BR112015000475A2 - métodos de indução de anestesia - Google Patents

métodos de indução de anestesia

Info

Publication number
BR112015000475A2
BR112015000475A2 BR112015000475A BR112015000475A BR112015000475A2 BR 112015000475 A2 BR112015000475 A2 BR 112015000475A2 BR 112015000475 A BR112015000475 A BR 112015000475A BR 112015000475 A BR112015000475 A BR 112015000475A BR 112015000475 A2 BR112015000475 A2 BR 112015000475A2
Authority
BR
Brazil
Prior art keywords
anesthetic
provides methods
methods
selectivity
determining
Prior art date
Application number
BR112015000475A
Other languages
English (en)
Inventor
J Brosnan Robert
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of BR112015000475A2 publication Critical patent/BR112015000475A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A61D7/04—Devices for anaesthetising animals by gases or vapours; Inhaling devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/01—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes specially adapted for anaesthetising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

abstract of the disclosure [0234] the present invention provides methods for determining the selectivity of an anesthetic for an anesthetic-sensitive receptor by determining the molar water solubility of the anesthetic. the invention further provides methods for modulating the selectivity of an anesthetic for an anesthetic-sensitive receptor by altering or modifying the anesthetic to have higher or lower water solubility. the invention further provides methods of inducing anesthesia in a subject by administering via the respiratory pathways (e.g., via inhalational or pulmonary delivery) an effective amount of an anesthetic compound identified according to the present methods. tradução do resumo resumo patente de invenção: "métodos de indução de anestesia". a presente invenção proporciona métodos para determinar a seletividade de um anestésico por um receptor sensível ao anestésico através de determinação da solubilidade em água molar do anestésico. a invenção proporciona ainda métodos para modulação da seletividade de um anestésico por um receptor sensível ao anestésico ao alterar ou modificar o anestésico para ter maior ou menor solubilidade em água. a invenção proporciona ainda métodos para induzir à anestesia em um indivíduo por meio de administração, através das vias respiratórias (por exemplo, através de distribuição por inalação ou pulmonar) de uma quantidade eficaz de um composto anestésico identificado de acordo com os presentes métodos.
BR112015000475A 2012-07-10 2013-03-14 métodos de indução de anestesia BR112015000475A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261670098P 2012-07-10 2012-07-10
US201261681747P 2012-08-10 2012-08-10
PCT/US2013/031668 WO2014011235A1 (en) 2012-07-10 2013-03-14 Methods of inducing anesthesia

Publications (1)

Publication Number Publication Date
BR112015000475A2 true BR112015000475A2 (pt) 2017-08-08

Family

ID=49914505

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015000475A BR112015000475A2 (pt) 2012-07-10 2013-03-14 métodos de indução de anestesia

Country Status (12)

Country Link
US (6) US20140018414A1 (pt)
EP (3) EP4032533A1 (pt)
JP (4) JP2015525757A (pt)
KR (4) KR20230078698A (pt)
CN (3) CN116585292A (pt)
AU (4) AU2013289204B2 (pt)
BR (1) BR112015000475A2 (pt)
CA (2) CA2878686A1 (pt)
GB (1) GB2507936A (pt)
IL (3) IL301618A (pt)
IN (1) IN2015KN00299A (pt)
WO (2) WO2014011235A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107898791A (zh) 2010-06-03 2018-04-13 药品循环有限责任公司 布鲁顿酪氨酸激酶(btk)抑制剂的应用
EP4032533A1 (en) 2012-07-10 2022-07-27 The Regents of The University of California Methods of inducing anesthesia
KR20150032340A (ko) 2012-07-24 2015-03-25 파마시클릭스, 인코포레이티드 브루톤 티로신 키나제(btk)의 억제제에 대한 내성과 관련된 돌연변이
US9885086B2 (en) 2014-03-20 2018-02-06 Pharmacyclics Llc Phospholipase C gamma 2 and resistance associated mutations
WO2015187918A2 (en) * 2014-06-05 2015-12-10 The Regents Of The University Of California Halogenated ether compounds and methods of inducing anesthesia
EP3040061A1 (en) * 2015-01-02 2016-07-06 Fitesa Germany GmbH Nonwoven fabric and process for forming the same
CN105168202A (zh) * 2015-10-09 2015-12-23 烟台毓璜顶医院 一种吸入式复合麻醉维持剂
US10467138B2 (en) * 2015-12-28 2019-11-05 Advanced Micro Devices, Inc. Caching policies for processing units on multiple sockets
WO2020050249A1 (ja) * 2018-09-03 2020-03-12 東ソ－株式会社 ヘキサフルオロプロピレンオキシドへのアルデヒド類付加体、トリフルオロピルビン酸フルオリドダイマーの製造方法およびパーフルオロ（２，４－ジメチル－２－フルオロホルミル－１，３－ジオキソラン）の製造方法
CN112638891A (zh) 2018-09-03 2021-04-09 东曹株式会社 六氟环氧丙烷的醛类加成物、三氟丙酮酰氟二聚体的制造方法及全氟(2,4-二甲基-2-氟甲酰基-1,3-二氧戊环)的制造方法
JP7307586B2 (ja) * 2019-04-26 2023-07-12 東ソー株式会社 パーフルオロ（２，４－ジメチル－２－フルオロホルミル－１，３－ジオキソラン）の製造方法
JP7307587B2 (ja) * 2018-09-03 2023-07-12 東ソー株式会社 ヘキサフルオロプロピレンオキシドへのアルデヒド類付加体、およびトリフルオロピルビン酸フルオリドダイマーの製造方法
US11325893B2 (en) * 2018-09-26 2022-05-10 3M Innovative Properties Company Hydrofluoroethers and methods of using same
KR20210102936A (ko) * 2018-12-10 2021-08-20 헤일로 사이언스 엘엘씨 안정적인 마취제 제제 및 관련 복용량 형태
WO2021146371A1 (en) * 2020-01-17 2021-07-22 Expanesthetics, Inc. Method of inducing analgesia using a halogenated alcohol
WO2022204459A1 (en) * 2021-03-25 2022-09-29 University Of Florida Research Foundation, Inc. Methods and compositions for treatment of low circulating testosterone conditions

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1069639B (de) 1959-11-26 Salline Ludwigshalle A.G., Bad Wimpfen Verfahren zur Herstellung von cyclischen Perfluorkohlcnstoffäthern mit 5- oder 6-gliedrigen Ringen
US2594272A (en) 1948-09-10 1952-04-29 Minnesota Mining & Mfg Cyclic fluoroalkylene oxide compounds
GB718318A (en) 1952-06-24 1954-11-10 Minnesota Mining & Mfg Improvements in or relating to process of preparing cyclic fluoroalkylene oxide compounds and the cyclic fluoroalkylene oxide compounds resulting from said process
ES251349A1 (es) 1958-08-21 1960-01-16 Ludwigshalle Saline PROCEDIMIENTO PARA LA OBTENCIoN DE ÉTERES PERFLUOROCARBoNICOS CiCLICOS CON ANILLOS DE 5 o 6 MIEMBROS
US3187748A (en) 1963-04-29 1965-06-08 Merck And Company Inc Inhalation-actuated aerosol device
US3314850A (en) * 1965-09-17 1967-04-18 Allied Chem 2, 2-bis(trifluoromethyl)-1, 3-dioxolane as inhalation anesthetic
US3476860A (en) 1966-12-08 1969-11-04 Air Reduction Halomethyl fluoroisopropyl ethers as anesthetic agents
US3565070A (en) 1969-02-28 1971-02-23 Riker Laboratories Inc Inhalation actuable aerosol dispenser
NL7103057A (pt) 1970-03-12 1971-09-14
US3683092A (en) 1970-07-31 1972-08-08 Baxter Laboratories Inc Method of anesthesia
JPS4812742B1 (pt) 1970-08-17 1973-04-23
JPS4927588B1 (pt) 1970-10-14 1974-07-18
US3749791A (en) * 1971-07-15 1973-07-31 Airco Inc Fluorine or chlorine-substituted 2,2-bis(trifluoromethyl)-1,3-dioxolane anesthetics
NO134730L (pt) 1971-07-19 1900-01-01
US3749793A (en) * 1971-08-02 1973-07-31 Airco Inc Ether compounds as inhalation anesthetics
US3870797A (en) 1971-08-09 1975-03-11 Grace W R & Co Anesthetic halogenated cyclobutanes
NL7115894A (pt) * 1971-08-09 1973-02-13
US3954893A (en) 1971-08-09 1976-05-04 W. R. Grace & Co. New halogenated cyclobutanes
NL7115893A (pt) 1971-08-09 1973-02-13
US3749794A (en) * 1971-08-13 1973-07-31 Airco Inc Ether compounds as inhalation anesthetics
US3897502A (en) 1971-10-22 1975-07-29 Airco Inc Process for making fluorinated ethers
GB1413285A (en) 1971-11-25 1975-11-12 Bespak Industries Ltd Aerosol devices
US4060532A (en) 1972-03-15 1977-11-29 Ici United States Inc. Halogenated dioxolane tranquilizers
GB1448981A (en) * 1972-06-09 1976-09-08 Ici Ltd Fluorinated dioxan derivatives
US4017519A (en) 1973-04-05 1977-04-12 Airco, Inc. Fluoro dioxolane anesthetic compounds
US4113435A (en) 1973-07-16 1978-09-12 Massachusetts Institute Of Technology Cryogenically controlled direct fluorination apparatus
JPS514994B2 (pt) 1974-01-31 1976-02-16
DE2520962A1 (de) 1975-05-12 1976-12-02 Hoechst Ag 1.2.2.2-tetrafluoraethyl-fluormethylaether und verfahren zu dessen herstellung
DE2524956A1 (de) 1975-06-05 1976-12-16 Hoechst Ag 2-hydro-perfluor-n-propyl-fluormethylaether und verfahren zu seiner herstellung
DE2604350A1 (de) * 1975-09-22 1977-03-24 Stanford Research Inst Anaesthetisch wirksame halogen-substituierte 2,2-difluor-1,3-dioxolane und verfahren zur inhalations-anaesthesie
JPS5145594B2 (pt) 1975-12-10 1976-12-04
JPS5325552A (en) 1976-08-21 1978-03-09 Agency Of Ind Science & Technol Preparation of perfluorotetrahydrofuran derivatives
JPS53124259A (en) 1977-04-06 1978-10-30 Agency Of Ind Science & Technol Preparation of perfluoro (3-methyltetrahydrofran)
JPS5551084A (en) 1978-10-11 1980-04-14 Agency Of Ind Science & Technol Purification of perfluoro(2-alkyltetrahydropyran)
DE2906447A1 (de) * 1979-02-20 1980-09-04 Hoechst Ag Verfahren zur herstellung von 4,5- perfluor-1,3-dioxolanen und neue verbindungen dieser klasse
US4346246A (en) 1979-03-12 1982-08-24 Airco, Inc. Process for adjusting the halogen content of halogenated aliphatic ethers
US4334105A (en) 1979-04-25 1982-06-08 Airco, Inc. Method for the dehalogenation of ethers
JPS56142877A (en) 1980-07-23 1981-11-07 Agency Of Ind Science & Technol Manufacture of perfluoro (3-methyltetrahydrofuran)
US4533741A (en) 1981-11-19 1985-08-06 E. I. Dupont De Nemours And Company 4,5-Dichloro-2,2,4,5,-tetrafluoro-1,3-dioxolane
US4648393A (en) 1984-11-02 1987-03-10 Ackrad Laboratories, Inc. Breath activated medication spray
US4592348A (en) 1984-12-17 1986-06-03 Waters Iv William C Aerosol inhaler
US4803978A (en) 1985-08-09 1989-02-14 Johnson Iv John J Apparatus for actuating an inhaler
EP0271272B1 (en) 1986-12-01 1992-04-15 Tokuyama Corporation Process for preparation of perfluoro organic compounds
US4762856A (en) 1987-02-02 1988-08-09 Boc, Inc. Anesthetic composition and method of using the same
US4896832A (en) 1987-09-07 1990-01-30 Bespak Plc Dispensing apparatus for metered quantities of pressurised fluid
DE3735467A1 (de) 1987-10-20 1989-05-03 Bayer Ag Verfahren zur herstellung von fluorierten c(pfeil abwaerts)4(pfeil abwaerts)- bis c(pfeil abwaerts)6(pfeil abwaerts)-kohlenwasserstoffen und neue cyclische fluorierte kohlenwasserstoffe, sowie die verwendung von fluorierten c(pfeil abwaerts)4(pfeil abwaerts)- bis c(pfeil abwaerts)6(pfeil abwaerts)-kohlenwasserstoffen als treibgas und arbeitsfluessigkeit fuer waermepumpensysteme
JP2606875B2 (ja) 1988-03-31 1997-05-07 株式会社トクヤマ 有機化合物のフッ素化方法
IT1230873B (it) 1989-06-20 1991-11-08 Ausimont Srl Processo per la preparazione di peraloeteri da peraloolefine e nuovi peraloeteri ottenuti.
US5026801A (en) 1989-09-18 1991-06-25 E. I. Du Pont De Nemours And Company Polyhalodihydrodioxins and polyhalodioxoles
CA2071201A1 (en) 1989-12-11 1991-06-12 Ronald J. Mckinney Partially fluorinated compounds and polymers
DE4004494A1 (de) 1990-02-14 1991-08-22 Bayer Ag Verfahren zur herstellung von gesaettigten, fluorhaltigen und chlorfreien kohlenwasserstoffen
WO1991013846A1 (en) 1990-03-05 1991-09-19 E.I. Du Pont De Nemours And Company 1,1,2,2,3,3-hexafluorocyclopentane and use thereof in compositions and processes for cleaning
IT1249208B (it) * 1990-06-07 1995-02-20 Ausimont Srl Processo per la preparazione di 1,3-diossolani alogenati e nuovi prodotti ottenuti
IT1244708B (it) 1991-02-07 1994-08-08 Ausimont Spa Processo di dealogenazione di 1,3-diossolani
US5268122A (en) 1991-08-28 1993-12-07 E. I. Du Pont De Nemours And Company Gem-dihydropolyfluoroalkanes and monohydropolyfluoroalkenes, processes for their production, and use of gem-dihydropolyfluoroalkanes in cleaning compositions
WO1994007829A1 (en) 1992-09-30 1994-04-14 Nippon Zeon Co., Ltd. Process for producing fluorinated saturated hydrocarbon
US5488189A (en) 1993-12-14 1996-01-30 E. I. Du Pont De Nemours And Company Process for fluorinated propanes and pentanes
IT1269517B (it) 1994-05-19 1997-04-01 Ausimont Spa Polimeri e copolimeri fluorurati contenenti strutture cicliche
JP3818395B2 (ja) 1994-06-30 2006-09-06 独立行政法人産業技術総合研究所 弗素化アルケン誘導体及び弗素化アルカン誘導体の製造方法
JP3729281B2 (ja) 1994-11-24 2005-12-21 独立行政法人産業技術総合研究所 弗素化アルケン誘導体および弗素化アルカン誘導体の製造方法
JPH10316597A (ja) 1997-05-15 1998-12-02 Agency Of Ind Science & Technol 弗素化飽和炭化水素
JP4538953B2 (ja) 1997-12-26 2010-09-08 日本ゼオン株式会社 −ｃｈ２−ｃｈｆ−基を有する化合物の製造方法
IT1298257B1 (it) 1998-02-17 1999-12-20 Ausimont Spa Perfluorodiossoli
JP4186253B2 (ja) 1998-03-31 2008-11-26 日本ゼオン株式会社 フッ素化飽和炭化水素の製造方法
JP4120043B2 (ja) 1998-04-01 2008-07-16 日本ゼオン株式会社 フッ素化不飽和炭化水素の製造方法
JP3072083B2 (ja) 1998-11-04 2000-07-31 財団法人地球環境産業技術研究機構 含フッ素ジオキソランおよびその製造方法
EP0999195B1 (en) 1998-11-05 2006-02-08 Central Glass Company, Limited Method for preparing perhalogenated five-membered cyclic compound
JP3856076B2 (ja) 1998-11-30 2006-12-13 日本ゼオン株式会社 ヘプタフルオロシクロペンタンの製造方法
JP3794859B2 (ja) 1999-03-01 2006-07-12 セントラル硝子株式会社 パーハロゲン化シクロペンタンの製造方法
JP4423414B2 (ja) 2000-02-29 2010-03-03 独立行政法人産業技術総合研究所 ヘプタフルオロシクロペンタンの製造方法
JP2001240569A (ja) 2000-02-29 2001-09-04 Nippon Zeon Co Ltd −ｃｈ２−ｃｈｆ−基を有する化合物の製造方法
JP4306081B2 (ja) 2000-03-07 2009-07-29 日本ゼオン株式会社 １，１，２，２，３，３，４−ヘプタフルオロシクロペンタンの製造方法およびその製造装置
JP3897081B2 (ja) 2000-03-17 2007-03-22 日本ゼオン株式会社 １−クロロヘプタフルオロシクロペンテンの製造方法
JP4169121B2 (ja) 2001-02-13 2008-10-22 日本ゼオン株式会社 ヘプタフルオロシクロペンタンの製造方法
JP4846977B2 (ja) 2001-10-17 2011-12-28 ピラマル クリティカル ケアー インコーポレイテッド 意識下鎮静のための薬物送達システム
ITMI20030606A1 (it) 2003-03-27 2004-09-28 Solvay Solexis Spa Procedimento per preparare idrofluoroeteri.
US7067468B2 (en) 2003-06-20 2006-06-27 Degroot Richard J Azeotrope compositions containing a fluorocyclopentane
ITMI20071481A1 (it) 2007-07-23 2009-01-24 Milano Politecnico Processo per la sintesi di perfluoroalchileteri
KR20100049663A (ko) 2007-08-27 2010-05-12 와이어쓰 엘엘씨 마취제-절감 효과를 달성하기 위해 ｎｍｄａ 길항제를 사용하는 조성물 및 방법
EP2459182B1 (en) 2009-07-30 2017-09-06 University of Zürich Injectable formulation for treatment and protection of patients having an inflammatory reaction or an ischemia-reperfusion event
CN101698649B (zh) * 2009-10-22 2012-03-07 李世系 一种用于麻醉的短效催眠镇静的化合物
EP4032533A1 (en) 2012-07-10 2022-07-27 The Regents of The University of California Methods of inducing anesthesia
WO2015187918A2 (en) 2014-06-05 2015-12-10 The Regents Of The University Of California Halogenated ether compounds and methods of inducing anesthesia

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