MX355654B - Derivado de paroxetina. - Google Patents

Derivado de paroxetina.

Info

Publication number
MX355654B
MX355654B MX2014007620A MX2014007620A MX355654B MX 355654 B MX355654 B MX 355654B MX 2014007620 A MX2014007620 A MX 2014007620A MX 2014007620 A MX2014007620 A MX 2014007620A MX 355654 B MX355654 B MX 355654B
Authority
MX
Mexico
Prior art keywords
paroxetine
formula
derivative
paroxetine derivative
retains
Prior art date
Application number
MX2014007620A
Other languages
English (en)
Other versions
MX2014007620A (es
Inventor
Tanaka Keigo
Nishioka Tomoki
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of MX2014007620A publication Critical patent/MX2014007620A/es
Publication of MX355654B publication Critical patent/MX355654B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom

Abstract

Un compuesto representado por la fórmula (1) o una sal farmacológicamente aceptable de este retiene el efecto terapéutico principal de la paroxetina y tiene un efecto inhibitorio de CYP mejorado, (ver Fórmula) donde R1 es un átomo de hidrógeno o grupo alquilo C1-6.
MX2014007620A 2012-01-31 2013-01-29 Derivado de paroxetina. MX355654B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261592896P 2012-01-31 2012-01-31
PCT/JP2013/051858 WO2013115163A1 (ja) 2012-01-31 2013-01-29 パロキセチン誘導体

Publications (2)

Publication Number Publication Date
MX2014007620A MX2014007620A (es) 2014-09-15
MX355654B true MX355654B (es) 2018-04-26

Family

ID=48870749

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014007620A MX355654B (es) 2012-01-31 2013-01-29 Derivado de paroxetina.

Country Status (16)

Country Link
US (1) US8933100B2 (es)
EP (1) EP2810942B1 (es)
JP (1) JP6055784B2 (es)
KR (1) KR101950057B1 (es)
CN (1) CN104039777B (es)
AR (1) AR089837A1 (es)
AU (1) AU2013216123B2 (es)
BR (1) BR112014016197A8 (es)
CA (1) CA2861479C (es)
ES (1) ES2576082T3 (es)
IL (1) IL233327A (es)
IN (1) IN2014CN04922A (es)
MX (1) MX355654B (es)
RU (1) RU2616610C2 (es)
TW (1) TW201334783A (es)
WO (1) WO2013115163A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA43313B1 (fr) * 2015-09-02 2022-06-30 Trevena Inc Aza-hétérocyclique à 6 éléments contenant des composés modulateurs de récepteurs opioïdes delta, et leurs procédés de fabrication et d'utilisation
EP3582783B1 (en) 2017-02-17 2023-06-07 Trevena, Inc. 7-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
CN111533682B (zh) * 2020-05-29 2022-03-01 清华大学 帕罗西汀及其类似物的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
HUP0003141A3 (en) * 1997-06-10 2001-04-28 Synthon Bv 4-phenylpiperidine derivatives, process for producing them and pharmaceutical compositions containing them
IT1308629B1 (it) * 1999-02-23 2002-01-09 Recordati Chem Pharm Processo per la produzione di paroxetina.
KR101380190B1 (ko) 2005-07-29 2014-04-11 콘서트 파마슈티컬즈, 인크. 벤조 〔ｄ〕〔１,３〕―디옥솔 유도체
US20070142389A1 (en) * 2005-12-20 2007-06-21 Pfizer Inc. Piperidine derivatives
JP2009184924A (ja) 2006-05-31 2009-08-20 Eisai R & D Management Co Ltd 生物学的試薬用化合物

Also Published As

Publication number Publication date
ES2576082T3 (es) 2016-07-05
CN104039777B (zh) 2016-03-02
MX2014007620A (es) 2014-09-15
US20130197033A1 (en) 2013-08-01
JPWO2013115163A1 (ja) 2015-05-11
KR20140117454A (ko) 2014-10-07
AR089837A1 (es) 2014-09-17
IL233327A (en) 2016-03-31
BR112014016197A8 (pt) 2017-07-04
BR112014016197A2 (pt) 2017-06-13
EP2810942B1 (en) 2016-03-30
AU2013216123A1 (en) 2014-07-17
IL233327A0 (en) 2014-08-31
CA2861479A1 (en) 2013-08-08
RU2616610C2 (ru) 2017-04-18
KR101950057B1 (ko) 2019-02-19
CN104039777A (zh) 2014-09-10
EP2810942A4 (en) 2015-07-01
RU2014126321A (ru) 2016-03-20
CA2861479C (en) 2017-10-10
US8933100B2 (en) 2015-01-13
TW201334783A (zh) 2013-09-01
EP2810942A1 (en) 2014-12-10
IN2014CN04922A (es) 2015-09-18
WO2013115163A1 (ja) 2013-08-08
JP6055784B2 (ja) 2016-12-27
AU2013216123B2 (en) 2016-10-20

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