BR0316363A - Nucleosìdeos 2'-ramificado e mutação de flaviviridae - Google Patents

Nucleosìdeos 2'-ramificado e mutação de flaviviridae

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Publication number
BR0316363A
BR0316363A BR0316363A BR0316363A BR0316363A BR 0316363 A BR0316363 A BR 0316363A BR 0316363 A BR0316363 A BR 0316363A BR 0316363 A BR0316363 A BR 0316363A BR 0316363 A BR0316363 A BR 0316363A
Authority
BR
Brazil
Prior art keywords
mutation
flaviviridae
nucleosides
branched nucleosides
xrxsgxxxt
Prior art date
Application number
BR0316363A
Other languages
English (en)
Inventor
Jean-Pierre Sommadossi
Paolo La Colla
David Standring
Vadim Bichko
Lin Qu
Original Assignee
Idenix Cayman Ltd
Univ Cagliari
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32326395&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0316363(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Idenix Cayman Ltd, Univ Cagliari filed Critical Idenix Cayman Ltd
Publication of BR0316363A publication Critical patent/BR0316363A/pt

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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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Abstract

"NUCLEOSìDEOS 2<39>-RAMIFICADO E MUTAçãO DE FLAVIVIRIDAE". A presente invenção divulga um método para o tratamento de infecção por Flaviviridae que inclui a administração de um nucleosídeo 2<39>-ramificado ou uma pródroga e/ou sal farmaceuticamente aceitável do mesmo, a um ser humano que precisa de terapia, em combinação ou alternação com uma droga que induz direta ou indiretamente a uma mutação no genoma viral em um outro local que não uma mutação de um nucleotídeo que resulta em uma alteração de serina para um aminoácido diferente na seq³ência consensus altamente conservada, XRXSGXXXT, do domínio B da região de RNA polimerase ou está associada a tal mutação. A invenção também inclui um método para detectar um gênero mutante de Flaviviridae e um método para seu tratamento.
BR0316363A 2002-11-15 2003-11-17 Nucleosìdeos 2'-ramificado e mutação de flaviviridae BR0316363A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42667502P 2002-11-15 2002-11-15
PCT/US2003/036714 WO2004046331A2 (en) 2002-11-15 2003-11-17 2’-branched nucleosides and flaviviridae mutation

Publications (1)

Publication Number Publication Date
BR0316363A true BR0316363A (pt) 2005-10-04

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ID=32326395

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BR0316363A BR0316363A (pt) 2002-11-15 2003-11-17 Nucleosìdeos 2'-ramificado e mutação de flaviviridae

Country Status (21)

Country Link
US (4) US7824851B2 (pt)
EP (1) EP1576138B1 (pt)
JP (4) JP2006519753A (pt)
KR (1) KR20050088079A (pt)
CN (1) CN1849142A (pt)
AU (1) AU2003298658A1 (pt)
BR (1) BR0316363A (pt)
CA (1) CA2506129C (pt)
CY (1) CY1118931T1 (pt)
DK (1) DK1576138T3 (pt)
ES (1) ES2624353T3 (pt)
HU (1) HUE033832T2 (pt)
LT (1) LT1576138T (pt)
MX (1) MXPA05005192A (pt)
NO (1) NO20052920L (pt)
PL (1) PL377342A1 (pt)
PT (1) PT1576138T (pt)
RU (1) RU2005118421A (pt)
SI (1) SI1576138T1 (pt)
WO (1) WO2004046331A2 (pt)
ZA (1) ZA200503834B (pt)

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EA200601591A1 (ru) * 2000-05-26 2007-02-27 Айденикс (Кайман) Лимитед Применение рибонуклеозидных соединений для лечения флавивирусных и пестивирусных инфекций
WO2003068244A1 (en) 2002-02-13 2003-08-21 Merck & Co., Inc. Methods of inhibiting orthopoxvirus replication with nucleoside compounds
CN101172993A (zh) * 2002-06-28 2008-05-07 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷
BR0312278A (pt) * 2002-06-28 2007-06-19 Idenix Cayman Ltd éster 2'-c-metil-3'-o-l-valina de ribofuranosil citidina para tratamento de infecções por flaviviridae
US7608600B2 (en) * 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
AU2003256619A1 (en) 2002-07-24 2004-02-09 Isis Pharmaceuticals, Inc. Pyrrolopyrimidine thionucleoside analogs as antivirals
DE10238722A1 (de) 2002-08-23 2004-03-11 Bayer Ag Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse
DK1576138T3 (en) * 2002-11-15 2017-05-01 Idenix Pharmaceuticals Llc 2'-METHYL NUCLEOSIDES IN COMBINATION WITH INTERFERON AND FLAVIVIRIDAE MUTATION
US7598373B2 (en) * 2002-12-12 2009-10-06 Idenix Pharmaceuticals, Inc. Process for the production of 2-C-methyl-D-ribonolactone
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US20110129813A1 (en) 2011-06-02
EP1576138B1 (en) 2017-02-01
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CN1849142A (zh) 2006-10-18
JP6063073B2 (ja) 2017-01-18
JP2011024578A (ja) 2011-02-10
EP1576138A2 (en) 2005-09-21
WO2004046331A2 (en) 2004-06-03
SI1576138T1 (sl) 2017-07-31
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