BR112012008080A2 - ensaios de rastreamento in vivo. - Google Patents
ensaios de rastreamento in vivo.Info
- Publication number
- BR112012008080A2 BR112012008080A2 BR112012008080A BR112012008080A BR112012008080A2 BR 112012008080 A2 BR112012008080 A2 BR 112012008080A2 BR 112012008080 A BR112012008080 A BR 112012008080A BR 112012008080 A BR112012008080 A BR 112012008080A BR 112012008080 A2 BR112012008080 A2 BR 112012008080A2
- Authority
- BR
- Brazil
- Prior art keywords
- screening assays
- vivo screening
- vivo
- assays
- screening
- Prior art date
Links
- 238000003556 assay Methods 0.000 title 1
- 238000012750 in vivo screening Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0045—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent agent being a peptide or protein used for imaging or diagnosis in vivo
- A61K49/0047—Green fluorescent protein [GFP]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23584609P | 2009-08-21 | 2009-08-21 | |
PCT/US2010/046196 WO2011022670A1 (en) | 2009-08-21 | 2010-08-20 | In vivo screening assays |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112012008080A2 true BR112012008080A2 (pt) | 2017-07-04 |
Family
ID=43605534
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012008080A BR112012008080A2 (pt) | 2009-08-21 | 2010-08-20 | ensaios de rastreamento in vivo. |
BR112012008111A BR112012008111A2 (pt) | 2009-08-21 | 2010-08-20 | métodos e composições para tratamento de desordens fibróticas pulmonares |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012008111A BR112012008111A2 (pt) | 2009-08-21 | 2010-08-20 | métodos e composições para tratamento de desordens fibróticas pulmonares |
Country Status (15)
Country | Link |
---|---|
US (1) | US20110044981A1 (pt) |
EP (2) | EP2467169A4 (pt) |
JP (3) | JP2013502589A (pt) |
KR (2) | KR20120054077A (pt) |
CN (2) | CN102711839A (pt) |
AU (2) | AU2010284039A1 (pt) |
BR (2) | BR112012008080A2 (pt) |
CA (2) | CA2771778A1 (pt) |
IL (2) | IL218210A0 (pt) |
MX (2) | MX2012002270A (pt) |
NZ (2) | NZ598464A (pt) |
RU (3) | RU2012110580A (pt) |
SG (1) | SG178846A1 (pt) |
WO (1) | WO2011022706A2 (pt) |
ZA (1) | ZA201201290B (pt) |
Families Citing this family (18)
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US20030114410A1 (en) | 2000-08-08 | 2003-06-19 | Technion Research And Development Foundation Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis |
EP2537529B1 (en) * | 2007-08-02 | 2018-10-17 | Gilead Biologics, Inc. | Loxl2 inhibitory antibodies and uses thereof |
US9107935B2 (en) | 2009-01-06 | 2015-08-18 | Gilead Biologics, Inc. | Chemotherapeutic methods and compositions |
WO2011022670A1 (en) * | 2009-08-21 | 2011-02-24 | Arresto Biosciences, Inc | In vivo screening assays |
JP2013502437A (ja) * | 2009-08-21 | 2013-01-24 | ギリアド バイオロジクス,インク. | 治療方法及び組成物 |
AU2010284036B2 (en) * | 2009-08-21 | 2014-12-18 | Gilead Biologics, Inc. | Catalytic domains from lysyl oxidase and LOXL2 |
WO2011041309A1 (en) * | 2009-09-29 | 2011-04-07 | Arresto Biosciences, Inc | Methods and compositions for treatment of ocular fibrosis |
CN103370080A (zh) * | 2010-02-04 | 2013-10-23 | 吉联亚生物科技有限公司 | 结合赖氨酰氧化酶样2(loxl2)的抗体和其使用方法 |
CA2837534A1 (en) * | 2011-06-01 | 2012-12-06 | Gilead Biologics, Inc. | Lysyl oxidase-like 2 assay and methods of use thereof |
US20140120102A1 (en) * | 2012-10-30 | 2014-05-01 | Gilead Sciences, Inc. | Therapeutic and diagnostic methods related to lysyl oxidase-like 2 (loxl2) |
BR112015023699A2 (pt) * | 2013-03-15 | 2017-07-18 | Intermune Inc | método de determinação de um nível de expressão de uma proteína marcadora de doença pulmonar fibrótica, método de determinação se um indivíduo tem ou está em risco de desenvolvimento de uma doença pulmonar fibrótica, método de determinação se um paciente de doença pulmonar fibrótica está em risco de progressão da doença pulmonar fibrótica, método de determinação de uma atividade de doença pulmonar fibrótica em um paciente, e método de tratamento de uma doença pulmonar fibrótica em um indivíduo em necessidade do mesmo |
JP2019510752A (ja) | 2016-03-04 | 2019-04-18 | ギリアード サイエンシーズ, インコーポレイテッド | オートタキシン阻害剤の組成物及び合剤 |
EP3644983B1 (en) | 2017-06-29 | 2023-10-25 | Yale University | Compositions and methods of treating or preventing fibrotic lung diseases |
WO2019178023A1 (en) * | 2018-03-12 | 2019-09-19 | Yale University | Methods of Treating or Preventing Acute Respiratory Distress Syndrome |
CN110917351A (zh) * | 2018-09-20 | 2020-03-27 | 华中科技大学同济医学院附属同济医院 | Mbd2抑制剂在预防和治疗纤维化疾病中的用途 |
CN112138159B (zh) * | 2019-06-28 | 2022-07-12 | 复旦大学 | 乳酸脱氢酶在组织炎症和纤维化治疗中的应用 |
WO2021015218A1 (ja) * | 2019-07-24 | 2021-01-28 | 国立大学法人九州大学 | 転写関連因子を標的とする線維化疾患の予防または治療 |
EP4034645A1 (en) * | 2019-09-23 | 2022-08-03 | Ecole Polytechnique Federale De Lausanne (Epfl) | Treatment and prevention of aging related-disease and/or aging by the inhibition of sphingolipids |
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-
2010
- 2010-08-20 EP EP10810675A patent/EP2467169A4/en not_active Withdrawn
- 2010-08-20 SG SG2012012167A patent/SG178846A1/en unknown
- 2010-08-20 RU RU2012110580/15A patent/RU2012110580A/ru unknown
- 2010-08-20 KR KR1020127007167A patent/KR20120054077A/ko not_active Application Discontinuation
- 2010-08-20 NZ NZ598464A patent/NZ598464A/en unknown
- 2010-08-20 MX MX2012002270A patent/MX2012002270A/es unknown
- 2010-08-20 RU RU2012110578/15A patent/RU2561672C2/ru active
- 2010-08-20 EP EP20100810702 patent/EP2470218A4/en not_active Withdrawn
- 2010-08-20 CA CA2771778A patent/CA2771778A1/en not_active Abandoned
- 2010-08-20 RU RU2015124151/15A patent/RU2015124151A/ru not_active Application Discontinuation
- 2010-08-20 JP JP2012525736A patent/JP2013502589A/ja not_active Withdrawn
- 2010-08-20 US US12/860,834 patent/US20110044981A1/en not_active Abandoned
- 2010-08-20 CN CN2010800479711A patent/CN102711839A/zh active Pending
- 2010-08-20 JP JP2012525746A patent/JP2013502435A/ja active Pending
- 2010-08-20 WO PCT/US2010/046244 patent/WO2011022706A2/en active Application Filing
- 2010-08-20 AU AU2010284039A patent/AU2010284039A1/en not_active Abandoned
- 2010-08-20 BR BR112012008080A patent/BR112012008080A2/pt not_active IP Right Cessation
- 2010-08-20 NZ NZ625850A patent/NZ625850A/en not_active IP Right Cessation
- 2010-08-20 BR BR112012008111A patent/BR112012008111A2/pt not_active IP Right Cessation
- 2010-08-20 CN CN2010800479707A patent/CN102711820A/zh active Pending
- 2010-08-20 MX MX2012002269A patent/MX2012002269A/es not_active Application Discontinuation
- 2010-08-20 CA CA2771786A patent/CA2771786A1/en not_active Abandoned
- 2010-08-20 AU AU2010283997A patent/AU2010283997B2/en active Active
- 2010-08-20 KR KR1020127007162A patent/KR20120089274A/ko not_active Application Discontinuation
-
2012
- 2012-02-20 IL IL218210A patent/IL218210A0/en unknown
- 2012-02-20 IL IL218211A patent/IL218211A0/en unknown
- 2012-02-21 ZA ZA2012/01290A patent/ZA201201290B/en unknown
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2015
- 2015-10-22 JP JP2015207723A patent/JP2016029085A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ZA201201290B (en) | 2014-01-29 |
JP2016029085A (ja) | 2016-03-03 |
EP2467169A1 (en) | 2012-06-27 |
AU2010283997A1 (en) | 2012-03-22 |
EP2467169A4 (en) | 2013-01-02 |
KR20120089274A (ko) | 2012-08-09 |
CA2771778A1 (en) | 2011-02-24 |
NZ625850A (en) | 2015-12-24 |
US20110044981A1 (en) | 2011-02-24 |
AU2010284039A1 (en) | 2012-03-22 |
RU2015124151A (ru) | 2015-12-27 |
AU2010283997B2 (en) | 2015-04-09 |
WO2011022706A3 (en) | 2011-04-14 |
JP2013502435A (ja) | 2013-01-24 |
CN102711839A (zh) | 2012-10-03 |
CA2771786A1 (en) | 2011-02-24 |
BR112012008111A2 (pt) | 2017-02-21 |
EP2470218A2 (en) | 2012-07-04 |
MX2012002269A (es) | 2012-07-20 |
WO2011022706A2 (en) | 2011-02-24 |
IL218210A0 (en) | 2012-04-30 |
NZ598464A (en) | 2014-07-25 |
RU2561672C2 (ru) | 2015-08-27 |
KR20120054077A (ko) | 2012-05-29 |
CN102711820A (zh) | 2012-10-03 |
RU2012110580A (ru) | 2013-09-27 |
MX2012002270A (es) | 2012-07-20 |
JP2013502589A (ja) | 2013-01-24 |
IL218211A0 (en) | 2012-04-30 |
EP2470218A4 (en) | 2013-04-03 |
RU2012110578A (ru) | 2013-09-27 |
SG178846A1 (en) | 2012-04-27 |
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