125053A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112015001213A2 (pt) | pirimidinas fundidas como inibidores de complexo p97 | |
CO7091186A2 (es) | N-ciclilamidas como nematicidas | |
DK2841428T3 (da) | Dna-pk-inhibitorer | |
ES2643056T3 (es) | Piridina-2-amidas útiles como agonistas de cb2 | |
CL2013001163S1 (es) | Maquina de afeitar | |
BR112015003218A2 (pt) | pirazolil-ureias como inibidores de cinase | |
CO6880068A2 (es) | Aminoquinazolinas como inhibidores de quinasa | |
FI20125861A (fi) | Tiivistetty pipetti | |
CO7020919A2 (es) | Derivados de tetrahidro-quinazolinona | |
CL2014002030A1 (es) | Alfa-amilasa | |
BR112015002950A2 (pt) | novos derivados de bicíclico-piridina | |
CL2013001162S1 (es) | Maquina de afeitar | |
FR2997393B1 (fr) | Suspension calco-magnesienne maniable | |
DE112012006872T8 (de) | Numeriksteuervorrichtung | |
CO7020914A2 (es) | Nievos derivados de morofolinilo útiles como inhibidores de mogat-2 | |
BR112014016917A2 (pt) | processamento de células | |
FI20125972A (fi) | Sovitin | |
DE102012112915A8 (de) | Phosphorspender | |
FR2994990B1 (fr) | Volet de desenfumage | |
ES1076665Y (es) | Transportador manual de paellas | |
FR2997712B1 (fr) | Manchon de raccordement | |
ES1076984Y (es) | Transportador de palots | |
DK2875120T3 (da) | Amylasedeficient stamme | |
FI10573U1 (fi) | Hitsaustyöasema | |
ES1078331Y (es) | Pieza de reposteria decorable |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2629 DE 25-05-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |