BR112014016710A8 - compostos, métodos de tratamento de uma condição inflamatória, de artrite reumatoide, de asma, de um distúrbio imunológico, composição farmacêutica, uso de um composto e invenção - Google Patents

compostos, métodos de tratamento de uma condição inflamatória, de artrite reumatoide, de asma, de um distúrbio imunológico, composição farmacêutica, uso de um composto e invenção

Info

Publication number
BR112014016710A8
BR112014016710A8 BR112014016710A BR112014016710A BR112014016710A8 BR 112014016710 A8 BR112014016710 A8 BR 112014016710A8 BR 112014016710 A BR112014016710 A BR 112014016710A BR 112014016710 A BR112014016710 A BR 112014016710A BR 112014016710 A8 BR112014016710 A8 BR 112014016710A8
Authority
BR
Brazil
Prior art keywords
asthma
treating
compounds
compound
methods
Prior art date
Application number
BR112014016710A
Other languages
English (en)
Other versions
BR112014016710A2 (pt
Inventor
Padilla Fernando
Cornelius Hermann Johannes
C Lucas Matthew
T Le Nam
Chen Shaoqing
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112014016710A2 publication Critical patent/BR112014016710A2/pt
Publication of BR112014016710A8 publication Critical patent/BR112014016710A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
BR112014016710A 2012-01-10 2013-01-07 compostos, métodos de tratamento de uma condição inflamatória, de artrite reumatoide, de asma, de um distúrbio imunológico, composição farmacêutica, uso de um composto e invenção BR112014016710A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261584863P 2012-01-10 2012-01-10
PCT/EP2013/050139 WO2013104575A1 (en) 2012-01-10 2013-01-07 Thienopyrimidine compounds

Publications (2)

Publication Number Publication Date
BR112014016710A2 BR112014016710A2 (pt) 2017-06-13
BR112014016710A8 true BR112014016710A8 (pt) 2017-07-04

Family

ID=47553050

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014016710A BR112014016710A8 (pt) 2012-01-10 2013-01-07 compostos, métodos de tratamento de uma condição inflamatória, de artrite reumatoide, de asma, de um distúrbio imunológico, composição farmacêutica, uso de um composto e invenção

Country Status (11)

Country Link
US (1) US9701691B2 (pt)
EP (1) EP2802590B1 (pt)
JP (1) JP6109193B2 (pt)
KR (1) KR20140110066A (pt)
CN (1) CN104159904B (pt)
BR (1) BR112014016710A8 (pt)
CA (1) CA2860548A1 (pt)
HK (1) HK1203933A1 (pt)
MX (1) MX349548B (pt)
RU (1) RU2637925C2 (pt)
WO (1) WO2013104575A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6001048B2 (ja) * 2011-03-28 2016-10-05 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ チアゾロピリミジン化合物
BR112016016098A2 (pt) * 2014-01-09 2017-08-08 Intracellular Therapies Inc Compostos orgânicos
CN111542529B (zh) * 2017-11-30 2023-06-30 韩美药品株式会社 对蛋白激酶具有抑制活性的噻吩并[3,2-d]嘧啶化合物
US11292799B2 (en) * 2017-12-15 2022-04-05 UNION therapeutics A/S Substituted azetidine dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
JP2022526713A (ja) 2019-03-21 2022-05-26 オンクセオ がんの処置のための、キナーゼ阻害剤と組み合わせたＤｂａｉｔ分子
CN110183464B (zh) * 2019-05-31 2021-08-31 淮阴工学院 一种抗癌化合物艾斯替尼及其合成方法和应用
CN114761006A (zh) 2019-11-08 2022-07-15 Inserm(法国国家健康医学研究院) 对激酶抑制剂产生耐药性的癌症的治疗方法
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
US20230250088A1 (en) * 2020-07-15 2023-08-10 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK6652000A3 (en) 1997-11-11 2002-05-09 Pfizer Prod Inc Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
WO2002026745A1 (fr) * 2000-09-29 2002-04-04 Nippon Soda Co., Ltd. Composes de thienopyrimidine et leurs sels et procede de preparation
CN1897950A (zh) * 2003-10-14 2007-01-17 惠氏公司 稠合芳基和杂芳基衍生物及其使用方法
US20080269238A1 (en) 2004-04-01 2008-10-30 Takeda Pharmaceutical Company Limited Thiazolopyrimidine Derivative
WO2008059368A2 (en) 2006-11-17 2008-05-22 Pfizer Products Inc. Fused 2-amino pyrimidine compounds and their use for the treatment of cancer
GB0718432D0 (en) 2007-09-21 2007-10-31 Vernalis R&D Ltd New chemical compounds
ATE537175T1 (de) * 2007-10-19 2011-12-15 Boehringer Ingelheim Int Neue piperazino-dihydrothienopyrimidin-derivate
EP2215094B1 (en) * 2007-11-15 2016-01-27 YM BioSciences Australia Pty Ltd N-containing heterocyclic compounds
WO2010023181A1 (en) * 2008-08-26 2010-03-04 Boehringer Ingelheim International Gmbh Thienopyrimidines for pharmaceutical compositions
KR101147550B1 (ko) * 2009-10-22 2012-05-17 한국과학기술연구원 단백질 키나아제 저해활성을 가지는 2,7-치환된 티에노［3,2-ｄ］피리미딘 화합물
KR101094446B1 (ko) * 2009-11-19 2011-12-15 한국과학기술연구원 단백질 키나아제 저해활성을 가지는 2,4,7-치환된 티에노［3,2-ｄ］피리미딘 화합물
KR101483215B1 (ko) * 2010-01-29 2015-01-16 한미약품 주식회사 단백질 키나아제 저해활성을 갖는 비시클릭 헤테로아릴 유도체
JP2013519044A (ja) * 2010-02-08 2013-05-23 ナショナル ウィンド エナジー カンパニー リミテッド 垂直軸盤式発電機用磁気浮上支持構造とそれを用いた垂直軸盤式発電機
KR20190077610A (ko) * 2010-07-13 2019-07-03 에프. 호프만-라 로슈 아게 Irak4 조절제로서 피라졸로[1,5a]피리미딘 및 티에노[3,2b]피리미딘 유도체

Also Published As

Publication number Publication date
RU2637925C2 (ru) 2017-12-08
US9701691B2 (en) 2017-07-11
CN104159904A (zh) 2014-11-19
JP2015503576A (ja) 2015-02-02
CN104159904B (zh) 2016-12-14
BR112014016710A2 (pt) 2017-06-13
US20130178460A1 (en) 2013-07-11
EP2802590A1 (en) 2014-11-19
HK1203933A1 (en) 2015-11-06
MX2014008155A (es) 2014-10-14
EP2802590B1 (en) 2017-03-01
JP6109193B2 (ja) 2017-04-05
WO2013104575A1 (en) 2013-07-18
RU2014131367A (ru) 2016-02-27
KR20140110066A (ko) 2014-09-16
MX349548B (es) 2017-08-02
CA2860548A1 (en) 2013-07-18

Similar Documents

Publication Publication Date Title
BR112014004569A2 (pt) composto da fórmula i, métodos para tratar condição inflamatória, artrite reumatoide, asma e distúrbio imune, composição farmacêutica e uso do composto
BR112014016710A2 (pt) compostos, métodos de tratamento de uma condição inflamatória, de artrite reumatoide, de asma, de um distúrbio imunológico, composição farmacêutica, uso de um composto e invenção
HK1249507A1 (zh) 用於治療炎性障礙的新化合物及其藥物組合物
ZA201802150B (en) Compounds useful as modulators of trpm8
CO6950482A2 (es) Composiciones para el tratamiento de la artritis reumatoide y métodos para su utilización
DK3181128T3 (da) Farmaceutisk nilotinib-sammensætning
BR112016003229A2 (pt) Composto, composição farmacêutica, e, uso de um composto ou de uma composição farmacêutica
CO6930350A2 (es) Mezclas de cemento-scm de partículas empacadas
ITUD20130141A1 (it) Adsorbente di vaglio molecolare 5a e metodo per la preparazione dello stesso
DK2898061T3 (da) Probiotiske sammensætninger til behandlingen af fedme og fedme-relaterede tilstande
BR112014023200A2 (pt) uso de uma composição
BR112015024772A2 (pt) composições para tratamento bucal contendo partículas de poli-organossilsesquioxano
DK2900767T3 (da) Superhydrofobe pulverbelægninger
PL3106150T3 (pl) Ulepszone kompozycje farmaceutyczne pimobendanu
BR112014013660A2 (pt) uso de uma partícula
FR2987086B1 (fr) Joint lineaire de plateforme inter-aubes
DK2897594T3 (da) Farmaceutisk sammensætning
BR112015004427A2 (pt) compostos , métodos para o tratamento de um estado inflamatório , da artrite reumatóide , da asma , de um distúrbio imunológico e de um distúrbio imune e composição farmacêutica
EP2906554A4 (en) SOLID FORMS OF NILOTINIB HYDROCHLORIDE
EP2897630A4 (en) ANTI-INFLAMMATORY COMPOSITIONS FOR THE TREATMENT OF NEUROGENIC INFLAMMATION
FI20125937A (fi) Järjestely ja menetelmä rakenneosan kannattamiseksi
BR112014016736A8 (pt) composto, composição farmacêutica, método para tratamento, uso de um composto e invenção
PL2991618T3 (pl) Stabilna kompozycja farmaceutyczna o wysokim stężeniu lewoleukoworyny
CL2015000389A1 (es) Aditivos para autorregeneracion de revestimientos epóxi
BR112014026397A2 (pt) composição e uso de uma composição

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements
B350 Update of information on the portal [chapter 15.35 patent gazette]