BR112014016197A2 - derivado de paroxetina - Google Patents

derivado de paroxetina

Info

Publication number
BR112014016197A2
BR112014016197A2 BR112014016197A BR112014016197A BR112014016197A2 BR 112014016197 A2 BR112014016197 A2 BR 112014016197A2 BR 112014016197 A BR112014016197 A BR 112014016197A BR 112014016197 A BR112014016197 A BR 112014016197A BR 112014016197 A2 BR112014016197 A2 BR 112014016197A2
Authority
BR
Brazil
Prior art keywords
paroxetine
derivative
paroxetine derivative
retains
abstract
Prior art date
Application number
BR112014016197A
Other languages
English (en)
Other versions
BR112014016197A8 (pt
Inventor
Tanaka Keigo
Nishioka Tomoki
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of BR112014016197A2 publication Critical patent/BR112014016197A2/pt
Publication of BR112014016197A8 publication Critical patent/BR112014016197A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom

Abstract

resumo “derivado de paroxetina” um composto representado pela fórmula (1) ou um seu sal farmacologicamente aceitável retém os principais efeitos benéficos da paroxetina tendo ao mesmo tempo uma ação inibidora de cyp melhorada. em que r1 é um átomo de hidrogênio ou um grupo alquila c1-6.]
BR112014016197A 2012-01-31 2013-01-29 derivado de paroxetina BR112014016197A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261592896P 2012-01-31 2012-01-31
PCT/JP2013/051858 WO2013115163A1 (ja) 2012-01-31 2013-01-29 パロキセチン誘導体

Publications (2)

Publication Number Publication Date
BR112014016197A2 true BR112014016197A2 (pt) 2017-06-13
BR112014016197A8 BR112014016197A8 (pt) 2017-07-04

Family

ID=48870749

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014016197A BR112014016197A8 (pt) 2012-01-31 2013-01-29 derivado de paroxetina

Country Status (16)

Country Link
US (1) US8933100B2 (pt)
EP (1) EP2810942B1 (pt)
JP (1) JP6055784B2 (pt)
KR (1) KR101950057B1 (pt)
CN (1) CN104039777B (pt)
AR (1) AR089837A1 (pt)
AU (1) AU2013216123B2 (pt)
BR (1) BR112014016197A8 (pt)
CA (1) CA2861479C (pt)
ES (1) ES2576082T3 (pt)
IL (1) IL233327A (pt)
IN (1) IN2014CN04922A (pt)
MX (1) MX355654B (pt)
RU (1) RU2616610C2 (pt)
TW (1) TW201334783A (pt)
WO (1) WO2013115163A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016315720B2 (en) * 2015-09-02 2021-02-25 Trevena, Inc. 6-membered AZA-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
CN110446495B (zh) 2017-02-17 2023-09-05 特维娜有限公司 含有7元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法
CN111533682B (zh) * 2020-05-29 2022-03-01 清华大学 帕罗西汀及其类似物的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
WO1998056787A1 (en) * 1997-06-10 1998-12-17 Synthon B.V. 4-Phenylpiperidine compounds
IT1308629B1 (it) * 1999-02-23 2002-01-09 Recordati Chem Pharm Processo per la produzione di paroxetina.
KR101380190B1 (ko) * 2005-07-29 2014-04-11 콘서트 파마슈티컬즈, 인크. 벤조 〔ｄ〕〔１,３〕―디옥솔 유도체
US20070142389A1 (en) * 2005-12-20 2007-06-21 Pfizer Inc. Piperidine derivatives
JP2009184924A (ja) 2006-05-31 2009-08-20 Eisai R & D Management Co Ltd 生物学的試薬用化合物

Also Published As

Publication number Publication date
IL233327A (en) 2016-03-31
EP2810942A4 (en) 2015-07-01
EP2810942A1 (en) 2014-12-10
WO2013115163A1 (ja) 2013-08-08
MX2014007620A (es) 2014-09-15
AU2013216123A1 (en) 2014-07-17
RU2616610C2 (ru) 2017-04-18
KR101950057B1 (ko) 2019-02-19
JPWO2013115163A1 (ja) 2015-05-11
RU2014126321A (ru) 2016-03-20
EP2810942B1 (en) 2016-03-30
CN104039777A (zh) 2014-09-10
CN104039777B (zh) 2016-03-02
JP6055784B2 (ja) 2016-12-27
MX355654B (es) 2018-04-26
IL233327A0 (en) 2014-08-31
US20130197033A1 (en) 2013-08-01
BR112014016197A8 (pt) 2017-07-04
TW201334783A (zh) 2013-09-01
CA2861479A1 (en) 2013-08-08
US8933100B2 (en) 2015-01-13
AR089837A1 (es) 2014-09-17
KR20140117454A (ko) 2014-10-07
ES2576082T3 (es) 2016-07-05
AU2013216123B2 (en) 2016-10-20
IN2014CN04922A (pt) 2015-09-18
CA2861479C (en) 2017-10-10

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06T Formal requirements before examination [chapter 6.20 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time
B350 Update of information on the portal [chapter 15.35 patent gazette]