BR112013003823A2 - conjugados de peptídeo terapêutico-políemro, partículas, composições, e métodos relacionados - Google Patents
conjugados de peptídeo terapêutico-políemro, partículas, composições, e métodos relacionadosInfo
- Publication number
- BR112013003823A2 BR112013003823A2 BR112013003823A BR112013003823A BR112013003823A2 BR 112013003823 A2 BR112013003823 A2 BR 112013003823A2 BR 112013003823 A BR112013003823 A BR 112013003823A BR 112013003823 A BR112013003823 A BR 112013003823A BR 112013003823 A2 BR112013003823 A2 BR 112013003823A2
- Authority
- BR
- Brazil
- Prior art keywords
- conjugates
- particles
- polymer
- therapeutic peptide
- compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
- C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Polymers & Plastics (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
Abstract
conjugados de peptídeo terapêutico-polímero, partículas, composições, e métodos relacionados. são descritos aqui conjugados (por exemplo, conjugados de peptídeo terapêutico polímero e conjugados de proteína polímero) e partículas, que podem ser usadas, por exemplo, no tratamento de um distúrbio tal como o câncer. também são descritas aqui misturas, composições e formas de dosagem contendo as partículas, métodos de uso das partículas (por exemplo, para tratar um distúrbio), kits incluindo os conjugados (por exemplo, conjugados de peptídeo terapêutico-polímeroe conjugados de proteína e conjuagdos de proteína-polímero) e pastículas, métodos de fazer os conjugados (por exemplo, conjugados de pepetídeo terapêutico-polímero e conjugados de proteína polímero) e as partículas, métodos de armazenamento das patículas e métodos de analisar as partículas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37577110P | 2010-08-20 | 2010-08-20 | |
US201161477827P | 2011-04-21 | 2011-04-21 | |
PCT/US2011/048309 WO2012024530A2 (en) | 2010-08-20 | 2011-08-18 | Therapeutic peptide-polymer conjugates, particles, compositions, and related methods |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112013003823A2 true BR112013003823A2 (pt) | 2016-06-28 |
Family
ID=45605679
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013003823A BR112013003823A2 (pt) | 2010-08-20 | 2011-08-18 | conjugados de peptídeo terapêutico-políemro, partículas, composições, e métodos relacionados |
Country Status (10)
Country | Link |
---|---|
US (2) | US20120052097A1 (pt) |
EP (1) | EP2605797A2 (pt) |
JP (2) | JP5655147B2 (pt) |
CN (1) | CN103079546A (pt) |
AU (1) | AU2011291586A1 (pt) |
BR (1) | BR112013003823A2 (pt) |
CA (1) | CA2808907A1 (pt) |
EA (1) | EA201390144A1 (pt) |
MX (1) | MX2013002051A (pt) |
WO (1) | WO2012024530A2 (pt) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL1865976T3 (pl) | 2005-04-07 | 2012-11-30 | Cardiorentis Ag | Zastosowanie peptydu natriuretycznego do leczenia niewydolności serca |
WO2010114770A1 (en) * | 2009-03-30 | 2010-10-07 | Cerulean Pharma Inc. | Polymer-agent conjugates, particles, compositions, and related methods of use |
BR112014011144A2 (pt) | 2011-11-09 | 2017-05-16 | Bristol Myers Squibb Co | tratamento de malignidades hematológicas com um anticorpo anti-cxcr4 |
EP2841486B1 (en) * | 2012-04-23 | 2020-01-15 | NanoProteagen Ltd. | Polymeric nanoparticles and a process of preparation thereof |
US9636376B2 (en) * | 2012-09-11 | 2017-05-02 | Innopharma, Inc. | Stable compositions of peptide epoxy ketones |
NZ710246A (en) * | 2013-01-25 | 2016-11-25 | Cardiorentis Ltd | Methods of treating cardiovasular indications |
EP3052471B1 (en) * | 2013-09-30 | 2023-06-21 | The University of Akron | Methods for post-fabrication functionalization of poly(ester ureas) |
US20170037234A1 (en) * | 2014-02-26 | 2017-02-09 | The Trustees Of Princeton University | Polymer nanoparticles |
US20150320988A1 (en) * | 2014-05-09 | 2015-11-12 | Ocusoft, Inc. | Systems, Methods, and Kits for Cleansing an Ocular Region |
US20160122713A1 (en) * | 2014-10-14 | 2016-05-05 | Medgenics Medical Israel Ltd. | Genetically-modified micro-organ secreting a therapeutic peptide and methods of use thereof |
JP2018521068A (ja) * | 2015-07-15 | 2018-08-02 | セレーター ファーマシューティカルズ インコーポレイテッド | 改善されたナノ粒子送達系 |
CN106924715A (zh) * | 2015-12-31 | 2017-07-07 | 深圳翰宇药业股份有限公司 | 特利加压素脂质体及其制备方法 |
US10039801B2 (en) | 2016-02-16 | 2018-08-07 | Strongbridge Ireland Limited | Pharmaceutical compositions of water soluble peptides with poor solubility in isotonic conditions and methods for their use |
SI3506921T1 (sl) * | 2016-08-31 | 2023-10-30 | Mapi Pharma Ltd. | Depojski sistemi, ki vsebujejo glatiramer acetat |
US11484507B2 (en) | 2016-11-02 | 2022-11-01 | Hillstream Biopharma, Inc. | Polymeric nanoparticles providing nucleic acids encoding TNF-α |
WO2018175589A1 (en) * | 2017-03-22 | 2018-09-27 | The Regents Of The University Of California | Modified peptides and uses thereof for treating cancer |
EP3600553A4 (en) | 2017-03-26 | 2020-09-02 | Mapi Pharma Ltd. | GLATIRAMER DEPOT SYSTEMS FOR TREATMENT OF PROGRESSIVE FORMS OF MULTIPLE SCLEROSIS |
US11214672B2 (en) | 2018-01-19 | 2022-01-04 | The Trustees Of Princeton University | Hybrid polymer-inorganic nanocolloids and methods of making them |
WO2019149946A1 (en) | 2018-02-02 | 2019-08-08 | Danmarks Tekniske Universitet | Therapeutics for autoimmune kidney disease: synthetic antigens |
WO2022108870A1 (en) * | 2020-11-17 | 2022-05-27 | 9 Meters Biopharma, Inc. | Compositions and methods for treating pulmonary fibrosis |
WO2023141278A2 (en) * | 2022-01-20 | 2023-07-27 | The University Of North Carolina At Chapel Hill | Composite particle formulations and applications thereof |
CN114835888B (zh) * | 2022-04-18 | 2023-08-08 | 广州市第一人民医院(广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院) | 一种肿瘤原位组装的纳米载体***、载药体系及应用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5565215A (en) * | 1993-07-23 | 1996-10-15 | Massachusettes Institute Of Technology | Biodegradable injectable particles for imaging |
EP0712421A1 (en) * | 1993-07-23 | 1996-05-22 | Massachusetts Institute Of Technology | Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers |
US6007845A (en) * | 1994-07-22 | 1999-12-28 | Massachusetts Institute Of Technology | Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers |
KR19990085365A (ko) * | 1998-05-16 | 1999-12-06 | 허영섭 | 지속적으로 약물 조절방출이 가능한 생분해성 고분자 미립구 및그 제조방법 |
JP2002521343A (ja) * | 1998-07-23 | 2002-07-16 | ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス | 水溶性ペプチドのカプセル化 |
US8137699B2 (en) * | 2002-03-29 | 2012-03-20 | Trustees Of Princeton University | Process and apparatuses for preparing nanoparticle compositions with amphiphilic copolymers and their use |
US20040142887A1 (en) * | 2002-07-10 | 2004-07-22 | Chengji Cui | Antigen-polymer compositions |
EP1786443B1 (en) * | 2004-07-19 | 2018-06-06 | Celator Pharmaceuticals, Inc. | Particulate constructs for release of active agents |
CA2624174A1 (en) * | 2005-09-28 | 2007-04-05 | The Trustees Of The University Of Pennsylvania | Self-assembled biodegradable polymersomes |
US20070071790A1 (en) * | 2005-09-28 | 2007-03-29 | Northwestern University | Biodegradable nanocomposites with enhance mechanical properties for soft tissue |
WO2010046681A1 (en) * | 2008-10-24 | 2010-04-29 | Fujifilm Manufacturing Europe Bv | Nanoparticles |
-
2011
- 2011-08-18 US US13/212,971 patent/US20120052097A1/en not_active Abandoned
- 2011-08-18 CN CN2011800403740A patent/CN103079546A/zh active Pending
- 2011-08-18 MX MX2013002051A patent/MX2013002051A/es unknown
- 2011-08-18 WO PCT/US2011/048309 patent/WO2012024530A2/en active Application Filing
- 2011-08-18 AU AU2011291586A patent/AU2011291586A1/en not_active Abandoned
- 2011-08-18 BR BR112013003823A patent/BR112013003823A2/pt not_active IP Right Cessation
- 2011-08-18 JP JP2013524987A patent/JP5655147B2/ja not_active Expired - Fee Related
- 2011-08-18 CA CA2808907A patent/CA2808907A1/en not_active Abandoned
- 2011-08-18 EA EA201390144A patent/EA201390144A1/ru unknown
- 2011-08-18 EP EP11818802.8A patent/EP2605797A2/en not_active Withdrawn
-
2013
- 2013-03-28 US US13/852,738 patent/US20140135254A1/en not_active Abandoned
-
2014
- 2014-11-21 JP JP2014236423A patent/JP2015052012A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2012024530A3 (en) | 2012-05-03 |
CN103079546A (zh) | 2013-05-01 |
US20140135254A1 (en) | 2014-05-15 |
US20120052097A1 (en) | 2012-03-01 |
CA2808907A1 (en) | 2012-02-23 |
WO2012024530A2 (en) | 2012-02-23 |
EP2605797A2 (en) | 2013-06-26 |
JP2015052012A (ja) | 2015-03-19 |
EA201390144A1 (ru) | 2013-06-28 |
AU2011291586A1 (en) | 2013-03-07 |
JP5655147B2 (ja) | 2015-01-14 |
MX2013002051A (es) | 2013-06-28 |
JP2013536198A (ja) | 2013-09-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112013003823A2 (pt) | conjugados de peptídeo terapêutico-políemro, partículas, composições, e métodos relacionados | |
PH12019500436A1 (en) | Adenovirus armed with bispecific t cell engager (bite) | |
PH12015501092A1 (en) | Anti-ceacam5 antibodies and uses thereof | |
CR20180027A (es) | Nuevos péptidos y nuevas combinaciones de péptidos para el uso en la misma terapia contra el cáncer epitelial de ovario y otros tipos de cáncer. | |
BR112018001687A2 (pt) | peptídeos e combinações de peptídeos para uso na imunoterapia contra o câncer de próstata e outros cânceres | |
EA201890278A1 (ru) | Антитела к pd-l1 | |
BR112014018728A8 (pt) | Compostos de purinonas como inibidores de quinase | |
EA201171195A1 (ru) | Конъюгаты, частицы, композиции "полимер-агент" и способы их применения | |
CR20180174A (es) | Nuevos péptidos, combinaciones de péptidos y soportes para el uso en el tratamiento inmunoterapéutico de varios tipos de cáncer | |
CL2011001578A1 (es) | Anticuerpo que inhibe selectivamente al receptor del peptido relacionado al gen de la calcitonina ( cgrp r) humano; polinucleotido que lo codifica; vector; celula; metodo de produccion; composicion farmaceutica que lo comprende; y su uso para tratar un medicamento para tratar una condicion asociada con cgrp r en un paciente, como migraña. | |
CL2013000018A1 (es) | Compuestos derivados de indolizina , su procedimiento de preparacion; composicion farmaceutica; y uso en el tratamiento del cancer, entre otros. | |
UA108193C2 (uk) | Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань | |
NZ761006A (en) | Plasma kallikrein binding proteins and uses thereof in treating hereditary angioedema | |
CL2012000238A1 (es) | Polipéptido del factor ix; secuencia de adn que lo codifica; célula huésped eucariota; procedimiento de producción; conjugado; composición que lo comprende; y su uso para el tratamiento de la hemofilia b. | |
TR201905101T4 (tr) | Doku faktörü yolak inhibitörüne (TFPI) karşı monoklonal antikorlar. | |
EA201500261A1 (ru) | Конъюгаты антитело-лекарственное средство (adc), которые связываются с белками 158p1d7 | |
PE20160528A1 (es) | Anticuerpos | |
EA201290759A1 (ru) | Антитела | |
BR112015024621A8 (pt) | usos de dose unitária de unidades formadoras de colônia de c. novyi, composição farmacêutica compreendendo a referida dose unitária, kit para tratar ou atenuar um efeito de um tumor sólido presente em um ser humano e dose unitária de unidades formadoras de colônia de c. novyi | |
MX2016014826A (es) | Conjugados de peptido-curcumina y formulaciones de los mismos. | |
EA201491352A1 (ru) | Способ лечения рака груди | |
AR069958A1 (es) | Metodo para producir una proteina heterologa de interes | |
MX369414B (es) | Peptido. | |
EA201590521A1 (ru) | Инъекционные раковые композиции | |
BR112013022557A2 (pt) | ligantes de peptídeo composições de polipeptídeo e métodos para uso dos mesmos |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2377 DE 26-07-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |