GB924246A - Purine derivatives and their preparation - Google Patents

Purine derivatives and their preparation

Info

Publication number
GB924246A
GB924246A GB4111159A GB4111159A GB924246A GB 924246 A GB924246 A GB 924246A GB 4111159 A GB4111159 A GB 4111159A GB 4111159 A GB4111159 A GB 4111159A GB 924246 A GB924246 A GB 924246A
Authority
GB
United Kingdom
Prior art keywords
tri
preparation
chloro
purine derivatives
ribofuranosylpurines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4111159A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US782410A external-priority patent/US3074929A/en
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of GB924246A publication Critical patent/GB924246A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Abstract

The invention comprises 2-amino-6-chloro-9-21,31, 51-tri-O-acylb -D-ribofuranosylpurines and the preparation thereof and of 6-chloro-9-21,31, 51- tri-O-acyl-b -D- ribofuranosylpurine by treating 21,31,51-tri-O-acylguanosines or 21,31,51-tri-O-acylinosines with a chlorinating agent, e.g. phosphoryl chloride. 21,31,51-Tri-O-acetyl- and -benzoyl-guanosine and -inosine are prepared by treating guanosine or inosine with acetic anhydride or benzoyl chloride, in the presence of pyridine. 6-Mercapto- and 2-amino-6-mercapto-9-b -D-ribofuranosylpurines are prepared from the corresponding 6-chloro-tri-O-acyl compounds by thiation followed by deacylation.
GB4111159A 1958-12-23 1959-12-03 Purine derivatives and their preparation Expired GB924246A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US782410A US3074929A (en) 1955-08-11 1958-12-23 Glycosides of 6-mercaptopurine

Publications (1)

Publication Number Publication Date
GB924246A true GB924246A (en) 1963-04-24

Family

ID=25125964

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4111159A Expired GB924246A (en) 1958-12-23 1959-12-03 Purine derivatives and their preparation

Country Status (2)

Country Link
CH (1) CH388321A (en)
GB (1) GB924246A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7625875B2 (en) 2002-06-28 2009-12-01 Idenix Pharmaceuticals, Inc. 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7781576B2 (en) 2005-12-23 2010-08-24 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
US7824851B2 (en) 2002-11-15 2010-11-02 Idenix Pharmaceuticals, Inc. 2′-branched nucleosides and Flaviviridae mutation
US8299038B2 (en) 2000-05-23 2012-10-30 Idenix Pharmaceuticals, Inc. Methods and compositions for treating hepatitis C virus
US8343937B2 (en) 2000-05-26 2013-01-01 Idenix Pharmaceuticals, Inc. Methods and compositions for treating flaviviruses and pestiviruses

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8299038B2 (en) 2000-05-23 2012-10-30 Idenix Pharmaceuticals, Inc. Methods and compositions for treating hepatitis C virus
US10758557B2 (en) 2000-05-23 2020-09-01 Idenix Pharmaceuticals Llc Methods and compositions for treating hepatitis C virus
US10363265B2 (en) 2000-05-23 2019-07-30 Idenix Pharmaceuticals Llc Methods and compositions for treating hepatitis C virus
US9968628B2 (en) 2000-05-26 2018-05-15 Idenix Pharmaceuticals Llc Methods and compositions for treating flaviviruses and pestiviruses
US8343937B2 (en) 2000-05-26 2013-01-01 Idenix Pharmaceuticals, Inc. Methods and compositions for treating flaviviruses and pestiviruses
US7662798B2 (en) 2002-06-28 2010-02-16 Idenix Pharmaceuticals, Inc. 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7635689B2 (en) 2002-06-28 2009-12-22 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7625875B2 (en) 2002-06-28 2009-12-01 Idenix Pharmaceuticals, Inc. 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7824851B2 (en) 2002-11-15 2010-11-02 Idenix Pharmaceuticals, Inc. 2′-branched nucleosides and Flaviviridae mutation
US8674085B2 (en) 2002-11-15 2014-03-18 Idenix Pharmaceuticals, Inc. 2′-branched nucleosides and Flaviviridae mutation
US10525072B2 (en) 2002-11-15 2020-01-07 Idenix Pharmaceuticals Llc 2′-branched nucleosides and flaviviridae mutation
US7781576B2 (en) 2005-12-23 2010-08-24 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides

Also Published As

Publication number Publication date
CH388321A (en) 1965-02-28

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