IT1198449B - Esteri di alcoli polivalenti di acido ialuronico - Google Patents

Esteri di alcoli polivalenti di acido ialuronico

Info

Publication number
IT1198449B
IT1198449B IT48546/86A IT4854686A IT1198449B IT 1198449 B IT1198449 B IT 1198449B IT 48546/86 A IT48546/86 A IT 48546/86A IT 4854686 A IT4854686 A IT 4854686A IT 1198449 B IT1198449 B IT 1198449B
Authority
IT
Italy
Prior art keywords
esters
hyaluronic acid
polyvalent alcohols
polyvalent
alcohols
Prior art date
Application number
IT48546/86A
Other languages
English (en)
Other versions
IT8648546A0 (it
Inventor
Valle Francesco Della
Aurelio Romeo
Original Assignee
F I D I Farmaceutici Italiani
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F I D I Farmaceutici Italiani filed Critical F I D I Farmaceutici Italiani
Publication of IT8648546A0 publication Critical patent/IT8648546A0/it
Priority to IT48546/86A priority Critical patent/IT1198449B/it
Priority to IE872618A priority patent/IE872618L/xx
Priority to IL84032A priority patent/IL84032A/xx
Priority to NZ221994A priority patent/NZ221994A/xx
Priority to EP87308863A priority patent/EP0265116B1/en
Priority to AT87308863T priority patent/ATE163942T1/de
Priority to DE3752176T priority patent/DE3752176T2/de
Priority to ES87308863T priority patent/ES2115583T3/es
Priority to CA000548921A priority patent/CA1317287C/en
Priority to ZA877559A priority patent/ZA877559B/xx
Priority to IN787/CAL/87A priority patent/IN170801B/en
Priority to NO874251A priority patent/NO175374C/no
Priority to PH35917A priority patent/PH26025A/en
Priority to US07/106,658 priority patent/US4957744A/en
Priority to HU874614A priority patent/HU204858B/hu
Priority to JP62258165A priority patent/JP2648308B2/ja
Priority to PT85908A priority patent/PT85908B/pt
Priority to KR1019870011311A priority patent/KR920002702B1/ko
Priority to AR87308948A priority patent/AR247406A1/es
Priority to CN87106919A priority patent/CN1025035C/zh
Priority to FI874504A priority patent/FI96610C/fi
Priority to DK536087A priority patent/DK536087A/da
Priority to AU79600/87A priority patent/AU610087B2/en
Application granted granted Critical
Publication of IT1198449B publication Critical patent/IT1198449B/it
Priority to IN91/CAL/90A priority patent/IN170958B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/00272-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28Polysaccharides or their derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06At least partially resorbable materials
    • A61L17/10At least partially resorbable materials containing macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/20Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
IT48546/86A 1986-10-13 1986-10-13 Esteri di alcoli polivalenti di acido ialuronico IT1198449B (it)

Priority Applications (24)

Application Number Priority Date Filing Date Title
IT48546/86A IT1198449B (it) 1986-10-13 1986-10-13 Esteri di alcoli polivalenti di acido ialuronico
IE872618A IE872618L (en) 1986-10-13 1987-09-29 Cross-linked esters of hyaluronic acid
IL84032A IL84032A (en) 1986-10-13 1987-09-29 Totally or partially cross- linked esters of hyaluronic acid, salts of partially cross-linked esters, their preparation, pharmaceutical and cosmetic compositions containing them and sanitary, medical and surgical articles prepared therefrom
NZ221994A NZ221994A (en) 1986-10-13 1987-09-30 Cross-linked esters of hyaluronic acid; preparation and uses thereof
EP87308863A EP0265116B1 (en) 1986-10-13 1987-10-06 Cross-linked esters of hyaluronic acid
AT87308863T ATE163942T1 (de) 1986-10-13 1987-10-06 Vernetzte ester von hyaluronsäure
DE3752176T DE3752176T2 (de) 1986-10-13 1987-10-06 Vernetzte Ester von Hyaluronsäure
ES87308863T ES2115583T3 (es) 1986-10-13 1987-10-06 Esteres reticulados de acido hialuronico.
CA000548921A CA1317287C (en) 1986-10-13 1987-10-08 Cross-linked esters of hyaluronic acid
ZA877559A ZA877559B (en) 1986-10-13 1987-10-08 Cross-linked esters of hyaluronic acid
IN787/CAL/87A IN170801B (it) 1986-10-13 1987-10-09
PH35917A PH26025A (en) 1986-10-13 1987-10-12 Esters of polyvalent alcohols of hyaluronic acid
NO874251A NO175374C (no) 1986-10-13 1987-10-12 Fremgangsmåte for fremstilling av tverrbundne partialestere av hyaluronsyre
AR87308948A AR247406A1 (es) 1986-10-13 1987-10-13 Un procedimiento para la preparacion de esteres total o parcialmente reticulados de acido hialuronico
HU874614A HU204858B (en) 1986-10-13 1987-10-13 Process for producing bridge bonded esters of hyaluronic acid
JP62258165A JP2648308B2 (ja) 1986-10-13 1987-10-13 ヒアルロン酸の架橋エステル
PT85908A PT85908B (pt) 1986-10-13 1987-10-13 Processo para a preparacao de esteres do acido hialuronico total ou parcialmente recticulados
KR1019870011311A KR920002702B1 (ko) 1986-10-13 1987-10-13 히알루론산의 가교결합형 에스테르와 그 염
US07/106,658 US4957744A (en) 1986-10-13 1987-10-13 Cross-linked esters of hyaluronic acid
CN87106919A CN1025035C (zh) 1986-10-13 1987-10-13 制备透明质酸的交联酯类的方法
FI874504A FI96610C (fi) 1986-10-13 1987-10-13 Menetelmä hyaluronihapon täydellisesti tai osittain silloitettujen esterien valmistamiseksi
DK536087A DK536087A (da) 1986-10-13 1987-10-13 Tvaerbundne hyaluronsyreestere
AU79600/87A AU610087B2 (en) 1986-10-13 1987-10-13 Cross-linked ester of hyaluronic acid
IN91/CAL/90A IN170958B (it) 1986-10-13 1990-02-01

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT48546/86A IT1198449B (it) 1986-10-13 1986-10-13 Esteri di alcoli polivalenti di acido ialuronico

Publications (2)

Publication Number Publication Date
IT8648546A0 IT8648546A0 (it) 1986-10-13
IT1198449B true IT1198449B (it) 1988-12-21

Family

ID=11267232

Family Applications (1)

Application Number Title Priority Date Filing Date
IT48546/86A IT1198449B (it) 1986-10-13 1986-10-13 Esteri di alcoli polivalenti di acido ialuronico

Country Status (23)

Country Link
US (1) US4957744A (it)
EP (1) EP0265116B1 (it)
JP (1) JP2648308B2 (it)
KR (1) KR920002702B1 (it)
CN (1) CN1025035C (it)
AR (1) AR247406A1 (it)
AT (1) ATE163942T1 (it)
AU (1) AU610087B2 (it)
CA (1) CA1317287C (it)
DE (1) DE3752176T2 (it)
DK (1) DK536087A (it)
ES (1) ES2115583T3 (it)
FI (1) FI96610C (it)
HU (1) HU204858B (it)
IE (1) IE872618L (it)
IL (1) IL84032A (it)
IN (1) IN170801B (it)
IT (1) IT1198449B (it)
NO (1) NO175374C (it)
NZ (1) NZ221994A (it)
PH (1) PH26025A (it)
PT (1) PT85908B (it)
ZA (1) ZA877559B (it)

Families Citing this family (199)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202431A (en) * 1985-07-08 1993-04-13 Fidia, S.P.A. Partial esters of hyaluronic acid
US4851521A (en) * 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
US5227157A (en) * 1986-10-14 1993-07-13 Board Of Regents, The University Of Texas System Delivery of therapeutic agents
US5403592A (en) * 1987-08-25 1995-04-04 Macnaught Pty Limited Lubricant composition for rheumatism
IT1219587B (it) * 1988-05-13 1990-05-18 Fidia Farmaceutici Polisaccaridi carbossiilici autoreticolati
US5470829A (en) * 1988-11-17 1995-11-28 Prisell; Per Pharmaceutical preparation
US5783691A (en) * 1989-02-08 1998-07-21 Biomatrix, Inc. Crosslinked hyaluronate gels, their use and method for producing them
CA1340994C (en) 1989-09-21 2000-05-16 Rudolf Edgar Dr. Falk Treatment of conditions and disease
US5910489A (en) * 1990-09-18 1999-06-08 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
US5639738A (en) * 1992-02-20 1997-06-17 Hyal Pharmaceutical Corporation Treatment of basal cell carcinoma and actinic keratosis employing hyaluronic acid and NSAIDs
US5990096A (en) * 1990-09-18 1999-11-23 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US5824658A (en) * 1990-09-18 1998-10-20 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
CA2061703C (en) * 1992-02-20 2002-07-02 Rudolf E. Falk Formulations containing hyaluronic acid
US5626863A (en) * 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5462990A (en) * 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
IT1247175B (it) * 1991-04-19 1994-12-12 Fidia Spa Procedimento per la purificazione di acido ialuronico e frazione di acido ialuronico puro per uso oftalmico.
US5234914A (en) * 1991-06-11 1993-08-10 Patent Biopharmaceutics, Inc. Methods of treating hemorrhoids and anorecial disease
US6103704A (en) * 1991-07-03 2000-08-15 Hyal Pharmaceutical Corporation Therapeutic methods using hyaluronic acid
US6022866A (en) * 1991-07-03 2000-02-08 Hyal Pharmaceutical Corporation Use of hyaluronic acid and forms to prevent arterial restenosis
US5792753A (en) * 1991-07-03 1998-08-11 Hyal Pharmaceutical Corporation Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs
US5977088A (en) * 1991-07-03 1999-11-02 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US5990095A (en) * 1991-07-03 1999-11-23 Hyal Pharmaceutical Corporation Use of hyaluronic acid and forms to prevent arterial restenosis
WO1994007505A1 (en) * 1991-07-03 1994-04-14 Norpharmco Inc. Use of hyaluronic acid and forms to prevent arterial restenosis
US5817644A (en) * 1991-07-03 1998-10-06 Hyal Pharmaceutical Corporation Targeting of dosages of medicine and therapeutic agents
AU3124793A (en) * 1991-10-29 1993-06-07 Clover Consolidated, Limited Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release
IT1254704B (it) * 1991-12-18 1995-10-09 Mini Ricerca Scient Tecnolog Tessuto non tessuto essenzialmente costituito da derivati dell'acido ialuronico
IT1254170B (it) * 1991-12-18 1995-09-11 Mini Ricerca Scient Tecnolog Membrane composite per la rigenerazione guidata di tessuti
US5824335A (en) * 1991-12-18 1998-10-20 Dorigatti; Franco Non-woven fabric material comprising auto-crosslinked hyaluronic acid derivatives
US6218373B1 (en) 1992-02-20 2001-04-17 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US6147059A (en) * 1992-02-20 2000-11-14 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
CA2061567C (en) * 1992-02-20 1998-02-03 Rudolf E. Falk Use of hyaluronic acid to repair ischemia reperfusion damage
US6114314A (en) * 1992-02-21 2000-09-05 Hyal Pharmaceutical Corp. Formulations containing hyaluronic acid
US5767106A (en) * 1992-02-21 1998-06-16 Hyal Pharmaceutical Corporation Treatment of disease and conditions associated with macrophage infiltration
US5573934A (en) * 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
JP3011768B2 (ja) * 1992-02-28 2000-02-21 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム 組織接触材料および制御放出キャリアとしての光重合性生分解性親水ゲル
IT1259090B (it) 1992-04-17 1996-03-11 Fidia Spa Biomaterialli per protesi d'osso
IT1259100B (it) * 1992-05-20 1996-03-11 Lanfranco Callegaro Uso di idrogeli per il bloccaggio di sistemi protesici
IT1260154B (it) * 1992-07-03 1996-03-28 Lanfranco Callegaro Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn)
US5550112A (en) * 1992-12-30 1996-08-27 Patent Biopharmaceutics, Inc. Hyaluronic acid-urea pharmaceutical compositions and uses
DE784487T1 (de) * 1993-03-19 1999-11-04 Q Med Ab Uppsala Ein präparat und ein verfahren zur gewebevermehrung
CA2127636C (en) * 1993-07-21 2009-10-20 Cheng-Kung Liu Plasticizers for fibers used to form surgical devices
US6005019A (en) * 1993-07-21 1999-12-21 United States Surgical Corporation Plasticizers for fibers used to form surgical devices
IT1263394B (it) * 1993-07-30 1996-08-05 Fidia Advanced Biopolymers Srl Composizioni farmaceutiche per uso topico a base di acido ialuronico e suoi derivati
US5631242A (en) * 1993-08-04 1997-05-20 Patent Biopharmaceutics, Inc. Hyaluronic acid-urea pharmaceutical compositions utilized for treatment of diseases of cutis
US5531716A (en) * 1993-09-29 1996-07-02 Hercules Incorporated Medical devices subject to triggered disintegration
US5399358A (en) * 1993-11-12 1995-03-21 Edward Mendell Co., Inc. Sustained release formulations for 24 hour release of metroprolol
CA2164513C (en) * 1994-04-25 1999-09-21 Anand R. Baichwal Sustained release excipient
US5399362A (en) * 1994-04-25 1995-03-21 Edward Mendell Co., Inc. Once-a-day metoprolol oral dosage form
US5690961A (en) * 1994-12-22 1997-11-25 Hercules Incorporated Acidic polysaccharides crosslinked with polycarboxylic acids and their uses
CZ293637B6 (cs) * 1995-02-07 2004-06-16 Fidia Advanced Biopolymers, S.R.L. Způsob potahování povrchu předmětu kyselinou hyaluronovou nebo jejím derivátem
ATE306903T1 (de) * 1995-03-24 2005-11-15 Genzyme Corp Verminderung von adhäsionen durch gesteuerte verabreichung von aktivsauerstoffinhibitoren
IT1281870B1 (it) * 1995-04-27 1998-03-03 Fidia Advanced Biopolymers Srl Pelle artificiale umana costituita da materiali biocompatibili a base di derivati dell'acido ialuronico
IT1281886B1 (it) * 1995-05-22 1998-03-03 Fidia Advanced Biopolymers Srl Processo per la preparazione di idrogel ottenuti da derivati chimici dell'acido ialuronico mediante irradiazioni ultraviolette e loro
US5747058A (en) * 1995-06-07 1998-05-05 Southern Biosystems, Inc. High viscosity liquid controlled delivery system
US6413536B1 (en) * 1995-06-07 2002-07-02 Southern Biosystems, Inc. High viscosity liquid controlled delivery system and medical or surgical device
US7833543B2 (en) * 1995-06-07 2010-11-16 Durect Corporation High viscosity liquid controlled delivery system and medical or surgical device
US5968542A (en) * 1995-06-07 1999-10-19 Southern Biosystems, Inc. High viscosity liquid controlled delivery system as a device
US5612321A (en) * 1995-06-22 1997-03-18 Hercules Incorporated Antioxidant grafted polysaccharides
US5827937A (en) * 1995-07-17 1998-10-27 Q Med Ab Polysaccharide gel composition
ATE342295T1 (de) 1995-07-28 2006-11-15 Genzyme Corp Biologische abbaubare multiblokhydrogene und ihre verwendung wie trägerstoffe fur kontrollierte freisetzung pharmakologisch activen werstoffe und gewebekontaktmaterialen
IT1282207B1 (it) * 1995-11-20 1998-03-16 Fidia Advanced Biopolymers Srl Sistemi di coltura di cellule staminali di midollo osseo umano in matrici tridimensionali costituiti da esteri dell'acido ialuronico
AU2068797A (en) * 1996-01-29 1997-08-20 Edward Mendell Co. Inc. Sustained release excipient
US5939047A (en) * 1996-04-16 1999-08-17 Jernberg; Gary R. Local delivery of chemotherapeutic agents for treatment of periodontal disease
US6060534A (en) 1996-07-11 2000-05-09 Scimed Life Systems, Inc. Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties
US6368356B1 (en) 1996-07-11 2002-04-09 Scimed Life Systems, Inc. Medical devices comprising hydrogel polymers having improved mechanical properties
US20050090662A1 (en) * 1997-01-15 2005-04-28 Beavers Ellington M. Method of making free acids from polysaccharide salts
US6294170B1 (en) 1997-08-08 2001-09-25 Amgen Inc. Composition and method for treating inflammatory diseases
CA2285542C (en) * 1997-04-04 2007-07-17 Fidia Advanced Biopolymers Srl N-sulphated hyaluronic acid compounds, derivatives thereof and a process for their preparation
IT1291452B1 (it) 1997-04-14 1999-01-11 Fidia Advanced Biopolymers Srl Rivestimento a base di acido ialuronico e suoi derivati per la protezione di parti elettroniche da agenti esterni
US20060025328A1 (en) * 1997-05-28 2006-02-02 Burns Patrick J Compositions suitable for controlled release of the hormone GnRH and its analogs
IT1294797B1 (it) 1997-07-28 1999-04-15 Fidia Advanced Biopolymers Srl Uso dei derivati dell'acido ialuronico nella preparazione di biomateriali aventi attivita' emostatica fisica e tamponante
WO1999010385A1 (fr) 1997-08-22 1999-03-04 Denki Kagaku Kogyo Kabushiki Kaisha Gel d'acide hyaluronique, son procede de production et substance therapeutique le contenant
US6503527B1 (en) * 1997-11-17 2003-01-07 Haemacure Corporation Fibrin sealants or adhesives comprising a hyaluronic acid derivative material
ITPD980149A1 (it) 1998-06-17 1999-12-17 Fidia Advanced Biopolymers Srl Protesi tridimensionali comprendenti derivati dell'acido ialuronico per riparare o ricostruire i tessuti danneggiati e processo per la
US6630457B1 (en) 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
IT1303735B1 (it) * 1998-11-11 2001-02-23 Falorni Italia Farmaceutici S Acidi ialuronici reticolati e loro usi medici.
IT1303738B1 (it) * 1998-11-11 2001-02-23 Aquisitio S P A Processo di reticolazione di polisaccaridi carbossilati.
DE60036915T2 (de) 1999-01-13 2008-08-07 Alchemia Oncology Pty Ltd., Hawthorn Verwendung von hyaluronan zur herstellung eines medikaments zur erhöhung der wirksamkeit von zytotoxischen arzneimitteln
GB9902412D0 (en) * 1999-02-03 1999-03-24 Fermentech Med Ltd Process
IT1306644B1 (it) 1999-04-08 2001-10-02 Fidia Advanced Biopolymers Srl Strutture tridimensionali comprendenti derivati dell'acido ialuronicoottenibili mediante la tecnica antisolvente supercritico.
US6187822B1 (en) * 1999-06-11 2001-02-13 University Of Medicine & Dentistry Of Nj Wound treatment through inhibition of adenosine diphosphate ribosyl transferase
AU780363B2 (en) 1999-07-28 2005-03-17 United States Surgical Corporation Hyaluronic acid anti-adhesion barrier
US7279176B1 (en) 1999-09-02 2007-10-09 Rice University Nitric oxide-producing hydrogel materials
US7052711B2 (en) * 1999-09-02 2006-05-30 Rice University Nitric oxide-producing hydrogel materials
EP1223990B1 (en) * 1999-10-15 2004-07-28 Genetics Institute, LLC Formulations of hyaluronic acid for delivery of osteogenic proteins
EP1110971B1 (en) * 1999-12-14 2004-08-11 Kibun Food Chemifa Co., Ltd. Propylene glycol hyaluronate and agent for external use to skin using the same
DE60012866T2 (de) * 1999-12-14 2005-09-08 Kibun Food Chemifa Co., Ltd. Propylenglykolhyaluronat und äusserlich anzuwendendes Hautpflegemittel, das dieses enthält
US6710038B1 (en) 1999-12-14 2004-03-23 Kibun Food Chemifa Co., Ltd. Emulsification method using propylene glycol hyaluronate
WO2001072323A2 (en) * 2000-03-24 2001-10-04 Genentech, Inc. Use of insulin for the treatment of cartilagenous disorders
US9066919B2 (en) 2000-07-14 2015-06-30 Alchemia Oncology Pty Limited Hyaluronan as a chemo-sensitizer in the treatment of cancer
AUPQ879500A0 (en) 2000-07-14 2000-08-10 Meditech Research Limited Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease
WO2002015887A1 (en) * 2000-08-17 2002-02-28 Machines Industrielles Etablissements Consumable container
IT1317359B1 (it) * 2000-08-31 2003-06-16 Fidia Advanced Biopolymers Srl Polisaccaridi percarbossilati, quali l'acido ialuronico, processo perla loro preparazione e loro impiego in campo farmaceutico e
WO2002028366A2 (en) * 2000-10-06 2002-04-11 Durect Corporation Devices and methods for management of inflammation
AU2002239697A1 (en) * 2000-10-24 2002-06-03 Clear Solutions Biotech, Inc. Sodium hyaluronate microspheres
US6726898B2 (en) 2000-11-17 2004-04-27 Gary R. Jernberg Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease
US6576226B1 (en) 2000-11-17 2003-06-10 Gary R. Jernberg Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease
US6586493B1 (en) 2001-03-07 2003-07-01 Arizona Board Of Regents Arizona State University Polysaccharide-based hydrogels and pre-gel blends for the same
US20020192182A1 (en) * 2001-03-12 2002-12-19 Stephen Massia Polysaccharide-based polymerizable hydrogels
US6913765B2 (en) 2001-03-21 2005-07-05 Scimed Life Systems, Inc. Controlling resorption of bioresorbable medical implant material
US20030114061A1 (en) * 2001-12-13 2003-06-19 Kazuhisa Matsuda Adhesion preventive membrane, method of producing a collagen single strand, collagen nonwoven fabric and method and apparatus for producing the same
MXPA04011337A (es) * 2002-05-17 2005-07-01 Wyeth Corp Portadores de acido hialuronico solidos y susceptibles de ser inyectados para la liberacion de proteinas osteogenicas.
DE10223310A1 (de) * 2002-05-24 2003-12-11 Biotronik Mess & Therapieg Verfahren zum Beschichten von Implantaten mit einer Polysaccharid-Lage
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
KR100507545B1 (ko) * 2002-09-03 2005-08-09 주식회사 엘지생명과학 히알루론산 유도체 및 그의 제조방법
US7407672B2 (en) * 2002-11-04 2008-08-05 National Heart Center Composition derived from biological materials and method of use and preparation
CN1849142A (zh) 2002-11-15 2006-10-18 埃迪尼克斯(开曼)有限公司 2′-支链核苷和黄病毒突变
WO2004046200A1 (ja) * 2002-11-21 2004-06-03 Chugai Seiyaku Kabushiki Kaisha 薬物徐放担体
DK1575569T3 (da) * 2002-12-13 2011-01-10 Durect Corp Oralt indgivelsessystem omfattende flydende bærematerialer med høj viskositet
US20040185022A1 (en) * 2003-02-19 2004-09-23 Steven Rubin Regimen for acne treatment
US20040167480A1 (en) * 2003-02-21 2004-08-26 Advanced Medical Optics, Inc. Administration of multiple viscoelastic solutions with a multi-compartment syringe
WO2004081055A1 (ja) * 2003-02-21 2004-09-23 Terumo Kabushiki Kaisha 架橋性多糖誘導体、その製造方法、架橋性多糖組成物および医療用処置材
EP1628529A2 (en) 2003-05-30 2006-03-01 Nederlandse Organisatie voor Toegepast- Natuurwetenschappelijk Onderzoek Inducible release vehicles
DE10328815A1 (de) * 2003-06-21 2005-01-05 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Beschichtungssystem für Implantate zur Erhöhung der Gewebsverträglichkeit
JP2007500027A (ja) * 2003-07-30 2007-01-11 アンタイス エス.エイ. 生物医学的な使用のための複合マトリックス
US7783006B2 (en) * 2003-10-10 2010-08-24 Xoft, Inc. Radiation treatment using x-ray source
US20050080313A1 (en) * 2003-10-10 2005-04-14 Stewart Daren L. Applicator for radiation treatment of a cavity
GB2408741B (en) * 2003-12-04 2008-06-18 Ind Tech Res Inst Hyaluronic acid derivative with urethane linkage
US8313765B2 (en) * 2003-12-04 2012-11-20 Industrial Technology Research Institute Biodegradable hyaluronic acid derivative, biodegradable polymeric micelle composition and pharmaceutical or bioactive composition
US8124120B2 (en) 2003-12-22 2012-02-28 Anika Therapeutics, Inc. Crosslinked hyaluronic acid compositions for tissue augmentation
WO2005067889A1 (en) * 2003-12-30 2005-07-28 Durect Corporation Polymeric implants, preferably containing a mixture of peg and plg, for controlled release of active agents, preferably a gnrh
EP2497785B1 (en) 2004-01-07 2018-09-12 Seikagaku Corporation Hyaluronic acid derivative and drug containing the same
US20080241203A1 (en) * 2004-03-31 2008-10-02 Nipro Corporation Antiadhesive Kit, Process for Producing the Same and Method of Adhesion Prevention
US8293890B2 (en) * 2004-04-30 2012-10-23 Advanced Cardiovascular Systems, Inc. Hyaluronic acid based copolymers
CA2567532C (en) * 2004-05-20 2013-10-01 Mentor Corporation Methods for making injectable polymer hydrogels
EP1753787B1 (en) * 2004-05-20 2016-10-19 Mentor Worldwide LLC Method of covalently linking hyaluronan and chitosan
US7956180B2 (en) * 2004-05-27 2011-06-07 Novozymes A/S Dried and agglomerated hyaluronic acid product
WO2006004774A2 (en) * 2004-06-28 2006-01-12 Stanford University Laulimalide analogues as therapeutic agents
EP1896053B1 (en) 2004-07-06 2018-10-31 ZymoGenetics, Inc. Pharmaceutical composition comprising fgf18 and il-1 antagonist and method of use
ITMI20041373A1 (it) 2004-07-09 2004-10-09 Lima Lto S P A N-metil-ammidi di carbossimetilcellulosa acido alginico o carbossimetalamido
WO2006033698A2 (en) * 2004-07-12 2006-03-30 Isto Technologies, Inc. Tissue matrix system
US8512730B2 (en) * 2004-07-12 2013-08-20 Isto Technologies, Inc. Methods of tissue repair and compositions therefor
US7858107B2 (en) * 2004-09-10 2010-12-28 Medtronic Xomed, Inc. Flexible bioresorbable hemostatic packing and stent having a preselectable in-vivo residence time
EA014852B1 (ru) 2004-09-17 2011-02-28 Дьюрект Корпорейшн Система контролируемой доставки
PL1817347T3 (pl) 2004-11-24 2017-10-31 Albumedix As Sposób sieciowania kwasu hialuronowego za pomocą diwinylosulfonu
WO2006067608A1 (en) * 2004-12-22 2006-06-29 Laboratoire Medidom S.A. Aqueous formulations based on sodium hyaluronate for parenteral use
WO2006069578A1 (en) * 2004-12-30 2006-07-06 Novozymes Biopolymer A/S Hyaluronic acid linked with a polymer of an alpha hydroxy acid
GB0513552D0 (en) 2005-07-01 2005-08-10 Bristol Myers Squibb Co Bandage
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
JP5465431B2 (ja) 2005-07-27 2014-04-09 アルケミア オンコロジー ピーティーワイ リミテッド ヒアルロナンを用いる治療プロトコル
US8623354B2 (en) 2005-09-07 2014-01-07 Alchemia Oncology Pty Limited Therapeutic compositions comprising hyaluronan and therapeutic antibodies as well as methods of treatment
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
US8444968B2 (en) * 2005-12-07 2013-05-21 Isto Technologies, Inc. Cartilage repair methods
ES2643140T3 (es) * 2005-12-22 2017-11-21 Oakwood Laboratories L.L.C. Sistema de suministro de liberación lenta sublimable y procedimiento de realización del mismo
US20070280986A1 (en) * 2006-06-01 2007-12-06 Carlos Gil Intra-operative coating of implants
WO2008000260A1 (en) * 2006-06-28 2008-01-03 Novozymes Biopolymer A/S Compositions with several hyaluronic acid fractions for cosmetic and medical uses
AU2007295894B2 (en) 2006-09-13 2013-10-17 Enhance Skin Products, Inc. Cosmetic composition for the treatment of skin and methods thereof
PT2117521E (pt) 2006-11-03 2012-09-10 Durect Corp Sistemas de administração transdérmica que compreendem bupivacaína
EP1942117A1 (en) * 2006-12-29 2008-07-09 Sigea S.R.L. Derivatives of acid polysaccharides
EP3115038A1 (en) 2007-05-18 2017-01-11 DURECT Corporation Improved depot formulations
MX337286B (es) 2007-05-25 2016-02-22 Indivior Uk Ltd Formulaciones de transferencia sostenida de compuestos de risperidona.
WO2009019840A1 (ja) * 2007-08-09 2009-02-12 Kibun Food Chemifa Co., Ltd. ヒアルロン酸プロピレングリコールエステルおよびそれを用いた皮膚外用剤
AU2008347158B8 (en) 2007-12-06 2013-08-22 Durect Corporation Oral pharmaceutical dosage forms
EP2222715B1 (en) * 2007-12-19 2019-07-24 Evonik Degussa GmbH Crosslinked hyaluronic acid in emulsion
AU2009288118B2 (en) 2008-09-02 2014-12-11 Allergan, Inc. Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
IT1395392B1 (it) 2009-08-27 2012-09-14 Fidia Farmaceutici Geli viscoelastici come nuovi filler
US8273725B2 (en) * 2009-09-10 2012-09-25 Genzyme Corporation Stable hyaluronan/steroid formulation
EP2523672B1 (en) 2010-01-15 2016-07-13 Rutgers, the State University of New Jersey Use of vanadium compounds to accelerate bone healing
IL206739A (en) * 2010-06-30 2016-06-30 David Segal An injectable drug containing silitol as an active substance
TWI561535B (en) 2011-10-06 2016-12-11 Bvw Holding Ag Copolymers of hydrophobic and hydrophilic segments that reduce protein adsorption
WO2013055832A1 (en) * 2011-10-11 2013-04-18 Tautona Group Lp Threads of cross-linked hyaluronic acid and methods of use thereof
US9089574B2 (en) 2011-11-30 2015-07-28 Emory University Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections
FR2983483B1 (fr) 2011-12-02 2014-11-14 Vivacy Lab Procede de substitution et reticulation simultanees d'un polysaccharide via ses fonctions hydroxyles
US10245306B2 (en) 2012-11-16 2019-04-02 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
ITMI20130162A1 (it) * 2013-02-06 2014-08-07 Fidia Farmaceutici Derivati fotoreticolati di acido ialuronico, loro processo di preparazione ed impiego
US20140308352A1 (en) 2013-03-11 2014-10-16 Zogenix Inc. Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material
CN115804749A (zh) 2013-03-11 2023-03-17 度瑞公司 包含高粘度液体载体的可注射控制释放组合物
WO2014165113A1 (en) * 2013-03-12 2014-10-09 Allergan Holdings France S.A.S. Cross-linked hyaluronic acid threads for treatment of striae
CN105120659A (zh) 2013-03-15 2015-12-02 度瑞公司 用于降低溶解可变性的具有流变改性剂的组合物
US20140350518A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Syringe extrusion accessory
PT3613423T (pt) 2013-07-10 2022-12-07 Matrix Biology Inst Composições de hialuronano de elevada elasticidade e suas utilizações
CN103450368B (zh) * 2013-07-25 2014-05-07 山东福瑞达生物工程有限公司 一种硅烷化玻璃酸酯复合物的制备方法
US10265292B2 (en) * 2013-09-18 2019-04-23 The Werc Shop, LLC Terpene-based compositions, processes methodologies
WO2015112912A1 (en) 2014-01-27 2015-07-30 Allergan Holdings France S.A.S. Substance delivery device
US10472334B2 (en) 2014-03-14 2019-11-12 The University Of North Carolina At Chapel Hill Small molecules for inhibiting male fertility
US10029048B2 (en) 2014-05-13 2018-07-24 Allergan, Inc. High force injection devices
US10226585B2 (en) 2014-10-01 2019-03-12 Allergan, Inc. Devices for injection and dosing
US10179191B2 (en) 2014-10-09 2019-01-15 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
BR112017019272A2 (pt) 2015-03-10 2018-05-02 Allergan Pharmaceuticals Holdings Ireland Unlimited Company injetor de múltiplas agulhas
RU2582702C1 (ru) * 2015-08-19 2016-04-27 федеральное государственное бюджетное учреждение "Федеральный научно-исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации (ФГБУ "ФНИЦЭМ им. Н.Ф. Гамалеи" Минздрава России) Способ получения композиции на основе модифицированного гиалуроната натрия, композиция на основе модифицированного гиалуроната натрия и ее применение
JP6948716B2 (ja) 2015-09-24 2021-10-13 マトリックス バイオロジー インスティテュート 高弾性ヒアルロナン組成物およびその使用の方法
CN105418803A (zh) * 2015-12-30 2016-03-23 山东天晟生物科技有限公司 一种透明质酸的酯化方法
CA3020146A1 (en) 2016-04-08 2017-10-12 Allergan, Inc. Aspiration and injection device
CN105949478B (zh) * 2016-05-05 2021-10-01 宜昌东阳光生化制药有限公司 除去交联透明质酸中交联剂的方法
US10595977B2 (en) 2017-01-24 2020-03-24 Allergan Industrie, Sas Thread insertion devices
US10709444B2 (en) 2017-01-24 2020-07-14 Allergan Industrie Sas Thread insertion devices
US10820900B2 (en) 2017-01-24 2020-11-03 Allergan Industrie Sas Thread insertion devices
US10258447B2 (en) 2017-01-24 2019-04-16 Allergan Industrie Sas Thread insertion devices
US10265151B2 (en) 2017-01-24 2019-04-23 Allergan Industrie Sas Thread insertion devices
IT201700008651A1 (it) * 2017-01-26 2018-07-26 Beauty System Pharma Ltd Acido ialuronico reticolato con agenti reticolanti di tipo naturale o semisintetico
USD867582S1 (en) 2017-03-24 2019-11-19 Allergan, Inc. Syringe device
KR20220005465A (ko) * 2019-04-19 2022-01-13 조인테라퓨틱스 에스알엘 작용화된 히알루론산의 가교결합 중합체 및 염증 상태의 치료에서의 이의 용도
CN115666621A (zh) 2020-01-13 2023-01-31 度勒科特公司 具有减少的杂质的持续释放药物递送***及相关方法
IT202100012737A1 (it) 2021-05-18 2022-11-18 Jointherapeutics S R L Miscele di polisaccaridi e poliamminosaccaridi con proprietà reologiche migliorate
IT202100013787A1 (it) 2021-05-27 2022-11-27 Farmigea Spa Composizione per l’uso nel trattamento di affezioni oculari, quali sindrome dell’occhio secco, specialmente post-chirurgico oftalmico / a composition for use in the treatment of ocular affections, such as dry eye disease, especially after eye surgery
CN114085373B (zh) * 2021-12-09 2023-07-14 万华化学集团股份有限公司 一种透明质酸聚醚多元醇及其制备方法和应用
WO2023169949A1 (en) 2022-03-10 2023-09-14 Cmed Aesthetics S.R.L. Process for the preparation of sterile products

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3589364A (en) * 1968-03-14 1971-06-29 Buckeye Cellulose Corp Bibulous cellulosic fibers
US4280954A (en) * 1975-07-15 1981-07-28 Massachusetts Institute Of Technology Crosslinked collagen-mucopolysaccharide composite materials
US4060081A (en) * 1975-07-15 1977-11-29 Massachusetts Institute Of Technology Multilayer membrane useful as synthetic skin
US4141973A (en) * 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
DE2833138A1 (de) * 1978-07-28 1980-02-07 Bayer Ag Methylolierte mono- und oligosaccharide
US4303676A (en) * 1980-03-21 1981-12-01 Balazs Endre A Hyaluronate based compositions and cosmetic formulations containing same
FR2482603A1 (fr) * 1980-05-14 1981-11-20 Pharmindustrie Nouveaux esters d'heparine utilisables pour la preparation de medicaments, et procedes pour leur preparation
US4328803B1 (en) * 1980-10-20 1994-01-11 Opthalmic Systems, Inc. Opthalmological procedures
US4500676A (en) * 1983-12-15 1985-02-19 Biomatrix, Inc. Hyaluronate modified polymeric articles
US4487865A (en) * 1983-12-15 1984-12-11 Biomatrix, Inc. Polymeric articles modified with hyaluronate
JPS60130601A (ja) * 1983-12-15 1985-07-12 バイオマトリツクス,インコ−ポレイテツド ヒアルロン酸水不溶性組成物の製法
CA1238043A (en) * 1983-12-15 1988-06-14 Endre A. Balazs Water insoluble preparations of hyaluronic acid and processes therefor
CA1295796C (en) * 1984-03-27 1992-02-18 Conrad Whyne Biodegradable matrix and methods for producing same
US4716224A (en) * 1984-05-04 1987-12-29 Seikagaku Kogyo Co. Ltd. Crosslinked hyaluronic acid and its use
JP2501551B2 (ja) * 1984-05-04 1996-05-29 生化学工業 株式会社 架橋ヒアルロン酸
SE442820B (sv) * 1984-06-08 1986-02-03 Pharmacia Ab Gel av tverbunden hyaluronsyra for anvendning som glaskroppssubstitut
US4629623A (en) * 1984-06-11 1986-12-16 Biomatrix, Inc. Hyaluronate-poly (ethylene oxide) compositions and cosmetic formulations thereof
US4582865A (en) * 1984-12-06 1986-04-15 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US4605691A (en) * 1984-12-06 1986-08-12 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US4636524A (en) * 1984-12-06 1987-01-13 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
SE8501022L (sv) * 1985-03-01 1986-09-02 Pharmacia Ab Format alster och forfarande for dess framstellning
US4713448A (en) * 1985-03-12 1987-12-15 Biomatrix, Inc. Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues
US4851521A (en) * 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
DE3684887D1 (de) * 1985-11-29 1992-05-21 Biomatrix Inc Arzneistoffabgabesysteme auf basis von hyaluronan, dessen derivaten und salzen sowie verfahren zu deren herstellung.
GB8601100D0 (en) * 1986-01-17 1986-02-19 Cosmas Damian Ltd Drug delivery system
SE452469B (sv) * 1986-06-18 1987-11-30 Pharmacia Ab Material bestaende av en tverbunden karboxylgrupphaltig polysackarid och forfarande vid framstellning av detsamma
AU610512B2 (en) * 1986-12-11 1991-05-23 Biomatrix Incorporated Improved hyaluronate-poly (ethylene oxide) mixtures
US4795741A (en) * 1987-05-06 1989-01-03 Biomatrix, Inc. Compositions for therapeutic percutaneous embolization and the use thereof

Also Published As

Publication number Publication date
IT8648546A0 (it) 1986-10-13
DE3752176D1 (de) 1998-04-16
ATE163942T1 (de) 1998-03-15
AU7960087A (en) 1988-04-21
IL84032A (en) 1997-11-20
PT85908B (pt) 1990-08-31
HUT45734A (en) 1988-08-29
IE872618L (en) 1988-04-13
DE3752176T2 (de) 1998-10-29
IN170801B (it) 1992-05-23
DK536087D0 (da) 1987-10-13
PT85908A (en) 1987-11-01
AU610087B2 (en) 1991-05-16
CN1025035C (zh) 1994-06-15
FI96610B (fi) 1996-04-15
ZA877559B (en) 1988-04-13
NO874251D0 (no) 1987-10-12
AR247406A1 (es) 1994-12-29
PH26025A (en) 1992-01-29
CA1317287C (en) 1993-05-04
KR920002702B1 (ko) 1992-03-31
NO874251L (no) 1988-04-14
EP0265116A2 (en) 1988-04-27
NZ221994A (en) 1990-07-26
FI874504A (fi) 1988-04-14
CN87106919A (zh) 1988-08-24
EP0265116A3 (en) 1989-02-08
US4957744A (en) 1990-09-18
EP0265116B1 (en) 1998-03-11
FI96610C (fi) 1996-07-25
DK536087A (da) 1988-04-14
FI874504A0 (fi) 1987-10-13
NO175374C (no) 1994-10-05
JPS63105003A (ja) 1988-05-10
ES2115583T3 (es) 1998-07-01
KR880005155A (ko) 1988-06-28
JP2648308B2 (ja) 1997-08-27
NO175374B (no) 1994-06-27
HU204858B (en) 1992-02-28

Similar Documents

Publication Publication Date Title
IT1198449B (it) Esteri di alcoli polivalenti di acido ialuronico
IT1203814B (it) Esteri dell'acido alginico
IT8567584A0 (it) Procedimento per la produzione di esteri dell acido acrilico e metacrilico mediante esterificazione
IT1183674B (it) Procedimento di fermentazione per produrre acido ialuronico
IT8567583A0 (it) Procedimento per la produzione di esteri dell acido acrilico e metacrilico mediante esterificazione
IT1170727B (it) Processo per la preparazione di esteri dell'acido carbamico n-monosostituito
IT1076798B (it) Procedimento per la preparazione di acido pent-3-enico e di suoi esteri alchilici
IT1078033B (it) Processo per la preparazione di esteri dell'acido ossalico
IT1138104B (it) Produzione di esteri saccarosio-acidi grassi
IT8719085A0 (it) Procedimento per la produzione di esteri alchilici dell'acido tetracloro-2-cianbenzoico.
IT1200961B (it) Procedimento di preparazione di esteri dell acido apovincamminico
IT1148180B (it) Preparazione di esteri di acido carbossilico
IT1157325B (it) Esteri dell'acido antranilico
IT1134999B (it) Procedimento per preparare esteri alchilici di acidi c-alchil-tartronici o c-alogenoalchil-tartronici
IT7948720A0 (it) Procedimento per la produzione di tetraalchil esteri di acido ortosilicico
IT1163005B (it) Procedimento per la preparazione di esteri dell'acido vincaminico
IT1191210B (it) Procedimento per la preparazione di esteri dell acido alcossivincaminico e di esteri dell acido alcossia povincaminico
IT1142034B (it) Procedimento per la preparazione di esteri dell'acido
IT7949339A0 (it) Procedimento per la produzione di esteri di acido benzoico
IT1146707B (it) Procedimento per la preparazione di esteri dell acido apovincamminico
IT8421460A0 (it) Processo per la preparazione di esteri alchilici dell'acido metiltartronico.
IT7948270A0 (it) Procedimento per produrre esteri di acido 2 3 4 4-tetracloro-3butenoico
IT1102568B (it) Procedimento per la produzione di esteri di acido alfaformiletan-fosfonico
IT7867263A0 (it) Procedimento per la preparazione dell acido 2 4 4 clorobenzoil 2metilpropionico e di alcuni suoi esteri
IT1088881B (it) Processo per la preparazione di esteri dell'acido gliolico

Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19981002