CO7020919A2 - Derivados de tetrahidro-quinazolinona - Google Patents

Derivados de tetrahidro-quinazolinona

Info

Publication number
CO7020919A2
CO7020919A2 CO14165918A CO14165918A CO7020919A2 CO 7020919 A2 CO7020919 A2 CO 7020919A2 CO 14165918 A CO14165918 A CO 14165918A CO 14165918 A CO14165918 A CO 14165918A CO 7020919 A2 CO7020919 A2 CO 7020919A2
Authority
CO
Colombia
Prior art keywords
tetrahydroquinazolinone
derivatives
tetrahydroquinazolinone derivatives
Prior art date
Application number
CO14165918A
Other languages
English (en)
Inventor
Hans-Peter Buchstaller
Christina Esdar
Brigitta Leuthner
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47628092&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO7020919(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of CO7020919A2 publication Critical patent/CO7020919A2/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/95Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
CO14165918A 2012-02-09 2014-07-30 Derivados de tetrahidro-quinazolinona CO7020919A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12000841 2012-02-09

Publications (1)

Publication Number Publication Date
CO7020919A2 true CO7020919A2 (es) 2014-08-11

Family

ID=47628092

Family Applications (1)

Application Number Title Priority Date Filing Date
CO14165918A CO7020919A2 (es) 2012-02-09 2014-07-30 Derivados de tetrahidro-quinazolinona

Country Status (32)

Country Link
US (1) US9339503B2 (es)
EP (1) EP2812323B1 (es)
JP (1) JP6116592B2 (es)
KR (1) KR20140121477A (es)
CN (1) CN104093714B (es)
AR (1) AR089944A1 (es)
AU (1) AU2013218357B2 (es)
BR (1) BR112014019357A8 (es)
CA (1) CA2863991C (es)
CL (1) CL2014002097A1 (es)
CO (1) CO7020919A2 (es)
DK (1) DK2812323T3 (es)
EA (1) EA026611B1 (es)
EC (1) ECSP14017586A (es)
ES (1) ES2579980T3 (es)
HK (1) HK1202551A1 (es)
HR (1) HRP20160735T1 (es)
HU (1) HUE029717T2 (es)
IL (1) IL233984A (es)
MX (1) MX349736B (es)
NZ (1) NZ630170A (es)
PE (1) PE20141823A1 (es)
PH (1) PH12014501581B1 (es)
PL (1) PL2812323T3 (es)
PT (1) PT2812323T (es)
RS (1) RS55377B1 (es)
SG (1) SG11201404654SA (es)
SI (1) SI2812323T1 (es)
TW (1) TWI572593B (es)
UA (1) UA116627C2 (es)
WO (1) WO2013117288A1 (es)
ZA (1) ZA201406579B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX346147B (es) 2012-03-07 2017-03-09 Inst Of Cancer Research: Royal Cancer Hospital (The) Compuestos de 3-aril-5-substituido-isoquinolin-1-ona y su uso terapeutico.
US9505749B2 (en) 2012-08-29 2016-11-29 Amgen Inc. Quinazolinone compounds and derivatives thereof
DK2938598T3 (en) 2012-12-31 2017-02-13 Cadila Healthcare Ltd Substituted phthalazine-1 (2H) -one derivatives as selective inhibitors of poly (adp-ribose) polymerase-1
CA2922469A1 (en) 2013-09-11 2015-03-19 Institute Of Cancer Research: Royal Cancer Hospital (The) 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
WO2015069512A1 (en) 2013-11-07 2015-05-14 Eli Lilly And Company PYRIDO[2,3-d]PYRIMIDIN-4-ONE COMPOUNDS AS TANKYRASE INHIBITORS
US10316025B2 (en) 2015-06-03 2019-06-11 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof
KR101777475B1 (ko) * 2015-12-08 2017-09-11 에스티팜 주식회사 신규한 디히드로피라노피리미디논 유도체 및 이들의 용도
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
NZ749946A (en) * 2016-06-30 2023-11-24 Yakult Honsha Kk Novel compound or pharmaceutically acceptable salt thereof
CN108727302A (zh) * 2017-10-23 2018-11-02 科迈化工股份有限公司 一种环保型n-叔丁基-2-苯并噻唑次磺酰胺(ns)合成工艺
US20210060016A1 (en) * 2017-12-27 2021-03-04 Japanese Foundation For Cancer Research Anticancer agent
JP7288161B2 (ja) 2017-12-27 2023-06-07 国立研究開発法人理化学研究所 新規ジヒドロキナゾリノン系化合物又はその薬理学的に許容される塩、及び細胞増殖阻害剤
MA51777A (fr) 2018-08-16 2021-04-21 Hoffmann La Roche Composés cycliques condensés

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
TR199801530T2 (xx) 1996-02-13 1998-11-23 Zeneca Limited VEGF �nhibit�rleri olarak kinazolin t�revleri.
JP4464466B2 (ja) 1996-03-05 2010-05-19 アストラゼネカ・ユーケイ・リミテッド 4―アニリノキナゾリン誘導体
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
WO2001092224A1 (en) 2000-05-31 2001-12-06 Astrazeneca Ab Indole derivatives with vascular damaging activity
BR0112225A (pt) 2000-07-07 2003-05-06 Angiogene Pharm Ltd Composto, composição farmacêutica, uso de um composto, e, processo papa preparar um composto
IL153484A0 (en) 2000-07-07 2003-07-06 Angiogene Pharm Ltd Colchinol derivatives as angiogenesis inhibitors
AUPR201600A0 (en) * 2000-12-11 2001-01-11 Fujisawa Pharmaceutical Co., Ltd. Quinazolinone derivative
AUPR975601A0 (en) 2001-12-24 2002-01-31 Fujisawa Pharmaceutical Co., Ltd. Quinazolinone derivatives
AUPS019702A0 (en) * 2002-01-29 2002-02-21 Fujisawa Pharmaceutical Co., Ltd. Condensed heterocyclic compounds
DE602005026391D1 (de) * 2004-06-30 2011-03-31 Janssen Pharmaceutica Nv Chinazolinonderivate als parp-hemmer
JP5102196B2 (ja) * 2005-03-11 2012-12-19 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング テトラヒドロキナゾリノンおよびジヒドロキナゾリノン
US8299256B2 (en) 2007-03-08 2012-10-30 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP and TANK inhibitors
WO2011078143A1 (ja) 2009-12-22 2011-06-30 塩野義製薬株式会社 ピリミジン誘導体およびそれらを含有する医薬組成物
WO2011111880A1 (ko) * 2010-03-08 2011-09-15 주식회사 메디젠텍 세포핵에서 세포질로의 gsk3의 이동을 억제하는 화합물을 함유하는 세포핵에서 세포질로의 gsk3 이동에 의해 발생되는 질환의 치료 또는 예방용 약학적 조성물

Also Published As

Publication number Publication date
RS55377B1 (sr) 2017-03-31
ZA201406579B (en) 2015-12-23
EP2812323B1 (en) 2016-04-06
US9339503B2 (en) 2016-05-17
PH12014501581A1 (en) 2014-10-08
DK2812323T3 (en) 2016-05-09
JP6116592B2 (ja) 2017-04-19
WO2013117288A1 (en) 2013-08-15
TW201336828A (zh) 2013-09-16
AR089944A1 (es) 2014-10-01
CN104093714B (zh) 2016-08-24
NZ630170A (en) 2016-03-31
SI2812323T1 (sl) 2016-08-31
AU2013218357A1 (en) 2014-09-25
CN104093714A (zh) 2014-10-08
UA116627C2 (uk) 2018-04-25
CA2863991C (en) 2020-08-11
BR112014019357A8 (pt) 2017-07-11
AU2013218357B2 (en) 2017-01-05
JP2015506965A (ja) 2015-03-05
HK1202551A1 (zh) 2015-10-02
PT2812323T (pt) 2016-07-13
PE20141823A1 (es) 2014-11-29
MX2014009491A (es) 2014-08-29
AU2013218357A8 (en) 2015-01-22
IL233984A (en) 2017-09-28
US20150025071A1 (en) 2015-01-22
PL2812323T3 (pl) 2016-09-30
MX349736B (es) 2017-08-10
EP2812323A1 (en) 2014-12-17
EA201400879A1 (ru) 2015-01-30
ES2579980T3 (es) 2016-08-18
SG11201404654SA (en) 2014-09-26
PH12014501581B1 (en) 2014-10-08
HRP20160735T1 (hr) 2016-07-29
BR112014019357A2 (es) 2017-06-20
TWI572593B (zh) 2017-03-01
EA026611B1 (ru) 2017-04-28
WO2013117288A8 (en) 2014-07-31
HUE029717T2 (en) 2017-03-28
CL2014002097A1 (es) 2014-11-07
ECSP14017586A (es) 2015-09-30
CA2863991A1 (en) 2013-08-15
KR20140121477A (ko) 2014-10-15

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