ES2752025T8 - Métodos de cribado de proteínas - Google Patents
Métodos de cribado de proteínasInfo
- Publication number
- ES2752025T8 ES2752025T8 ES09801086T ES09801086T ES2752025T8 ES 2752025 T8 ES2752025 T8 ES 2752025T8 ES 09801086 T ES09801086 T ES 09801086T ES 09801086 T ES09801086 T ES 09801086T ES 2752025 T8 ES2752025 T8 ES 2752025T8
- Authority
- ES
- Spain
- Prior art keywords
- screening methods
- protein screening
- protein
- methods
- screening
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 238000012216 screening Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1062—Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8381308P | 2008-07-25 | 2008-07-25 | |
US9011108P | 2008-08-19 | 2008-08-19 | |
US17002909P | 2009-04-16 | 2009-04-16 | |
PCT/US2009/051716 WO2010011944A2 (en) | 2008-07-25 | 2009-07-24 | Protein screeing methods |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2752025T3 ES2752025T3 (es) | 2020-04-02 |
ES2752025T8 true ES2752025T8 (es) | 2021-11-11 |
Family
ID=41570886
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09801086T Active ES2752025T3 (es) | 2008-07-25 | 2009-07-24 | Métodos de cribado de proteínas |
Country Status (7)
Country | Link |
---|---|
US (4) | US9134304B2 (es) |
EP (2) | EP3629022A1 (es) |
JP (4) | JP5924937B2 (es) |
KR (1) | KR20110036638A (es) |
CN (1) | CN102177438A (es) |
ES (1) | ES2752025T3 (es) |
WO (1) | WO2010011944A2 (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20110036638A (ko) * | 2008-07-25 | 2011-04-07 | 리차드 더블유. 와그너 | 단백질 스크리닝 방법 |
US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
AU2009311588B2 (en) | 2008-11-07 | 2016-07-28 | Adaptive Biotechnologies Corp. | Methods of monitoring conditions by sequence analysis |
HUE029424T2 (en) | 2009-01-15 | 2017-02-28 | Adaptive Biotechnologies Corp | Adaptive immunity profiling and a method for producing monoclonal antibodies |
KR102091207B1 (ko) | 2009-02-13 | 2020-03-20 | 엑스-켐, 인크. | Dna―코딩된 라이브러리의 생성 및 스크리닝 방법 |
KR20120044941A (ko) | 2009-06-25 | 2012-05-08 | 프레드 헛친슨 켄서 리서치 센터 | 적응 면역의 측정방법 |
EP2686349B1 (en) | 2011-03-15 | 2020-12-09 | X-Body, Inc. | Antibody screening methods |
EA032438B1 (ru) | 2011-09-07 | 2019-05-31 | Икс-Чем, Инк. | Способы мечения днк-кодированных библиотек |
US10385475B2 (en) | 2011-09-12 | 2019-08-20 | Adaptive Biotechnologies Corp. | Random array sequencing of low-complexity libraries |
WO2013085972A1 (en) | 2011-12-05 | 2013-06-13 | X-Body, Inc. | Pdgf receptor beta binding polypeptides |
DK2823060T3 (en) | 2012-03-05 | 2018-05-28 | Adaptive Biotechnologies Corp | Determination of associated immune receptor chains from frequency-matched subunits |
EP2831276B1 (en) | 2012-05-08 | 2016-04-20 | Adaptive Biotechnologies Corporation | Compositions and method for measuring and calibrating amplification bias in multiplexed pcr reactions |
NZ739931A (en) | 2012-07-13 | 2019-08-30 | X Chem Inc | Dna-encoded libraries having encoding oligonucleotide linkages not readable by polymerases |
US20140128275A1 (en) * | 2012-08-21 | 2014-05-08 | Syndecion, LLC | Complex of non-covalently bound protein with encoding nucleic acids and uses thereof |
WO2014055561A1 (en) | 2012-10-01 | 2014-04-10 | Adaptive Biotechnologies Corporation | Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization |
EP2952582A4 (en) * | 2013-01-30 | 2016-11-16 | Peptidream Inc | FLEXIBLE DISPLAY METHOD |
JP6020865B2 (ja) | 2013-03-13 | 2016-11-02 | 国立大学法人 東京大学 | 核酸リンカー |
CN105659090B (zh) | 2013-06-28 | 2020-03-06 | X博迪公司 | 用于鉴别靶细胞特异性靶表位的靶抗原发现、表型筛选及其用途 |
US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
WO2015042528A1 (en) | 2013-09-23 | 2015-03-26 | X-Body Biosciences, Inc. | Methods and compositions for generation of binding agents against cell surface antigens |
US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
US11390921B2 (en) | 2014-04-01 | 2022-07-19 | Adaptive Biotechnologies Corporation | Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs) |
ES2777529T3 (es) | 2014-04-17 | 2020-08-05 | Adaptive Biotechnologies Corp | Cuantificación de genomas de células inmunitarias adaptativas en una mezcla compleja de células |
TWI751102B (zh) | 2014-08-28 | 2022-01-01 | 美商奇諾治療有限公司 | 對cd19具專一性之抗體及嵌合抗原受體 |
ES2784343T3 (es) | 2014-10-29 | 2020-09-24 | Adaptive Biotechnologies Corp | Detección simultánea altamente multiplexada de ácidos nucleicos que codifican heterodímeros de receptores inmunes adaptativos emparejados de muchas muestras |
US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
AU2015353581A1 (en) | 2014-11-25 | 2017-06-15 | Adaptive Biotechnologies Corporation | Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing |
CA2976580A1 (en) | 2015-02-24 | 2016-09-01 | Adaptive Biotechnologies Corp. | Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing |
US11041202B2 (en) | 2015-04-01 | 2021-06-22 | Adaptive Biotechnologies Corporation | Method of identifying human compatible T cell receptors specific for an antigenic target |
EP3472376A4 (en) | 2016-06-16 | 2019-12-18 | Richard Edward Watts | DIRECTED AND RECORDED COMBINATORY SYNTHESIS OF OLIGONUCLEOTIDES OF CODED PROBE MOLECULES |
EP3475446A1 (en) | 2016-06-27 | 2019-05-01 | Juno Therapeutics, Inc. | Method of identifying peptide epitopes, molecules that bind such epitopes and related uses |
MA45491A (fr) | 2016-06-27 | 2019-05-01 | Juno Therapeutics Inc | Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés |
US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
AU2018244030B2 (en) * | 2017-03-29 | 2021-10-21 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Purification of an agent of interest |
EP3619340A4 (en) * | 2017-05-02 | 2021-01-20 | Haystack Sciences Corporation | MOLECULES FOR THE VERIFICATION OF OLIGONUCLEOTIDE DIRECTED COMBINATIONAL SYNTHESIS AND METHOD OF MANUFACTURING AND USING THEREOF |
US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
WO2020095985A1 (ja) * | 2018-11-07 | 2020-05-14 | 公益財団法人川崎市産業振興財団 | ペプチド-核酸複合体 |
WO2020205426A1 (en) * | 2019-03-29 | 2020-10-08 | The Regents Of The University Of California | Comprehensive identification of interacting protein targets using mrna display of uniform libraries |
KR102376443B1 (ko) * | 2020-02-26 | 2022-03-17 | 포항공과대학교 산학협력단 | 나노구조체, 나노구조체를 포함하는 바이오센서, 및 스크리닝 방법 |
US20230125614A1 (en) * | 2020-03-05 | 2023-04-27 | The Trustees Of Columbia University In The City Of New York | IN VIVO mRNA DISPLAY: LARGE-SCALE PROTEOMICS BY NEXT GENERATION SEQUENCING |
Family Cites Families (141)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US40307A (en) | 1863-10-13 | Improvement in steam-engines | ||
US1311003A (en) | 1919-07-22 | Planooraph co | ||
US1316003A (en) | 1919-09-16 | William clair toll | ||
US700501A (en) | 1901-06-17 | 1902-05-20 | Willard C James | Apartment-house. |
US2223603A (en) | 1938-07-15 | 1940-12-03 | William A Darrah | Equipment for heat treating |
US2719403A (en) | 1951-07-14 | 1955-10-04 | Gisiger Armin | Tight container |
US6361943B1 (en) | 1996-10-17 | 2002-03-26 | Mitsubishi Chemical Corporation | Molecule that homologizes genotype and phenotype and utilization thereof |
US3983001A (en) | 1972-05-10 | 1976-09-28 | Ceskoslovenska Akademie Ved | Isolation of biologically active compounds by affinity chromatography |
US4213860A (en) | 1976-06-30 | 1980-07-22 | Board of Regents, State of Florida for and on behalf of the University of Florida | Affinity chromatography and substrate useful therefor |
GB1602432A (en) | 1976-12-15 | 1981-11-11 | Atomic Energy Authority Uk | Affinity chromatography |
US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
US4175182A (en) | 1978-07-03 | 1979-11-20 | Research Corporation | Separation of high-activity heparin by affinity chromatography on supported protamine |
DE3169595D1 (en) | 1980-11-10 | 1985-05-02 | Gersonde Klaus | Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application |
US4475196A (en) | 1981-03-06 | 1984-10-02 | Zor Clair G | Instrument for locating faults in aircraft passenger reading light and attendant call control system |
US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
EP0064833B1 (en) | 1981-04-27 | 1986-06-25 | The Public Health Laboratory Service Board | High pressure liquid affinity chromatography |
GB2097279B (en) | 1981-04-27 | 1984-08-01 | Health Lab Service Board | Affinity chromatography in presence of metal ions |
US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
EP0088046B1 (de) | 1982-02-17 | 1987-12-09 | Ciba-Geigy Ag | Lipide in wässriger Phase |
US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
EP0102324A3 (de) | 1982-07-29 | 1984-11-07 | Ciba-Geigy Ag | Lipide und Tenside in wässriger Phase |
US4447224A (en) | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
US4486194A (en) | 1983-06-08 | 1984-12-04 | James Ferrara | Therapeutic device for administering medicaments through the skin |
US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
EP0350973B1 (de) | 1983-09-26 | 1997-11-05 | Udo Dr. Ehrenfeld | Mittel und Erzeugnis für die Diagnose und Therapie von Tumoren sowie zur Behandlung von Schwächen der zelligen und humoralen Immunabwehr |
DE3474511D1 (en) | 1983-11-01 | 1988-11-17 | Terumo Corp | Pharmaceutical composition containing urokinase |
US5171534A (en) | 1984-01-16 | 1992-12-15 | California Institute Of Technology | Automated DNA sequencing technique |
US5821058A (en) | 1984-01-16 | 1998-10-13 | California Institute Of Technology | Automated DNA sequencing technique |
US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
US4811218A (en) | 1986-06-02 | 1989-03-07 | Applied Biosystems, Inc. | Real time scanning electrophoresis apparatus for DNA sequencing |
US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
US5149625A (en) | 1987-08-11 | 1992-09-22 | President And Fellows Of Harvard College | Multiplex analysis of DNA |
SE8801070D0 (sv) | 1988-03-23 | 1988-03-23 | Pharmacia Ab | Method for immobilizing a dna sequence on a solid support |
US4962020A (en) | 1988-07-12 | 1990-10-09 | President And Fellows Of Harvard College | DNA sequencing |
US5075216A (en) | 1988-09-23 | 1991-12-24 | Cetus Corporation | Methods for dna sequencing with thermus aquaticus dna polymerase |
DE68913658T3 (de) | 1988-11-11 | 2005-07-21 | Stratagene, La Jolla | Klonierung von Immunglobulin Sequenzen aus den variablen Domänen |
US5043062A (en) | 1989-02-21 | 1991-08-27 | Eastman Kodak Company | High performance affinity chromatography column comprising non-porous, nondisperse polymeric packing material |
US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
DE69032483T2 (de) | 1989-10-05 | 1998-11-26 | Optein, Inc., Seattle, Wash. | Zellfreie synthese und isolierung von genen und polypeptiden |
US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
CA2079802C (en) | 1990-04-05 | 2001-09-18 | Roberto Crea | Walk-through mutagenesis |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
US5843701A (en) | 1990-08-02 | 1998-12-01 | Nexstar Pharmaceticals, Inc. | Systematic polypeptide evolution by reverse translation |
US5846951A (en) | 1991-06-06 | 1998-12-08 | The School Of Pharmacy, University Of London | Pharmaceutical compositions |
ATE463573T1 (de) | 1991-12-02 | 2010-04-15 | Medimmune Ltd | Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken |
EP2224006A1 (en) | 1991-12-02 | 2010-09-01 | MedImmune Limited | Production of anti-self antibodies from antibody segment repertoires and displayed on phage |
GB9208733D0 (en) | 1992-04-22 | 1992-06-10 | Medical Res Council | Dna sequencing method |
US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
US6765087B1 (en) | 1992-08-21 | 2004-07-20 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
EP0679196B1 (en) | 1993-01-07 | 2004-05-26 | Sequenom, Inc. | Dna sequencing by mass spectrometry |
US5374527A (en) | 1993-01-21 | 1994-12-20 | Applied Biosystems, Inc. | High resolution DNA sequencing method using low viscosity medium |
EP0682671A4 (en) | 1993-02-01 | 1998-01-14 | Seq Ltd | METHOD AND DEVICES FOR SEQUENCING DNA. |
EP0689610B1 (en) | 1993-03-19 | 2002-07-03 | Sequenom, Inc. | Dna sequencing by mass spectrometry via exonuclease degradation |
WO1994025591A1 (en) | 1993-04-29 | 1994-11-10 | Unilever N.V. | PRODUCTION OF ANTIBODIES OR (FUNCTIONALIZED) FRAGMENTS THEREOF DERIVED FROM HEAVY CHAIN IMMUNOGLOBULINS OF $i(CAMELIDAE) |
US5922545A (en) | 1993-10-29 | 1999-07-13 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
SE9400088D0 (sv) | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
US5654419A (en) | 1994-02-01 | 1997-08-05 | The Regents Of The University Of California | Fluorescent labels and their use in separations |
UA71889C2 (uk) | 1996-04-02 | 2005-01-17 | Йєда Рісерч Енд Дівелопмент Ко. Лтд. | Модулятори зв'язаного з рецептором tnf фактора (traf), їх одержання та застосування |
US5846727A (en) | 1996-06-06 | 1998-12-08 | Board Of Supervisors Of Louisiana State University And Agricultural & Mechanical College | Microsystem for rapid DNA sequencing |
US6258533B1 (en) | 1996-11-01 | 2001-07-10 | The University Of Iowa Research Foundation | Iterative and regenerative DNA sequencing method |
US5858671A (en) | 1996-11-01 | 1999-01-12 | The University Of Iowa Research Foundation | Iterative and regenerative DNA sequencing method |
US5876934A (en) | 1996-12-18 | 1999-03-02 | Pharmacia Biotech Inc. | DNA sequencing method |
AU776478B2 (en) | 1997-01-21 | 2004-09-09 | General Hospital Corporation, The | Selection of proteins using RNA-protein fusions |
US6261804B1 (en) | 1997-01-21 | 2001-07-17 | The General Hospital Corporation | Selection of proteins using RNA-protein fusions |
JP3692542B2 (ja) | 1997-01-21 | 2005-09-07 | ザ ジェネラル ホスピタル コーポレーション | Rna−蛋白質の融合体を用いた蛋白質の選抜 |
GB9703369D0 (en) | 1997-02-18 | 1997-04-09 | Lindqvist Bjorn H | Process |
US6090800A (en) * | 1997-05-06 | 2000-07-18 | Imarx Pharmaceutical Corp. | Lipid soluble steroid prodrugs |
ATE321849T1 (de) | 1997-04-23 | 2006-04-15 | Univ Zuerich | Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren |
US6620587B1 (en) | 1997-05-28 | 2003-09-16 | Discerna Limited | Ribosome complexes as selection particles for in vitro display and evolution of proteins |
DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
US6153383A (en) * | 1997-12-09 | 2000-11-28 | Verdine; Gregory L. | Synthetic transcriptional modulators and uses thereof |
US6565403B1 (en) | 1997-12-15 | 2003-05-20 | E. I. Du Pont De Nemours And Company | Ion-bombarded graphite electron emitters |
ATE340870T1 (de) | 1998-04-03 | 2006-10-15 | Compound Therapeutics Inc | Adressierbare protein arrays |
US6143503A (en) | 1998-04-17 | 2000-11-07 | Whitehead Institute For Biomedical Research | Use of a ribozyme to join nucleic acids and peptides |
US6846655B1 (en) | 1998-06-29 | 2005-01-25 | Phylos, Inc. | Methods for generating highly diverse libraries |
WO2000009741A1 (en) * | 1998-08-13 | 2000-02-24 | The Trustees Of The University Of Pennsylvania | Method of identifying proteins |
EP1105360B1 (en) | 1998-08-17 | 2009-07-29 | Bristol-Myers Squibb Company | Identification of compound-protein interactions using libraries of protein-nucleic acid fusion molecules |
EP1105516A4 (en) | 1998-08-17 | 2002-01-09 | Phylos Inc | METHODS FOR PRODUCING PRIVATE NUCLEIC ACIDS FROM 3 'NON-TRANSLATED REGIONS AND FOR OPTIMIZING THE FORMATION OF A CELL-PROTEIN RNA FUSION |
DE69935248T2 (de) | 1998-12-02 | 2007-11-08 | Adnexus Therapeutics, Inc., Waltham | Dna-protein fusionen sowie anwendungen derselben |
US7115396B2 (en) | 1998-12-10 | 2006-10-03 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
US6413720B1 (en) * | 1999-01-11 | 2002-07-02 | Signal Pharmaceuticals, Inc. | Method for the affinity isolation of newly synthesized RNA |
US6623926B1 (en) | 1999-06-01 | 2003-09-23 | Phylos, Inc. | Methods for producing 5′-nucleic acid-protein conjugates |
AU778194B2 (en) | 1999-07-12 | 2004-11-18 | Bristol-Myers Squibb Company | C-terminal protein tagging |
US6429300B1 (en) | 1999-07-27 | 2002-08-06 | Phylos, Inc. | Peptide acceptor ligation methods |
WO2001016352A1 (en) | 1999-08-27 | 2001-03-08 | Phylos, Inc. | Methods for encoding and sorting in vitro translated proteins |
WO2001016600A1 (fr) | 1999-08-31 | 2001-03-08 | Mitsubishi Chemical Corporation | Methode d'analyse d'une interaction mutuelle entre une proteine et une molecule |
US20010046680A1 (en) | 1999-10-01 | 2001-11-29 | Zhongping Yu | Identification of polypeptides and nucleic acid molecules using linkage between DNA and polypeptide |
US6794132B2 (en) | 1999-10-02 | 2004-09-21 | Biosite, Inc. | Human antibodies |
WO2001053539A1 (en) | 2000-01-24 | 2001-07-26 | Phylos, Inc. | Sensitive, multiplexed diagnostic assays for protein analysis |
US7022479B2 (en) | 2000-01-24 | 2006-04-04 | Compound Therapeutics, Inc. | Sensitive, multiplexed diagnostic assays for protein analysis |
DE60115405T2 (de) | 2000-03-31 | 2006-08-03 | Cambridge Antibody Technology Ltd. | Verbesserungen in bezug auf ribosom-komplexe als selektionspartikel |
WO2001079221A2 (en) | 2000-04-12 | 2001-10-25 | Genaissance Pharmaceuticals, Inc. | Haplotypes of the il8rb gene |
CA2409705A1 (en) | 2000-05-16 | 2001-11-22 | Merck & Co., Inc. | Gene responsible for stargardt-like dominant macular dystrophy |
US7417130B2 (en) | 2000-09-08 | 2008-08-26 | University Of Zurich | Collection of repeat proteins comprising repeat modules |
WO2002046395A1 (fr) * | 2000-12-07 | 2002-06-13 | Keio University | Proteine a c-terminaison modifiee et procede permettant d'obtenir cette proteine, agent de modification et matrice de traduction necessaire a la production d'une proteine a c-terminaison modifiee, et procede de detection de l'interaction proteique avec l'utilisation de ladite proteine |
JP4963142B2 (ja) | 2000-12-14 | 2012-06-27 | 学校法人慶應義塾 | 遺伝子型と表現型の対応付け分子とその構成要素、および対応付け分子の製造方法と利用方法 |
US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
AU2002256371B2 (en) | 2001-04-26 | 2008-01-10 | Amgen Mountain View Inc. | Combinatorial libraries of monomer domains |
US20050048512A1 (en) | 2001-04-26 | 2005-03-03 | Avidia Research Institute | Combinatorial libraries of monomer domains |
US20030157561A1 (en) | 2001-11-19 | 2003-08-21 | Kolkman Joost A. | Combinatorial libraries of monomer domains |
US20060223114A1 (en) | 2001-04-26 | 2006-10-05 | Avidia Research Institute | Protein scaffolds and uses thereof |
US20050089932A1 (en) | 2001-04-26 | 2005-04-28 | Avidia Research Institute | Novel proteins with targeted binding |
US20050053973A1 (en) | 2001-04-26 | 2005-03-10 | Avidia Research Institute | Novel proteins with targeted binding |
US20040175756A1 (en) | 2001-04-26 | 2004-09-09 | Avidia Research Institute | Methods for using combinatorial libraries of monomer domains |
WO2002101036A1 (fr) | 2001-05-11 | 2002-12-19 | Kazunari Taira | Methode de formation d'un complexe stable d'un transcrit d'adn codant un peptide arbitraire a l'aide d'un produit de traduction, construction d'acide nucleique utilisee dans cette methode, complexe obtenu par cette methode et criblage de proteine fonctionnelle et marn ou adn codant la proteine a l'aide de cette methode |
AU2002310502A1 (en) | 2001-06-21 | 2003-01-08 | Phylos, Inc. | In vitro protein interaction detection systems |
JP4303105B2 (ja) | 2001-06-28 | 2009-07-29 | ドマンティス リミテッド | 二重特異性リガンドとその利用 |
WO2004058821A2 (en) | 2002-12-27 | 2004-07-15 | Domantis Limited | Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand |
JP2004537312A (ja) | 2001-07-31 | 2004-12-16 | フィロス インク. | 核酸−蛋白質融合多量体のモジュラーアッセンブリ |
AU2002365404A1 (en) | 2001-11-27 | 2003-06-10 | Compound Therapeutics, Inc. | Solid-phase immobilization of proteins and peptides |
US20060002935A1 (en) | 2002-06-28 | 2006-01-05 | Domantis Limited | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
ATE328906T1 (de) | 2002-06-28 | 2006-06-15 | Domantis Ltd | Dual-specifische liganden mit erhöhter halbwertszeit |
US20040043384A1 (en) * | 2002-08-28 | 2004-03-04 | Oleinikov Andrew V. | In vitro protein translation microarray device |
JP4664677B2 (ja) | 2002-09-06 | 2011-04-06 | イソゲニカ リミテッド | イン・ビトロでのペプチド発現ライブラリー |
US20040259155A1 (en) | 2002-09-30 | 2004-12-23 | Compound Therapeutics, Inc. | Methods of engineering spatially conserved motifs in polypeptides |
EP1558645B1 (en) | 2002-11-08 | 2011-07-27 | Ablynx N.V. | Stabilized single domain antibodies in pharmaceutical composition adapted for inhalation |
JP4478772B2 (ja) * | 2002-12-11 | 2010-06-09 | 学校法人慶應義塾 | c−Fos蛋白質と複合体を形成する蛋白質、及び、それをコードする核酸、ならびに、それらの利用方法 |
US7572577B2 (en) | 2003-03-19 | 2009-08-11 | Crescendo Biologics Limited | Methods for recovery of DNA from mRNA in ribosome display complexes |
EP1627062A1 (en) | 2003-05-14 | 2006-02-22 | Domantis Limited | A process for recovering polypeptides that unfold reversibly from a polypeptide repertoire |
AU2004220325B2 (en) | 2003-06-30 | 2011-05-12 | Domantis Limited | Polypeptides |
ATE374788T1 (de) | 2003-08-12 | 2007-10-15 | Lipoxen Technologies Ltd | Polysialinsäurederivate |
WO2005030957A1 (de) | 2003-10-01 | 2005-04-07 | ETH Zürich | Verfahren zur in vitro evolution von polypeptiden |
EP1675878A2 (en) | 2003-10-24 | 2006-07-05 | Avidia, Inc. | Ldl receptor class a and egf domain monomers and multimers |
US20060008844A1 (en) | 2004-06-17 | 2006-01-12 | Avidia Research Institute | c-Met kinase binding proteins |
CA2587424A1 (en) | 2004-11-16 | 2006-05-26 | Avidia Research Institute | Protein scaffolds and uses thereof |
WO2006079372A1 (en) | 2005-01-31 | 2006-08-03 | Ablynx N.V. | Method for generating variable domain sequences of heavy chain antibodies |
US20090286696A1 (en) * | 2005-02-04 | 2009-11-19 | University Of Wollongong | Double-Stranded Olidonucleotides and Uses Therefor |
CN103626884B (zh) | 2005-02-23 | 2016-05-18 | 利普生技术有限公司 | 用于蛋白质衍生和缀合的活化的唾液酸衍生物 |
EP1929073A4 (en) | 2005-09-27 | 2010-03-10 | Amunix Inc | PROTEIN MEDICAMENT AND ITS USE |
AU2006317242A1 (en) | 2005-11-28 | 2007-05-31 | Genmab A/S | Recombinant monovalent antibodies and methods for production thereof |
JP4616237B2 (ja) | 2006-11-07 | 2011-01-19 | 日本電信電話株式会社 | シリコン化合物薄膜の形成方法 |
US8236508B2 (en) | 2008-01-29 | 2012-08-07 | Drexel University | Detecting and measuring live pathogens utilizing a mass detection device |
KR20110036638A (ko) * | 2008-07-25 | 2011-04-07 | 리차드 더블유. 와그너 | 단백질 스크리닝 방법 |
US8698004B2 (en) | 2008-10-27 | 2014-04-15 | Ibiden Co., Ltd. | Multi-piece board and fabrication method thereof |
US8876866B2 (en) | 2010-12-13 | 2014-11-04 | Globus Medical, Inc. | Spinous process fusion devices and methods thereof |
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2009
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- 2009-07-24 EP EP19192666.6A patent/EP3629022A1/en not_active Withdrawn
- 2009-07-24 ES ES09801086T patent/ES2752025T3/es active Active
- 2009-07-24 JP JP2011520232A patent/JP5924937B2/ja active Active
- 2009-07-24 WO PCT/US2009/051716 patent/WO2010011944A2/en active Application Filing
- 2009-07-24 EP EP09801086.1A patent/EP2316030B1/en active Active
- 2009-07-24 CN CN200980137939XA patent/CN102177438A/zh active Pending
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US11268090B2 (en) | 2022-03-08 |
ES2752025T3 (es) | 2020-04-02 |
JP6239654B2 (ja) | 2017-11-29 |
JP7123092B2 (ja) | 2022-08-22 |
EP2316030B1 (en) | 2019-08-21 |
JP6725473B2 (ja) | 2020-07-22 |
US9134304B2 (en) | 2015-09-15 |
US20160040158A1 (en) | 2016-02-11 |
JP2018015013A (ja) | 2018-02-01 |
JP5924937B2 (ja) | 2016-05-25 |
EP2316030A4 (en) | 2011-10-12 |
CN102177438A (zh) | 2011-09-07 |
US20200172897A1 (en) | 2020-06-04 |
WO2010011944A3 (en) | 2010-05-06 |
US10519438B2 (en) | 2019-12-31 |
JP2016127845A (ja) | 2016-07-14 |
US20180094256A1 (en) | 2018-04-05 |
EP2316030A2 (en) | 2011-05-04 |
JP2011528912A (ja) | 2011-12-01 |
WO2010011944A2 (en) | 2010-01-28 |
US9803193B2 (en) | 2017-10-31 |
KR20110036638A (ko) | 2011-04-07 |
JP2020178697A (ja) | 2020-11-05 |
US20110183863A1 (en) | 2011-07-28 |
EP3629022A1 (en) | 2020-04-01 |
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