BR112012015740A2 - anticorpos de anti-flt3 e metodos de uso dos mesmos - Google Patents

anticorpos de anti-flt3 e metodos de uso dos mesmos

Info

Publication number
BR112012015740A2
BR112012015740A2 BR112012015740A BR112012015740A BR112012015740A2 BR 112012015740 A2 BR112012015740 A2 BR 112012015740A2 BR 112012015740 A BR112012015740 A BR 112012015740A BR 112012015740 A BR112012015740 A BR 112012015740A BR 112012015740 A2 BR112012015740 A2 BR 112012015740A2
Authority
BR
Brazil
Prior art keywords
antibodies
methods
flt3
flt3 antibodies
relates
Prior art date
Application number
BR112012015740A
Other languages
English (en)
Other versions
BR112012015740B1 (pt
Inventor
Jung Grundram
Buhring Hans-Jorg
Grosse-Hovest Ludger
Hofmann Martin
Aulwurm Steffen
Original Assignee
Synimmune Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synimmune Gmbh filed Critical Synimmune Gmbh
Publication of BR112012015740A2 publication Critical patent/BR112012015740A2/pt
Publication of BR112012015740B1 publication Critical patent/BR112012015740B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

Abstract

anticorpos de anti-flt3 e métodos de uso dos mesmos. a presente invenção refere-se a anticorpos de anti-flt3 com uma região de fc modificada compreendendo as substituições de aminoácidos 239d e 332e para aumentar citotoxicidade de célula dependente de anticorpo (adcc) desses anticorpos. a invenção ulteriormente refere-se a composições farmacêuticas contendo esses anticorpos, ácidos nucleicos que codificam esses anticorpos bem como métodos de uso de tais anticorpos
BR112012015740-0A 2009-12-23 2010-12-23 Anticorpo anti-flt3, seu uso,bem como composição compreendendo o referido anticorpo e molécula de ácido nucleico BR112012015740B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28952909P 2009-12-23 2009-12-23
US61/289,529 2009-12-23
PCT/EP2010/070659 WO2011076922A1 (en) 2009-12-23 2010-12-23 Anti-flt3 antibodies and methods of using the same

Publications (2)

Publication Number Publication Date
BR112012015740A2 true BR112012015740A2 (pt) 2017-04-25
BR112012015740B1 BR112012015740B1 (pt) 2020-09-29

Family

ID=43719470

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012015740-0A BR112012015740B1 (pt) 2009-12-23 2010-12-23 Anticorpo anti-flt3, seu uso,bem como composição compreendendo o referido anticorpo e molécula de ácido nucleico

Country Status (14)

Country Link
US (1) US9023996B2 (pt)
EP (1) EP2516468B1 (pt)
JP (1) JP5944831B2 (pt)
CN (1) CN102770453B (pt)
BR (1) BR112012015740B1 (pt)
CA (1) CA2785178C (pt)
DK (1) DK2516468T3 (pt)
EA (1) EA027502B1 (pt)
ES (1) ES2573642T3 (pt)
HK (1) HK1172910A1 (pt)
HR (1) HRP20160422T1 (pt)
HU (1) HUE028629T2 (pt)
SI (1) SI2516468T1 (pt)
WO (1) WO2011076922A1 (pt)

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Also Published As

Publication number Publication date
EP2516468A1 (en) 2012-10-31
BR112012015740B1 (pt) 2020-09-29
US9023996B2 (en) 2015-05-05
US20120328612A1 (en) 2012-12-27
HK1172910A1 (zh) 2013-05-03
CA2785178A1 (en) 2011-06-30
JP2013515472A (ja) 2013-05-09
EA027502B1 (ru) 2017-08-31
CN102770453A (zh) 2012-11-07
CN102770453B (zh) 2014-10-08
EA201290370A1 (ru) 2013-04-30
CA2785178C (en) 2019-09-03
JP5944831B2 (ja) 2016-07-05
SI2516468T1 (sl) 2016-06-30
HUE028629T2 (en) 2016-12-28
ES2573642T3 (es) 2016-06-09
HRP20160422T1 (hr) 2016-05-20
EP2516468B1 (en) 2016-03-02
WO2011076922A1 (en) 2011-06-30
DK2516468T3 (en) 2016-05-23

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