CN105168202A - 一种吸入式复合麻醉维持剂 - Google Patents

一种吸入式复合麻醉维持剂 Download PDF

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Publication number
CN105168202A
CN105168202A CN201510648398.4A CN201510648398A CN105168202A CN 105168202 A CN105168202 A CN 105168202A CN 201510648398 A CN201510648398 A CN 201510648398A CN 105168202 A CN105168202 A CN 105168202A
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anesthesia
inhalational
sevoflurane
agent
wogonin
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胡宝红
李鹏
陈剑
隋洺骅
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Yantai Yuhuangding Hospital
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Yantai Yuhuangding Hospital
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Abstract

本发明提供一种吸入式复合麻醉维持剂，包括氟烷、七氟烷、薄荷脑、绿原酸、汉黄芩素和乙醇，具体配比为氟烷含量0.5％ˉ1％，七氟烷含量0.4％ˉ0.8％，薄荷脑含量0.1％ˉ0.3％，绿原酸含量0.2％ˉ0.6％，汉黄芩素含量0.1％ˉ0.4％，乙醇含量0.4％ˉ1％。本发明不但具有良好的麻醉维持作用，还具有抗炎、调节血压以及保护心血管的功效，减少了麻醉复苏期间部分病人出现肌阵挛、恶心、头痛等不良反应。

Description

一种吸入式复合麻醉维持剂
技术领域
本发明涉及一种吸入式麻醉剂，具体为一种吸入式复合麻醉维持剂。
背景技术
吸入式麻醉作为一种全身麻醉施用，可产生呼吸道损伤、呼吸抑制、心律失常等不良副作用。现在常用的吸入式***为***、氟烷、七氟烷、氧化亚氮等。***具有毒性低、安全范围较大的优点，但是对呼吸器官具有刺激作用，遇明火极易产生***。氟烷、七氟烷虽然具有性稳定、不燃不爆、麻醉作用强等优点，但易出现血压降低、心率失常等副作用。氧化亚氮诱导期短、镇痛效果好，但肌松不完全，全麻效能弱。现常用吸入式***物在麻醉复苏期间，易出现恶心、呕吐及头痛等现象。
发明内容
针对现有麻醉存在的问题，结合麻醉临床的需要，研发一种吸入式复合麻醉维持剂。本发明具有良好的麻醉效果，同时将各单药的副作用降低，克服普通吸入麻醉产生的恶心、呕吐、镇痛效果差等问题。
本发明提供了一种吸入式复合麻醉维持剂，包括氟烷、七氟烷、薄荷脑、绿原酸、汉黄芩素和乙醇。
所述的吸入式复合麻醉维持剂中氟烷含量为0.5％-1％，七氟烷含量为0.4％-0.8％，薄荷脑含量为0.1％-0.3％，绿原酸含量为0.2％-0.6％，汉黄芩素含量为0.1％-0.4％，乙醇含量为0.4％-1％。
本发明的制备过程为：将薄荷脑、绿原酸、汉黄芩素按照配方剂量，加入到乙醇中，在室温下溶解，然后将氟烷、七氟烷加入到溶解的混合液中，将复合麻醉维持剂封存。
本发明的使用方法为：本发明用于全身麻醉中的麻醉维持期，采用半闭合式或闭合式麻醉机给药。成人用药量为0.5-0.25mL/(Kg·h)，儿童用药量为0.8-0.32mL/(Kg·h)。
本发明的有益效果：本发明以氟烷、七氟烷为基础药物，辅助药物为具有消炎、止痛效果的薄荷脑，调控血压、保护心血管功效的绿原酸，抗炎及抗痉挛功效的汉黄芩素；本发明不但具有良好的麻醉维持作用，还具有抗炎、调节血压以及保护心血管的功效，减少了麻醉复苏期间部分病人出现肌阵挛、恶心、头痛等不良反应。
具体实施方式
实施例1：
一种吸入式复合麻醉维持剂，包括氟烷、七氟烷、薄荷脑、绿原酸、汉黄芩素和乙醇。
所述复合麻醉维持剂的具体含量配比为：氟烷0.5％，七氟烷0.8％，薄荷脑0.15％，绿原酸0.35％，汉黄芩素0.2％，乙醇0.5％。
将薄荷脑、绿原酸、汉黄芩素按照配方剂量，加入到乙醇中，在室温下溶解，然后将氟烷、七氟烷加入到溶解的混合液中，将复合麻醉维持剂封存。
本发明用于全身麻醉中的麻醉维持期，采用半闭合式或闭合式麻醉机给药。成人用药量为0.5-0.25mL/(Kg·h)，儿童用药量为0.8-0.32mL/(Kg·h)。
实施例2：
一种吸入式复合麻醉维持剂，包括氟烷、七氟烷、薄荷脑、绿原酸、汉黄芩素和乙醇。
所述复合麻醉维持剂的具体含量配比为：氟烷0.75％，七氟烷0.6％，薄荷脑0.3％，绿原酸0.5％，汉黄芩素0.3％，乙醇0.8％。
将薄荷脑、绿原酸、汉黄芩素按照配方剂量，加入到乙醇中，在室温下溶解，然后将氟烷、七氟烷加入到溶解的混合液中，将复合麻醉维持剂封存。
本发明用于全身麻醉中的麻醉维持期，采用半闭合式或闭合式麻醉机给药。成人用药量为0.5-0.25mL/(Kg·h)，儿童用药量为0.8-0.32mL/(Kg·h)。
实施例3：
一种吸入式复合麻醉维持剂，包括氟烷、七氟烷、薄荷脑、绿原酸、汉黄芩素和乙醇。
所述复合麻醉维持剂的具体含量配比为：氟烷1％，七氟烷0.4％，薄荷脑0.2％，绿原酸0.4％，汉黄芩素0.25％，乙醇0.6％。
将薄荷脑、绿原酸、汉黄芩素按照配方剂量，加入到乙醇中，在室温下溶解，然后将氟烷、七氟烷加入到溶解的混合液中，将复合麻醉维持剂封存。
本发明用于全身麻醉中的麻醉维持期，采用半闭合式或闭合式麻醉机给药。成人用药量为0.5-0.25mL/(Kg·h)，儿童用药量为0.8-0.32mL/(Kg·h)。

Claims (2)

1.一种吸入式复合麻醉维持剂，包括氟烷、七氟烷、薄荷脑、绿原酸、汉黄芩素和乙醇，其特征在于：所述的吸入式复合麻醉维持剂的具体配比为氟烷含量为0.5％ˉ1％，七氟烷含量为0.4％ˉ0.8％，薄荷脑含量为0.1％ˉ0.3％，绿原酸含量为0.2％ˉ0.6％，汉黄芩素含量为0.1％ˉ0.4％，乙醇含量为0.4％ˉ1％。
2.根据权利要求1所述的吸入式复合麻醉维持剂，其特征在于：成人用药量为0.5ˉ0.25mL/(Kg〃h)，儿童用药量为0.8ˉ0.32mL/(Kg〃h)。
CN201510648398.4A 2015-10-09 2015-10-09 一种吸入式复合麻醉维持剂 Pending CN105168202A (zh)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN88100564A (zh) * 1987-02-02 1988-08-17 Boc公司 麻醉组成物及其使用方法
CN102973722A (zh) * 2012-11-28 2013-03-20 赵作君 新型麻醉剂
CN104619319A (zh) * 2012-07-10 2015-05-13 加利福尼亚大学董事会 引起麻醉的方法
CN104623084A (zh) * 2015-02-06 2015-05-20 孟建 一种吸入式复合麻醉剂

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN88100564A (zh) * 1987-02-02 1988-08-17 Boc公司 麻醉组成物及其使用方法
CN104619319A (zh) * 2012-07-10 2015-05-13 加利福尼亚大学董事会 引起麻醉的方法
CN102973722A (zh) * 2012-11-28 2013-03-20 赵作君 新型麻醉剂
CN104623084A (zh) * 2015-02-06 2015-05-20 孟建 一种吸入式复合麻醉剂

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
M.R.J.SURY 等: "A comparison of the recovery characteristics of sevoflurane and halothane in children", 《ANAESTHESIA》 *
刘中景 等: "《中西医结合营养学》", 31 August 2013, 科学技术文献出版社 *
刘斌: "《中药成分体内代谢与分析》", 31 August 2011, 中国中医药出版社 *

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